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Fragile hearts:Unveiling the crucial layers of frailty in elderly patients undergoing percutaneous coronary interventions

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World Journal of Clinical Cases 2024年第26期12卷 5998-6000页

作者： Andreas mitsis Michael Myrianthefs Department of Cardiology Nicosia General HospitalNicosia 2026Cyprus

Wang and Liu's systematic review of frailty among elderly patients undergoing percutaneous coronary intervention(PCI)revealed that patients with frailty have significantly higher risks of all-cause and in-hospital death,major undesirable cardiovascular events,and major *** is associated with adverse events,prolonged hospital stays,increased complications,and elevated mortality risk due to diminished physiological *** frailty into risk assessment tools is crucial,and gait speed has emerged as a key predictor of *** the impact of frailty leads to personalized and informed decisionmaking,and frailty assessments should be *** holistic approach can inform tailored interventions,thereby optimizing outcomes for this vulnerable population undergoing PCI.

关键词： Frailty Elderly Percutaneous coronary intervention Outcomes Risk assessment tools

Safety and effectiveness of neuromuscular electrical stimulation in cardiac surgery:A systematic review

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World Journal of Cardiology 2024年第1期16卷 27-39页

作者： Christos Kourek Marios Kanellopoulos Vasiliki Raidou michalis Antonopoulos Eleftherios Karatzanos Irini Patsaki Stavros Dimopoulos Medical School of Athens National and Kapodistrian University of AthensAthens 15772Greece Clinical Ergospirometry Exercise and Rehabilitation LaboratoryEvangelismos HospitalAthens 10676Greece Intensive Care Unit Onassis Cardiac Surgery CenterKallithea 17674Greece Department of Physiotherapy University of West AtticaAthens 12243Greece

BACKGROUND Lack of mobilization and prolonged stay in the intensive care unit(ICU)are major factors resulting in the development of ICU-acquired muscle weakness(ICUAW).ICUAW is a type of skeletal muscle dysfunction and a common complication of patients after cardiac surgery,and may be a risk factor for prolonged duration of mechanical ventilation,associated with a higher risk of readmission and higher *** mobilization in the ICU after cardiac surgery has been found to be low with a significant trend to increase over ICU stay and is also associated with a reduced duration of mechanical ventilation and ICU length of *** electrical stimulation(NMES)is an alternative modality of exercise in patients with muscle weakness.A major advantage of NMES is that it can be applied even in sedated patients in the ICU,a fact that might enhance early mobilization in these *** To evaluate safety,feasibility and effectiveness of NMES on functional capacity and muscle strength in patients before and after cardiac *** We performed a search on Pubmed,Physiotherapy Evidence Database(PEDro),Embase and CINAHL databases,selecting papers published between December 2012 and April 2023 and identified published randomized controlled trials(RCTs)that included implementation of NMES in patients before after cardiac *** were assessed for methodological rigor and risk of bias via the *** primary outcomes were safety and functional capacity and the secondary outcomes were muscle strength and *** Ten studies were included in our systematic review,resulting in 703 *** half of them performed NMES and the other half were included in the control group,treated with usual *** studies investigated patients after cardiac surgery and 1 study before cardiac *** capacity was assessed in 8 studies via 6MWT or other indices,and improved only in 1 study before and in 1 after cardiac *** studies

关键词： Neuromuscular electrical stimulation Cardiac surgery coronary artery bypass grafting Heart valve replacement Peak VO2 Safety

Translation and cross-cultural adaptation of the Kidney Transplant Questionnaire 25 to Greek

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World Journal of Transplantation 2024年第2期14卷 148-154页

作者： Vasileios Koutlas Eirini Tzalavra Vasileios Tatsis Charalampos Pappas Stavroula Vovlianou Stefanos Bellos Anila Duni Eleni Stamellou Konstantinos I Tsamis Michail mitsis Evangelia Dounousi Department of Surgery and Kidney Transplant Unit University Hospital of IoanninaIoannina 45500EpirusGreece Department of Surgery Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece Department of Nephrology University Hospital of IoanninaIoannina 45500EpirusGreece Department of Nephrology General Hospital of KavalaKavala 65500Greece Department of Physiology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece Department of Nephrology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece

BACKGROUND Kidney transplantation leads to continuous improvement in the survival rates of kidney transplant recipients(KTRs)and has been established as the treatment of choice for patients with end-stage kidney ***-related quality of life(HRQoL)has become an important outcome *** is highly important to develop reliable methods to evaluate HRQoL with disease-specific *** To translate the disease-specific instrument Kidney Transplant Questionnaire 25(KTQ-25)to the Greek language and perform a cross-cultural *** The translation and adaptation of the original English version of the KTQ-25 to the Greek language were performed based on the International Quality of Life RESULTS Eighty-four KTRs(59 males;mean age 53.5±10.7 years;mean estimated glomerular filtration rate 47.7±15.1 mL/min/1.73 m2;mean transplant vintage 100.5±83.2 months)completed the Greek version of the KTQ-25 and the 36-item Short-Form Health Survey,and the results were used to evaluate the reliability of the Greek *** Cronbach alpha coefficients for all the KTQ-25 dimensions were satisfactory(physical symptoms=0.639,fatigue=0.856,uncertainty/fear=0.661,appearance=0.593,emotions=0.718,total score=0.708).The statistically significant correlation coefficients among the KTQ-25 dimensions ranged from 0.226 to *** correlation coeffi-cients of the KTQ-25 dimensions with the SF-36 physical component summary(PCS)ranged from 0.196 to 0.550;the correlation coefficients of the KTQ-25 with the SF-36 mental component summary(MCS)ranged from 0.260 to 0.655;and the correlation coefficients of the KTQ-25 with the total scores with the SF-36 PCS and MCS were 0.455 and 0.613,*** According to the findings,the Greek version of the KTQ-25 is valid and reliable for administration among kidney transplant patients in Greece.

关键词： Kidney Transplant Questionnaire 25 Kidney transplantation Kidney transplant recipients Health-related quality of life Quality of life

Effects of combined aerobic,resistance and inspiratory training in patients with pulmonary hypertension:A systematic review

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World Journal of Critical Care Medicine 2024年第2期13卷 168-179页

作者： Christos Kourek Antonia Zachariou Eleftherios Karatzanos michalis Antonopoulos Theodora Soulele Andreas Karabinis Serafim Nanas Stavros Dimopoulos Department of Clinical Ergospirometry Exercise and Rehabilitation Laboratory1^(st)Department of Critical Care MedicineEvangelismos HospitalNational and Kapodistrian University of AthensAthens 10676Greece Department of Cardiology 417 Army Share Fund Hospital of AthensAthens 11521Greece Cardiac Surgery ICU Onassis Cardiac Surgery centerAthens 17674AtticaGreece Cardiac Surgery ICU Onassis Cardiac Surgery CenterAthens 17674Greece Cardiac Surgery Intensive Care Unit Onassis Cardiac Surgery CenterAthens 17674Greece Department of Clinical Ergospirometry Exercise and Rehabilitation LaboratoryNational and Kapodistrian University of AthensAthens 10676Greece

BACKGROUND Pulmonary hypertension(PH)is a serious progressive disorder of the modern world,characterized by endothelial dysfunction and impaired *** with PH usually present exercise intolerance from the very early stages and reduced exercise *** training has been shown to have beneficial effects in patients with cardiovascular ***,data regarding the effects of combined exercise training programs in patients with PH still remains *** To investigate the effects of combined exercise training programs on exercise capacity and quality of life in patients with *** Our search included all available randomized controlled trials(RCTs)regarding combined aerobic,resistance and inspiratory training programs in patients with PH in 4 databases(Pubmed,PEDro,Embase,CINAHL)from 2012 to *** RCTs were included in the final *** capacity,assessed by peak VO_(2)or 6-min walking test(6MWT),as well as quality of life,assessed by the SF-36 questionnaire,were set as the primary outcomes in our *** Peak VO_(2)was measured in 4 out of the 5 RCTs while 6MWT was measured in all *** indices of functional capacity were significantly increased in patients with PH who underwent combined exercise training compared to the controls in all of the included RCTs(P<0.05).Quality of life was measured in 4 out of 5 *** patients improved their quality of life in each group,however,only 2 RCTs demonstrated further improvement in patients performing combined training compared to *** By this systematic review,we have demonstrated that combined aerobic,resistance and inspiratory exercise training is safe and has beneficial effects on aerobic capacity and quality of life in patients with *** exercise training regimen may be part of the therapeutic strategy of the syndrome.

关键词： Pulmonary hypertension Exercise training Peak VO2 Functional capacity Quality of life

Evaluation of Corvis ST tonometer with the updated software in glaucoma practice

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International Journal of Ophthalmology(English edition) 2022年第3期15卷 438-445页

作者： Ioannis Halkiadakis Vasilios Tzimis Alexandros Gryparis Ioannis Markopoulos Vasiliki Konstadinidou Elias Zintzaras michalis Tzakos Ophthalmiatrion Athinon Athens Eye HospitalEl Venizelou 26&Sina 2Athens 10672Greece Unit of Endocrinology Diabetes Mellitus and MetabolismAretaieion HospitalNational and Kapodistrian University of AthensSchool of MedicineAthens 11528Greece Department of Biomathematics University of Thessaly School of Medicine LarissaGreece and Institute for Clinical Research and Health Policy Studies Tufts University School of MedicineBostonMA 02111USA

AIM: To evaluate the agreement of biomechanically corrected intraocular pressure(b-IOP) and central corneal thickness(CCT) measurements obtained with the updated Corvis ST tonometer versus Goldmann applanation tonometry(GAT) and optical-based corneal pachymetry(OB-CCT) in controls, patients with ocular hypertension(OHT) and primary open angle glaucoma(POAG).Additionally, we examined the differences in corneal deformation parameters provided by the updated Corvis ST among the three ***: For each participant, GAT IOP, OB-CCT and measurements with a Corvis ST with updated software were ***-Altman analysis was used to assess the agreement between the two measurement ***: A consecutive series of 80 eyes from 80 participants(30 with POAG, 25 with OHT and 25 normal controls) were included in this prospective *** mean GAT IOP of all eyes was 17.2±3.6 mm Hg, and the mean b-IOP was 15.9±3.7 mm Hg(Spearman’s rho=0.767, P<0.001).The 95% limits of agreement(Lo As) ranged from-3.1 mm Hg to 5.5 mm Hg for GAT IOP and b-IOP.b-IOP was not correlated with OB-CCT(Spearman’s rho=-0.13 P=0.917).Meanwhile there was a weak positive corelation between OB-CCT and GAT IOP–b-IOP difference(Spearman’s rho=0.378, P=0.001).The mean OB-CCT was 549.5±36.4 μm, and the Corvis-CCT was 556.1±41.5 μm(Spearman’s rho=0.900, P<0.001).No statistically significant difference in the new indices provided by the updated Corvis ST was detected among the three *** with control eyes, POAG eyes had a significantly reduced applanation time 2 after adjusting for OB-CCT and GAT IOP(P=0.048).CONCLUSION: Corvis b-IOP and CCT correlate well with GAT IOP and OB-CCT.b-IOP is not affected by CCT, which might be an advantage, especially in thick or thin *** ST yields shorter applanation time 2 measurements in patients with POAG, which might reflect altered corneal viscoelasticity.

关键词： glaucoma tonometry intraocular pressure ocular hypertension corneal biomechanics

Special Focus on Natural Language Processing and Social Computing

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Science China(Information Sciences) 2017年第11期60卷 5-6页

作者： Jie TANG Hanghang TONG michalis VAZIRGIANNIS Tsinghua University Arizona State University Ecole Polytechnique

Natural language processing(NLP)and social network analysis(SNA)technologies are among the most active research and development areas due to rapid advancement of the Internet as well as the worldwide proliferation of social *** are living in an increasingly networked ***,information and other entities are connected via World Wide Web,email networks,instant messaging networks,mobile communication networks,online social networks,*** online networks grow fast and possess huge amount of recorded information,which presents great opportunities in understanding the science of these networks,and in developing new applications for these ***,new challenges have to be met—the networks are huge and information is noisy,and they demand new methodologies in analyzing these networks,and in developing theories and applications for the big networked data.

关键词： Special Focus on Natural Language Processing and Social Computing

Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis

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Cell Research 2007年第4期17卷 324-332页

作者： michalis V Karamouzis Panagiotis A Konstantinopoulos Athanasios G Papavassiliou Department of Biological Chemistry Medical SchoolUniversity of Athens75M Asias Street11527 AthensGreece

CREB-binding protein(CBP)and its homologue p300 are transcriptional co-activators of various sequence-specifictranscription factors that are involved in a wide array of cellular activities,such as DNA repair,cell growth,differentia-tion and *** studies have suggested that CBP and p300 might be considered as tumour suppressors,withtheir prominent role being the cross-coupling of distinct gene expression patterns in response to various *** their actions mainly via acetylation of histones and other regulatory proteins(e.g.p53).A major paradox in CBP/p300 function is that they seem capable of contributing to various opposed cellular *** epitheliumtumorigenesis represents a complex process of multi-step accumulations of a gamut of genetic and epigenetic *** modulation through the alternate formation of activating and repressive complexes is the ultimateconverging point of these derangements,and CBP/p300 represents key participants in this ***,illuminationof their molecular actions and interactions could reveal new potential targets for pharmacological interventions in re-spiratory epithelium carcinogenesis.

关键词： CBP p300 lung cancer acetylation transcription factor

Implication of gut microbiome in immunotherapy for colorectal cancer

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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1665-1674页

作者： Evangelos Koustas Eleni-Myrto Trifylli Panagiotis Sarantis Nikolaos Papadopoulos Georgios Aloizos Ariadne Tsagarakis Christos Damaskos Nikolaos Garmpis Anna Garmpi Athanasios G Papavassiliou michalis V Karamouzis Department of Biological Chemistry Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece 1st Department of Internal Medicine 417 Army Share Fund Hospital of AthensAthens 11521AtticaGreece Beth Israel Deaconess Medical Center BostonMA 02215United States N.S.Christeas Laboratory of Experimental Surgery and Surgical Research Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece Second Department of Propedeutic Surgery Laiko General HospitalMedical SchoolNational and Kapodistrian University of AthensAthens 11527Greece First Department of Pathology Medical SchoolNational and Kapodistrian University of AthensAthens 11527Greece

Colorectal cancer(CRC) constitutes the third most frequently reported malignancy in the male population and the second most common in women in the last two decades. Colon carcinogenesis is a complex, multifactorial event, resulting from genetic and epigenetic aberrations, the impact of environmental factors, as well as the disturbance of the gut microbial ecosystem. The relationship between the intestinal microbiome and carcinogenesis was relatively undervalued in the last decade. However, its remarkable effect on metabolic and immune functions on the host has been in the spotlight as of recent years. There is a strong relationship between gut microbiome dysbiosis, bowel pathogenicity and responsiveness to anti-cancer treatment;including immunotherapy. Modifications of bacteriome consistency are closely associated with the immunologic response to immunotherapeutic agents. This condition that implies the necessity of gut microbiome manipulation. Thus, creatingan optimal response for CRC patients to immunotherapeutic agents. In this paper, we will review the current literature observing how gut microbiota influence the response of immunotherapy on CRC patients.

关键词： Colorectal cancer Gut microbiome Immunotherapy Checkpoint inhibitors Tumor micro-environment

Pancreatic ductal adenocarcinoma: Treatment hurdles, tumor microenvironment and immunotherapy

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World Journal of Gastrointestinal Oncology 2020年第2期12卷 173-181页

作者： Panagiotis Sarantis Evangelos Koustas Adriana Papadimitropoulou Athanasios G Papavassiliou michalis V Karamouzis Molecular Oncology Unit Department of Biological ChemistryMedical SchoolNational and Kapodistrian University of AthensAthens 11527Greece Center of Basic Research Biomedical Research Foundation of the Academy of AthensAthens 11527Greece First Department of Internal Medicine “Laiko”General HospitalMedical SchoolNational and Kapodistrian University of AthensAthens 11527Greece

Pancreatic ductal adenocarcinoma(PDAC)is one of the most lethal diseases,with an average 5-year survival rate of less than 10%.Unfortunately,the majority of patients have unresectable,locally advanced,or metastatic disease at the time of ***,traditional treatments such as chemotherapy,surgery,and radiation have not been shown to significantly improve ***,there has been a swift increase in cancer treatments that incorporate immunotherapybased strategies to target all the stepwise events required for tumor initiation and *** results in melanoma,non-small-cell lung cancer and renal cell carcinoma are very ***,the application of checkpoint inhibitors,including anti-CTLA4,anti-PD-1,and anti-PD-L1 antibodies,in pancreatic cancer has been *** studies have revealed that the PDAC microenvironment supports tumor growth,promotes metastasis and consists of a physical barrier to drug *** therapies hold great promise for enhancing immune responses to achieve a better therapeutic *** this review,we provide an outline of why pancreatic cancer is so lethal and of the treatment hurdles that *** emphasis is given to the role of the tumor microenvironment,and some of the latest and most promising studies on immunotherapy in PDAC are also presented.

关键词： Pancreatic ductal adenocarcinoma Tumor microenvironment Immunotherapy Gemcitabine Treatment Cancer stem cells