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Call it sleep-what animals without backbones can tell us about the phylogeny of intrinsically generated neuromotor rhythms during early development

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Neuroscience Bulletin 2013年第3期29卷 373-380页

作者： michael A. Corner Netherlands Institute for Brain Research Amsterdam The Netherlands Université de Basse Normandie Caen France Harmoniehof 16/i 1071TC Amsterdam The Netherlands

A comprehensive overview is presented of the literature dealing with the development of sleep-like motility and neuronal activity patterns in non-vertebrate animals. It has been established that spontaneous, periodically modulated, neurogenic bursts of movement appear to be a universal feature of prenatal behavior. New empirical data are presented showing that such ＇seismic sleep＇ or ＇rapid-body-movement＇ bursts in cuttlefish persist for some time after birth. Extensive ontogenetic research in both vertebrates and non-vertebrates is thus essential before current hypotheses about the phylogeny of motorically active sleep-like states can be taken seriously.

关键词： sleep phylogeny behavior development spontaneous motility neuronal networks cuttlefish

The Agricultural-Industrial Partnership for Eliminating Micronutrient Malnutrition: The Investment Bargain of the Decade

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Biomedical and Environmental Sciences 2001年第1期14卷 104-123页

作者： JOSEPH michael HUNT Senior Health and Nutrition Economist Asian Development Bank Manila Philippines

The limitations of conventional approaches to eliminating micronutrient deficiencies drives the search for a sustainable paradigm. This manuscript argues that the public and private sectors must embark on modernization of the Asian food industry and reorientation of the international agricultural research complex so that nutritionally enriched essential foods will be affordable and accessible to the poor. It is recommended that this partnership take special care of the needs of Asian children. The costs of chronic undernutrition, availability of cost effective strategies, and benefits of sustained nutrition improvement to individuals, families and nations are reviewed. The roles of food fortification, plant breeding and biotechnology, both actual and imminent, are described. The paper concludes that a recast Green Revolution directed to dietary quality may be the key to enhancing the learning and earning capacity of young Asians of the new millenium. “No other technology offers as large an opportunity to improve lives\{…\}at such a low cost and in such a short time\{…\}” World Bank [1] .

关键词： Agriculture Child Welfare Industry Micronutrients Nutrition Policy Biotechnology Child Food Industry Food Fortified Humans Interprofessional Relations Nutrition Disorders Policy Making

Hemagglutinin-esterase-fusion （HEF） protein of influenza C virus

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Protein & Cell 2016年第1期7卷 28-45页

作者： MingyangWang michael Veilt Institute of Virology Veterinary Medicine Free University BerLin BerLin Germany

Influenza C virus, a member of the Orthomyxoviridae family, causes flu-like disease but typically only with mild symptoms. Humans are the main reservoir of the virus, but it also infects pigs and dogs. Very recently, influenza C-like viruses were isolated from pigs and cattle that differ from classical influenza C virus and might constitute a new influenza virus genus. Influenza C virus is unique since it contains only one spike protein, the hemagglu- tinin-esterase-fusion glycoprotein HEF that possesses receptor binding, receptor destroying and membrane fusion activities, thus combining the functions of Hemaggiutinin （HA） and Neuraminidase （NA） of influenza A and B viruses. Here we briefly review the epidemiology and pathology of the virus and the morphology of virus particles and their genome. The main focus is on the structure of the HEF protein as well as on its co- and post- translational modification, such as N-glycosylation, disulfide bond formation, S-acylation and proteolytic cleavage into HEF1 and HEF2 subunits. Finally, we describe the functions of HEF： receptor binding, esterase activity and membrane fusion.

关键词： influenza C virus HEF structure receptorbinding esterase membrane fusion

PM2.5： global progress in controlling the motor vehicle contribution

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Frontiers of Environmental Science & Engineering 2014年第1期8卷 1-17页

作者： michael Patrick WALSH International Consultant Arlington VA 22207 USA

It is well established that ambient particles in the size range of 2.5 microns or less case a wide variety of adverse health effects. According to a recent study from the World Health Organization, in 2010 these effects resulted in approximately 3.2million premature deaths with vehicles being one of the significant contributors. Diesel vehicle particulate emissions which are virtually all smaller than 2.5 microns raise additional special concerns due to their carcinogenicity and high ratio of black carbon （BC） to organic carbon; black carbon has recently been found to be the second most important contributor to climate change after carbon dioxide. Other pollutants emitted by diesels and other vehicles such as the oxides of nitrogen and volatile organic compounds also contribute to ambient particulate matter smaller than 2.5 microns in size （PM2.5） after undergoing secondary transformations in the atrno- sphere. Technologies have dramatically reduce vehicle been developed that can emissions when clean, low sulfur fuels are available and these technologies are being phased in throughout the industrialized world resulting in a global decrease in particulate matter （PM） and BC emissions from vehicles. However the vehicle population is growing rapidly in the developing world, leading to increases in emissions in many countries. Unless these rapidly industrializing countries move to state of the art vehicles and clean fuels, global PM, BC and NOx emissions from road vehicles will start to turn up over the next 10 to 15 years.

关键词： particulate black carbon climate change,diesels

A class of singular integrals on the n-complex unit sphere

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Science China Mathematics 1999年第12期42卷 1233-1245页

作者： michael Cowling 钱涛 Department of Pure Mathematics University of New South Walse

The operaton on the n-complex unit sphere under study have three forms: the singular integrals with holomorphic kernels, the bounded and holomorphic Fourier multipliers, and the Cauchy-Dunford bounded and holomorphic functional calculus of the radial Dirac operator $D = \sum\nolimits_{k = 1}^n {z_k \frac{\partial }{{\partial _{z_k } }}} $ . The equivalence between the three fom and the strong-type (p,p), 1

关键词： singular integral Fourier multiplier the unit sphere in C n lunetional calculus

The Short Local Algebras of Dimension 6 with Non-projective Reflexive Modules

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Communications in Mathematics and Statistics 2023年第2期11卷 195-227页

作者： Claus michael Ringel Fakultät für Mathematik Universität BielefeldPO Box 10013133501 BielefeldGermany

Let A be a finite-dimensional local algebra over an algebraically closed field,let J be the radical of *** modules we are interested in are the finitely generated left *** are always reflexive,and an algebra is self-injective iff allmodules are *** discuss the existence of non-projective reflexive modules in case A is not *** assume that A is short(this means that J^(3)=0).In a joint paper with Zhang Pu,it has been shown that 6 is the smallest possible dimension of A that can occur and that in this case the following conditions have to be satisfied:J^(2)is both the left socle and the right socle of A and there is no uniform ideal of length *** present paper is devoted to showing the converse.

关键词： Short local algebra Reflexive module Gorenstein-projective module Bristle Atom Bar Bristle-bar layout

On Multi-Level Thinking and Scientific Understanding

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Advances in Atmospheric Sciences 2017年第10期34卷 1150-1158页

作者： michael Edgeworth McINTYRE Department of Applied Mathematics and Theoretical Physics University of CambridgeCambridge CB3 0WAUnited Kingdom.

Professor Duzheng YE＇s name has been familiar to me ever since my postdoctoral years at MIT with Professors Jule CHARNEY and Norman PHILLIPS, back in the late 1960 s. I had the enormous pleasure of meeting Professor YE personally in 1992 in Beijing. His concern to promote the very best science and to use it well, and his thinking on multi-level orderly human activities, reminds me not only of the communication skills we need as scientists but also of the multi-level nature of science itself. Here I want to say something（a） about what science is;（b） about why multi-level thinking—and taking more than one viewpoint—is so important for scientific as well as for other forms of understanding; and（c） about what is meant, at a deep level, by ＂scientific understanding＂ and trying to communicate it, not only with lay persons but also across professional disciplines. I hope that Professor YE would approve.

关键词： communication skills cross-disciplinary communication scientific understanding unconscious assumptions multiple viewpoints brain hemispheres biological evolution

Regulation of antitumor immunity by inflammation-induced epigenetic alterations

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Cellular & Molecular Immunology 2022年第1期19卷 59-66页

作者： michael Karin Shabnam Shalapour Department of Pharmacology School of MedicineUniversity of California San DiegoLa JollaCAUSA Laboratory of Gene Regulation and Signal Transduction Department of PharmacologySchool of MedicineUniversity of California San DiegoLa JollaCAUSA Department of Cancer Biology University of Texas MD Anderson Cancer CenterHoustonTXUSA

Chronic inflammation promotes tumor development,progression,and metastatic dissemination and causes treatment *** accumulation of genetic alterations and loss of normal cellular regulatory processes are not only associated with cancer growth and progression but also result in the expression of tumor-specific and tumor-associated antigens that may activate antitumor *** antagonism between inflammation and immunity and the ability of cancer cells to avoid immune detection affect the course of cancer development and treatment *** inflammation,particularly acute inflammation,supports T-cell priming,activation,and infiltration into infected tissues,chronic inflammation is mostly ***,the main mechanisms that dictate the outcome of the inflammation-immunity interplay are not well *** data suggest that inflammation triggers epigenetic alterations in cancer cells and components of the tumor *** alterations can affect and modulate numerous aspects of cancer development,including tumor growth,the metabolic state,metastatic spread,immune escape,and immunosuppressive or immunosupportive leukocyte *** this review,we discuss the role of inflammation in initiating epigenetic alterations in immune cells,cancer-associated fibroblasts,and cancer cells and suggest how and when epigenetic interventions can be combined with immunotherapies to improve therapeutic outcomes.

关键词： Inflammation Epigenetics Antitumor immunity Immunotherapy

The Neglected Role of Risk Mitigation Perception in the Risk Governance of Underground Technologies——The Example of Induced Seismicity

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International Journal of Disaster Risk Science 2020年第5期11卷 630-639页

作者： Lisa Haemmerli michael Stauffacher D-USYS Transdisciplinarity Lab Department of Environmental Systems Science(D-USYS)ETH Zurich(Swiss Federal Institute of Technology/Eidgenossische Technische Hochschule)8092 ZurichSwitzerland

Subsurface technologies,such as geothermal energy and carbon capture and storage,are options to help limit global *** tech no logies involve the risk of induced *** successful implementation of these technologies depends on the public perception of these *** governance frameworks propose assessing the level of public concern and designing adapted risk mitigation *** propose that concerns should not only be investigated with respect to the perceived risks but also with respect to the potential mitigation *** explore this by analyzing the perception of risk mitigation measures for different subsurface *** an online survey(N=808)in Switzerland we analyzed four technologies(in-between subject design)and four mitigation measures(within subject design).We found that risk mitigation measures are perceived differently,within and across ***,public concerns about risk mitigation really *** suggest that future research should focus on how risk mitigation measures can be applied and communicated to realize the full potential of risk governance frameworks.

关键词： Carbon capture and storage Enhanced geothermal systems Induced seismicity Risk mitigation perception Shale gas Switzerland