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Evaluation of the diuretic effects of crude stem bark extraction of Zanthoxylum heitzii(Rutaceae) in Wistar rats

Journal of Integrative Medicine 2015年第5期13卷 326-335页

作者： Fidèle Ntchapda Maguirgue Kakesse michel archange tagne fokam Olivier Mbouemboue Pancha Djedouboum Abakar Théophile Dimo Department of Biological Sciences Faculty of Science University of Ngaoundéré Cameroon Department of Biomedical Sciences Faculty of Science University of Ngaoundéré Cameroon Department of Animal Biology and Physiology Faculty of Science University of Yaoundé I

OBJECTIVE： Zanthoxylum heitzii is a medicinal plant widely used in central Africa for the treatment of many diseases, especially cardiovascular diseases and hypertension. The diuretic effects of crude stern bark extraction were determined and its safety in rats was evaluated. METHODS： The diuretic effects of crude stem bark extraction of Z. heitzii were investigated in Wistar rats （250 g ＋ 10 g） of both sexes. The crude stem bark extraction of Z. heitzii at the doses of 225, 300 and 375 mg/kg was administered to rats at 5 mL/kg body weight. Urine volume was determined 1, 2, 3, 4, 5, 6 and 24 h after administration of the extract. Kinetics of electrolyte elimination in response to a single oral administration dose of acute treatment was measured. The experiments were performed under the same conditions with two synthetic pharmacological diuretics considered as reference （furosemide and hydrochlorothiazide）. Urinary and plasma concentrations of sodium and potassium ions were determined using flame photometry. Concentrations of creatinine, urea, glucose, albumin and electrolytes in the plasma and urine samples were evaluated using a two-way digital bidirectional spectrophotometer. The osmolarity of plasma and urine samples was measured by cytometry using an osmometer. Aldosterone was measured by radioimmunoassay. RESULTS： The plant extract accelerated the elimination of overloaded fluid and increased urine volume and the excretion of Na＋, K＋ and CI 24 h after administration （P〈0.05）. The increase in elimination of Na＋, K＋, and Cl- induced by the extract caused alkalinization of the urine, and showed a strong inhibitory effect on carbonic anhydrase and saluretic. These effects were mainly observed at the dose of 375 mg/kg. At the maximum diuretic response, urinary osmolarity decreased significantly （P 〈 0.05） when compared to controls. The stability of aldosterone level, the absence of correlation with the plasma levels of Na＋, and increased clearance of free water in t

关键词： Zanthoxylum heitzii diuretic urine volume urine pH electrolytes temperature rectal

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Antioxidant activity of dichloromethane fraction of Dichrocephala integrifolia in Salmonella typhi-infected rats

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Journal of Integrative Medicine 2019年第6期17卷 438-445页

作者： Gaetan Olivier Fankem michel archange fokam tagne Paul Aime Noubissi Angèle Foyet Fondjo Idrice Kamtchouing Adela Ngwewondo Henri Wambe Joseph Ngakou Mukam Rene Kamgang Animal Physiology Laboratory Faculty of ScienceUniversity of YaoundéI237Cameroon Department of Biological Science Faculty of ScienceUniversity of Ngaoundéré237Cameroon Department of Zoology and Animal Physiology Faculty of ScienceUniversity of Buea237Cameroon Department of Applied Sciences for Health Higher Institute of Applied SciencesUniversity Institute of Gulf of Guinea237Cameroon Laboratory of Endocrinology and Radioisotopes Institute of Medical Research and Medicinal Plants Studies(IMPM)Yaoundé237Cameroon Department of Biological Science Faculty of ScienceUniversity of Dschang237Cameroon

Objective: Infectious diseases such as typhoid fever lead to the formation of free radicals which can damage the body. Many medicinal plants have antioxidant molecules that neutralize free radicals. The present work evaluated the antioxidant activity and histopathological effects of the dichloromethane fraction of Dichrocephala integrifolia in Salmonella typhi-infected ***: The S. typhi-infected rats concurrently received daily doses of D. integrifolia extract at doses of 25, 50 and 100 mg/kg body weight or ciprofloxacin(5 mg/kg body weight) for 15 days. Body temperature was measured daily during infection and treatment periods. At the end of treatment period, the animals were sacrificed and biological responses including hematological parameters, superoxide dismutase and catalase activities, and glutathione, malondialdehyde and nitric oxide concentrations were ***: The elevated body temperature induced by infection was significantly decreased in animals treated with 25, 50 or 100 mg/kg of the extract. Platelet levels decreased slightly in infected rats, while treatment with the dichloromethane fraction of D. integrifolia significantly increased platelet levels;this response was greater than that elicited by ciprofloxacin. The doses of 50 and 100 mg/kg of the dichloromethane fraction of D. integrifolia notably decreased monocyte and neutrophil values. Activity of superoxide dismutase and catalase and levels of glutathione in the tissues of treated animals were increased significantly(P < 0.01), while malondialdehyde and nitric oxide levels were significantly decreased(P < 0.01), following treatment with the dichloromethane fraction of D. ***: The results of this study show that the dichloromethane fraction of D. integrifolia has protective effects against a series of pathological conditions initiated by oxidation and tissue damage in the course of a S. typhi infection.

关键词： Typhoid fever Salmonella typhi Dichrocephala integrifolia Antioxidant stress Hematology

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