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Preservation of the Intercostobrachial Nerve during Axillary Dissection for Breast Cancer at the Surgical Oncology Unit of Cancer Department of Dakar University

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Advances in Breast Cancer Research 2022年第1期11卷 63-68页

作者： Sidy ka michel Auguste Mouelle Mohammed Ezzet Charfi Jaafar Thiam Souleymane Dieng Salif Balde Moustapha Dieng Ahmadou Dem Centre Hospitalier Universitaire Le Dantec Dakar Sénégal

The intercostobrachial nerve (ICBN) is responsible for the sensory innervation of a part of the inner side of the arm. Injury of the intercostobrachial nerve is a complication of axillary dissection during lymph node dissection. Objective: This study aimed to determine the effect of preservation of the intercostobrachial nerve on postoperative sensory disturbances. Methods: This is a prospective, single-center study which was carried out in 90 patients followed in the oncology department of the Aristide Le Dantec hospital in Dakar, suffering from breast cancer and having undergone breast surgery associated with axillary dissection, for a period of 6 months. The patients were divided into two groups depending on whether the intercostobrachial nerve (ICBN) was preserved or not. The two groups were compared in terms of the incidence of sensory disturbances. Results: Sixty patients without nerve preservation and 30 patients with nerve preservation were included in the study, i.e., 90 patients in total.

关键词： Axillary Dissection Intercostobrachial Nerve Pain Hypoesthesia

Paleoseismological Analysis Along the Astara Fault System(Talesh Mountain, North Iran)

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Acta Geologica Sinica(English Edition) 2017年第5期91卷 1553-1572页

作者： Amir BARZEGARI Manouchehr GHORASHI Hamid NAZARI michel FONTUGNE Mohammad A. SHOKRI Mohsen POURKERMANI Department of geology North Tehran Branch Islamic Azad University Tehran Iran Research institute for earth sciences geological survey of Iran PO Box 13185 1494 Tehran Iran Center des Faibles Radioactivites (CNRS-CEA) Avenue de la Terrasse.F.91198 Gif-sur-Ycette CedexFrance Geologicalsurvey of Iran PO Box 13185 1494 Tehran Iran

The Astara Fault System（AFS） is located in the northwest Alborz, east of Talesh Mountain（TM） and west of the South Caspian Basin（SCB）. The AFS is one of the basement rock faults in Iran that is heavily involved in seismotectonic activity of the Talesh region, and to which subsidence of the SCB is attributed. There is little information available concerning previous AFS seismic activities and its properties. In order to elucidate the seismic behavior and activities of the AFS, we conducted a research study on paleoseismology of the fault. Based on paleoseismic evidence, two scenarios could be taken into consideration, one of which has three and another has four seismic events with magnitudes Mw in the range of 6.7 to 7.2. Evidence of these seismic events is within sedimentary succession as they have occurred during the past 3 ka（this age is determined based on the deposition rate of the region）. Six carbon samples were taken for C^14 age determination tests, the results of which clearly demonstrated that the EvIV（scenario A） and EvⅢ（scenario B） had occurred before 27,444 cal BP, while other events occurred in the time period between 27,444 cal BP and 3 ka ago. If we consider the occurrence of three or four seismic events（based on the two scenarios） to be between 27,444 cal BP and 3 ka ago, the average recurrence interval is 7,119 ± 1,017, but evidence for these events has been removed. If we assume EvI to be the youngest event（in both scenarios）, the minimum elapsed time is therefore 3 ka.

关键词： Paleoseismology morphotectonic active fault Astara fault system Iran

Diabetes and cognitive function:An evidence-based current perspective

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World Journal of Diabetes 2023年第2期14卷 92-109页

作者： Meghna Julian Sebastian Shahanas ka Khan Joseph M Pappachan Mohammad Sadiq Jeeyavudeen School of Life Sciences Keele UniversityStoke-on-Trent ST55BGUnited Kingdom Department of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PLUnited Kingdom Department of Endocrinology and Metabolism University Hospitals of EdinburghEdinburgh EH164SAUnited Kingdom

Several epidemiological studies have clearly identified diabetes mellitus(DM)as a major risk factor for cognitive dysfunction,and it is going to be a major public health issue in the coming years because of the alarming rise in diabetes prevalence across the *** and neural tissues predominantly depend on glucose as energy substrate and hence,any alterations in carbohydrate metabolism can directly impact on cerebral functional output including cognition,executive capacity,and *** affects neuronal function and mental capacity in several ways,some of which include hypoperfusion of the brain tissues from cerebrovascular disease,diabetes-related alterations of glucose transporters causing abnormalities in neuronal glucose uptake and metabolism,local hyper-and hypometabolism of brain areas from insulin resistance,and recurrent hypoglycemic episodes inherent to pharmacotherapy of diabetes resulting in neuronal *** decline can further worsen diabetes care as DM is a disease largely self-managed by ***,it is crucial to understand the pathobiology of cognitive dysfunction in relation to DM and its management for optimal long-term care plan for patients.A thorough appraisal of normal metabolic characteristics of the brain,how alterations in neural metabolism affects cognition,the diagnostic algorithm for patients with diabetes and dementia,and the management and prognosis of patients when they have this dangerous combination of illnesses is imperative in this *** evidence-based narrative with the backup of latest clinical trial reviews elaborates the current understanding on diabetes and cognitive function to empower physicians to manage their patients in day-to-day clinical practice.

关键词： Diabetes mellitus Dementia Cognitive function Antidiabetic medications Hyperglycemia Hypoglycemia

Morbi Infectious Mortality of Diabetics Hospitalized at the Medical Clinic of Abass Ndao Health Center

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Open Journal of Endocrine and Metabolic Diseases 2018年第1期8卷 1-8页

作者： Djiby Sow Demba Diédhiou Ibrahima Mané Diallo michel Assane Ndour Mahecor Diouf Marie ka-Cissé Anna Sarr Maimouna Ndour-Mbaye Clinique Médicale II Centre Hospitalier Abass Ndao (UCAD) Dakar Senegal Medical Clinic of Abass Ndao Health Center Cheikh Anta Diop University Dakar Senegal

Introduction: Diabetes is a public health problem and is exposed to some complications, particularly infectious. The work on this entity remains segmentary in Africa. The objective was to describe the morbi infectious mortality of the diabetics at the Medical Clinic II of Abass Ndao Health Center of Dakar. Patients and Methods: This was a cross-sectional, descriptive and analytical study conducted from 01 January 2016 to 31 December 2016. It covered patients with diabetes hospitalized during the study period. Epidemiological data and infectious diseases were evaluated. Results: During the study period, 346 diabetics have respected the inclusion criteria. These were 165 men (47.68%), a sex ratio of 0.91. The mean age was 56.17 years. The age group of [60 - 69 years] accounted for 31.5% and 95.6% of the patients came from the Dakar region. The average age of diabetes was 10.31. Diabetes had been evolving for less than 5 years in 25.15% of patients and inaugural in 11.46%. About 82.36% of our patients had type 2 diabetes. The acute complications of diabetes were ketoacidosis (51.89%), hyperosmolar hyperglycemia (0.58%), and hypoglycemia (1.45%). The mean infections were the skin and soft tissues (54.91%), urogenital infections (16.18%), respiratory infections (14.45%), malaria (3.46), infections of the skin and soft tissues were dominated by the diabetic foot (41.90%). The 125 non-diabetic patients developed 38 infectious pathologies, the main ones being respiratory infections (24.32%), infections of the skin and soft parts (24.32%). HIV infection was observed in 0.28% of diabetics and 8.10% of non-diabetic patients. 93 patients died (15.70%). Fifty-one of them died of infectious diseases (54.8%), 42 non-infectious diseases (45.16%), and subjects aged over 60 years, representing 72.54%. The means of consultation was 30 days. The highest rates of lethality were diabetes (37.41%), acute gastroenteritis (17.64%), and acute pyelonephritis (12.5%). The lethality rates of in

关键词： Morbimortality Diabetes Infection Senegal

The Knowledge, Attitudes and Practices of Diabetics on Physical Activity at the Marc Sankale Center of Dakar

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Open Journal of Internal Medicine 2018年第1期8卷 33-41页

作者： Sow Djiby Diédhiou Demba Ndour michel Assane Diallo Ibrahima Mané Diouf Mahecor ka-Cissé Marie Sarr Anna Ndour Mbaye Maimouna Clinique Médicale II Centre Hospitalier Abass Ndao UCAD Dakar

Introduction: The objective of that study was to evaluate diabetics knowledge, attitudes and practices on physical activity. Patients and Methods: That study has concerned 200 diabetics at Marc Sankale antidiabetic Center of Abass Ndao Hospital in Dakar. Women represent 76% with a sex ratio M: F0.13. The average age is 54 years with extremes of 4 to 84 years. The housewives are 29% and among them 15% haven’t any professional activity. 45.07% of the population is illiterate. In our study, 63.13% of patients have low socio economic level. In our series, the majority of patients is type 2 diabetes (89.5%). The diabetes evolution time is about 8 years inferior to 7% in 84 patients. In our study obesity is noted in 17.20% of cases. The HTA is present in 56% of cases. 54% of the studied population presents a dyslipidemia. Physical activity is practiced in 81% of patients. In our study the doctor’ advice motivates the half of our patients to practice physical activity (62.26%). The lack of time (43.2%) and volution (8.1%), the useless character of physical activity (2.7%) and the patients’ health state 45.9% are the obstacles to the practice of physical activity. The average frequency of physical activity practiced by patients is about 4 times a week with extremes ranging from 1 to 7 stages a week. The average time of activity practiced by patients is 39.72% with extremes ranging from 10 to 150 mn. 87% of patients practice physical activity at least 3 times a week. The main risks noted from intense physical activity in diabetics are hypertension 39.0%, ortestic hypertension 3.0%. In the contrary 58.8% of patients ignore the answer. Conclusion: Our study demonstrates the ignorance of diabetics on physical activity. Therefore it would be necessary to reinforce the training mainly therapeutic education in the patients taken into account.

关键词： Diabetes Mellitus Risk Factor Knowledge Physical Activity Senegal

Prevalence of Microalbuminury and Associated Risk Factors in a Population of Diabetics Followed at the Marc Sankale Center of Dakar

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Open Journal of Internal Medicine 2018年第1期8卷 24-32页

Introduction: To describe the epidemiologic profile, clinical and paraclinical of diabetics presenting microalbuminuria at Marc Sankale center. Patients and methods: We have done cross-sectional and retrospective study in a descriptive and analytic view or way. It happened within 6 months. Diabetic patients who performed the nycthemeral urinary albumin dose and mentioned in the file were included. The last study is considered as a positive one from 30 to 299mg/24h: Microalbuminuria. The creatinine has been noted and the clearing of the creatinine is calculated through the formula of Cockcroft and Gault. The statistical analysis of data has been done thanks to software such as excel 2013 and SPSS VER 18.0. Results: 221 patients have been noted with 70% women and 30% men. The age varied between 30 years and 85 years with an average of 56, 62 against 9.97 years. Sixty three (63) patients have microalbuminuria (29%);creatinine has been regularized to 25 patients with 14.8% of cases. Among the microalbuminuria patients having completed the creatinine, 32 patients (42.7%) and 16 (21.3%) are respectively in a state of chronical renal failure, light and moderated. Conclusion: The microalbuminuria is frequent to diabetics. But in our series a starting renal insufficiency could precede that microalbuminuria.

关键词： Diabetics Microalbuminuria Renal Insufficiency Senegal

Evolution of Graves’s Disease: Impact of Socio-Demographic and Clinical Factors in Senegalese Subject

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Open Journal of Internal Medicine 2020年第2期10卷 160-170页

作者： Djiba Boundia Diedhiou Demba Sow Djiby Ndour michel Assane Diallo Ibrahima Mané Barrage Ahmed Limane ka-Cissé Mariama Sarr Anna Ndour-Mbaye Maimouna Department of Internal Medicine II University Hospital Center of Dakar Cheikh Anta Diop University Dakar Senegal Department of Internal Medicine I University Hospital Center of Dakar Cheikh Anta Diop University Dakar Senegal

Background: In Graves’s disease, there is a lack of description specific to the gender and age among sub-Saharan African subject. The objective was to evaluate the impact of gender and age on the profile of Graves’ disease in Senegalese subject in order to understand the evolution and improve the therapeutic choices. Methods: This is a retrospective study conducted from January 1, 2010 to December 31, 2017 (07 years) at Abass Ndao University Hospital (Senegal), focused on patients with Graves’ disease followed up under antithyroid drugs treatment for at least 18 months. Results: There were 244 men, 404 subjects between [0 - 25 years], and 101 subjects more than 50 years old. Factors associated with goitre size were male gender (p Conclusion: In our Senegalese study, men and young patients are particularized by a trend of voluminous goitre and low rate of remission. These data remain a basis for predicting the outcome of medical treatment and make timely use of radical treatments such as surgery or irratherapy in the presence of risk factors for recurrence.

关键词： Graves’s Disease Profile Gender Age Senegal

Epidemiological, Clinical, Paraclinical and Evolutionary Aspects of Urinary Tract Infection in Diabetics Hospitalized at the Department of Medicine of Abass Ndao Hospital from January 01, 2018, to December 31, 2018

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Advances in Infectious Diseases 2022年第2期12卷 203-215页

作者： Ndeye Fatou Ngom Djiby Sow Demba Diedhiou michel Assane Ndour Cheikh Tacko Diop Fulgence Abdou Faye Ousseynou ka Anna Sarr Maimouna Ndour Mbaye Department of Medicine Faculty of Health and Sustainable Development Alioune Diop University of Bambey Bambey Senegal Faculty of Medicine Cheikh Anta Diop University Dakar Senegal Internal Medicine Department Abass Ndao Hospital Dakar Senegal Department of Community Health Faculty of the Health and Sustainable Development Alioune Diop University of Bambey Bambey Senegal

Introduction: Urinary tract infection (UTI) is a major public health problem because of its morbidity and mortality. It occurs with increased frequency during diabetes. The objective of this work was to study the frequency and etiologies of urinary tract infections in diabetics hospitalized at the department of medicine of Abass Ndao Hospital. Patients and Methods: This work was a cross-sectional, descriptive, and analytical study conducted from January 01, 2018, to December 31, 2018. It focused on hospitalized diabetic patients with urinary tract infection. Epidemiological, clinical, and evolutionary data of UTI were evaluated. Results: One hundred and twenty-eight (128) diabetic patients had a cytobacteriological urine exam (CUE). 44 of who had a positive CUE (34.4%). The age group [60 - 69] years was the most represented (31.8%). Women predominated (61.4%) with a sex ratio (m/f) of 0.63. Abdominal pain was the most frequent reason for consultation, followed by polydipsia. Fever was recorded in 21 patients (47.7%). Type 2 diabetes was found in most patients (70.5%). Glycemia above 2g/l was found in 34 patients (89.5%). Anemia accounted for more than half of the patients with 29 cases (65.9%). Leukocytosis was noted in 28 patients (63.6%) and a positive CRP in 33 patients (75%). An increase in urea-creatinine was noted in 23 cases (52.3%). The results of the CUE revealed Escherichia coli as predominant (43.2%, n = 19), followed by Candida with 22.7% (n = 10). Antibiotic therapy was given to all patients. The mostly used antibiotic in the treatment of UTI was Cefotaxime 27.3% (n = 12). Older age and female gender were associated with the presence of E. coli. Four (4) deaths were recorded (9%). They were all male over the age of 65. Conclusion: UTI in diabetes is an important cause of morbidity and mortality. The development and implementation of a prevention and management program are essential.

关键词： Urinary Tract Infection Diabetes Risk Factors Mortality Senegal

Knowledge, Attitudes and Practices (K.A.P) of Pharmacy Pharmacists of the Department of Dakar in the Care of Diabetics

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Journal of Diabetes Mellitus 2019年第3期9卷 113-125页

作者： Diallo Ibrahima Mane Diédhiou Demba Sow Djiby Ndour michel Assane Aissatou Camara Ahmet Limane Barrage M. ka-Cissé Sarr Anna Ndour-Mbaye Maimouna Clinique Médicale II Centre Hospitalier Abass Ndao UCAD Dakar Senegal

Aim: To evaluate the attitude practice and knowledge of pharmacists in the management of diabetes in the department of Dakar. Methodology: Cross-sectional study, conducted from 01 March to 30 September 2017 including all pharmacists in the Dakar region who agreed to participate in the survey. Data was collected through a pre-established questionnaire. Results: A total of 144 pharmacists were included in the study, representing a participation rate of 87.58%. The average age was 33.90 years, with a sex ratio of 1.69. Pharmacists were single in 50.88% of cases, and a minimum experience of 5 years was found in 64.03% of cases. Pharmacist assistants accounted for 57.9% of our study population. The assessment of knowledge based on 16 items shows an average score of 9.02. The level of knowledge was low to insufficient in 37.21% of cases, average in (50%) half of cases and good for (13.16%). Less than half (34.21%) of pharmacists had received training and the average date of last training was 33.76 ± 24.6 months. Training was provided by medical representatives and academics in 66.66% and 26.67% respectively. The most felt positive feelings were respectively the need for help, the compassion in respectively 98.42%, 42.11%. Feelings felt and simultaneously cited were: need for help and compassion in more than 40% of respondents. Only 29% of pharmacists did not have a lot of difficulty with patient questions and the only reason was the lack of awareness (84.68%) of patients about their disease. Screening for diabetes by capillary blood glucose was performed by 57% of pharmacists. Dietary advice (76.15%) and referral to the hospital (94.41%) were the most common practices in case of blood sugar disruption. The dialogue with patients was impossible in 22.81% of pharmacists and the main reasons given were lack of time (53.85%) and lack of knowledge (34.62%). The method of delivery of insulin was done on: medical prescription (98.25%), presentation of the box (69.30%), on reques

关键词： Management Pharmacist Diabetes Dakar