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Lipopolysaccharide induces and activates the Nalp3 inflammasome in the liver

World Journal of Gastroenterology 2011年第43期17卷 4772-4778页

作者： michal ganz Timea Csak Bharath Nath Gyongyi Szabo Department of Medicine University of Massachusetts Medical School

AIM:To examine the activation of the Nalp3 inflammasome and its downstream targets following lipopolysaccharide(LPS) -induced stimulation in the liver. METHODS:Six-to-eight-week-old C57BL/6 chow fed mice were injected intraperitoneally with 0.5μg/g bodyweight LPS and sacrificed 2,4,6,18 or 24 h later. LPS-induced liver damage was confirmed by a biochemical assay to detect alanine aminotransferase(ALT) *** determine if LPS stimulation in the liver led to activation of the inflammasome,real-time quantitative polymerase chain reaction was used to evaluate the mRNA expression of components of the Nalp3 ***-linked immunosorbent assays were used to determine the protein expression levels of several downstream targets of the Nalp3 inflammasome,including caspase-1 and two cytokine targets of caspase-1,interleukin(IL) -1βand IL-18. RESULTS:We found that LPS injection resulted in liver damage as indicated by elevated ALT *** was associated with a significant increase in both mRNA and protein levels of the proinflammatory cy-tokine tumor necrosis factor(TNF) -αin the liver,as well as increased levels of TNFs in *** showed that LPS stimulation led to upregulation of mRNA levels in the liver for all the receptor components of the inflammasome,including Nalp3,Nalp1,pannexin-1 and the adaptor molecule apoptosis-associated specklike,caspase recruitment domain-domain containing *** also found increased levels of mRNA and protein for caspase-1,a downstream target of the *** addition,LPS challenge led to increased levels of both mRNA and protein in the liver for two cytokine targets of caspase-1,IL-1βand IL-18. Interestingly,substantial baseline expression of pre-IL1βand pre-IL-18 was found in the *** and caspase-1 activation was indicated by the significant increase in the active forms of IL-1βand IL-18 after LPS stimulation. CONCLUSION:Our results show that the Nalp3 inflammasome is upregulated and activated in the

关键词：脂多糖肝脏激活诱导 mRNA表达 IL-18 酶联免疫吸附试验聚合酶链反应

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High fat diet feeding results in gender specific steatohepatitis and inflammasome activation

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World Journal of Gastroenterology 2014年第26期20卷 8525-8534页

作者： michal ganz Timea Csak Gyongyi Szabo Department of Medicine University of Massachusetts Medical School

AIM:To develop an animal model that encompasses the different facets of non-alcoholic steatohepatitis(NASH),which has been a ***:In this study,we used a high fat diet(HFD)feeding supplemented with fructose and sucrose in the water mimicking the high-fructose corn syrup that is abundant in the diet in the United *** used C57Bl/6 wild-type mice for short and long-term feedings of 6 and 16 wk respectively,and evaluated the extent of liver damage,steatosis,and inflammasome *** methods included histopathological analysis to assess liver damage and steatosis,which involved H and E and oil-red-o staining;biochemical studies to look at ALT and triglyceride levels;RNA analysis using quantitative polymerase chain reaction;and cytokine analysis,which included the enzyme-linked immunosorbent assay method to look at interleukin(IL)-1βand tumor necrosis factor-α(TNFα)***,at each length of feeding we also looked at insulin resistance and glucose tolerance using insulin tolerance tests(ITT)and glucose tolerance ***:There was no insulin resistance,steatosis,or inflammasome activation at 6 *** contrast,at16 wk we found significant insulin resistance demonstrated by impaired glucose and ITT in male,but not female *** males,elevated alanine aminotransferase and triglyceride levels,indicated liver damage and steatosis,*** liver TNFαand monocyte chemoattractant protein-1 mRNA and protein,correlated with *** inflammasome components,adaptor molecule,Aim2,and NOD-like receptor 4,increased at the mRNA level,and functional inflammasome activation was indicated by increased caspase-1 activity and IL-1βprotein levels in male mice fed a long-term *** mice on HFD had increasedα-smooth muscle actin and pro-collagen-1 mRNA indicating evolving *** contrast,female mice displayed only elevated triglyceride levels,steatosis,and no ***:Our data indicate gender differences in NASH

关键词： Gender differences Non-alcoholic steatohepatitis I

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Structural correlation and chemistry of molten NaF-ScF3 with dissolved metal aluminium:TG/DTA,XRD,NMR and molecular dynamics simulations

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Rare Metals 2024年第7期43卷 3356-3369页

作者： Aydar Rakhmatullin Franti?ek ?imko Didier Zanghi Zuzana Netriová Ilya B.Polovov Ayrat Dimiev Konstantin V.Maksimtsev Catherine Bessada michal Korenko Conditions Extrêmes et Materiaux:Haute Température et Irradiation CEMHTIUPR 3079-CNRS Univ Orleans Department of Molten Systems Institute of Inorganic ChemistrySlovak Academy of Sciences Centre of Excellence for Advanced Materials Application-CEMEA Slovak Academy of Sciences Department of Rare Metals and Nanomaterials Institute of Physics and TechnologyUral Federal University Alexander Butlerov Institute of Chemistry Kazan Federal University

For the first time,the mechanism of metal aluminum dissolution in NaF-ScF3eutectic melts and the chemical interaction between the constituents of this mixture have been thoroughly studied by a combination of differential thermal analysis（DTA）,high temperature and solid-state nuclear magnetic resonance（NMR）,and X-ray diffraction（XRD） coupled with the molecular dynamic *** formation of an insoluble Al3Sc alloy in molten（NaF-ScF3）eutsystem was proven,and the chemical mechanism of this aluminothermic Al3Sc alloy production was *** ex situ examinations bring to light the formation of NaScF4and solid solution of Na3（Al,Sc）F6in cooled *** molecular dynamics calculations of the bath allow us to construct the structural model and to predict viscosity,density and electrical conductivity of the reagent melt to help to optimize the conditions of the alloy synthesis.

关键词： Scandium Alloy Molten salts NMR Molecular dynamics

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Visual guidelines and tutoring in pediatric urological surgery

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当代泌尿学（英文） 2024年第1期18卷 18-22页

作者： Stanislav Kotcherov Shahar Rotem Jawdat Jaber Galit Avraham Gennady Lev michal Darmon Yudith Gabay Boris Chertin Department of Pediatric Urology Shaare Zedek Medical CenterFaculty of MedicineHebrew UniversityJerusalemIsrael Department of Pediatric Surgery Shaare Zedek Medical CenterFaculty of MedicineHebrew UniversityJerusalemIsrael The Operation Room Shaare Zedek Medical CenterJerusalemIsrael

Background:The aim of this prospective randomized study was to evaluate the impact of visual guidelines(picture book)and parents tutoring on pediatric urological surgery on parent's stress and anxiety,the number of postoperative contacts,and complications.Materials and methods:Following institutional ethical committee approval,a special picture book reflecting different stages of the con-valescent period following multiple types of pediatric urological surgery was *** were randomly divided into 2 groups in which 33 parents in Group 1 received the picture book in addition to routine instructions prior to the surgery and 31 in Group 2 received only routine postoperative *** parents were asked to answer a questionnaire(Amsterdam Preoperative Anxiety and Infor-mation Scale)regarding the level of anxiety before surgery and immediately after surgery in the recovery *** number of postop-erative parent's calls,nonplaned emergency room visits,and complications were recorded.Results:No statistically significant difference in perioperative parental anxiety was found(p=0.88).The visual tutoring group had a sig-nificantly lower rate of emergency room admissions(6.6％vs.18.6％,p=0.0433),however parents from this group made a higher num-ber of postoperative calls(9.9％vs.3.1％,p=0.38).Two(6.6％)from the tutoring group expressed their desire to omit visual counseling in future surgical preparation and 4(13.2％)did not have an *** satisfaction with regards to the preoperative counseling and information and the number of postoperative complications was similar in both groups.Conclusions:Visual tutoring does not add any value to parental anxiety but seems helpful in reducing postoperative emergency room *** parents preferred to exclude visual information from future preoperative counseling.

关键词： Anesthesia Children Hypospadias Pediatric case Questionnaires

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Adaptive Network Sustainability and Defense Based on Artificial Bees Colony Optimization Algorithm for Nature Inspired Cyber Security

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Computer Systems Science & Engineering 2024年第3期48卷 739-758页

作者： Chirag Ganguli Shishir Kumar Shandilya michal Gregus Oleh Basystiuk Institute of Technology VIT Bhopal UniversityBhopalIndia School of Data Science and Forecasting Devi Ahilya UniversityIndore452001India Department of Information Systems Comenius University in BratislavaBratislava82005Slovak Republic Department of Artificial Intelligence Lviv Polytechnic National UniversityLviv79013Ukraine

Cyber Defense is becoming a major issue for every organization to keep business continuity *** presented paper explores the effectiveness of a meta-heuristic optimization algorithm-Artificial Bees Colony Algorithm(ABC)as an Nature Inspired Cyber Security mechanism to achieve adaptive *** experiments on the Denial-Of-Service attack scenarios which involves limiting the traffic flow for each *** today have adapted their service distribution models to include the use of the Internet,allowing them to effectively manage and interact with their customer *** shift has created an increased reliance on online services to store vast amounts of confidential customer data,meaning any disruption or outage of these services could be disastrous for the business,leaving them without the knowledge to serve their *** can exploit such an event to gain unauthorized access to the confidential data of the *** proposed algorithm utilizes an Adaptive Defense approach to continuously select nodes that could present characteristics of a probable malicious *** any changes in network parameters,the cluster of nodes is selected in the prepared solution set as a probable malicious node and the traffic rate with the ratio of packet delivery is managed with respect to the properties of normal nodes to deliver a disaster recovery plan for potential businesses.

关键词： Artificial bee colonization adaptive defense cyber attack nature inspired cyber security cyber security cyber physical infrastructure

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Rice-wheat comparative genomics:Gains and gaps

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The Crop Journal 2024年第3期12卷 656-669页

作者： Akila Wijerathna-Yapa Ruchi Bishnoi Buddhini Ranawaka Manu Maya Magar Hafeez Ur Rehman Swati G.Bharad michal T.Lorenc Vinita Ramtekey Sasha Gohar Charu Lata Md.Harun-Or-Rashid Maryam Razzaq Muhammad Sajjad Bhoja *** School of Agriculture and Food Sustainability The University of QueenslandSt LuciaQLD 4072Australia ARC Centre of Excellence for Plant Success in Nature and Agriculture The University of QueenslandSt LuciaQLD 4072Australia Department of Genetics and Plant Breeding College of AgricultureUmmedganj-KotaAgriculture UniversityKotaRajasthan 324001India Centre for Agriculture and the Bioeconomy Queensland University of Technology(QUT)2 George StreetBrisbaneQLD 4000Australia UWA School of Agriculture and Environment The University of Western Australia35 Stirling HighwayCrawleyWA 6009Australia Nepal Agriculture Research Council KhumaltarLalitpurNepal Department of Agronomy University of AgricultureFaisalabad 38040Pakistan Department of Agricultural Botany Dr Panjabrao Deshmukh Krishi VidyapeethAkola 444104MaharashtraIndia ICAR-Indian Institute of Seed Science MauUttar Pradesh 275103India School of Natural Sciences Macquarie UniversityMacquarie ParkNSW 2109Australia ICAR-Indian Institute of Wheat and Barley Research Flowrdale 54642ShimlaIndia International Maize and Wheat Improvement Center(CIMMYT)Bangladesh Office Gulshan-2Dhaka 1212Bangladesh Center for Seed Science University of AgricultureFaisalabad 38000Pakistan Department of Biosciences COMSATS University IslamabadPark RoadTarlai KalanIslamabad 45550Pakistan CGIAR’s Excellence in Breeding(EiB)Platform/Accelerated Breeding Initiative International Maize and Wheat Improvement Center(CIMMYT)El Batán 56237Mexico

Rice and wheat provide nearly 40%of human calorie and protein *** share a common ancestor and belong to the Poaceae(grass)*** their genetic homology is crucial for developing new cultivars with enhanced *** wheat genes and gene families have been characterized based on their rice ***–wheat orthology can identify genetic regions that regulate similar traits in both ***–wheat comparative genomics can identify candidate wheat genes in a genomic region identified by association or QTL mapping,deduce their putative functions and biochemical pathways,and develop molecular markers for marker-assisted breeding.A knowledge of gene homology facilitates the transfer between crops of genes or genomic regions associated with desirable traits by genetic engineering,gene editing,or wide crossing.

关键词： Comparative genomics Orthologs Genes Synteny Genetic engineering Molecular breeding

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Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

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Matter and Radiation at Extremes 2024年第1期9卷 71-84页

作者： Josef Krása Tomás Burian Vera Hájková Jaromír Chalupský Šimon Jelínek Katerina Frantálová michal Krupka Zuzana Kuglerová Sushil Kumar Singh Vojtech Vozda Ludek Vysín michalŠmíd Pablo Perez-Martin Marion Kühlman Juan Pintor Jakub Cikhardt Matthias Dreimann Dennis Eckermann Felix Rosenthal Sam M.Vinko Alessandro Forte Thomas Gawne Thomas Campbell Shenyuan Ren YuanFeng Shi Trevor Hutchinson Oliver Humphries Thomas Preston Mikako Makita Motoaki Nakatsutsumi Xiayun Pan Alexander Köhler Marion Harmand Sven Toleikis Katerina Falk Libor Juha Department of Radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of Physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany DESY Photon Science Notkestraße 85D-22607 HamburgGermany Institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft Nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL GmbH Holzkoppel 4D-22869 SchenefeldGermany Technische Universität Dresden 01062 DresdenGermany

We report on an experiment performed at the FLASH2 free-electron laser(FEL)aimed at producing warm dense matter via soft x-ray isochoric *** the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups with varying *** find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi

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基于聚合物分散液晶的频率可重构贴片天线

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液晶与显示 2024年第1期39卷 17-24页

作者：储怡冰项颖张文慧郝禄国江博韬陈凯高延子胡湧川 michal KOHOUT 广东工业大学信息工程学院广东广州510006 北京科技大学新材料技术研究院北京100083 Department of Organic Chemistry University of Chemistry and Technology PragueCZ-16628 PragueCzech Republic

本文设计了一种以液晶聚合物为介质基板的频率可重构天线,通过调节贴片的位置及尺寸实现天线的阻抗匹配。制备聚合物分散液晶薄膜作为天线的介质,并根据液晶与聚合物的比例分别为7∶3、6∶4、5∶5这3种不同配比以及50μm和100μm两种不... 详细信息

本文设计了一种以液晶聚合物为介质基板的频率可重构天线,通过调节贴片的位置及尺寸实现天线的阻抗匹配。制备聚合物分散液晶薄膜作为天线的介质,并根据液晶与聚合物的比例分别为7∶3、6∶4、5∶5这3种不同配比以及50μm和100μm两种不同膜的厚度来考察其效果。在电场作用下,液晶微滴会沿着电场方向重新取向排列,通过改变驱动电压的大小,实现天线的频率可重构。经过对比分析得出,液晶含量(质量分数)为70%的聚合物分散液晶薄膜具有最佳的效果,在48 V的驱动电压下实现了62 MHz的频率连续调节,天线的最大增益为3.5 dBi。该基于液晶聚合物的频率可重构贴片天线结构简单、体积小、质量轻,易于集成在各种移动设备中,发展前景广阔。

关键词：液晶聚合物频率可重构贴片天线

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Proteomic-based evidence for adult neurogenesis in birds and mammals as indicated from cerebrospinal fluid

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Neural Regeneration Research 2022年第12期17卷 2576-2581页

作者： Eleni Voukali michal Vinkler Department of Zoology Faculty of ScienceCharles UniversityPragueCzech Republic

Adult neurogenesis is the life-long process of neural stem cell proliferation,differentiation into neurons,migration,and incorporation into the existing neuronal *** decades of research,it is now widely accepted that mammals and birds retain the capacity to regenerate neurons even after their subadult *** fluid participates in the regulation of the neurogenic niches of the vertebrate brain through signaling pathways not fully *** studies of cerebrospinal fluid have the potential to allow the in-depth characterization of its molecular *** studies help to delineate those pathways that are universally critical for the regulation of neurogenesis in *** this review,we performed literature-based data mining in studies using liquid chromatography-tandem mass spectroscopy that analyzed cerebrospinal fluid samples from healthy adult humans(Homo sapiens);mice(Mus musculus);sheep(Ovis aries);chickens(Gallus gallus);and two parrot species,the budgerigar(Melopsittacus undulatus)and cockatiel(Nymphicus hollandicus).We identified up to 911 proteins represented in cerebrospinal fluid,involved in various pathways regulating adult ***,only 196 proteins were common across humans,mice,and *** components involved in nervous system development,cell migration,and axonal guidance were commonly evident in all species investigated so *** bioinformatic analysis revealed that the universally over-represented pathways involved L1 cell adhesion molecule protein interactions,cell-adhesion molecules,signals regulating extracellular matrix remodeling,regulation of insulin growth factor signaling,axonal guidance,programmed cell death,immune signaling,and post-translational *** of the reported proteins are part of extracellular vesicles enriched in cerebrospinal ***,the information presently available is still highly fragmentary,and far more questions persist than

关键词： adult neurogenesis birds cerebrospinal fluid chicken comparative proteomics human mammals mass spectrometry parrots

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Literary placemaking and narrative immersion in extended reality virtual geographic environments

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International Journal of Digital Earth 2022年第1期15卷 853-867页

作者： michal Rzeszewski Jeneen Naji Faculty of Human Geography and Planning Adam Mickiewicz University in PoznanPoznanPoland Department of Media Studies Maynooth UniversityMaynoothIreland

Virtual geographical environments(VGEs)are being used to represent our sense of place through the application of extended-reality or cross-reality(XR)technologies with a focus on technological advancement and *** light of this,we propose that an expanded and interdisciplinary understanding of the concept of immersion is required to facilitate an understanding of spatial data to a broader *** potential of focusing on narrative immersion and literary placemaking in VGEs is discussed to evoke a stronger sense of place and a feeling of presence and belonging in *** paper seeks to highlight the unique affordances and potentialities of XR narrative style GIS digital representations through an interdisciplinary theoretically lead analysis of outputs created by the Building City dashboards project towards the goal of expanding audiences of non-specialist stakeholders in urban planning processes.

关键词： Literary placemaking immersion extended-reality(XR) virtual geographic environments(VGE) urban planning

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