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Matrix metalloproteinase 13,a new target for therapy in Alzheimer’s disease

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Genes & Diseases 2019年第1期6卷 1-2页

作者： Jean-michel Paumier Gopal Thinakaran Departments of Neurobiology Neurologyand PathologyThe University of ChicagoChicagoIL60637USA

Alzheimer’s disease(AD),the most common neurodegenerative disorder,affects millions of people *** a recent publication,Guo-Jun Chen and colleagues highlight the role of matrix metalloproteinase(MMP)13(also called Collagenase 3)in AD pathogenesis through regulating BACE1,1 a rate-limiting enzyme for b-amyloid(Ab)peptide production.2 Proteolytic processing of amyloid precursor protein(APP)by BACE1 and g-secretase generates Ab,which accumulate in brain senile plaques in AD.3 MMPs are a group of enzymes that degrade extracellular matrix and cleave proteins involved in signal transduction.

关键词： Alzheimer’s disease BACE1 eIF4B MMP MMP13 PI3K signaling

Assessment of ship maneuvering simulation with different propeller models

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Journal of Hydrodynamics 2022年第3期34卷 422-433页

作者： Ganbo Deng Patrick Queutey Jeroen Wackers michel Visonneau Emmanuel Guilmineau Alban Leroyer LHEEA Lab Ecole Centrale de NantesNantesFrance

This paper is devoted to the assessment of ship maneuvering simulation using different propeller models with the focus on a simplified propeller model that represents the action of the propeller by body force and uses propeller performance curve to determine propeller loading during ship *** are also performed with an actual propeller approach with which the propeller rotation is simulated directly with the Reynolds averaged Navier-Stokes equation(RANSE)*** time accurate simulations using sliding grid and rotating frame approximations have been performed for *** zigzag and turning circle maneuvers in calm water have been simulated for two different ship models,namely the ONR tumblehome(ONRT)test case and the KRISO(Korea Research Institute of Ship and Ocean)Container Ship(KCS)test *** ship motion is compared with measurement data to assess the accuracy of the numerical prediction using RANSE computations with different propeller models.

关键词： Ship zigzag and turning circle motion simplified propeller model with body force actual propeller approach

Structural analysis of rubble-pile asteroids applied to collisional evolution

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Astrodynamics 2017年第1期1卷 57-69页

作者： Yang Yu Derek CRichardson Patrick michel School of Aeronautic Science and Technology Beihang UniversityBeijing 100191China Department of Astronomy University of MarylandCollege Park MD 20740-2421USA Observatoire de la Cote d'Azur UMR 7293 Lagrange/CNRS06304 Nice Cedex 4France

Solar system small bodies come in a wide variety of shapes and sizes,which are achieved following very individual evolutional paths through billions of ***,some common mechanisms can still be found during these processes,e.g.,rubble-pile asteroids tend towards fluid equilibrium as they are reshaped by external *** paper focuses on the reshaping process of rubble-pile asteroids driven by meteorite impacts.A mesoscale cluster of solid spheres is employed as the principal model for a rubble-pile asteroid,for which little is actually known about their interior *** take this simple model as a rough guide to the qualitative aspects of the reshaping processes,and it can reveal,to some degree,the inner workings of rubble-pile *** our study,numerous possible equilibrium configurations are obtained via Monte Carlo simulation,and the structural stability of these configurations is determined via eigen analysis of the geometric *** eigen decomposition reveals a connection between the cluster’s reactions and the types of external *** simulations are performed to verify the analytical *** gravitational N-body code pkdgrav is used to mimic the responses of the cluster under intermittent non-dispersive *** statistically confirm that the stability index I S,the total gravitational potential P G,and the volume of inertia ellipsoid V E show consistent tendency of variation.A common regime is found in which the clusters tend towards crystallization under intermittent impacts,i.e.,only the configurations with high structural stability survive under the external *** results suggest the trivial non-disruptive impacts might play an important role in the rearrangement of the constituent blocks,which may strengthen these rubble piles and help to build a robust structure under impacts of similar *** final part of this study consists of systematic simulations over two parameters

关键词： asteroids interior structure geological processes N-body simulations gravitational aggregates meteorite impacts

Development and application of an interface constitutive model for fully grouted rock-bolts and cable-bolts

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第4期13卷 811-819页

作者： Emad Jahangir Laura Blanco-Martin Faouzi Hadj-Hassen michel Tijani MINES ParisTech PSL Research UniversityDepartment of Geosciences35 Rue Saint Honoré77300FontainebleauFrance

This paper proposes a new interface constitutive model for fully grouted rock-bolts and cable-bolts based on pull-out test results.A database was created combining published experimental data with in-house *** means of a comprehensive framework,a Coulomb-type failure criterion accounting for friction mobilization was *** the elastic phase,in which the interface joint is not yet created,the proposed model provides zero radial displacement,and once the interface joint is created,interface dilatancy is modeled using a non-associated plastic potential inspired from the behavior of rock *** results predicted by the proposed model are in good agreement with experimental *** model has been implemented in a finite element method(FEM)code and numerical simulations have been performed at the elementary and the structural *** results obtained provide confidence in the ability of the new model to assist in the design and optimization of bolting patterns.

关键词： Fully grouted bolts Interface constitutive model Dilatancy Pull-out tests Finite element method(FEM)modeling

Electrolyte and anode-electrolyte interphase in solid-state lithium metal polymer batteries:A perspective

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SusMat 2021年第1期1卷 24-37页

作者： Heng Zhang Yuhui Chen Chunmei Li michel Armand Key Laboratory of Material Chemistry for Energy Conversion and Storage(Ministry of Education) School of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhanP.R.China State Key Laboratory of Materials-Oriented Chemical Engineering School of EnergyNanjing Tech UniversityNanjingJiangsuP.R.China Centre for Cooperative Research on Alternative Energies(CIC energiGUNE) Basque Research and Technology Alliance(BRTA)GipuzkoaSpain

The interest for solid-state lithium metal(Li◦)batteries(SSLMBs)has been growing exponentially in recent years in view of their higher energy density and eliminated safety *** polymer electrolytes(SPEs)are soft ionic conductors which can be easily processed into thin films at industrial level;these unique features confer solid-state Li◦polymer batteries(SSLMPBs,i.e.,SSLMBs utilizing SPEs as electrolytes)distinct advantages compared to SSLMBs containing other *** this article,we briefly review recent progresses and achievements in SSLMPBs including the improvement of ionic conductivity of SPEs and their interfacial stability with Li◦***,we outline several advanced in-situ and ex-situ characterizing techniques which could assist in-depth understanding of the anode-electrolyte interphases in *** article is hoped not only to update the state-of-the-art in the research on SSLMPBs but also to bring intriguing insights that could improve the fundamental properties(e.g.,transport,dendrite formation,and growth,etc.)and electrochemical performance of SSLMPBs.

关键词： anode-electrolyte interphase solid polymer electrolytes solid-state batteries solid-state lithium metal polymer batteries

STUDYING THE IDENTIFIABILITY OF EPIDEMIOLOGICAL MODELS USING MCMC

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International Journal of Biomathematics 2013年第2期6卷 155-172页

作者： ANTTISOLONEN HEIKKI HAARIO JEAN michel TCHUENCHE HERIETH RWEZAURA Department of Mathematics and Physics Lappeenranta University of TechnologyP. O. Box 20 53851 Lappeenranta Finland Department of Mathematics University of Dar es Salaam P. O. Box 35062 Dares Salaam Tanzania

Studying different theoretical properties of epidemiological models has been widely addressed, while numerical studies and especially the calibration of models, which are often complicated and loaded with a high number of unknown parameters, against mea- sured data have received less attention. In this paper, we describe how a combination of simulated data and Markov Chain Monte Carlo （MCMC） methods can be used to study the identifiability of model parameters with different type of measurements. Three known models are used as case studies to illustrate the importance of parameter identi- fiability： a basic SIR model, an influenza model with vaccination and treatment and a HIV-Malaria co-infection model. The analysis reveals that calibration of complex models commonly studied in mathematical epidemiology, such as the HIV Malaria co-dynamics model, can be difficult or impossible, even if the system would be fully observed. The pre- sented approach provides a tool for design and optimization of real-life field campaigns of collecting data, as well as for model selection.

关键词： Epidemiology compartmental models MCMC parameter estimation.

LUCE:A blockchain-based data sharing platform for monitoring data License accoUntability and CompliancE

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Blockchain(Research and Applications) 2022年第4期3卷 123-132页

作者： Visara Urovi Vikas Jaiman Arno Angerer michel Dumontier Institute of Data Science(IDS) Maastricht University6200 MD Maastrichtthe Netherlands School of Business and Economics Maastricht University6200 MD Maastrichtthe Netherlands

Easy access to data is one of the main avenues to accelerate scientific *** a key element of scientific innovations,data sharing allows the reproduction of results and helps prevent data fabrication,falsification,and *** the research benefits from data reuse are widely acknowledged,the data collections existing today are still kept in ***,monitoring what happens to data once they have been handed to a third party is currently not feasible within the current data sharing *** propose a blockchain-based system to trace data collections and potentially create a more trustworthy data sharing *** this paper,we present the LUCE(License accoUntability and CompliancE)architecture as a decentralized blockchain-based platform supporting data sharing and *** is designed to provide full transparency on what happens to the data after they are shared with third *** contributions of this work consist of i)the design of a decentralized data sharing solution with accountability and compliance by design and ii)the inclusion of a dynamic consent model for personalized data sharing preferences and for enabling legal compliance *** test the scalability of the platform in a real-time environment where a growing number of users access and reuse different *** to existing data sharing solutions,LUCE provides transparency over data sharing practices,enables data reuse,and supports regulatory *** experimentation shows that the platform can be scaled for a large number of users.

关键词： Blockchain Distributed ledgers Data sharing Data reuse Dataset tracking GDPR

Dynamic Regulation of DELLA Protein Activity： SPINDLY and SECRET AGENT Unmasked!

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Molecular Plant 2017年第6期10卷 785-787页

作者： Lucie Camut Jean-michel Daviere Patrick Achard Institut de biologie moleculaire des plantes CNRS Universite de Strasbourg 12 rue du General Zimmer 67084 Strasbourg Cedex France

Plants are sessile organisms that integrate growth responses to multiple endogenous and environmental signals. The DELLA family of transcription regulators, first identified as key repressors of gibberellin （GA） signaling, have emerged as a central node of integration, thus providing a mechanism for environmentally responsive growth regulation （Oh et al., 2014）.

关键词： Dynamic Regulation DELLA Protein Activity SECRET AGENT Unmasked

Monitoring stress and recovery states: Structural and external stages of the short version of the RESTQ sport in elite swimmers before championships

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Journal of Sport and Health Science 2019年第1期8卷 77-88页

作者： michel Nicolas Philippe Vacher Guillaume Martinent Laurent Mourot Laboratory of Socio Psychology and Management of Sport (SPMS EA 4180) University of Burgundy Laboratory of Vulnerabilities and Innovation in Sport (L-ViS EA 7428) Univ Lyon University of Claude Bernard Lyon 1 University of Franche Comt-Prognostic Markers and Regulatory Factors of Heart and Vascular Diseases and Exercise Performance Health Innovation Platform

Background: Psychological stress and recovery monitoring is a key issue for increasing athletes' health, well-being, and performance. This multistudy report examined changes and the doseàresponse relationships between recoveryàstress psychological states, training load(TL), heart rate(HR), heart rate recovery(HRR), and heart rate variability(HRV) while providing evidence for the factorial validity of a short French version of the RecoveryàStress Questionnaire for Athletes(RESTQ-36-R-Sport).Methods: Four hundred and seventy-three university athletes(Study 1), 72 full expert swimmers(Study 2), and 11 national to international swimmers(Study 3) participated in the study. Data were analyzed through confirmatory factor analyses(Study 1), repeated ANOVAs and correlational analyses(Study 2), t tests and correlational analyses(Study 3).Results: Multiple-group confirmatory factor analyses showed that the RESTQ-36-R-Sport scores were partially invariant across gender, type of sport, and practice level(Study 1). A doseàresponse relationship was performed between TL and RESTQ-36-R-Sport scores during an ecological training program(Study 2). Finally, relationships were found between physiological(HRR) and psychological(RESTQ-36-R-Sport) states during an ecological tapering period leading to a national championship(Study 3).Conclusion: As a whole, these findings provided evidence for the usefulness of the short version of the RESTQ-36-R-Sport for regular monitoring to prevent potential maladaptation due to intensive competitive sport practice.

关键词： Adaptation Confirmatory factor analysis Heart rate variability Monitoring Recovery Stress