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Short vs long-course antibiotic therapy in adults with acute cholangitis:A systematic review,meta-analysis,and evidence quality assessment

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World Journal of Gastroenterology 2023年第19期29卷 3027-3039页

作者： Karampet Kasparian Chrysanthos D Christou Konstantinos Petidis michail doumas Olga Giouleme Clinic of Oncology Gastroenterology and HematologyAlfried Krupp HospitalEssen 45131Germany Second Propedeutic Department of Internal Medicine Hippokration General HospitalAristotle University of ThessalonikiThessaloniki 54642Greece Department of Transplantation Surgery Hippokration General HospitalAristotle University of ThessalonikiThessaloniki 54642Greece

BACKGROUND Acute cholangitis(AC)constitutes an infection with increased mortality rates in the *** to new diagnostic tools and therapeutic methods,the mortality of AC has been significantly reduced *** initial antibiotic treatment of AC has been oriented to the most common pathogens connected to this ***,the optimal duration of the antibiotic treatment of AC is still *** To investigate if shorter-course antibiotic treatments could be similarly effective to long-course treatments in adults with *** This study constitutes a systematic review and meta-analysis of the existing literature concerning the duration of antibiotic therapy of AC and an assessment of the quality of the *** study was conducted in accordance with the recommendations of the Preferred Reporting Items for Systematic Review and *** studies were included in the systematic review,and eight were eligible for *** to heterogeneous duration cutoffs,three study-analysis groups were formed,with a cutoff of 2-3,6-7,and 14 *** A total of 2763 patients were included in the systematic review,and 1313 were accounted for the *** mean age was 73.66±14.67 years,and the male and female ratio was 1:*** significant differences were observed in the mortality rates of antibiotic treatment of 2-3 d,compared to longer treatments(odds ratio=0.78,95% confidence interval:0.23-2.67,I2=9%)and the recurrence rates and hospitalization length were also not different in all study *** Short-and long-course antibiotic treatments may be similarly effective concerning the mortality and recurrence rates of *** conclusions cannot be extracted concerning the hospitalization duration.

关键词： Acute cholangitis Antibiotic Short-course Long-course Antimicrobial Treatment duration

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Translation and cross-cultural adaptation of the Kidney Transplant Questionnaire 25 to Greek

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World Journal of Transplantation 2024年第2期14卷 148-154页

作者： Vasileios Koutlas Eirini Tzalavra Vasileios Tatsis Charalampos Pappas Stavroula Vovlianou Stefanos Bellos Anila Duni Eleni Stamellou Konstantinos I Tsamis michail Mitsis Evangelia Dounousi Department of Surgery and Kidney Transplant Unit University Hospital of IoanninaIoannina 45500EpirusGreece Department of Surgery Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece Department of Nephrology University Hospital of IoanninaIoannina 45500EpirusGreece Department of Nephrology General Hospital of KavalaKavala 65500Greece Department of Physiology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece Department of Nephrology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece

BACKGROUND Kidney transplantation leads to continuous improvement in the survival rates of kidney transplant recipients(KTRs)and has been established as the treatment of choice for patients with end-stage kidney ***-related quality of life(HRQoL)has become an important outcome *** is highly important to develop reliable methods to evaluate HRQoL with disease-specific *** To translate the disease-specific instrument Kidney Transplant Questionnaire 25(KTQ-25)to the Greek language and perform a cross-cultural *** The translation and adaptation of the original English version of the KTQ-25 to the Greek language were performed based on the International Quality of Life RESULTS Eighty-four KTRs(59 males;mean age 53.5±10.7 years;mean estimated glomerular filtration rate 47.7±15.1 mL/min/1.73 m2;mean transplant vintage 100.5±83.2 months)completed the Greek version of the KTQ-25 and the 36-item Short-Form Health Survey,and the results were used to evaluate the reliability of the Greek *** Cronbach alpha coefficients for all the KTQ-25 dimensions were satisfactory(physical symptoms=0.639,fatigue=0.856,uncertainty/fear=0.661,appearance=0.593,emotions=0.718,total score=0.708).The statistically significant correlation coefficients among the KTQ-25 dimensions ranged from 0.226 to *** correlation coeffi-cients of the KTQ-25 dimensions with the SF-36 physical component summary(PCS)ranged from 0.196 to 0.550;the correlation coefficients of the KTQ-25 with the SF-36 mental component summary(MCS)ranged from 0.260 to 0.655;and the correlation coefficients of the KTQ-25 with the total scores with the SF-36 PCS and MCS were 0.455 and 0.613,*** According to the findings,the Greek version of the KTQ-25 is valid and reliable for administration among kidney transplant patients in Greece.

关键词： Kidney Transplant Questionnaire 25 Kidney transplantation Kidney transplant recipients Health-related quality of life Quality of life

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Incidence, risk factors and clinical outcome of multidrug-resistant organisms after heart transplantation

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World Journal of Transplantation 2024年第2期14卷 107-118页

作者： Sophia Hatzianastasiou Paraskevas Vlachos Georgios Stravopodis Dimitrios Elaiopoulos Afentra Koukousli Josef Papaparaskevas Themistoklis Chamogeorgakis Kyrillos Papadopoulos Theodora Soulele Despoina Chilidou Kyriaki Kolovou Aggeliki Gkouziouta michail Bonios Stamatios Adamopoulos Stavros Dimopoulos Microbiology Department and Infection Control Office Onassis Cardiac Surgery CenterAthens 17674Greece Heart Transplantation Unit Onassis Cardiac Surgery CenterAthens 17674Greece Cardiac Surgery Intensive Care Unit Onassis Cardiac Surgery CenterAthens 17674Greece

BACKGROUND Transplant recipients commonly harbor multidrug-resistant organisms(MDROs),as a result of frequent hospital admissions and increased exposure to antimi-crobials and invasive *** To investigate the impact of patient demographic and clinical characteristics on MDRO acquisition,as well as the impact of MDRO acquisition on intensive care unit(ICU)and hospital length of stay,and on ICU mortality and 1-year mortality post heart *** This retrospective cohort study analyzed 98 consecutive heart transplant patients over a ten-year period(2013-2022)in a single transplantation *** was collected regarding MDROs commonly encountered in critical *** Among the 98 transplanted patients(70%male),about a third(32%)acquired or already harbored MDROs upon transplantation(MDRO group),while two thirds did not(MDRO-free group).The prevalent MDROs were Acinetobacter baumannii(14%),Pseudomonas aeruginosa(12%)and Klebsiella pneumoniae(11%).Compared to MDRO-free patients,the MDRO group was characterized by higher body mass index(P=0.002),higher rates of renal failure(P=0.017),primary graft dysfunction(10%vs 4.5%,P=0.001),surgical re-exploration(34%vs 14%,P=0.017),mechanical circulatory support(47%vs 26%P=0.037)and renal replacement therapy(28%vs 9%,P=0.014),as well as longer extracorporeal circulation time(median 210 vs 161 min,P=0.003).The median length of stay was longer in the MDRO group,namely ICU stay was 16 vs 9 d in the MDRO-free group(P=0.001),and hospital stay was 38 vs 28 d(P=0.006),while 1-year mortality was higher(28%vs 7.6%,log-rank-χ2:7.34).CONCLUSION Following heart transplantation,a predominance of Gram-negative MDROs was *** acquisition was associated with higher complication rates,prolonged ICU and total hospital stay,and higher post-transplantation mortality.

关键词： Heart transplantation Multi drug resistant organisms Transplantation complications Transplantation outcome

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Management of distal cholangiocarcinoma with arterial involvement: Systematic review and case series on the role of neoadjuvant therapy

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2689-2701页

作者： Lewis A Hall Duncan Loader Santiago Gouveia Marta Burak James Halle-Smith Peter Labib Moath Alarabiyat Ravi Marudanayagam Bobby V Dasari Keith J Roberts Syed S Raza michail Papamichail David C Bartlett Robert P Sutcliffe Nikolaos A Chatzizacharias Department of Hepatopancreatobiliary Surgery and Liver Transplantation University Hospitals Birmingham NHS Foundation TrustBirmingham B152GWUnited Kingdom Institute of Immunology and Immunotherapy University of BirminghamBirmingham B152TTUnited Kingdom College of Medical and Dental Sciences University of BirminghamBirmingham B152TTUnited Kingdom Institute of Clinical Sciences University of BirminghamBirmingham B152TTUnited Kingdom

BACKGROUND The use of neoadjuvant therapy(NAT)in distal cholangiocarcinoma(dCCA)with regional arterial or extensive venous involvement,is not widely accepted and evidence is *** To synthesise evidence on NAT for dCCA and present the experience of a highvolume tertiary-centre managing dCCA with arterial *** A systematic review was performed according to PRISMA guidance to identify all studies reporting outcomes of patients with dCCA who received *** patients from 2017 to 2022 who were referred for NAT for dCCA at our centre were retrospectively collected from a prospectively maintained *** characteristics,NAT type,progression to surgery and oncological outcomes were *** Twelve studies were *** definition of“unresectable”locally advanced dCCA was *** studies reported outcomes for 9 patients who received NAT for dCCA with extensive vascular involvement.R0 resection rate ranged between 0 and 100%but without survival benefit in most *** studies considered either NAT in resectable dCCA or inclusive with extrahepatic *** presented case series includes 9 patients(median age 67,IQR 56-74 years,male:female 5:4)referred for NAT for borderline resectable or locally advanced *** patients progressed to surgery and 2 were *** patient died at 14 months with evidence of recurrence at 6 months and the other died at 51 months following recurrence 6 months *** Evidence for benefit of NAT is *** on criteria for uniform definition of resectability for dCCA is *** propose using the established National-Comprehensive-Cancer-Network®criteria for pancreatic ductal adenocarcinoma.

关键词： Cholangiocarcinoma Neoadjuvant therapy Arterial involvement Locally advanced Systematic review

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Single-center experience with Knee+^(TM) augmented reality navigation system in primary total knee arthroplasty

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World Journal of Orthopedics 2024年第3期15卷 247-256页

作者： Evangelos Sakellariou Panagiotis Alevrogiannis Fani Alevrogianni Athanasios Galanis michail Vavourakis Panagiotis Karampinas Panagiotis Gavriil John Vlamis Stavros Alevrogiannis The 3^(rd)Department of Orthopaedic Surgery National&Kapodistrian University of AthensKAT General HospitalAthens 14561Greece The 1^(st)Department of Orthopaedic Surgery National&Kapodistrian University of AthensAttikon General HospitalAthens 14561Greece Department of Anesthesiology KAT General HospitalAthens 14561Greece Department of Robotic Hip&Knee Orthopaedic Surgery Metropolitan General HospitalAthens 14561Greece

BACKGROUND Computer-assisted systems obtained an increased interest in orthopaedic surgery over the last years,as they enhance precision compared to conventional *** expansion of computer assistance is evolving with the employment of augmented ***,the accuracy of augmented reality navigation systems has not been *** To examine the accuracy of component alignment and restoration of the affected limb’s mechanical axis in primary total knee arthroplasty(TKA),utilizing an augmented reality navigation system and to assess whether such systems are conspicuously fruitful for an accomplished knee *** From May 2021 to December 2021,30 patients,25 women and five men,under-went a primary unilateral *** cases were excluded.A preoperative radiographic procedure was performed to evaluate the limb’s axial *** patients were operated on by the same team,without a tourniquet,utilizing three distinct prostheses with the assistance of the Knee+™augmented reality navigation system in every ***,the same radiographic exam protocol was executed to evaluate the implants’position,orientation and coronal plane *** recorded measurements in 3 stages regarding femoral varus and flexion,tibial varus and posterior ***,the expected values from the Augmented Reality system were *** we calculated the same values after each cut and finally,the same measurements were recorded radiolo-gically after the *** statistical analysis,Lin’s concordance correlation coefficient was estimated,while Wilcoxon Signed Rank Test was performed when *** A statistically significant difference was observed regarding mean expected values and radiographic mea-surements for femoral flexion measurements only(Z score=2.67,P value=0.01).Nonetheless,this difference was statistically significantly lower than 1 degree(Z score=-4.21,P value<0.01).In terms of discrepancies in the calculations of

关键词： Augmented reality Orthopedics Total knee arthroplasty Robotics Knee Navigation

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非洲最恐怖的生命禁区一百年里无人敢涉足的达洛尔

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环球人文地理 2024年第5期 96-103页

作者：李理 Vladislav Radek Benot ArtushFoto Lina dinozzaver michail mikhail cheremkin flickr

色彩绚丽的盐层让人称奇，强酸性的湖水腐蚀鞋子，车队时不时被袭击，还曾有游客被撕票……达洛尔深刻诠释了什么叫“越迷人的越危险”。达洛尔位于埃塞俄比亚东北角，被描述成一个鬼城。因为2005年之后，埃塞俄比亚中央统计局的人口报...

色彩绚丽的盐层让人称奇，强酸性的湖水腐蚀鞋子，车队时不时被袭击，还曾有游客被撕票……达洛尔深刻诠释了什么叫“越迷人的越危险”。达洛尔位于埃塞俄比亚东北角，被描述成一个鬼城。因为2005年之后，埃塞俄比亚中央统计局的人口报告中，就已没有此地区的人口数据。这里是世界上最遥远、最荒芜的地区之一，没有学校、没有商店，也没有公路，对外交通除了游客车队，就只有前往该地收集盐块的阿法尔人与骆驼。然而，这里的形势极不稳定，

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Minimizing the risk of small-for-size syndrome after liver surgery

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Hepatobiliary & Pancreatic Diseases International 2022年第2期21卷 113-133页

作者： michail Papamichail michail Pizanias NigelD Heaton Department of Hepato-Pancreato-Biliary Surgery Royal Blackburn HospitalBlackburn BB23HHUK Department of General Surgery Whittington HospitalLondon N195NFUK Department of Liver Transplant and Hepato-Pancreato-Biliary Surgery Institute of Liver StudiesKings Health Partners at King’s College Hospital NHS TrustLondon SE59RSUK

Background: Primary and secondary liver tumors are not always amenable to resection due to location and size. Inadequate future liver remnant(FLR) may prevent patients from having a curative resection or may result in increased postoperative morbidity and mortality from complications related to small-forsize syndrome(SFSS). Data sources: This comprehensive review analyzed the principles, mechanism and risk factors associated with SFSS and presented current available options in the evaluation of FLR when planning liver surgery. In addition, it provided a detailed description of specifc modalities that can be used before, during or after surgery, in order to optimize the conditions for a safe resection and minimize the risk of SFSS. Results: Several methods which aim to reduce tumor burden, preserve healthy liver parenchyma, induce hypertrophy of FLR or prevent postoperative complications help minimize the risk of SFSS. Conclusions: With those techniques the indications of radical treatment for patients with liver tumors have signifcantly expanded. The successful outcome depends on appropriate patient selection, the individualization and modifcation of interventions and the right timing of surgery.

关键词： Small-for-size syndrome Liver resection Future liver remnant

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Pre-processing for time domain image formation in SS-BSAR system

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Journal of Systems Engineering and Electronics 2012年第6期23卷 875-880页

作者： michail Antoniou Mikhail Cherniakov School of Electronic Electrical and Computer EngineeringUniversity of BirminghamBirmingham B15 2TTUK

A pre-processing procedure is designed for a space-surface bistatic synthetic aperture radar （SS-BSAR） system when a time domain image formation algorithm is employed. Three crucial technical issues relating to the procedure are fully discussed. Firstly, unlike image formation algorithms operating in the frequency domain, a time domain algorithm requires the accurate global navigation satellite system （GNSS） time and position. This paper proposes acquisition of this information using a time-and-spatial transfer with precise ephemeris and interpolation. Secondly, synchronization errors and compensation methods in SS-BSAR are analyzed. Finally, taking the non-ideal factors in the echo and the compatibility of image formation algorithms into account, a matched filter based on the minimum delay is constructed. Experimental result using real data suggest the pre-processing is functioning properly.

关键词： image formation space-surface bistatic syntheticaperture radar (SS-BSAR) global navigation satellite system(GNSS) synchronization range compression.

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Passive GNSS-based SAR imaging and opportunities using Galileo E5 signals

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Science China(Information Sciences) 2015年第6期58卷 84-94页

作者： MA Hui ANTONIOU michail CHERNIAKOV Mikhail School of Electronic and Information Engineering Beihang University Electronic Electrical and Systems Engineering Department University of Birmingham

This paper investigates the feasibility of Galileo navigation satellites as transmitters of opportunity in passive bistatic synthetic aperture radar(SAR) systems from the perspectives of signal processing and experiment program. Experimental images obtained using a single Galileo channel, E5 a or E5 b, are presented and analyzed. The paper also puts forward the channel combination scheme to jointly process E5 a and E5 b channels, which brings up high-resolution possibilities for passive SAR technique. By employing the entire E5 band for imaging, the range resolution may be potentially increased by up to 5 times. Preliminary experimental results for this concept are demonstrated.

关键词： bistatic synthetic aperture radar(BSAR) GNSS-based SAR Galileo E5 channel combination

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Space-surface bistatic synthetic aperture radar with navigation satellite transmissions: a review

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Science China(Information Sciences) 2015年第6期58卷 5-24页

作者： ANTONIOU michail CHERNIAKOV Mikhail MA Hui Electronic Electrical and Systems Engineering Department University of Birmingham School of Electronic and Information Engineering Beihang University

This paper reviews the theory and practice of Space-Surface Bistatic Synthetic Aperture Radar(SS-BSAR) using navigation satellites as transmitters. In recent years, this innovative technology has reached a maturity stage which allows it to be considered for a wide range of applications. The paper covers the fundamental aspects of this technology as a radar system, such as the resolution, power budget and Point Spread Function(PSF) analysis, as well as its signal processing aspects and the state of the art in terms of advanced SAR techniques that it enables. Finally, the theoretical aspects of the paper may be directly transferred to the more generic SS-BSAR concept.

关键词： bistatic synthetic aperture radar GNSS-based SAR space-surface bistatic SAR coherent change detection multi-perspective imaging

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