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Gastroenterology and liver disease during COVID-19 and in anticipation of post-COVID-19 era: Current practice and future directions

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World Journal of Clinical Cases 2021年第19期9卷 4918-4938页

作者： Katerina G Oikonomou Panagiotis Papamichalis Tilemachos Zafeiridis Maria Xanthoudaki Evangelia Papapostolou Asimina Valsamaki Konstantinos Bouliaris michail Papamichalis Marios Karvouniaris Panagiotis J Vlachostergios Apostolia-Lemonia Skoura Apostolos Komnos Intensive Care Unit General Hospital of LarissaLarissa 41221ThessalyGreece Surgical Department General Hospital of LarissaLarissa 41221ThessalyGreece Department of Cardiology University Hospital of LarissaLarissa 41110ThessalyGreece Intensive Care Unit University Hospital of LarissaLarissa 41110ThessalyGreece Division of Hematology and Medical Oncology Department of MedicineWeill Cornell MedicineNew YorkNY 10065United States Transfusion Medicine Department University Hospital of LarissaLarissa 41110ThessalyGreece

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has emerged as a major threat to global public *** virus causes the clinical syndrome known as coronavirus disease 2019(COVID-19),in which multiple organs can get *** from manifestations of the respiratory system,which predominate,its clinical presentation is frequently accompanied by symptoms of the gastrointestinal(GI)tract and liver *** correlation of symptoms and abnormalities with disease severity is discussed,leading to ambiguous results from international ***,the disease infects patients with coexisting liver and GI disorders affecting both their health status and the availability of healthcare services provided to *** risk of transmission of the disease during aerosol-generating procedures has changed the diagnostic approach and follow-up algorithms for liver and GI *** the safety of both doctors and patients,telemedicine and distant evaluation have become everyday practice,whereas several routines and emergency visits at outpatient and emergency departments have been postponed or *** against SARS-CoV-2 is underway,providing hope to humanity and the expectation that the post-COVID-19 era is *** review aims to update knowledge about the manifestations of COVID-19 related to liver and GI diseases and the effect of the pandemic on the diagnostic and therapeutic procedures for these diseases with a special focus on how current practices have changed and what changes will possibly remain in the future.

关键词： COVID-19 SARS-CoV-2 Liver disease Gastroenterology practice Endoscopy

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Giga- and terahertz-range nanoemitter based on peapod structure

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Nano Research 2015年第8期8卷 2595-2602页

作者： michail M. Slepchenkov Anna S. Kolesnikova George V. Savostyanov1 Igor S. Nefedov Ilya V. Anoshkin Albert G. Nasibulin Olga E. Glukhova Department of Physics Saratov State University Saratov 410012 Russia Department of Radio Science and Engineering Aalto University Aalto P.O. Box 13000 Finland kolkovo Institute of Science and Technology Skolkovo 143025 Russia

We propose a theoretical model of a nanoemitter for giga- and terahertz-range waves. The model is based on a peapod structure comprising a carbon nanotube with chiral indices （10, 10）. Three encapsulated and partially polymerized fuUerene C60 molecules and a positively charged C60 fullerene are trapped inside the nanotube. The motion of the charged fullerene and the radiation frequency were controlled using an external electric field. Stable terahertz radiation at a frequency of 0.36 THz was produced at 300 K with an external electrical field of 10 V/μm. Stable radiation in the gigahertz range was observed at 50 K with an electric field below 10 V/m. A theoretical simulation was performed using the tight-binding molecular dynamics method with a description of the van der Waals interaction by the Morse potential. The system described by the theoretical model was experimentally observed.

关键词： fullerenes nanotubes electronics simulations molecular modeling

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Angiomyolipoma arising in the gluteal region

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Chinese Medical Journal 2007年第14期120卷 1284-1286页

作者： Emmanouil Pikoulis Constantine Bramis Othon michail George Liapis Evangelos Felekouras Vassiliki Kyriakou John Griniatsos First Department of Surgery Laikon Hospital University of Athens Medical SchoolAthens 115-27Greece Department of Pathology Laikon Hospital University of Athens Medical SchoolAthens 115-27Greece

Angiomyolipoma （AML） is a tumour of uncertain .histogenesis originally believed to be a hamartomatous lesion, but recently recognized as a usually benign clonal mesenchymal neoplasm. Along with lymphagiomyomatosis （LAM）, clear cell ＂sugar＂ turnout （CCST） and clear cell myelomelanocytic tumour （CCMMT）, AML was classified in the so called perivascular epithelioid cell （PEComa） neoplasm family.

关键词： angiomyolipoma buttocks

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Elderly patients with non-cardiac admissions and elevated highsensitivity troponin:the prognostic value of renal function

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World Journal of Cardiology 2021年第10期13卷 566-573页

作者： Ioanna Samara Stavroula Tsiara michail I Papafaklis Konstantinos Pappas Georgios Kolios Nikolaos Vryzas Lampros K Michalis Eleni T Bairaktari Christos S Katsouras Second Department of Cardiology University Hospital of IoanninaIoannina 45110Greece Second Department of Internal Medicine University Hospital of IoanninaIoannina 45110Greece Laboratory of Biochemistry University Hospital of IoanninaIoannina 45110Greece Laboratory of Clinical Chemistry School of Health SciencesFaculty of MedicineUniversity of IoanninaIoannina 45110Greece

BACKGROUND High-sensitivity cardiac troponin(hs-cTn)levels are frequently elevated in elderly patients presenting to the emergency department for non-cardiac ***,most studies on the role of elevated hs-cTn in elderly populations have investigated the prognostic value of hs-cTn in patients with a specific diagnosis or have assessed the relationship between hs-cTn and *** To investigate the in-hospital prognosis of consecutive elderly patients admitted to the Internal Medicine Department with acute non-cardiac events and increased hs-cTnI *** In this retrospective study,we selected patients who were aged≥65 years and admitted to the Internal Medicine Department of our hospital between January 2019 and December 2019 for non-cardiac *** patients were those who had hs-cTnI concentrations≥100 ng/*** investigated the independent predictors of in-hospital mortality by multivariable logistic regression *** One hundred and forty-six patients(59%female)were selected with an age range from 65 to 100(mean±SD:85.4±7.61)*** median hs-cTnI value was 284.2 ng/*** 72(49%)patients the diagnosis of hospitalization was an infectious *** overall in-hospital mortality was 32%(47 patients).Individuals who died did not have higher hs-cTnI levels compared with those who were discharged alive(median:314.8 vs 282.5 ng/L;P=0.565).There was no difference in mortality in patients with infectious vs non-infectious disease(29%vs 35%).Multivariable analysis showed that age(OR 1.062 per 1 year increase,95%CI:1.000-1.127;P=0.048)and creatinine levels(OR 2.065 per 1 mg/dL increase,95%CI:1.383-3.085;P<0.001)were the only independent predictors of *** was 49%in patients with eGFR<30 mL/min/1.73 *** Myocardial injury is a malignant condition in elderly patients admitted to the hospital for non-cardiac *** presence of severe renal impairment is a marker of extremely high in-hospital mortality.

关键词： Internal medicine High sensitivity troponin Elderly Non-cardiac admissions Renal function Prognosis

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Whole genome re-sequencing of sweet cherry(Prunus avium L.)yields insights into genomic diversity of a fruit species

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Horticulture Research 2020年第1期7卷 1889-1902页

作者： Aliki Xanthopoulou Maria Manioudaki Christos Bazakos Christos Kissoudis Anna-Maria Farsakoglou Evangelos Karagiannis michail michailidis Chrysanthi Polychroniadou Antonios Zambounis Konstantinos Kazantzis Athanasios Tsaftaris Panagiotis Madesis Filippos Aravanopoulos Athanassios Molassiotis Ioannis Ganopoulos Laboratory of Pomology Department of AgricultureAristotle University of Thessaloniki54124 ThessalonikiGreece Institute of Plant Breeding and Genetic Resources ELGO-DEMETER.ThermiThessaloniki 570001Greece Perrotis College American Farm SchoolThessaloniki GR-57001Greece Laboratory of Forest Genetics&Tree Breeding Faculty of AgricultureForestry&Environmental ScienceAristotle University of ThessalonikiThessalonikiGreece Institute of Plant Breeding and Genetic Resources ELGO-DEMETER.Department of Deciduous Fruit GrowingNaoussa 59035Greece Institute of Applied Biosciences CERTHThermiThessaloniki 57001Greece

Sweet cherries,Prunus avium L.(Rosaceae),are gaining importance due to their perenniallity and nutritional attributes beneficial for human ***,sweet cherry cultivars exhibit a wide range of phenotypic diversity in important agronomic traits,such as flowering time and defense reactions against *** this study,wholegenome resequencing(WGRS)was employed to characterize genetic variation,population structure and allelic variants in a panel of 20 sweet cherry and one wild cherry genotypes,embodying the majority of cultivated Greek germplasm and a representative of a local wild cherry elite *** 21 genotypes were sequenced in an average depth of coverage of 33.91×.and effective mapping depth,to the genomic reference sequence of‘Satonishiki’cultivar,between 22.21×to 36.62×.Discriminant analysis of principal components(DAPC)with SNPs revealed two clusters of *** was a rapid linkage disequilibrium decay,as the majority of SNP pairs with r2 in near complete disequilibrium(>0.8)were found at physical distances less than 10 *** analysis of the variants showed that the genomic ratio of non-synonymous/synonymous(dN/dS)changes was *** higher dN frequency in the Greek cohort of sweet cherry could be the result of artificial selection pressure imposed by breeding,in combination with the vegetative propagation of domesticated cultivars through *** majority of SNPs with high impact(e.g.,stop codon gaining,frameshift),were identified in genes involved in flowering time,dormancy and defense reactions against pathogens,providing promising resources for future breeding *** study has established the foundation for further large scale characterization of sweet cherry germplasm,enabling breeders to incorporate diverse germplasm and allelic variants to fine tune flowering and maturity time and disease resistance in sweet cherry cultivars.

关键词： breeding sweet insight

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Red blood cell distribution width in elderly hospitalized patients with cardiovascular disease

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World Journal of Cardiology 2021年第9期13卷 503-513页

作者： Andrew Xanthopoulos Konstantinos Tryposkiadis Apostolos Dimos Angeliki Bourazana Alexandros Zagouras Nikolaos Iakovis michail Papamichalis Grigorios Giamouzis George Vassilopoulos John Skoularigis Filippos Triposkiadis Department of Cardiology University Hospital of LarissaLarissa 41110Greece Independent Biostatistician Athens 15669Greece Department of Haematology University of Thessaly Medical SchoolLarissa 41110Greece

BACKGROUND Red blood cell distribution width(RDW)is elevated in patients with cardiovascular disease(CVD).AIM To determine RDW values and impact of CV and non-CV coexisting morbidities in elderly patients hospitalized with chronic *** This prospective study included 204 consecutive elderly patients(age 77.5[7.41]years,female 94[46%],left ventricular ejection fraction 53.00%[37.50,55.00])hospitalized with chronic CVD at the Cardiology Department of Larissa University General Hospital(Larissa,Greece)from January 2019 to April *** patients were selected due to the high prevalence of coexisting morbidities in this patient *** patients with acute CVD(acute coronary syndromes,new-onset heart failure[HF],and acute pericarditis/myocarditis),primary isolated valvular heart disease,sepsis,and those with a history of blood transfusions or cancer were *** evaluation of the patients within 24 h from admission included clinical examination,laboratory blood tests,and *** The most common cardiac morbidities were hypertension and coronary artery disease,with acutely decompensated chronic heart failure(ADCHF)and atrial fibrillation(AF)also frequently being *** most common non-cardiac morbidities were anemia and chronic kidney disease followed by diabetes mellitus,chronic obstructive pulmonary disease,and sleep *** was significantly elevated 15.48(2.15);121(59.3%)of patients had RDW>14.5%which represents the upper limit of normal in our *** associated with RDW in stepwise regression analysis were ADCHF(coefficient:1.406;95%confidence interval[CI]:0.830-1.981;P<0.001),AF(1.192;0.673 to 1.711;P<0.001),and anemia(0.806;0.256 to 1.355;P=0.004).ADCHF was the most significant factor associated with *** was on average 1.41 higher for patients with than without ADCHF,1.19 higher for patients with than without AF,and 0.81 higher for patients with than without *** patients were grouped b

关键词： Red blood cell distribution width Elderly Cardiovascular disease Coexisting morbidities

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Advancing male age differentially alters levels and localization patterns of PLCzeta in sperm and testes from different mouse strains

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Asian Journal of Andrology 2021年第2期23卷 178-187页

作者： Junaid Kashir Bhavesh V Mistry Maha Adel Gumssani Muhammad Rajab Reema Abu-Dawas Falah AlMohanna michail Nomikos Celine Jones Raed Abu-Dawud Nadya Al-Yacoub Kevin Coward F Anthony Lai Abdullah M Assiri College of Medicine Alfaisal UniversityRiyadh 11533Saudi Arabia Department of Comparative Medicine King Faisal Specialist Hospital and Research CentreRiyadh 11211Saudi Arabia College of Medicine QU HealthQatar UniversityDoha PO Box 2713Qatar Nuffield Department of Women’s and Reproductive Health University of OxfordLevel 3Women’s CentreJohn Radcliffe HospitalOxford OX39DUUnited Kingdom Biomedical Research Centre Qatar UniversityDoha PO Box 2713Qatar

Sperm-specific phospholipase C zeta(PLCζ)initiates intracellular calcium(Ca2+)transients which drive a series of concurrent events collectively termed oocyte *** investigations have linked abrogation and absence/reduction of PLCζwith forms of male infertility in humans where oocyte activation ***,very few studies have examined potential relationships between PLCζand advancing male age,both of which are increasingly considered to be major effectors of male *** efforts in humans may be hindered by inherent PLCζvariability within the human population,alongside a lack of sufficient controllable ***,utilizing immunoblotting,immunofluorescence,and quantitative reverse transcription PCR(qRT-PCR)we examined for the first time PLCζprotein levels and localization patterns in sperm,and PLCζmRNA levels within testes,from mice at 8 weeks,12 weeks,24 weeks,and 36 weeks of age,from two separate strains of mice,C57BL/6(B6;inbred)and CD1(outbred).Collectively,advancing male age generally diminished levels and variability of PLCζprotein and mRNA in sperm and testes,respectively,when both strains were ***,advancing male age altered the predominant pattern of PLCζlocalization in mouse sperm,with younger mice exhibiting predominantly post-acrosomal,and older mice exhibiting both post-acrosomal and acrosomal populations of PLCζ.However,the specific pattern of such decline in levels of protein and mRNA was ***,our results demonstrate a negative relationship between advancing male age and PLCζlevels and localization patterns,indicating that aging male mice from different strains may serve as useful models to investigate PLCζin cases of male infertility and subfertility in humans.

关键词： ageing fertilization male infertility oocyte activation phospholipase C zeta sperm

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Nanoparticles of Palladium, Platinum and Silver:Incoporation into Perfluoro-Sulfonated Membrane MF-4SK and Ionic Nafion

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Advances in Nanoparticles 2013年第3期2卷 280-286页

作者： Alexandra Revina Sergey Busev Anatoly Kalinitchev michail Kuznetsov Ardalion Ponomarev Marina Lebedeva Institute of Physical Chemistry and Electrochemistry RAS Moscow Russia

The purpose of the investigation is the study of the physico-chemical properties and electro-catalytic characteristics of the Nafion and MF-4SK membranes with the author’s nanoparticles (A. Revina, 2008) incorporated into the perfluoro- sulphonated cationic membranes. An important advance in the creation of new nano-composite materials with poly-functional activity is the inclusion of nanoparticles of various metals (Pd, Pt, Ag) in these membranes. Polymer ion exchange membranes represent widely applicable materials in various areas of modern nanotechnologies. The obtained nanocomposites on the base of included nanoparticles have the perspective properties and polyfunctional activity for the applications.

关键词： UV-VIS Spectrophotometry AFM CVA-Measurements Palladium Nanoparticles Platinum Nanoparticles Silver Nanoparticles Perfluoro-Sulfonated Membranes Nafion MF-4SK Membrane

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Translation and cross-cultural adaptation of the Kidney Transplant Questionnaire 25 to Greek

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World Journal of Transplantation 2024年第2期14卷 148-154页

作者： Vasileios Koutlas Eirini Tzalavra Vasileios Tatsis Charalampos Pappas Stavroula Vovlianou Stefanos Bellos Anila Duni Eleni Stamellou Konstantinos I Tsamis michail Mitsis Evangelia Dounousi Department of Surgery and Kidney Transplant Unit University Hospital of IoanninaIoannina 45500EpirusGreece Department of Surgery Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece Department of Nephrology University Hospital of IoanninaIoannina 45500EpirusGreece Department of Nephrology General Hospital of KavalaKavala 65500Greece Department of Physiology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece Department of Nephrology Faculty of MedicineSchool of Health SciencesUniversity of IoanninaIoannina 45110EpirusGreece

BACKGROUND Kidney transplantation leads to continuous improvement in the survival rates of kidney transplant recipients(KTRs)and has been established as the treatment of choice for patients with end-stage kidney ***-related quality of life(HRQoL)has become an important outcome *** is highly important to develop reliable methods to evaluate HRQoL with disease-specific *** To translate the disease-specific instrument Kidney Transplant Questionnaire 25(KTQ-25)to the Greek language and perform a cross-cultural *** The translation and adaptation of the original English version of the KTQ-25 to the Greek language were performed based on the International Quality of Life RESULTS Eighty-four KTRs(59 males;mean age 53.5±10.7 years;mean estimated glomerular filtration rate 47.7±15.1 mL/min/1.73 m2;mean transplant vintage 100.5±83.2 months)completed the Greek version of the KTQ-25 and the 36-item Short-Form Health Survey,and the results were used to evaluate the reliability of the Greek *** Cronbach alpha coefficients for all the KTQ-25 dimensions were satisfactory(physical symptoms=0.639,fatigue=0.856,uncertainty/fear=0.661,appearance=0.593,emotions=0.718,total score=0.708).The statistically significant correlation coefficients among the KTQ-25 dimensions ranged from 0.226 to *** correlation coeffi-cients of the KTQ-25 dimensions with the SF-36 physical component summary(PCS)ranged from 0.196 to 0.550;the correlation coefficients of the KTQ-25 with the SF-36 mental component summary(MCS)ranged from 0.260 to 0.655;and the correlation coefficients of the KTQ-25 with the total scores with the SF-36 PCS and MCS were 0.455 and 0.613,*** According to the findings,the Greek version of the KTQ-25 is valid and reliable for administration among kidney transplant patients in Greece.

关键词： Kidney Transplant Questionnaire 25 Kidney transplantation Kidney transplant recipients Health-related quality of life Quality of life

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On the Effects of Platform Positional Instability on a UMTS System Served by HAPS

On the Effects of Platform Positional Instability on a UMTS ...

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IEEE第14届国际个人无线移动通信大会

作者： Dimitrios I. Axiotis michail E. Theologou Telecommunications Laboratory School of Electrical and Computer Engineering National Technical University of Athens Zografou Campus Greece Telecommunications Laboratory School of Electrical and Computer Engineering National Technical University of Athens Zografou Campus Greece

High Altitude Platform Stations (HAPS) are a new, promising means of providing International Mobile Telecommunications (IMT-2000). One of the potential problems of the system is th

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