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A phase 1 open-label pilot study of low-dose interleukine-2 immunotherapy in patients with Alzheimer’s disease

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Translational Neurodegeneration 2023年第1期12卷 130-133页

作者： Alireza faridar Abdulmunaim M.Eid Aaron D.Thome Weihua Zhao David R.beers Maria B.Pascual Mohammad O.Nakawah Gustavo C.Roman Charles S.Davis Michael Grundman Joseph C.Masdeu Stanley H.Appel Department of Neurology Houston Methodist Research Institute6565 Fannin StreetSuite P3-201HoustonTXUSA CSD Biostatistics Inc.Oro ValleyAZUSA Global R&D Partners LLCSan DiegoCAUSA University of California San Diego San DiegoCAUSA

Regulatory T cells(Tregs)constitute a subset of T cells that play a protective role by suppressing inflammation[1].We previously documented that the Treg immu-nomodulatory mechanisms are compromised in AD patients[2],resulting in an activation of peripheral monocytes,associated with upregulation of inflamma-tory mediators[3].Preclinical studies have suggested variable effects of Treg modification on the neurode-generative *** some studies propose that the Treg population might obstruct a selective gateway for immune cell trafficking to the CNS,thereby compromis-ing reparative immune responses[4,5],an increasing number of preclinical studies,including ours,indicate that systemic Treg expansion through interleukine-2(IL-2)administration or ex vivo expanded Treg administra-tion effectively modulates neuroinflammation and allevi-ates AD pathology[6,7].IL-2,originally described as the main T-cell growth factor,has been used in standard high doses for activation of cytotoxic T cells and NK cells[8].

关键词： inflammation patients doses

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防止老年人用药危险的指南

国外医学（老年医学分册） 1989年第5期10卷 211-213页

作者： beers MH Ouslander JG 郑年新

老年人中药源性疾病是医师面临的一个重要问题。本文介绍避免老年人用药危险的有关问题。多药合用问题不良反应的危险随着用药数量的增多而增加。北美老年人平均每年开13张处方药,明显的不良反应发生率平均为4％。波士顿协作组表明,每1... 详细信息

老年人中药源性疾病是医师面临的一个重要问题。本文介绍避免老年人用药危险的有关问题。多药合用问题不良反应的危险随着用药数量的增多而增加。北美老年人平均每年开13张处方药,明显的不良反应发生率平均为4％。波士顿协作组表明,每1000人中有1人死于药物不良反应。北美平均65岁的住院患者中有10％是由于药物中毒所致。老年人常常让多个医生看病,而每个医生都开药,老年人不懂得何时停药。

关键词：老年人药源性疾病用药

fixing the reference frame for PPMXL proper motions using extragalactic sources

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Research in Astronomy and Astrophysics 2015年第6期15卷 849-859页

作者： Kathleen Grabowski Jeffrey L. Carlin Heidi Jo Newberg Timothy C. beers Li Chen Li-Cai Deng Carl J. Grillmair Puragra Guhathakurta Jin-Liang Hou Yong-Hui Hou Se'bastien Le'pine Chao Liu Xiao-Wei Liu A-Li Luo Martin C. Smith Brian Yanny Hao-Tong Zhang Yong Zhang Zheng Zheng Department of Physics Applied Physics and Astronomy Rensselaer Polytechnic Institute 110 8th Street Troy NY 12180 USA Department of Physics and JINA: Joint Institute for Nuclear Astrophysics University of Notre Dame 225 Nieuwland Science Hall Notre Dame IN 46556 USA Shanghai Astronomical Observatory Key Lab of Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Spitzer Science Center 1200 E. California Blvd. Pasadena CA 91125 USA UCO/Lick Observatory Department of Astronomy and Astrophysics University of CaliforniaSanta Cruz CA 95064 USA Nanjing Institute of Astronomical Optics & Technology National Astronomical ObservatoriesChinese Academy of Sciences Department of Physics and Astronomy Georgia State University 25 Park Place Suite 605Atlanta GA 30303 USA Kavli Institute for Astronomy and Astrophysics Peking University Department of Astronomy Peking University fermi National Accelerator Laboratory P.O. Box 500 Batavia IL 60510 USA Department of Physics and Astronomy University of Utah

We quantify and correct systematic errors in PPMXL proper motions using extragalactic sources from the first two LAMOST data releases and the Vbron-Cetty ＆ Vebron Catalog of Quasars. Although the majority of the sources are from the Veron catalog, LAMOST makes important contributions in regions that are not well-sampled by previous catalogs, particularly at low Galactic latitudes and in the south Galactic cap. We show that quasars in PPMXL have measurable and significant proper motions, which reflect the systematic zero-point offsets present in the catalog. We confirm the global proper motion shifts seen by Wu et al., and additionally find smaller-scale fluctuations of the QSO-derived corrections to an absolute frame. We average the proper motions of 158 106 extragalactic objects in bins of 3° ×3° and present a table of proper motion corrections.

关键词： catalogs -- proper motions -- surveys LAMOST

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仔猪断奶综合征的发病机理及防制(上)

国外畜牧科技 1993年第3期20卷 38-40页

作者： H.M.G.van beers-Schreurs 严汝南

仔猪断奶综合征包括:断奶后腹泻(PWD)、水肿病(OD)和内毒素休克(ES)。讨论肠道不同致病性大肠杆菌的作用、仔猪断奶综合征(PWS)的诱发因素、预防 PWS的措施及研究方向。

关键词：猪病仔猪断奶综合征病理防制

LAMOST Experiment for Galactic Understanding and Exploration (LEGUE)——The survey's science plan

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Research in Astronomy and Astrophysics 2012年第7期12卷 735-754页

作者： Li-Cai Deng Heidi Jo Newberg Chao Liu Jeffrey L. Carlin Timothy C. beers Li Chen Hsu-Tai Lee Carl J. Grillmair Puragra Guhathakurta] Zhan-Wen Han Jin-Liang Hou Sebastien Lepine Jing Li Xiao-Wei Liu Kai-Ke Pan J. A. Sellwood Bo Wang Hong-Chi Wang fan Yang Brian Yanny Hao-Tong Zhang Yue-Yang Zhang Zheng Zheng Zi Zhu Key Lab for Optical Astronomy National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China licai@*** Department of Physics Applied Physics and Astronomy Rensselaer Polytechnic Institute 1108th Street Troy NY 12180 USA National Optical Astronomy Observatory Tucson AZ 85719 USA Shanghai Astronomical Observatory Chinese Academy of Sciences Shanghai 200030 China Institute of Astronomy and Astrophysics Academia Sinica EO. Box 23-141 Taipei 106 China University of Heidelberg Landessternwarte K6nigstuhl 12 D-69117 Heidelberg Germany Spitzer Science Center 1200 E. California Blvd. Pasadena CA 91125 USA Department of Astronomy and Astrophysics University of California Santa Cruz 1156 HighStreet Santa Cruz CA 95064 USA Yunnan Astronomical Observatory Chinese Academy of Sciences Kunming 650011 China American Museum of Natural History Central Park West at 79th Street New York NY 10024USA School of Physics and Electronic Information China West Normal University Nanchong637000 China ' Department of Astronomy & Kavli Institute of Astronomy and Astrophysics Peking University Beijing 100871 China Apache Point Observatory PO Box 59 Sunspot NM 88349 USA Department of Physics and Astronomy Rutgers University 136 Frelinghuysen RoadPiscataway NJ 08854-8019 USA Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China fermi National Accelerator Laboratory Batavia IL 60510 USA Department of Physics and Astronomy University of Utah Salt Lake City UT 84112 USA School of Astronomy and Space Science Nanjing University Nanjing 210008 China

We describe the current plans for a spectroscopic survey of millions of stars in the Milky Way galaxy using the Guo Shou Jing Telescope （GSJT, formerly calledthe Large sky Area Multi-Object fiber Spectroscopic Telescope -- LAMOST）. The survey will obtain spectra for 2.5 million stars brighter than r 〈 19 during dark/grey time, and 5 million stars brighter than r 〈 17 or J 〈 16 on nights that are moonlit or have low transparency. The survey will begin in the fall of 2012, and will run for at least four years. The telescope＇s design constrains the optimal declination range for observations to 10~ 〈 di 〈 50~, and site conditions lead to an emphasis on stars in the direction of the Galactic anticenter. The survey is divided into three parts with different target selection strategies： disk, anticenter, and spheroid. The resulting dataset will be used to study the merger history of the Milky Way, the substructure and evolution of the disks, the nature of the first generation of stars through identification of the lowest metallicity stars, and star formation through study of open clusters and OB associations. Detailed design of the LAMOST Experiment for Galactic Understanding and Exploration （LEGUE） survey will be completed in summer 2012, after a review of the results of the pilot survey.

关键词： techniques: spectroscopic -Galaxy: structure - Galaxy: evolution -Galaxy: kinematics and dynamics -- Galaxy: disk -- Galaxy: halo -- spectroscopy

An algorithm for preferential selection of spectroscopic targets in LEGUE

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Research in Astronomy and Astrophysics 2012年第7期12卷 755-771页

作者： Jeffrey L. Carlin Sebastien Lepine Heidi Jo Newberg Li-Cai Deng Timothy C. beers Yu-Qin Chen Norbert Christlie Xiao-Ting fu Shuang Gao Carl J. Grillmair PuragraGuhathakurta Zhan-Wen Han Jin-Liang Hou Hsu-Tai Lee Jing Li Chao Liu Xiao-Wei Liu Kai-Ke Pan J. A. Sellwood Hong-Chi Wang fan Yang Brian Yanny Yue-Yang Zhan Zheng Zheng Zi Zhu Department of Physics Applied Physics and Astronomy Rensselaer Polytechnic Institute 110 8th Street Troy NY 12180 USA carlij@rpi.edu Department of Astrophysics American Museum of Natural History Central Park West at 79thStreet New York NY 10024 USA City University of New York 365 Fifth Avenue New York NY 10016 USA National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China National Optical Astronomy Observatory Tucson AZ 85719 USA Center for Astronomy University of Heidelberg Landesstemwarte Ktinigstuhl 12 D-69117Heidelberg Germany Spitzer Science Center 1200 E. California Blvd. Pasadena CA 91125 USA JCO/Lick Observatory Department of Astronomy and Astrophysics University of CaliforniaSanta Cruz CA 95064 USA Yunnan Astronomical Observatory Chinese Academy of Sciences Kunming 650011 China Shanghai Astronomical Observatory Chinese Academy of Sciences Shanglai 200030 China Institute of Astronomy and Astrophysics Academia Sinica EO. Box 23-141 Taipei 106 China Department of Astronomy & Kavli institute of Astronomy and Astrophysics Peking UniversityBeijing 100875 China Apache Point Observatory PO Box 59 Sunspot NM 88349 USA Department of Physics and Astronomy Rutgers University 136 Frelinghuysen RoadPiscataway NJ 08854-8019 USA Purple Mountain Observatory Chinese Academy of Sciences Nanjing 210008 China fermi National Accelerator Laboratory EO. Box 500 Batavia IL 60510 USA Department of Physics and Astronomy University of Utah Salt Lake City UT 84112 USA Department of Astronomy Nanjing University Nanjing 210011 China

We describe a general target selection algorithm that is applicable to any survey in which the number of available candidates is much larger than the number of objects to be observed. This routine aims to achieve a balance between a smoothly- varying, well-understood selection function and the desire to preferentially select cer- tain types of targets. Some target-selection examples are shown that illustrate differentpossibilities of emphasis functions. Although it is generally applicable, the algorithm was developed specifically for the LAMOST Experiment for Galactic Understanding and Exploration （LEGUE） survey that will be carried out using the Chinese Guo Shou Jing Telescope. In particular, this algorithm was designed for the portion of LEGUE targeting the Galactic halo, in which we attempt to balance a variety of science goals that require stars at fainter magnitudes than can be completely sampled by LAMOST. This algorithm has been implemented for the halo portion of the LAMOST pilot sur- vey, which began in October 2011.

关键词： surveys: LAMOST -- Galaxy: halo -- techniques: spectroscopic

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拉斯维加斯大都会酒店

现代装饰 2011年第10期 76-87页

作者： Arquitectonica Jeffrey beers Adam D.Tihany SEED Asfor Guzy Studio Gaia Bentel & Bentel and United 代照 friedmutter Group Rockwell Group 拉斯维加斯旅游局

大都会赌场酒店是一家豪华的度假赌城及酒店，位于繁华的不夜城拉斯维加斯大道的核心位置。于2005年10月破土动工，并于2010年12月15日正式开业。主体建筑包括两栋高耸的塔楼，项目占地面积约35．208平方米。总造价高达39亿美元，共有房... 详细信息

大都会赌场酒店是一家豪华的度假赌城及酒店，位于繁华的不夜城拉斯维加斯大道的核心位置。于2005年10月破土动工，并于2010年12月15日正式开业。主体建筑包括两栋高耸的塔楼，项目占地面积约35．208平方米。总造价高达39亿美元，共有房间2，995间、赌场10．000平方米、零售和餐厅28，000平方米，Spa和健身设施3，700平方米，以及1．800个座位的剧场和14．000平方米的会议空间。

关键词：拉斯维加斯大都会酒店主体建筑占地面积平方 Spa 赌场

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空山新雨后,天气晚来秋——2021年7月8月宝石佩戴建议

作者： (美)凯琳·比尔斯(Kylene beers)，(美)罗伯特·E. 普罗布斯特(Robert E. Probst)

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中国宝石 2021年第3期30卷 114-115页

作者：陆永庆覃红梅戴比尔斯不详梅子宝石能量工坊

《荀子·议兵》载:“凡百事之成也,必在敬之;其败也,必在慢之。”敬业,是热爱自己的本职工作,这是走向事业成功的第一步。三百六十行,行行出状元,拥有敬业和乐业的心态,用心喜爱自己的工作,就能在各行各业取得理想的成就。

关键词：敬业事业成功本职工作