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Alternative polyadenylation events in epithelial cells sense endometritis progression in dairy cows

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Journal of Integrative Agriculture 2023年第6期22卷 1820-1832页

作者： Meagan J.STOTTS Yangzi ZHANG Shuwen ZHANG Jennifer J.michal Juan VELEZ Bothe HANS Martin MAQUIVAR Zhihua JIANG Department of Animal Sciences and Center for Reproductive Biology Washington State UniversityPullmanWA 99164-7620USA Aurora Organic Farms PlattevilleCO 80651USA

Endometritis(inflammation of the endometrial lining) is one of the most devastating reproductive diseases in dairy cattle, resulting in substantial production loss and causing more than $650 million in lost revenue annually in the *** hypothesize that alternative polyadenylation(APA) sites serve as decisive sensors for endometrium health and disease in dairy cows. Endometrial cells collected from 18 cows with purulent vaginal discharge scored 0 to 2 were used for APA profiling with our whole transcriptome termini site sequencing(WTTS-seq) method. Overall, pathogens trigger hosts to use more differentially expressed APA(DE-APA), more intronic DE-APA, more DE-APA sites per gene and more DE-genes associated with inflammation. Host CD59 molecule(CD59), Fc fragment of IgG receptor IIa(FCGR2A), lymphocyte antigen 75(LY75) and plasminogen(PLG) may serve as initial contacts or combats with pathogens on cell surface, followed by activation of nuclear receptor subfamily 1 group H member 4(NR1H4) to regulate AXL receptor tyrosine kinase(AXL), FGR proto-oncogene, Src family tyrosine kinase(FGR), HCK protooncogene, Src family tyrosine kinase(HCK) and integrin subunit beta 2(ITGB2) for anti-inflammation. This study is the first to show significance of cilium pathways in endometrium health and animal reproduction. MIR21 and MIR30A would be perfect antagonistic biomarkers for diagnosis of either inflammation or anti-inflammation. These novel findings will set precedent for future genomic studies to aid the dairy industry develop new strategies to reduce endometritis incidence and improve fertility.

关键词： organic dairy endometritis alternative polyadenylation infection progression antagonistic biomarkers

Changes in the speed of ants as a result of aggressive interactions

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Insect Science 2017年第5期24卷 842-852页

作者： Piotr Slipinski michal Zmihorski Laboratory of Social and Myrmecophilous Insects Museum and Institute of Zoology Polish Academy of Sciences Warsaw Poland Department of Ecology Swedish University of Agricultural Sciences Uppsala Sweden Institute of Nature Conservation PolishAcademy of Sciences Krakow Poland

Subordinate ant species utilize different tactics to reduce competition with the stronger, larger and more aggressive individuals of a dominant species. In our experimental study, we assessed the behavioral response of individual workers of 4 subordinate ant species during their co-occurrence with workers of a single dominant species. Contrary to most classical experiments focused on aggressive interactions, we assessed workers＇ speed as a crucial factor in the outcome of co-occurrence. Generally, there was a large intraspecific variation in the speed of the studied species--each had slow and fast individuals. Workers of all studied species moved faster just after interaction, suggesting that contact between 2 hostile workers is a stressful stimulus, generating a behavioral reaction of increasing speed. Also, the number of aggressive contacts experienced by a given individual positively affected its speed. Moreover, workers which were fast when exploring territory were also fast after interspecific interactions. The duration of aggression was significantly reduced by the speed and body size of a subordinate species worker--the more quickly a worker reacted and bigger it was, the shorter was the time of cumulative aggression. To our knowledge, this is the first study of this type to be conducted on ants and we conclude that speed is an overlooked and important characteristic of species and also individuals, therefore it should be considered as a driver of patterns of co-occurrence in ant assemblages.

关键词： hierarchy reaction response speed survival velocity

Complex experimental analysis of rifle-shooter interaction

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Defence Technology（防务技术） 2017年第5期13卷 346-352页

作者： michal Taraszewski Janusz Ewertowski Warsaw University of Technology Faculty of Production EngineeringDepartment of Mechanics and Armament Technologyul.Narbutta 8502-524 WarszawaPoland

In this study, a complex analysis of a man-weapon interaction based on experimental effort is *** attention is focused on how a shooter can influence on a rifle, opposite to generally considered in literature rifle's impact on a shooter. It is shown, based on the kbk AKM weapon, that each support point of the rifle has an substantial impact on the system. It is said that identifying human reactions on weapon may let to describe gun movement and thus may be applied to weapon accuracy determination.

关键词： Rifle-shooter interaction Man-weapon forces Muzzle climb Firearm Recoil Accuracy

Technologically Attractive High Thermostable Polynitro Arenes

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含能材料 2006年第5期14卷 361-366页

作者： Svatopluk ZEMAN michal ROHAC Institute of Energetic Materials University of Pardubice CZ-532 10 Pardubice Czech Republic

The paper is focused on 2,4,6,4′,6′,2″,4″,6″-octanitro[1,1′,3′,1″]-terphenyl (ONT), 2,2′,2″,4,4′,4″,6,6′,6″-nonanitro[1,1′,3′,1″]-terphenyl (NONA), 2,4,6-tris(2,4,6-trinitrophenyl)-1,3,5-triazine (TPT), N,N-bis(2,4-dinitrophenyl)-2,4,6-trinitroaniline (NTFA), 2,2′,4,4′,6,6′-hexanitrobiphenyl (HNB), 1,3-dinitrobenzene (1,3-DNB) and 1,3,5-trinitrobenzene (TNB). The initiation reactivity of these substances has been studied by means of the data obtained from non-isothermal differential thermal analysis (DTA), their ignition temperatures, impact sensitivity, the data obtained from the Russian manometric method and the detonation characteristics. For comparison, also the data published about 2,2′,2″,2″′,4,4′,4″,4″′,6,6′,6″,6″′-dodecanitro-[1,3′,1′,1″]quaterphenyl (DODECA) have been included. The paper specifies and discusses the relationships between the results of various methods used, inclusive of the forms of modified Evans-Polanyi-Semenov relationship. It has been stated that the technologically most attractive substances, out of those studied, can be ordered in the sequence ONT-TPT-NONA-NTFA according to their increasing thermal reactivity.

关键词： organic chemstry DTA explosives ignition temperature impact sensitivity thermal reactivity ONT NONA NTFA

Resource optimisation in aquaponics facility via process monitoring and graph-theoretical approach

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Carbon Resources Conversion 2022年第4期5卷 255-269页

作者： Vojtˇech Ondruˇska Bing Shen How michal Netolický Vítˇezslav M´aˇsa Sin Yong Teng Brno University of Technology Institute of Process Engineering&NETME CentreTechnick´a 2896/261669 BrnoCzech Republic Biomass Waste-to-Wealth Special Interest Group Research Centre for Sustainable TechnologiesFaculty of EngineeringComputing and ScienceSwinburne University of TechnologyJalan Simpang Tiga93350KuchingSarawakMalaysia Flenexa plus s.r.o. Pˇr´aslavice 33578354Pˇr´aslaviceOlomoucCzech Republic Radboud University Institute for Molecules and MaterialsP.O.Box 90106500 GL Nijmegenthe Netherlands

Energy efficiency and economic viability are the often-quoted issues in aquaponic *** work aims to(i)identify process technologies and technical measures which would enhance the profitability of aquaponics business while conserving energy and other resources,and(ii)to validate the determined optimal measures on the testing aquaponics *** process network synthesis technique was used to search for an optimal process pathway while the image processing technique was applied to automatically monitor the growth rate of produce since it is the main revenue stream in *** the aid of P-graph method,the optimal feasible structure has 9 times higher annual net income than that of the existing *** optimal solution includes the integration of electrical heat pump,biogas system,and utilizes black solider fly(BSF)facility to produce fish *** light energy savings were achieved by practical installation of reflective foils which improved 16.88%of Photosynthetic photon flux density(PPFD)on growth *** measures can help the aquaponics farms to become more competitive and to decrease their ecological footprint.

关键词： Aquaponics Process monitoring P-graph Process optimization Energy savings

Effect of Jet Vortex Generators on Shock Wave Induced Separation on Gas Turbine Profile

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Journal of Thermal Science 2021年第4期30卷 1435-1443页

作者： FLASZYNSKI Pawel DOERFFER Piotr PIOTROWICZ michal Szewalski Institute of Fluid-Flow Machinery Polish Academy of SciencesFiszera 14PL 80-231GdanskPoland

The interaction between a shock wave and a boundary layer on a suction side of gas turbine profile,namely Transition Location Effect on Shock Wave Boundary Layer Interaction,was one of main objectives of TFAST project.A generic test section in a transonic wind tunnel was designed to carry out such *** design criteria were to reproduce flow conditions on the profile in wind tunnel as the one existing on the suction side of the turbine guide *** this paper,the effect of film cooling and jet vortex generators on the shock wave boundary layer interaction and shock induced separation is *** results for Explicit Algebraic Reynolds Stress Model with transition modeling are compared with experimental data.

关键词： shock wave gas turbine flow control jet vortex generators

Analytic Invariant Curves for an Iterative Equation Related to Ricker-type Second-order Equation

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Acta Mathematica Sinica,English Series 2021年第7期37卷 1041-1052页

作者： Hou Yu ZHAO michal FECKAN School of Mathematics Chongqing Normal UniversityChongqing 401331P.R.China Department of Mathematical Analysis and Numerical Mathematics Comenius University in BratislavaMlynska dolina84248 BratislavaSlovakia Mathematical Institute of Slovak Academy of Sciences Stefanikova 4981473 BratislavaSlovakia

In this paper,we consider the existence of analytic invariant curves of an iterative equation f(f(x))=xea-x-f(x)which arises from Ricker-type second-order *** reducing the equation with the Schr?der transformation to an auxiliary equation,the author discusses not only that the parameter at resonance,i.e.,at a root of the unity,but also the parameter near resonance under the Brjuno condition.

关键词： Difference equation invariant curves analytic solution small divisor

Increased depth of focus in random-phase-free holographic projection

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Chinese Optics Letters 2016年第12期14卷 55-59页

作者： michal Makowski Tomoyoshi Shimobaba Tomoyoshi Ito Warsaw University of Technology Faculty of Physics Graduate School of Engineering Chiba University

The recently proposed random-phase-free method enables holographic reconstructions with very low noise,which allows fine projections without time integration of sub-holograms. Here, we describe the additional advantage of this method, namely, the extended depth of sharp imaging. It can be attributed to a lower effective aperture of the hologram section forming a given image point at the projection screen. We experimentally compare the depth of focus and imaging resolution for various defocusing parameters in the cases of the random-phase method and the random-phase-free method. Moreover, we discuss the influence of the effective aperture in the presence of local obstacles in the hologram＇s plane.

关键词： projection holographic aperture obstacles pixel sharp camera attributed convergent shadow

What do coaches want to know about sports-related concussion?A needs assessment study

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Journal of Sport and Health Science 2018年第1期7卷 102-108页

作者： Lindsay Sullivan michal Molcho School of Health Sciences Discipline of Health Promotion NUI Galway School of Arts Social Sciences and Celtic Studies Children’s Studies Programme NUI Galway

Purpose: This study aims to identify the concussion-related training and education needs of Gaelic Athletic Association(GAA) coaches in Ireland,as well as the preferred method of concussion education ***: We used a self-report questionnaire to collect data from a convenience sample of 108 GAA coaches in Ireland. Data were captured on(1) informational needs and desires,(2) preferred methods of delivery, and(3) concussion practices and procedures. Questionnaires were completed electronically from June 3 rd–September 29 th, ***: Coaches indicated that they were most interested in receiving information about the(1) signs and symptoms of concussion,(2) assessment of concussion, and(3) return-to-play guidelines. Over two-thirds of participants indicated that in-person training would be the most effective mode of delivery of concussion education for this population. Additionally, only 10% coaches reported that before the start of the season they talked to their athletes about concussion management and safety, and this was more common among coaches who reported being formally educated about ***: Our findings reveal a disconnect between the concussion education needs and the education that is currently provided to GAA coaches, in terms of content and delivery modality. Our results suggest a need for a multifaceted approach to concussion education, tailored to the needs and learning preferences of the target population.

关键词：运动员震动客车评价样品收集调查结果爱尔兰教育