检索结果-南通市图书馆

Cancer Communications 2024年第2期44卷 282-286页

作者： Bianca Cesaro Alessia Iaiza Fabio Piscopo Marco Tarullo Eleonora Cesari Dante Rotili Antonello Mai Alberto Diana michela Londero Luca Del Giacco Riccardo Masetti Alba Di Leone Chiara Naro Silvia Masciarelli Giulia Fontemaggi Claudio Sette Francesco Fazi Alessandro Fatica Department of Anatomical HistologicalForensic&Orthopedic SciencesSection of Histology&Medical EmbryologySapienza University of RomeRomeItaly Department of Biology and Biotechnologies“Charles Darwin” Sapienza University of RomeRomeItaly GSTeP Organoids Research Core Facility Fondazione Policlinico A.Gemelli Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)RomeItaly Department of Drug Chemistry and Technologies Sapienza University of RomeRomeItaly Pasteur Institute Cenci-Bolognetti FoundationSapienza University of RomeRomeItaly Department of BioSciences University of MilanMilanItaly Multidisciplinary Breast Center Dipartimento Scienze della Salute della Donna e del Bambino e di SanitàPubblicaCatholic University of the Sacred HeartRomeItaly Department of Neuroscience Section of Human AnatomyCatholic University of the Sacred HeartRomeItaly Oncogenomic and Epigenetic Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Dear Editor,N 6-methyladenosine(m^(6)A)is a critical mRNA modi-fication catalyzed by the enzyme methyltransferase-like 3(METTL3),with implications in RNA ***3 upregulation is associated with cancer progres-sion,metast... 详细信息

关键词： cancer methyltransferase metastasis

Dorsolateral prefrontal cortex, working memory and episodic memory processes: insight through transcranial magnetic stimulation techniques

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuroscience Bulletin 2013年第3期29卷 381-389页

作者： michela Balconi Laboratory of Cognitive Psychology Department of Psychology Catholic University of Sacred Heart

The ability to recall and recognize facts we experienced in the past is based on a complex mechanism in which several cerebral regions are implicated. Neuroimaging and lesion studies agree in identifying the frontal lobe as a crucial structure for memory processes, and in particular for working memory and episodic memory and their relationships. Furthermore, with the introduction of transcranial magnetic stimulation （TMS） a new way was proposed to investigate the relationships between brain correlates, memory functions and behavior. The aim of this review is to present the main findings that have emerged from experiments which used the TMS technique for memory analysis. They mainly focused on the role of the dorsolateral prefrontal cortex in memory process. Furthermore, we present state-of-the-art evidence supporting a possible use of TMS in the clinic. Specifically we focus on the treatment of memory deficits in depression and anxiety disorders.

关键词： transcranial magnetic stimulation dorsolateral prefrontal cortex memory working memory anxiety depression

Traces and echoes of De Architectura by Marcus Vitruvius Pollio in the work of Xu Guangqi in 17th century China

在线全文

学校读者我要写书评

暂无评论

Frontiers of Mechanical Engineering 2016年第1期11卷 3-11页

作者： michela CIGOLA Yibing FANG DART Laboratory of Documentation Analysis and Survey of Architecture and Territory University of Cassino and South LatiumCassino 03043 Italy Institute for the History of Natural Science Chinese Academy of Sciences

This study aims to investigate the role played by Xu Guangqi （1562-1633）, minister of the Ming Dynasty, in the development of European scientific and technical knowledge in China between the 16th and 17th centuries by analyzing a book of Western technology that he wrote, namely, Taixi Shuifa （On Western Hydraulics）. Several Western books related to machine knowledge are searched to trace the source of the illustrations in Taixi Shuifa. We found that Archimedes＇ screw and Ctesibius＇ machine, which are included in Vitruvius＇ De Architectura volumes, also appear in the work of Xu Guangqi.

关键词： Vitruvius' De Architectura Xu Guangqi'sTaixi Shuifa Jesuit missionaries Italian Renaissance,drawing representation

Estrogens still represent an attractive therapeutic approach for Alzheimer’s disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2022年第1期17卷 93-94页

作者： Elena Tamagno michela Guglielmotto Department of Neuroscience University of TorinoTorinoItaly(Tamagno EGuglielmotto M)Neuroscience Institute of Cavalieri Ottolenghi Foundation(NICO)University of TorinoTorinoItaly

Alzheimer’s disease(AD)is a progressive neurodegenerative condition that goes f rom mild cogni t ive impai rment in prodromal disease to severely disabling deficits in advanced *** risk for AD development,as well as progression and severity,clearly differ between men and women(Pike,2017).Epidemiological studies have shown that there is a significantly increased prevalence in the development of AD in women compared to men,which is usually explained by the longer lifespan of *** increased frequency may be due to the interplay between age and sex,in which genetic factors together with hormonal and metabolic patterns play a crucial ***,cognitive impairment has been confirmed to be greater in women than in men at the same stage of AD,likely due to reduced estrogen levels in postmenopausal women(Laws et al.,2016).

关键词： Alzheimer attractive therapeutic

Interpreting map usage patterns using geovisual analytics and spatiotemporal clustering

在线全文

学校读者我要写书评

暂无评论

International Journal of Digital Earth 2015年第8期8卷 599-622页

作者： Gavin McArdle Ali Tahir michela Bertolotto National Center for Geocomputation National University of IrelandMaynoothIreland Institute of Geographical Information Systems School of Civil and Environmental EngineeringNational University of Sciences and TechnologyIslamabadPakistan School of Computer Science and Informatics University College DublinDublinIreland

Extracting meaningful information from the growing quantity of spatial data is a *** issues are particularly evident with spatio-temporal data describing *** data typically corresponds to movement of humans,animals and machines in the physical *** article considers a special form of movement data generated through human–computer interactions with online web *** a user interacts with a web map using a mouse as a pointing tool,invisible trajectories are *** examining the spatial features on the map where the mouse cursor visits,a user’s interests and experience can be *** analyse this valuable information,we have developed a geovisual analysis tool which provides a rich insight into such user *** focus of this paper is on a clustering technique which we apply to mouse trajectories to group trajectories with similar behavioural *** experiments reveal that it is possible to identify experienced and novice users of web mapping environments using an incremental clustering *** results can be used to provide personalised map interfaces to users and provide appropriate interventions for completing spatial tasks.

关键词： geovisual analytics spatio-temporal clustering behavioural clustering map personalisation digital globe

MORTALITY AND FAME IN AKKADIAN TEXTS

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Ancient Civilizations 2018年第1期33卷 1-25页

作者： michela Piccin IHAC NENU

1. Introduction1Death, mankind’s unavoidable destiny, has been considered by humans from all eras and in all places, and our discomfort in dealing with death and dying connects us across historical and geographical divides.2 Following the example set by anthropologists, scholars in other fields have begun to realize the importance of studying the reactions of diferent civilizations to the eternal problem of death, both verbally and nonverbally. Among the classic studies on the subject, the work of Robert Hertz and Ernesto De Martino merits special mention.

关键词：死亡人文 mais

ASSYRIAN TREATIES: “PATCHWORK” TEXTS

在线全文

学校读者我要写书评

暂无评论

Journal of Ancient Civilizations 2020年第1期35卷 33-70,133,134页

作者： michela Piccin North-West University(NWU) SA

The article offers a linguistic and stylistic analysis of the Neo-Assyrian treaties culled from the SAA Ⅱ(1988).The analysis focuses on defining scribal procedures in building up the text,which may then be conclusively labelled as a“patchwork.”Proceeding through the preamble,list of witnesses,and content,I explore a range of sampling which demonstrates the substantially fixed-albeit expandable-structure of the treaties'texts.I argue that this evidence shows that the structure of the treaties’texts had a great communicative efficacy thanks to its standardized character,as well as facilitated the scribes’editorial *** fixed nature of these texts was also related to the principles of the legal tradition,which itself was adapted to the historical and political circumstances of the Neo-Assyrian period.

关键词： legal patch adapted

Heat Transfer,Knock Modeling and Cyclic Variability in a “Downsized”Spark-Ignition Turbocharged Engine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Advances in Applied Mathematics and Mechanics 2011年第3期3卷 310-326页

作者： Fabio Bozza Daniela Siano michela Costa Universita di Napoli “Federico II” DIMEVia Claudio 2180125 NapoliItaly Istituto Motori-CNR Viale Marconi 880125 NapoliItaly

In the present paper a combined procedure for the quasi-dimensional modelling of heat transfer,combustion and knock phenomena in a “downsized”Spark Ignition two-cylinder turbocharged engine is *** procedure is extended to also include the effects consequent the Cyclic *** transfer is modelled by means of a Finite Elements *** simulation is based on a fractal description of the flame front *** Variability(CV)is characterized through the introduction of a random variation on a number of parameters controlling the rate of heat release(air/fuel ratio,initial flame kernel duration and radius,laminar flame speed,turbulence intensity).The intensity of the random variation is specified in order to realize a Coefficient Of Variation(COV)of the Indicated Mean Effective Pressure(IMEP)similar to the one measured during an experimental ***,the relative importance of the various concurring effects is established on the overall COV.A kinetic scheme is then solved within the unburned gas zone,characterized by different thermodynamic conditions occurring *** this way,an optimal choice of the “knock-limited”spark advance is effected and compared with experimental ***,the CV effects on the occurrence of individual knocking cycles are assessed and discussed.

关键词： Finite elements in heat transfer internal combustion engines modelling cyclic variability knock

The Ins and Outs of the Rice AGAMOUS Subfamily

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2013年第3期6卷 650-664页

作者： Ludovico Dreni michela Osnato Martin M. Kater Department of Biosciences Università degli Studi di Milano via Celoria 26 20133 Milan Italy

Genes of the AGAMOUS subfamily have been shown to play crucial roles in reproductive organ identity determination, fruit, and seed development. They have been deeply studied in eudicot species and especially in Arabidopsis. Recently, the AGAMOUS subfamily of rice has been studied for their role in flower development and an enormous amount of data has been generated. In this review, we provide an overview of these data and discuss the conservation of gene functions between rice and Arabidopsis.

关键词： transcriptional control and transcription factors floral development reproductive biology Arabidopsis rice.

New drugs for the treatment of metastatic colorectal cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2021年第11期13卷 1551-1560页

作者： Sara Cherri michela Libertini Alberto Zaniboni Department of Oncology Fondazione PoliambulanzaBrescia 25124Italy

Colorectal cancer(CRC)represents one of the most frequent malignancies in terms of incidence and mortality,thus representing the third leading cause of cancer death *** the last decade,few drugs have enriched the treatment landscape of metastatic CRC and have significantly affected *** other neoplasms,metastatic CRC patients who have exhausted treatment options often still maintain a good performance *** are many challenges to increasing potential treatment options,notably a better understanding of disease biology and the mechanisms of resistance underlying cancer treatment *** development of new drugs for metastatic CRC certainly represents one of the most important challenges in medical *** article discusses the main limitations in the development of new drugs and potential future *** particular,we addressed three questions:(1)The main limitations of targeted therapy in the treatment of metastatic CRC(mCRC);(2)New target armamentarium that could escape primary and secondary resistance and lead to more personalized mCRC therapy;and(3)Future directions.

关键词： Colon cancer Colon rectal cancer New drugs Drug resistance Metastatic colorectal cancer