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Wafer-scale MOCVD growth of monolayer M0S2 on sapphire and SiO2

Nano Research 2019年第10期12卷 2646-2652页

作者： Huanyao Cun michal Macha HoKwon Kim Ke Liu Yanfei Zhao Thomas LaGrange Andras Kis Aleksa ndra Radeno vic Laboratory of Nanoscale Biology Institute of BioengineeringEcole Polytechnique Federate de Lausanne(EPFL)1015 LausanneSwitzerland Nanoscale Electronics and Structures Electrical Engineering InstituteEcole Poly technique Federate de Lausanne(EPFL)1015 LausanneSwitzerland Nanoscale Electronics and Structures Institute of Materials Science and EngineeringEcole Poly technique Federate de Lausanne(EPFL)1015 LausanneSwitzerland Interdisciplinary Center for Electron Microscopy(CIME) Ecole Polytechnique Federale de Lausanne(EPFL)1015 LausanneSwitzerland

High-quality and large-scale growth of monolayer molybdenum disulfide(MoS2)has caught intensive attention because of its potential in many applications due to unique electronic ***,we report the wafer-scale growth of high-quality mono layer MoS2 on singlecrystalline sapphire and also on SiO2 substrates by a facile metal-organic chemical vapor deposit!on(MOCVD)*** to growth,an aqueous solution of sodium molybdate(Na2MoO4)is spun onto the substrates as the molybdenum precursor and diethyl sulfide((C2H5)2S)is used as the sulfur precursor duri ng the *** grown MoS2 films exhibit crystal I i nity,good electrical performa nee(electro n mobility of 22 cm2·V^-1·s^-1)and structural continuity maintained over the entire *** sapphire substrates are reusable for subsequent *** same method is applied for the synthesis of tungsten disulfide(WS2).Our work provides a facile,reproducible and cost-efficient method for the scalable fabricati on of high-quality mono layer MoS2 for versatile applicati ons,such as electro nic and optoelectr onic devices as well as the membranes for desalination and power generation.

关键词： molybdenum disulfide two-dimensional(2D)materials metal-organic chemical vapor deposition(MOCVD) wafer-scale fabrication

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1例肉瘤起源于皮肤和皮下透明血管型Castleman病

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世界核心医学期刊文摘（皮肤病学分册） 2005年第12期1卷 28-29页

作者： Kazakov D.V. Morrisson C. Plaza J.A. M. michal 惠海英 Sikl' s Department of Pathology Charles University Medical Faculty HospitalAlej Svobody 80 304 60 Pilsen Czech Republic

We report on a case of a sarcoma arising in the hyaline- vascular variant of Castleman disease (HVCD) of the skin and subcutis. The patient was a 38- year- old man who clinically presented with a subcutaneous non- fixed cyst- like mass on his right shoulder with an unremarkable prior medical history. Histologic sections showed a biphasic tumor with numerous atretic lymphoid follicles located in the deep dermis and subcutis and a spindle- cell neoplasm mainly situated in the deep subcutis and adjacent soft tissue. The atretic lymphoid component fulfilled the criteria for HVCD, whereas the spindle- cell lesion showed all the criteria for sarcoma including nuclear atypia and frequent mitotic figures. The sarcomatous componentwas diffusely positive for fascin, nerve growth factor receptor, and CD34 with focal weak reactivity for CD21 and CNA.42. Stains for CD23, CD31, CD35, CD99, ALK- 1, SMA, ASMA, desmin, factor XIIIa,AE1- AE3, EMA, bcl- 2, S- 100, Melan- A,HMB- 45, Cam 5.2, and factor VIII were negative in the neoplastic spindle cells. No monoclonal population of lymphocyteswas detected andwe could not identify EBV or HHV- 8 virus by PCR. Electron microscopy of the sarcomatous component showed spindle cells with labyrinth- like invaginations of the nucleus and numerous long, slender, interwoven cytoplasmic processes. The sarcomatous component in this case is most consistent with a poorly differentiated follicular dendritic cell sarcoma based upon the morphologic and ultrastructural findings.

关键词： Castleman病血管型梭形细胞核异型真皮深层淋巴滤泡双相性组织学切片邻近软组织淋巴样

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Influence of physiological and supraphysiological hyperinsulinemia on skin microcirculation in healthy volunteers

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World Journal of Diabetes 2013年第6期4卷 372-377页

作者： michal Krma Daniela echurová Jitka Brozová Zdeněk Jankovec Silvie Lacigová michal Zourek Zdeněk Rusavy Diabetology Centre 1st Department of Clinic MedicineTeaching Hospital and Medical Faculty Charles University

AIM:To examine skin perfusion in dependency on insulinemia in healthy ***:All volunteers were informed in detail about the procedures and signed informed *** protocol of this study was approved by the ethical *** our study,a two stage hyperinsulinemic euglycemic clamp was performed,with insulinemia 100and 250 mIU/mL and glycemia 5.0 mmol/L(3%standard deviation).Before the clamp and in steady states,microcirculation was measured by laser Doppler flowmetry and transcutaneous oximetry and energy expenditure was measured by indirect ***(average and standard deviation)were evaluated with ***:Physiological(50 mIU/L)insulinemia led to higher perfusion in both tests;hyperemia after heating to 44%-1848%(984-2046)vs 1599%(801-1836),P<0.05,half time of reaching peak perfusion after occlusion release 1.2 s(0.9-2.6)vs 4.9 s(1.8-11.4),P<***(150 mIU/L)insulinemia led to even higher perfusion in both tests;hyperemia after heating to 44%-1937%(1177-2488)vs 1599%(801-1836),P<0.005,half time to reach peak perfusion after occlusion release 1.0 s(0.7-1.1)vs 4.9 s(1.8-11.4),P<0.005.A statistically significant increase occurred in tissue oxygenation in both *** difference in perfusion and oxygenation between physiological and supraphysiological hyperinsulinemia was not statistically ***:The post occlusive hyperemia test in accordance with heating test showed significantly increasing skin perfusion in the course of artificial *** effect rises non-linearly with increasing *** on the dose was not statistically significant.

关键词： Diabetes Insulin Laser Doppler flowmetry Microcirculation

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皮肤低分化毛母质癌肉瘤

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世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 23-24页

作者： Kazakov D.V. Kempf W. michal M. 李晓莉冯义国 Sikl s Department of Pathology Laboratore Spec. Diagnostiky Medical Faculty Hospital Alej Svobody 80 323 18 Pilsen Czech Republic Dr.

We present an unusual case of cutaneous carcinosarcoma with the epithelial component closely resembling nodular basal cell carcinoma, and the mesenchymal component composed of cells constituting extended follicular papillae. A solitary tumor was excised in an 80-year-old man. Histologic sections revealed an ulcerated, asymmetric, poorly circumscribed neoplasm composed of epithelial cells arranged in lobules with peripheral palisading or in a cribriform pattern. The epithelial cells were darkly basophilic with scant cytoplasm and round or oval nuclei with an indistinct chromatin pattern and nucleoli. Nuclei crowding and mitotic figures were observed. Some lobules contained melanin. There were no shadow cells, sebaceous or apocrine glandular differentiation. Each epithelial nodule was surrounded by multiple rows of cells with pale vesicular nuclei and scant cytoplasm. Smaller epithelial aggregations were encircled by these cells concentrically; in larger ones these cells were aligned across a broad front resembling so-called “continuous papillae”. Additionally, numerous small follicular germ-like structures associated with papillae were seen. The cells composing “continuous papillae”showed nuclear pleomorphism, numerous mitotic figures including atypical ones, and nuclear crowding. At foci, the transition fromthe multilayered arrangement of these cells into their diffuse proliferation in the stroma was seen. There were no transitions between the epithelial and stromal component; both were intermingled as though being mutually dependent, with no areas revealing a high-grade tumor or dedifferentiation. Immunohistochemically, the epithelial cell component stained with cytokeratins. The cells of the mesenchymal component tested positive for vimentin and negative for desmin and cytokeratins. The proliferation index (Ki-67)was high in both components. Therewere also a high number of p53-positive cells in both compartments. We propose the term “low-grade trichoblastic carcin

关键词：毛母质癌肉瘤毛乳头基底细胞癌上皮结节栅栏状顶泌汗腺上皮成分高分化肿瘤间叶组织

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多向(线性、三维囊性、圆柱性)分化的皮肤低度恶性附属器癌

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世界核心医学期刊文摘（皮肤病学分册） 2006年第11期2卷 35-36页

作者： Kazakov D.V. Kutzner H. Mukensnabl P. michal M. 李晓莉 Sikl's Department of Pathology Charles University Medical Faculty Hospital Alej Svobody 80 304 60 Pilsen Czech RepublicDr.

The conjoint occurrence of follicular, sebaceous, or apocrine differentiations in a cutaneous adnexal neoplasm is a known event, more often encountered in benign neoplasms, whereas reports of cutaneous malignant adnexal tumors with bilineage or trilineage differentiation are few. A new case of a cutaneous malignant adnexal neoplasm with multidirectional differentiation is reported here. A 57-year-old woman presented with a long-standing, slowly growing, asymptomatic solitary tumor the size of a large nut in the coccygeal area,whichwas surgically excised. Ten years after the surgery, there was no evidence of recurrence or metastasis. Microscopically, the neoplasm was located in the dermis with focal extension into the subcutis. It was asymmetric, horizontally oriented, and mostly composed of small nodules that varied in shape from round and oval aggregations to elongated strands and irregular islands; the nodules were either clustered, formed a jigsaw puzzlelike pattern or were dispersed. The nodules were composed of small basaloid cells sometimes intermixed with larger cells with ample cytoplasm forming glandular structures. Rare nodules resembled elements seen in a spiradenoma by containing scattered lymphocytes and globules of hyalinized eosinophilic basal membrane material. The stroma was paucicellular, but focally it resembled that seen in perifollicular mesenchyme. Mitotic figures, including abnormal ones, were infrequent, but mild nuclear pleomorphism, nuclear crowding, and individual cell necrosis were easily appreciable in both small basaloid cells and cells with clear cytoplasm. Perineural invasion was apparent. We classified this tumor as a well-differentiated adnexal carcinoma demonstrating combined follicular and apocrine differentiation. It differs from previously published cases of malignant adnexal tumors with multidirectional differentiation and further exemplifies the spectrum of diversity encountered in malignant proliferations with differentiation

关键词：附属器基底细胞汗腺腺瘤顶质分泌间充质腺样结构滤泡多形性新生物真皮层

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柬埔寨金边大屠杀纪念馆

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现代装饰 2014年第12期 118-121页

作者： Zaha Hadid Patrik Schumacher Malgorzata Kowalczyk michal Wojtkiewicz Torsten Broeder Fernanda Mugnaini Vlktor Fretyan 姜敏华 Zaha Hadia Architects(ZHA)

本案位于柬埔寨的首都金边,是由扎哈·哈迪德建筑师事务所设计的一个具有全新开拓性意义的大屠杀纪念馆。这个纪念馆也是集博物馆、研究中心、研究院、文件档案管理处和研究性图书馆为一身的综合性机构。本纪念馆的创始人Youk Chhang是... 详细信息

本案位于柬埔寨的首都金边,是由扎哈·哈迪德建筑师事务所设计的一个具有全新开拓性意义的大屠杀纪念馆。这个纪念馆也是集博物馆、研究中心、研究院、文件档案管理处和研究性图书馆为一身的综合性机构。本纪念馆的创始人Youk Chhang是一位不懈的致力于研究红色高棉暴行的人权活动家,也是柬埔寨文献中心的执行理事。纪念馆的名字Sleuk Rith意思是＂树叶的力量＂;旨在表达柬埔寨几个世纪的宗教领袖都曾用树叶记载历史、传播知识,并在严酷的统治和危险时期以此来保存文化。发生于柬埔寨红色高棉时期的大屠杀是整个东南亚历史上最大规模的屠杀行为,亦是柬埔寨历史中无法抹去的黑暗年代。金边大屠杀纪念馆的建造同它的名字一样,

关键词：纪念馆柬埔寨金建筑师事务所档案管理最大规模开拓性哈迪德

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The 2<sup>nd</sup>Step by Step International Spinal Cord Repair—Combining research Step by Step into multi-pronged approaches for spinal cord repair

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Journal of Biomedical Science and Engineering 2013年第7期6卷 21-32页

作者： Maria Teresa Moreno-Flores Francois Ferón Victor Arvanian Armin Blesch Armin Curt David J. Fink Marina Mata Kinichi Nakashima Xavier Navarro Francisco Javier Rodríguez michal Schwartz Mikael Svensson Erik Sundstrom Joan Romero Filip Lim Department of Biotechnology University Francisco de Vitoria Pozuelo de Alarcón Spain Department of Cell Biology Physiology and Immunology University Autonoma de Barcelona Barcelona Spain Department of Medicine University Hospital Balgrist Zurich Switzerland Department of Molecular Biology University Autónoma de Madrid Madrid Spain Department of Neurobiology Care Sciences and Society Karolinska Institute Stockholm Sweden Department of Neurobiology Weizmann Institute of Science Rehovot Israel Department of Neurology University of Michigan Ann Arbor USA Department of Stem Cell Biology and Medicine Kyushu University Fukuoka Japan Faculty of Medicine Aix Marseille University Marseille France National Paraplegics Hospital Toledo Spain Northport Veterans Affairs Medical Center Northport USA Spinal Cord Injury Center University Hospital Heidelberg Germany Step by Step Foundation Barcelona Spain

On April 26-27, 2013, the Step by Step Foundation hosted the Second International Spinal Cord Repair Meeting at the Fira Barcelona Convention Center in Hospitalet de Llobregat, Spain, highlighting some of the exciting research including clinical trials which show promise for treatments for this devastating disorder. This meeting brought together clinicians, clinical scientists and molecular biologists from more than 10 countries to evaluate current knowledge on clinical, cellular, and biomolecular aspects of spinal cord injury. A major goal of the conference in advancing the translation of research data to the clinic was to promote multi-pronged approaches for therapy of this complex problem.

关键词： Spinal Cord Injury Immunomodulation Glial Scar Nerve Grafts Neurotrophins Neural Stem Cells Electromagnetic Stimulation HSV-1 Vectors Cholecalciferol Vitamin D3 Wnt Proteins Neuroregeneration

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A Depth Resolved Insight into Benzoyl CoA Reductase and Benzoate Dioxygenase Gene Copy Numbers within a Marine Sediment Associated with Methane Seepage

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Open Journal of Marine Science 2013年第4期3卷 175-181页

作者： Paul V. Flanagan Brian P. Kelleher Shane S. O’Reilly michal T. Szpak Xavier Monteys Paul P. Kelly Anna N. Kulakova Leonid A. Kulakov Christopher C. R. Allen Geological Survey of Ireland Beggar’s Bush Dublin Ireland School of Biological Sciences Queen’s University Belfast Belfast UK School of Chemical Sciences Dublin City University Dublin Ireland

A marine sediment core obtained from a methane seepage site off the northern coast of Irelandwas analysed, at 3 depths, for catabolic genes associated with the aerobic and anaerobic degradation of aromatic compounds. Catabolic gene copy numbers varied through the core peaking at 2.1 meters below sediment surface (mbsf)-just above the sulphate boundary. Beyond the sulphate boundary gene copy numbers fell considerably, suggesting the boundary may be a critical factor in the degradation of aromatic compounds within marine sediments. At the 2.1 mbsf depth our data also suggest that known benzoyl CoA reductase utilizing bacteria are readily detectable.

关键词： Aromatic Compounds qPCR bcr bdo

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应用可靠性分析方法比较自酸蚀粘结剂和全酸蚀粘结剂与人牙本质的粘结性能

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中国口腔医学继续教育杂志 2010年第2期13卷 30-35页

作者： Pavel Bradna Radka Vrbova michal Dudek Adela Roubickova Devana Housova 陈瑞雪（译）梁宇红（译）岳林（审）不详北京大学口腔医学院牙体牙髓科北京海淀区中关村南大街22号100081

目的：对各种不同操作方法的典型自酸蚀粘结剂和全酸蚀粘结剂的粘结可靠性进行体外评价。材料和方法：在223颗人离体牙牙本质平面上分别应用下列牙本质粘结剂：自酸蚀两步法粘结剂：AdheSE（AH）．Clearfil SE Bond（CL）．OptiBond SE... 详细信息

目的：对各种不同操作方法的典型自酸蚀粘结剂和全酸蚀粘结剂的粘结可靠性进行体外评价。材料和方法：在223颗人离体牙牙本质平面上分别应用下列牙本质粘结剂：自酸蚀两步法粘结剂：AdheSE（AH）．Clearfil SE Bond（CL）．OptiBond SE（OS）；自酸蚀一步法粘结剂：Adper Prompt L-Pop（ADP）．Adper Prompt（AD），Xeno Ⅲ（XE）；自酸蚀多合一粘结剂：iBond（IB）：全酸蚀三步法粘结剂：OptiBond FL（OF）：全酸蚀两步法粘结剂：Gluma Comfort Bond（G），Excite（E），Prime＆BondNT（PB），之后，用微填料复合树脂Opticor New堆塑树脂块，在37℃的蒸馏水中放置24h后检测剪切强度。应用方差分析处理测量结果（统计因素为粘结剂和粘结剂类型）．随后通过组间一致性的Fisher分析（α=0.05）进行比较。采用二参数韦伯分布法计算临界剪切强度，系统可靠性取值为失败率5％。结果：方差分析显示各粘结系统呈现以下三组剪切强度的差异，各组平均剪切强度间的差异有统计学意义（P〈0001）AH=CL=OS=G=E=OF〉AD=IB=XE〉PB=ADP．但各组之内的全酸蚀粘结剂与自酸蚀粘结剂之间的差异无显著性（P〉0.48）。韦伯分布显示的对应粘结强度范围为12．1～241MPa，韦伯模量在21～83之间．临界剪切强度为30～160MPa。结论：临界剪切强度的显著不同提示所检测粘结系统可靠性的变异，这是源于粘结剂的化学成分不同．而非粘结剂的类型。

关键词：粘结强度牙本质粘结系统可靠性韦伯分析

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利用近场成像改进乳腺癌检测技术

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真空电子技术 2003年第5期16卷 5-11页

作者： Elise C.Fear Susan C.Hagness Paul M.Meaney michal Okoniewski Maria A.Stuchly 梁友焕

长时间以来,人们梦想用非电离电磁波的人体成像技术检测癌症,如今乳腺癌的检测已取得重大进展,使这一梦想成为现实.在今后的十年里,微波系统将成为许多妇女疾病的一种可行的诊断方法.与其它癌症不同的是,乳腺肿瘤在微波波段与健康的乳... 详细信息

长时间以来,人们梦想用非电离电磁波的人体成像技术检测癌症,如今乳腺癌的检测已取得重大进展,使这一梦想成为现实.在今后的十年里,微波系统将成为许多妇女疾病的一种可行的诊断方法.与其它癌症不同的是,乳腺肿瘤在微波波段与健康的乳房组织有着明显不同的电学特性.微波很容易穿透乳房,而对其他器官则相差很多.与其他的组织如肌肉和脑组织相比,正常的乳房组织对微波具有更高的透明度.

关键词：近场成像乳腺癌检测技术微波系统微波肿瘤检测无源微波成像乳房组织电特性

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