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Kinematics of whip spider pedipalps: a 3D comparative morpho-functional approach

Integrative Zoology 2022年第1期17卷 156-167页

作者： michel schmidt Roland R.MELZER Russell D.C.BICKNELL Bavarian State Collection of Zoology Bavarian Natural History CollectionsMunichGermany Department Biology II Ludwig-Maximilians-Universität MünchenMunichGermany GeoBio-Center Ludwig-Maximilians-Universität MünchenMunichGermany Palaeoscience Research Centre School of Environmental and Rural ScienceUniversity of New EnglandArmidaleAustralia

Amblypygi are tropical and subtropical ambush predators that use elongated,raptorial pedipalps for different *** pedipalp use in predation and courtship has been explored in videography in vivo analyses,kinematic ex vivo examination of these appendages has not been ***,we rectify this lack of data by using microCT scans to 3D-kinematically model the appendage morphology and the range of motion(ROM)of the joints for Damon medius and Heterophrynus *** illustrate the successful application of this technique to terrestrial euarthropods in determining the maximum ROM values for each pedipalp *** also note that,in life,these values would be lower due to motion restricting structures like tendons,arthrodial membranes,and *** further compare our maximum values obtained here with data from video-based motion *** ROM of each joint shows the greatest flexibility in the femur-tibia joint(140–150°),the lowest in the basitarsus-claw joint(35–40°).ROM in the tibia-basitarsus joint is markedly distinct(***:44°;***:105°).This disparity reflects how *** uses the joint in the capture basket,while *** uses the femur-tibia joint to form the capture *** further illustrate notable vertical motion of the *** pedipalp compared to *** difference reflects the retro-ventral trochanter apophysis of *** study opens the possibility to further whip spider kinematic *** of other taxa using this approach will result in a more comprehensive understanding of the ecological significance and ethological implications of this unique arachnid group.

关键词： 3D kinematic analyses Amblypygi arthropod joints Autodesk Maya Damon medius Heterophrynus elaphus range of motion analyses

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Predictors of long-term outcome in patients with biopsy proven inflammatory cardiomyopathy

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Journal of Geriatric Cardiology 2018年第5期15卷 363-371页

作者： Ohlow Marc-Alexander michel Christoph Ting-Hui Chen schmidt Andreas Saenger Joerg Lauer Bernward Brunelli michele Department of Cardiology Zentralklinik Bad Berka Germany Institute of Pathology Zentralklinik Bad Berka Germany Department of Cardiology Staedtisehes Klinikum Magdeburg Germany

Background The objective of this study was to identify prognostic indicators in patients with inflammatory cardiomyopathy （iCM） on endomyocardial biopsy （EMB）. Methods and results Between 2007 and 2011 all consecutive patients with diagnosed with iCM at EMB were retrospectively analyzed. The combined primary endpoint （EP）（1E°P） was cardiac death, aborted sudden cardiac death/appropriate implantable cardioverter defibrillator （ICD） shock, progressive heart failure requiring left venWicular assist device （LVAD） implantation and heart transplantation. 503 patients （mean age 58 ° 12 years, 73% male） were available for analysis. Genomes of cardiotrophic viruses were detected in 396 patients （79%） and immuno-histochemical signs of inflammation were present in 223 individuals （44%）. After 3.6 ° 2.4 years of follow-up, cardiac mortality was 3.0% （n = 14） and a total of 8.6% （n = 40） reached the primary endpoint. Independent predictors for the 1 °EP were： age 〉 50 years, presence and duration （〈 28 days） of symptomatic heart failure. A risk stratification approach based on the results of the multivariate analysis demonstrated that absence of signs and/or symptoms of congestive heart failure in younger （〈 50 years） patients with longer （〉 28 days） duration of disease appear to have an excellent prognosis with 100% survival and no events during follow-up The presence of all above mentioned independent risk factors results in an 1°EP occurrence of 35.9%. Conclusions Symptoms of heart fail- ure, short duration of disease, and older age are indicators of poor outcome in patients with iCM.

关键词： Endomyocardial biopsy Inflammatory cardiomyopathy Outcome

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Giant hepatic extra-gastrointestinal stromal tumor treated with cytoreductive surgery and adjuvant systemic therapy:A case report and review of literature

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World Journal of Gastrointestinal Surgery 2021年第3期13卷 315-322页

作者： michel Ribeiro Fernandes Caroline Lorenzoni Almeida Ghezzi Tomaz J M Grezzana-Filho Flávia Heinz Feier Ian Leipnitz Aljamir Duarte Chedid Carlos Thadeu schmidt Cerski Marcio Fernandes Chedid Cléber RositoPinto Kruel Department of Gastrointestinal Surgery and Transplantation Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007RSBrazil Division of Radiology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903RSBrazil Department of Pathology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-007RSBrazil

BACKGROUND Primary extra-gastrointestinal stromal tumors(E-GIST)of the liver are *** clinical presentation may range from asymptomatic to bleeding or manifestations of mass *** surgery followed by adjuvant therapy with imatinib is the standard of ***,under specific circumstances,a cytoreductive approach may represent a therapeutic *** describe herein the case of an 84-year-old woman who presented with a tender,protruding epigastric *** computed tomography scan revealed a large,heterogeneous mass located across segments III,IV,V,and VIII of the *** initial approach was transarterial embolization of the tumor,which elicited no appreciable *** the large size and central location of the tumor and the advanced age of the patient,non-anatomic complete resection was *** to substantial intraoperative bleeding and hemodynamic instability,only a near-complete resection could be *** and immunohistochemical staining confirmed the diagnosis of primary E-GIST of the *** the risk/benefit ratio for therapeutic options,debulking surgery may represent a strategy to control pain and prolong *** SUMMARY Here,we present a case report of a patient diagnosed with E-GIST primary of the liver,which was indicated a cytoreductive surgery and adjuvant therapy with *** E-GIST primary of the liver is a rare conditional,the treatment is with systemic therapy and total resection ***,a cytoreductive surgery will be necessary when a complete resection is no possible.

关键词： Extra-gastrointestinal stromal tumor Primary gastrointestinal stromal tumor of the liver Cytoreductive surgery Debulking surgery Case report

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Search for two-neutrino double-beta decay of^(136)Xe to the 0^(+)_(1)excited state of 136Ba with the complete EXO-200 dataset

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Chinese Physics C 2023年第10期47卷 1-9页

作者： S.Al Kharusi G.Anton I.Badhrees P.S.Barbeau D.Beck V.Belov T.Bhatta M.Breidenbach T.Brunner G.F.Cao W.R.Cen C.Chambers B.Cleveland M.Coon A.Craycraft T.Daniels L.Darroch S.J.Daugherty J.Davis S.Delaquis A.Der Mesrobian-Kabakian R.DeVoe J.Dilling A.Dolgolenko M.J.Dolinski J.Echevers W.Fairbank Jr. D.Fairbank J.Farine S.Feyzbakhsh P.Fierlinger Y.S.Fu D.Fudenberg P.Gautam R.Gornea G.Gratta C.Hall E.V.Hansen J.Hoessl P.Hufschmidt M.Hughes A.Iverson A.Jamil C.Jessiman M.J.Jewell A.Johnson A.Karelin L.J.Kaufman T.Koffas R.Krücken A.Kuchenkov K.S.Kumar Y.Lan A.Larson B.G.Lenardo D.S.Leonard G.S.Li S.Li Z.Li C.Licciardi Y.H.Lin R.MacLellan T.McElroy T.michel B.Mong D.C.Moore K.Murray O.Njoya O.Nusair A.Odian I.Ostrovskiy A.Perna A.Piepke A.Pocar F.Retière A.L.Robinson P.C.Rowson J.Runge S.schmidt D.Sinclair K.Skarpaas A.K.Soma V.Stekhanov M.Tarka S.Thibado J.Todd T.Tolba T.I.Totev R.Tsang B.Veenstra V.Veeraraghavan P.Vogel J.-L.Vuilleumier M.Wagenpfeil J.Watkins M.Weber L.J.Wen U.Wichoski G.Wrede S.X.Wu Q.Xia D.R.Yahne L.Yang Y.-R.Yen O.Ya.Zeldovich T.Ziegler 无 Physics Department McGill UniversityMontrealQuebec H3A 2T8Canada Erlangen Centre for Astroparticle Physics(ECAP) Friedrich-Alexander-University Erlangen-NürnbergErlangen 91058Germany Physics Department Carleton UniversityOttawaOntario K1S 5B6Canada Department of Physics Duke Universityand Triangle Universities Nuclear Laboratory(TUNL)DurhamNorth Carolina 27708USA Physics Department University of IllinoisUrbana-ChampaignIllinois 61801USA Institute for Theoretical and Experimental Physics named by A.I.Alikhanov of National Research Centre“Kurchatov Institute” Moscow 117218Russia Department of Physics University of South DakotaVermillionSouth Dakota 57069USA SLAC National Accelerator Laboratory Menlo ParkCalifornia 94025USA TRIUMF VancouverBritish Columbia V6T 2A3Canada Institute of High Energy Physics Beijing 100049China Department of Physics Laurentian UniversitySudburyOntario P3E 2C6Canada Physics Department Colorado State UniversityFort CollinsColorado 80523USA Department of Physics and Physical Oceanography University of North Carolina at WilmingtonWilmingtonNC 28403USA Physics Department and CEEM Indiana UniversityBloomingtonIndiana 47405USA Physics Department Stanford UniversityStanfordCalifornia 94305USA Department of Physics Drexel UniversityPhiladelphiaPennsylvania 19104USA Amherst Center for Fundamental Interactions and Physics Department University of MassachusettsAmherstMA 01003USA Technische Universität München Physikdepartment and Excellence Cluster UniverseGarching 80805Germany Physics Department University of MarylandCollege ParkMaryland 20742USA Department of Physics and Astronomy University of AlabamaTuscaloosaAlabama 35487USA Wright Laboratory Department of PhysicsYale UniversityNew HavenConnecticut 06511USA IBS Center for Underground Physics Daejeon 34126Korea Department of Physics and Astronomy Stony Brook UniversitySUNYStony BrookNew York 11794USA Kellogg Lab CaltechPasadenaCalifornia 91125USA LHEP Albert Einstein CenterUniversi

A new search for two-neutrino double-beta(2νββ)decay of^(136)Xe to the 0+1 excited state of 136Ba is performed with the full EXO-200 dataset.A deep learning-based convolutional neural network is used to discriminate signal from background *** detection efficiency is increased relative to previous searches by EXO-200 by more than a factor of *** the addition of the Phase II dataset taken with an upgraded detector,the median 90%confidence level half-life sensitivity of 2νββdecay to the 0+1 state of 136Ba is 2.9×10^(24)yr using a total^(136)Xe exposure of 234.1 kg *** statistically significant evidence for 2νββdecay to the 0^(+)_(1)state is observed,leading to a lower limit of T2ν1/2(0^(+)→0^(+)_(1))>1.4×10^(24)yr at 90%confidence level,improved by 70%relative to the current world's best constraint.

关键词： EXO-200 experiment neutrinoless double beta decay excited state

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Search for two-neutrino double-beta decay of 136Xe to the 01+excited state of136Ba with the complete EXO-200 dataset

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Chinese Physics C 2023年第10期47卷 5-13页

作者： S.Al Kharusi G.Anton I.Badhrees P.S.Barbeau D.Beck V.Belov T.Bhatta M.Breidenbach T.Brunner G.F.Cao W.R.Cen C.Chambers B.Cleveland M.Coon A.Craycraft T.Daniels L.Darroch S.J.Daugherty J.Davis S.Delaquis A.Der Mesrobian-Kabakian R.De Voe J.Dilling A.Dolgolenko M.J.Dolinski J.Echevers W.Fairbank Jr. D.Fairbank J.Farine S.Feyzbakhsh P.Fierlinger Y.S.Fu D.Fudenberg P.Gautam R.Gornea G.Gratta C.Hall E.V.Hansen J.Hoessl P.Hufschmidt M.Hughes A.Iverson A.Jamil C.Jessiman M.J.Jewell A.Johnson A.Karelin L.J.Kaufman T.Koffas R.Krücken A.Kuchenkov K.S.Kumar Y.Lan A.Larson B.G.Lenardo D.S.Leonard G.S.Li S.Li Z.Li C.Licciardi Y.H.Lin R.Mac Lellan T.Mc Elroy T.michel B.Mong D.C.Moore K.Murray O.Njoya O.Nusair A.Odian I.Ostrovskiy A.Perna A.Piepke A.Pocar F.Retière A.L.Robinson P.C.Rowson J.Runge S.schmidt D.Sinclair K.Skarpaas A.K.Soma V.Stekhanov M.Tarka S.Thibado J.Todd T.Tolba T.I.Totev R.Tsang B.Veenstra V.Veeraraghavan P.Vogel J.-L.Vuilleumier M.Wagenpfeil J.Watkins M.Weber L.J.Wen U.Wichoski G.Wrede S.X.Wu Q.Xia D.R.Yahne L.Yang Y.-R.Yen O.Ya.Zeldovich T.Ziegler EXO-200 Collaboration Physics Department McGill University Erlangen Centre for Astroparticle Physics (ECAP) Friedrich-Alexander-University Erlangen-Nürnberg Physics Department Carleton University King Abdulaziz City for Science and Technology Department of Physics Duke University and Triangle Universities Nuclear Laboratory (TUNL) Physics Department University of Illinois Institute for Theoretical and Experimental Physics named by A.I.Alikhanov of National Research Centre “Kurchatov Institute” a division of National Research Center “Kurchatov Institute” Department of Physics University of South Dakota Department of Physics and Astronomy University of Kentucky SLAC National Accelerator Laboratory TRIUMF Institute of High Energy Physics Witmem Technology Co. Ltd. Department of Physics Laurentian University Also at SNOLAB Physics Department Colorado State University Department of Physics and Physical Oceanography University of North Carolina at Wilmington Physics Department and CEEM Indiana University Carleton University Commissariat àl’Energie Atomique et auxénergies alternatives Physics Department Stanford University Department of Physics Drexel University University of California Amherst Center for Fundamental Interactions and Physics Department University of Massachusetts Technische Universit?t München Physikdepartment and Excellence Cluster Universe Qventus Department of Physics University of Virginia Physics Department University of Maryland Department of Physics at the University of California Department of Physics and Astronomy University of Alabama Wright Laboratory Department of Physics Yale University Department of Physics Princeton University IBS Center for Underground Physics Physics Department University of California SNOLAB Department of Physics and Astronomy Stony Brook University SUNY SCIPP University of California Institute for Experimental Physics Hamburg University Department of Physics and Astronomy Iowa State University Kellogg Lab Caltech LHEP Albert Einstein Center University of Ber

A new search for two-neutrino double-beta(2vββ) decay of136Xe to the 01+excited state of136Ba is performed with the full EXO-200 dataset.A deep learning-based convolutional neural network is used to discriminate signal from background *** detection efficiency is increased relative to previous searches by EXO-200 by more than a factor of *** the addition of the Phase Ⅱ dataset taken with an upgraded detector,the median 90%confidence level half-life sensitivity of 2vββ decay to the 01+state of136Ba is 2.9 × 1024yr using a total136Xe exposure of 234.1 kg *** statistically significant evidence for 2vββ decay to the 01+state is observed,leading to a lower limit of T1/22v(0+→01+)>1.4×1024yr at 90% confidence level,improved by 70% relative to the current world’s best constraint.

关键词： EXO-200 experiment neutrinoless double beta decay excited state

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