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Neuroretinal dysfunction in patients affected by neurofibromatosis type 1

International Journal of Ophthalmology(English edition) 2022年第5期15卷 773-779页

作者： Antonietta Moramarco Luca Lucchino Fabiana Mallone michela marcelli Ludovico Alisi Vincenzo Roberti Sandra Giustini Alessandro Lambiase Marcella Nebbioso Department of Sense Organs Sapienza University of RomePoliclinico Umberto IRome 00161Italy Department of Dermatology and Venereology Sapienza University of RomePoliclinico Umberto IRome 00161Italy

AIM:To examine neuroretinal function by using the multifocal electroretinography(mf ERG)test in patients with neurofibromatosis type 1(NF1)without optic pathway gliomas(OPGs).METHODS:This study was conducted on 35 patients(35 eyes)with NF1 and 30 healthy subjects(30 eyes)for the control *** subject underwent a complete ophthalmological examination including spectral domainoptical coherence tomography(SD-OCT)and mf *** 1.5-Tesla magnetic resonance imaging(MRI)scan of the brain was performed in NF1 patients to assess the presence of *** participants were recruited having a best corrected visual acuity(BCVA)of no less than 20/20 in each *** amplitude and implicit time of the P1 wave(first-order Kernel component)were evaluated on mf *** analysis was carried out in the two central degrees and in the four quadrants from two to 25 degrees of visual ***:Statistically significant results were obtained for the P1 wave amplitudes in the 4 quadrants in NF1 patients compared to healthy controls,while the reduction was not significant in the 2 central degrees between the groups.A statistically significant difference was observed among the P1 wave amplitudes as recorded in the 4 quadrants within the NF1 group,with lower amplitudes detected in the nasal *** differences in the implicit times were recorded in the 2 central degrees and in the 4 quadrants as compared between NF1 patients and ***:Impaired neuroretinal function in NF1 patients is expressed in a decreased amplitude of the P1-wave between 2 and 25 central retinal degrees on mf *** intracellular signal transduction due to abnormal neurofibromin-mediated cyclic adenosine monophosphate(c AMP)generation,can be *** possible use of mf ERG as subclinical retinal damage indicator has a potential utility in clinical practice for the follow-up of NF1 patients.

关键词： neurofibromatosis type 1 multifocal electroretinography neuroretinal function optic pathway gliomas neurofibromin

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Mitochondria replacement from transplanted amniotic fluid stem cells:a promising therapy for non-neuronal defects in spinal muscular atrophy

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Neural Regeneration Research 2024年第5期19卷 971-972页

作者： michela Pozzobon Camilla Bean Women’s and Children’s Health Department University of Padova Foundation Institute of Pediatric Research Cittàdella Speranza PadovaItaly Department of Medicine University of UdineUdineItaly

Spinal muscular atrophy(SMA)is a genetic disorder that primarily affects infants and leads to muscle weakness,atrophy,and *** main cause is the homozygous mutation or deletion of the SMN1 gene,resulting in inadequate levels of the survival motor neuron(SMN)*** treatments focus on restoring SMN levels through various approaches,but there is a need for“SMN-independent”therapies that target other pathological *** muscle is closely involved in SMA pathology,with impaired muscle function observed before motor neuron *** have revealed that SMN loss leads to skeletal muscle mitochondrial structural abnormalities,impaired respiration,and accumulation of reactive oxygen species.

关键词： impaired atrophy muscular

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Has the open surgical approach in colorectal cancer really become uncommon?

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1485-1492页

作者： Maria Cariati Giuseppe Brisinda Maria michela Chiarello Department of Surgery Azienda Sanitaria Provinciale di CrotoneCrotone 88900Italy Abdominal and Endocrine Metabolic Medical and Surgical Sciences Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Department of Surgery Azienda Sanitaria Provinciale di CosenzaCosenza 87100Italy

Colorectal cancer is the third most common cancer in the *** is man-datory to treat patients with colorectal *** colorectal cancer be treated in laparoscopy?Scientific literature has validated the oncological quality of laparo-scopic approach for the treatment of patients with colorectal *** non-inferiority trials with good remote control have answered positively to this long-debated *** as 1994,first publications demonstrated technical feasibility and compliance with oncological imperatives and,as far as short-term outcomes are concerned,there is no difference in terms of mortality and post-operative morbidity between open and minimally invasive surgical approaches,but only longer operating times at the beginning of the ***,from 2007 onwards,long-term results were published that demonstrated the ab-sence of a significant difference regarding overall survival,disease-free survival,quality of life,local and distant recurrence rates between open and minimally in-vasive *** this editorial,we aim to summarize the clinical and technical aspects which,even today,make the use of open surgery relevant and necessary in the treatment of patients with colorectal cancer.

关键词： Colorectal cancer Laparoscopy Laparoscopic colorectal resection Bowel obstruction Bowel perforation Advanced colorectal cancer

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How to identify early complications in patients undergoing distal gastrectomy?

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 974-981页

作者： Giuseppe Tropeano Maria michela Chiarello Valeria Fico Giuseppe Brisinda Emergency Surgery and Trauma Center Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy Department of Surgery Azienda Sanitaria Provinciale di CosenzaCosenza 87100Italy Department of Medical and Surgical Sciences UniversitàCattolica del Sacro CuoreRome 00168Italy

In this editorial we comment on the article by Zhang et al published in a recent issue of the World Journal of Gastrointestinal *** with appropriate lymph node dissection is still standard curative treatment in locally advanced gastric *** studies point out that gastric cancer surgery is a complex procedure that leads to a high risk of morbidity and *** factors can contribute to the onset of complications with consequent effects on prognosis and increased *** complications can be divided in complications related to anastomosis,to motility and to surgical site *** study presented by Zhang B et al represent an interesting analysis on the possibility to prevent postoperative *** study was performed on 131 patients with distal gastric cancer who underwent gastrectomy with D2 lymph node *** these patients,16%developed early postoperative *** univariate analysis showed that prealbumin level,hypertension,diabetes,history of abdominal surgery,R0 resection,and blood transfusion were factors influencing early postoperative complications after distal ***,the inclusion of the above significant variables in the logistic regression analysis revealed that hypertension,diabetes,a history of abdominal surgery,and blood transfusion were independent predictors of postoperative *** conclusion,preoperative and intraoperative factors can be used to establish an early postoperative nomogram *** results of the study presented by Zhang et al suggest that the prediction model can be used to guide the detection of postoperative complications and has clinical reference value.

关键词： Gastric cancer Gastrectomy Lymph node dissection Morbidity Mortality Surgical site infections

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Indocyanine green:The guide to safer and more effective surgery

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 641-649页

作者： Pietro Fransvea Maria michela Chiarello Valeria Fico Maria Cariati Giuseppe Brisinda Emergency Surgery and Trauma Center Fondazione Policlinico Universitario Agostino Gemelli IRCCSRome 00168Italy Department of Surgery Azienda Sanitaria Provinciale di CosenzaCosenza 87100Italy Department of Surgery Azienda Sanitaria Provinciale di CrotoneCrotone 88900Italy Department of Abdominal and Endocrine Metabolic Medical and Surgical Sciences Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy

In this editorial we comment on the article by Kalayarasan and co-workers published in the recent issue of the World Journal of Gastrointestinal *** authors present an interesting review on the use of indocyanine green fluo-rescence in different aspects of abdominal *** also highlight future perspectives of the use of indocyanine green in mini-invasive ***-cyanine green,used for fluorescence imaging,has been approved by the Food and Drug Administration and is safe for use in *** can be administered in-travenously or *** its advent,there have been several advance-ments in the applications of indocyanine green,especially in the surgical field,such as intraoperative mapping and biopsy of sentinel lymph node,measurement of hepatic function prior to resection,in neurosurgical cases to detect vascular anomalies,in cardiovascular cases for patency and assessment of vascular ab-normalities,in predicting healing following amputations,in helping visualization of hepatobiliary anatomy and blood vessels,in reconstructive surgery,to assess flap viability and for the evaluation of tissue perfusion following major trauma and *** these reasons,the intraoperative use of indocyanine green has become common in a variety of surgical specialties and transplant ***-lorectal surgery has just lately begun to adopt this technique,particularly for perfusion visualization to prevent anastomotic *** regular use of in-docyanine green coupled with fluorescence angiography has recently been pro-posed as a feasible tool to help improve patient *** the best available data,it has been shown that routine use of indocyanine green in colorectal surgery reduces the rates of anastomotic *** use of indocyanine green is proven to be safe,feasible,and effective in both elective and emergency ***,additional robust evidence from larger-scale,high-quality studies is essential before incorporating indocyanine g

关键词： Indocyanine green Colorectal surgery Fluorescence-guided surgery Gastrointestinal surgery Hepato-biliary surgery Pancreatic surgery Surgical oncology

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外推法导引及应用

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数学进展 2024年第1期53卷 13-40页

作者： Claude BREZINSKI michela REDIVO-ZAGLIA 保罗·潘勒韦实验室法国国家科学研究中心混合研究单位8524里尔大学法国里尔59655 帕多瓦大学意大利帕多瓦35122

在数值科学和应用科学中,人们经常需要考虑多种类型的序列:标量、向量、四元数、矩阵以及后来出现的张量.这些序列可能收敛,也可能发散.当它们收敛时,其收敛速度可能会非常缓慢,以至于其实际用途十分有限.在某些情况下,可以修改建立这... 详细信息

在数值科学和应用科学中,人们经常需要考虑多种类型的序列:标量、向量、四元数、矩阵以及后来出现的张量.这些序列可能收敛,也可能发散.当它们收敛时,其收敛速度可能会非常缓慢,以至于其实际用途十分有限.在某些情况下,可以修改建立这些序列的过程,但在其他情况下,这个过程是一个无法进入的黑箱.那么,规避这一困难的一个可行方法就是将序列变换成另一个序列,希望它能收敛到相同的极限,并且收敛得更快.这种序列变换背后的思想就是外推法.本文是关于这些方法中最重要的方法以及其理论基础和算法方面的导引.本文还介绍了一些应用.

关键词：外推法收敛加速序列变换安德森加速张量非线性方程吉布斯现象

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Enhancing sensitivity of triple-negative breast cancer to DNA-damaging therapy through chemical inhibition of the m6A methyltransferase METTL3

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Cancer Communications 2024年第2期44卷 282-286页

作者： Bianca Cesaro Alessia Iaiza Fabio Piscopo Marco Tarullo Eleonora Cesari Dante Rotili Antonello Mai Alberto Diana michela Londero Luca Del Giacco Riccardo Masetti Alba Di Leone Chiara Naro Silvia Masciarelli Giulia Fontemaggi Claudio Sette Francesco Fazi Alessandro Fatica Department of Anatomical HistologicalForensic&Orthopedic SciencesSection of Histology&Medical EmbryologySapienza University of RomeRomeItaly Department of Biology and Biotechnologies“Charles Darwin” Sapienza University of RomeRomeItaly GSTeP Organoids Research Core Facility Fondazione Policlinico A.Gemelli Istituto di Ricovero e Cura a Carattere Scientifico(IRCCS)RomeItaly Department of Drug Chemistry and Technologies Sapienza University of RomeRomeItaly Pasteur Institute Cenci-Bolognetti FoundationSapienza University of RomeRomeItaly Department of BioSciences University of MilanMilanItaly Multidisciplinary Breast Center Dipartimento Scienze della Salute della Donna e del Bambino e di SanitàPubblicaCatholic University of the Sacred HeartRomeItaly Department of Neuroscience Section of Human AnatomyCatholic University of the Sacred HeartRomeItaly Oncogenomic and Epigenetic Unit IRCCS Regina Elena National Cancer InstituteRomeItaly

Dear Editor,N 6-methyladenosine(m^(6)A)is a critical mRNA modi-fication catalyzed by the enzyme methyltransferase-like 3(METTL3),with implications in RNA ***3 upregulation is associated with cancer progres-sion,metast... 详细信息

关键词： cancer methyltransferase metastasis

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Estrogens still represent an attractive therapeutic approach for Alzheimer’s disease

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Neural Regeneration Research 2022年第1期17卷 93-94页

作者： Elena Tamagno michela Guglielmotto Department of Neuroscience University of TorinoTorinoItaly(Tamagno EGuglielmotto M)Neuroscience Institute of Cavalieri Ottolenghi Foundation(NICO)University of TorinoTorinoItaly

Alzheimer’s disease(AD)is a progressive neurodegenerative condition that goes f rom mild cogni t ive impai rment in prodromal disease to severely disabling deficits in advanced *** risk for AD development,as well as progression and severity,clearly differ between men and women(Pike,2017).Epidemiological studies have shown that there is a significantly increased prevalence in the development of AD in women compared to men,which is usually explained by the longer lifespan of *** increased frequency may be due to the interplay between age and sex,in which genetic factors together with hormonal and metabolic patterns play a crucial ***,cognitive impairment has been confirmed to be greater in women than in men at the same stage of AD,likely due to reduced estrogen levels in postmenopausal women(Laws et al.,2016).

关键词： Alzheimer attractive therapeutic

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Laboratory study of fracture initiation and propagation in Barre granite under fluid pressure at stress state close to failure

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第3期15卷 538-550页

作者： Bing Q.Li michela Casanova Herbert H.Einstein Department of Civil and Environmental Engineering Massachusetts Institute of TechnologyCambridgeUSA Department of Civil and Environmental Engineering Western UniversityLondonCanada School of Architecture Civil and Environmental EngineeringÉcole Polytechnique Fédérale de LausanneLausanneSwitzerland

Hydraulic fracturing is frequently used to increase the permeability of rock formations in energy extraction scenarios such as unconventional oil and gas extraction and enhanced geothermal systems(EGSs).The present study addresses uncertainties in the hydraulic fracturing process pertaining to EGSs in crystalline rock such as ***,there is debate in the literature on the mechanisms(*** and/or shear)by which these fractures initiate,propagate,and *** present experiments on Barre granite with pre-cut flaws where the material is loaded to high far-field stresses close to shear failure,and then the fluid pressure in the flaws is increased to move the Mohr’s circle to the left and observe the initiation and propagation of fractures using high-speed imaging and acoustic emissions(AEs).We find that the hydraulic fractures initiate as tensile microcracks at the flaw tips,and then propagate as a combination of tensile and shear *** focal mechanisms also show elevated levels of tensional microfracturing near the flaw tips during pressurization and final *** then consider a numerical model of the experimental setup,where we find that fractures are indeed likely to initiate at flaw tips in tension even at relatively high far-field stresses of 40 MPa where shear failure is generally expected.

关键词： Acoustic emission(AE) Hydraulic fracturing Enhanced geothermal system(EGS) Microseismicity

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Maize response to nitrogen and phosphorus starter fertilisation in mineral-fertilised or manured systems

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The Crop Journal 2023年第3期11卷 922-932页

作者： michela Battisti Barbara Moretti Massimo Blandino Carlo Grignani Laura Zavattaro Department of Agricultural Forest and Food SciencesUniversity of TurinLargo Braccini 2Grugliasco 10095TOItaly Department of Veterinary Sciences University of TurinLargo Braccini 2Grugliasco 10095TOItaly

Phosphorus(P)is an essential nutrient for maize production,but in temperate areas the P uptake during early growing stages can be limited due to low soil temperature,even though the soil was tested high in *** objective of this study was to assess the effects of nitrogen and phosphorous(NP)starter fertilisation during early growth stages and its carryover until maize harvest,in mineral-fertilised or manured systems.A field experiment was carried out in north-west Italy during the 2019 and 2020 growing *** trial compared sub-surface placement of NP(diammonium phosphate)or N alone(ammonium nitrate)in bands close to the maize seed furrows,in differing long-term(LT)fertilisation managements:two doses of urea(Min-L and Min-H),two doses of bovine slurry(Slu-L and Slu-H)or two doses of farmyard manure(Fym-L and Fym-H).The two rates,low(L)and high(H),corresponded to 170 and250 kg N ha^(-1)year^(-1) *** to N fertilisation,NP starter fertilisation improved early maize growth assessed by leaf area index(LAI)and shoot dry weight(SDW)in all *** effects differed between the two years(2019:LAI+63%,SDW+67%;2020:LAI+36%,SDW+38%),as 2019was cool during the first *** LAI and SDW values were confirmed at crop flowering in the mineral-fertilised systems *** shoot growth was enhanced by NP starter fertilisation,anthesis occurred 1 day earlier in all ***,a response to NP starter fertilisation at harvest was recorded in mineral-fertilised systems only(+1.3 and+3.2 t ha^(-1) in Min-L and Min-H,respectively).The uptake of P,used as a true indicator of soil nutrient availability,increased with increasing soil Olsen P until 39 mg kg^(-1).These results suggest that soil test thresholds should be revised for points above which P fertilisation should be suspended.

关键词： Long-term fertilisation Farmyard manure Bovine slurry Urea Diammonium phosphate

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