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j.urnal of Computer and Communications 2024年第2期12卷 156-172页

作者： Albert Eff michael s. j. walter Department of Engineering Ansbach University of Applied Sciences Ansbach Germany

In times.of digitalis.tion, vis.al as.is.ance s.s.ems.in as.embly are increas.ngly important. The des.gn of thes. as.embly s.s.ems.needs.to be highly complex to meet the requirements. Due to the increas.ng number of variants.in production proces.es. as.well as.s.orter innovation and product life cycles. as.is.ance s.s.ems.s.ould improve quality and reduce complexity of as.embly proces.es. However, many large kitchen manufacturers.s.ill as.emble kitchen cabinets.manually, due to the high variety of components. s.ch as.rails.and fittings. This.paper focus.s.on the analys.s.and evaluation of virtual as.is.ance s.s.ems.to improve quality and us.bility in individualis.d kitchen cabinet as.embly proces.es.at a large German manufacturer. A s.lution is.identified and detailed.

关键词： Digitalis.tion As.embly Proces. Vis.al As.is.ance Us.bility Human-Centred As.embly Des.gn

Editorial for the s.ecial Is.ue on Emerging Technology and Advanced Application of Nondes.ructive Detection for Power Equipment

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Chines. j.urnal of Electrical Engineering 2024年第1期10卷 1-2页

作者： Li j. Mei H. Li s. Tianj.n Univers.ty China Ts.nghua s.enzhen International Graduate s.hool China Lanzhou j.aotong Univers.ty China

The rapid development of clean and renewable energy technologies.repres.nted by wind and s.lar energy,as.well as.the continuous.growth of load demand,have put forward higher requirements.for the s.fe operation of the power *** performance of power equipment bas.d on traditional dielectric materials.is.often limited by various.defects.generated during molding,trans.ortation,as.embly,and operation,which cannot meet the reliability requirements.of power s.s.ems.in the new *** detection is.an es.ential technical method in indus.rial development,which can detect and evaluate the defect and damage s.atus.of in-s.rvice equipment,key components.and materials.without damaging the obj.ct.

关键词： s.rvice Application operation

Comparis.n of trigeminal lateralization with differing s.imulants

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World j.urnal of Otorhinolaryngology-Head and Neck s.rgery 2024年第1期10卷 66-69页

作者： Tiffany Chen Nicolas.s.Poupore michael C.s.ih Thomas.s.Edwards.s.aun A.Nguyen Zachary M.s.ler Rodney j.s.hlos.er Department of Otolaryngology‐Head and Neck s.rgery Medical University of South CarolinaCharlestonSouth CarolinaUSA

Trigeminal-s.ecific s.imulants.have been s.own to activate different receptors.preferentially and this.likely accounts.for variation in s.ns.ry *** is.unclear whether trigeminal s.ns.tivity is.s.milar acros. different trans.ent receptor potential(TRP)receptors.or if dys.unction of different receptors.res.lts.in differing patient ***,a pros.ective cohort s.udy was.conducted,cons.s.ing of trigeminal lateralization tes.ing with three different s.imulants.eucalyptol,is.thiocyanate,acetic acid),olfaction tes.ing with s.iffin's.icks.and meas.rement of various.patient‐reported outcome meas.res.PROMs..A total of 50 participants.were enrolled acros. the olfactory *** TDI s.ore was.27.1±8.3(range 7.0–39.5)with 38%normos.ic and 62%*** trigeminal lateralization s.ores.out of 20 in the overall cohort were 16.18(2.78)for eucalyptol,14.94(3.49)for mus.ard oil,and 15.28(3.68)for *** s.owed a s.gnificant correlation with thres.old s.ores.of s.iffin's.icks.A s.gnificant correlation was.found between acetic acid and various.*** of the lateralization s.ores.of the trigeminal s.imulants.correlated to each other s.gnificantly and there was.no correlation to *** lack of correlation s.gges.s.that the meas.red s.ns.tivity of one type of TRP receptor may not trans.ate to s.milar s.ns.tivity of the other *** inves.igations.with TRPV1 and TRPA1 agonis.s.are needed to corroborate our findings.

关键词： chemos.ns.ry olfaction trigeminal TRP receptor

Clus.er Modulation: A Generalized Modulation s.heme Leading to NOMA or Adaptive Modulation

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j.urnal of Computer and Communications 2024年第7期12卷 12-22页

作者： j.mal s. Rahhal s.liman j. Rahhal Electrical Engineering Department The University of Jordan Amman Jordan Invenco Co. Tampa USA

The need for higher data rate and higher s.s.ems.capacity leads.to s.veral s.lutions.including higher cons.ellation s.ze, s.atial multiplexing, adaptive modulation and Non-Orthogonal Multiple Acces. (NOMA). Adaptive Modulation makes.us. of the us.r’s.location from his.bas. s.ation, s.ch that, clos.r us.rs.get bigger cons.ellation s.ze and hence higher data rate. A s.milar idea of adaptive modulation that makes.us. of the us.r’s.locations.is.the NOMA technique. Here the bas. s.ation trans.its.compos.te s.gnals.each for a different us.r at a different dis.ance from the bas. s.ation. The trans.itted s.gnal is.formed by s.mming different us.r’s.cons.ellations.with different weights. The clos.r the us.rs.the les. average power cons.ellation is.us.d. This.will allow the clos.r us.r to the bas. s.ation to dis.inguis. his.cons.ellation and others.cons.ellation. The far us.r will only dis.inguis. his.cons.ellation and other us.r’s.data will appear as.a s.all interference added to his.s.gnal. In this.paper, it is.s.own that the Adaptive modulation and the NOMA are s.ecial cas.s.of the more general Clus.er Modulation technique. Therefore, a general frame can be s.t to des.gn both modulation s.hemes.and better unders.anding is.achieved. This.leads.to des.gning a multi-level NOMA and/or flexible adaptive modulation with combined channel coding.

关键词： Clus.er Modulation Adaptive Modulation NOMA

Harnes.ing naturally occurring mutations.for T-cell therapy:a potential new avenue to enhance treatment efficacy

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s.gnal Trans.uction and Targeted Therapy 2024年第5期9卷 1799-1801页

作者： michael Hiltens.erger j.rgen Ruland Kilian s.hober Mikrobiologis.hes.Ins.itut-Klinis.he Mikrobiologie Immunologie und HygieneFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany Ins.itute of Clinical Chemis.ry and Pathobiochemis.ry School of MedicineTechnical University of MunichMunichGermany Trans.aTUM Center for Translational Cancer ResearchTechnical University of MunichMunichGermany German Cancer Cons.rtium(DKTK) HeidelbergGermany German Center for Infection Res.arch(DZIF) partner site MunichMunichGermany FAU Profile Center Immunomedicine Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

In a recent s.udy publis.ed in Nature,Garcia et *** a s.phis.icated approach to identify fitnes.-enhancing mutations.for T cells.that was.ins.ired by cancer evolution.1 The identified CARD11-PIK3R3 gene fus.on enhanced tumor rej.ction and pers.s.ence of engineered T cells.in multiple tumor models.and might have the potential to improve efficacy of adoptive T-cell therapies.in cancer patients.

关键词： cancer potential

Application of a s.mplified ADM1 for full-s.ale anaerobic co-diges.ion of cattle s.urry and gras. s.lage:as.es.ment of input variability

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Frontiers.of Environmental s.ience & Engineering 2024年第4期18卷 125-139页

作者： s.fia Tis.cco s.ren Weinrich Gary Lyons.michael Wills.Xinmin Zhan Paul Cros.on Civil Engineering College of Science and EngineeringUniversity of GalwayGalwayH91 TK33Ireland Teagas. Animal and Bios.ience Res.arch Department Animal and Grassland Research and Innovation CentreDunsanyC15 PW93Ireland Biochemical Convers.on Department Deutsches Biomasseforschungszentrum gemeinnützige GmbHLeipzig 04347Germany Faculty of Energy·Building s.rvices.Environmental Engineering Münster University of Applied SciencesSteinfurt 48565Germany Agri-Food and Bios.iences.Ins.itute HillsboroughBT266DRUK Ryan Ins.itute University of GalwayGalwayH91 TK33Ireland MaREI Res.arch Centre for Energy Climate and MarineRyan InstituteUniversity of GalwayGalwayH91 TK33Ireland

Mathematical modeling of anaerobic diges.ion is.a powerful tool to predict gas.yields.and optimize the *** Anaerobic Diges.ion Model No.1(ADM1)is.a widely implemented model for this.***,modeling full-s.ale biogas.plants.is.challenging due to the extens.ve s.bs.rate and parameter characterization *** s.udy des.ribes.the modification of the ADM1 through a s.mplification of individual proces. phas.s.characteris.ic components.and required ***,the ability of the s.mplified model to s.mulate the co-diges.ion of gras. s.lage and cattle s.urry was.evaluated us.ng data from a full-s.ale biogas.*** impacts.of s.bs.rate compos.tion(crude carbohydrate,protein and lipid concentration)and variability of carbohydrate degradability on s.mulation res.lts.were as.es.ed to identify the mos. influential *** indicated that the s.mplified vers.on was.able to depict biogas.and biomethane production with average model efficiencies.according to the Nas.-s.tcliffe efficiency(Ns.)coefficient,of 0.70 and 0.67,res.ectively,and was.comparable to the original ADM1(average model efficiencies.of 0.71 and 0.63,res.ectively).The variability of crude carbohydrate,protein and lipid concentration did not s.gnificantly impact biogas.and biomethane output for the data s.ts.*** contras.,carbohydrate degradability s.emed to explain much more of the variability in the biogas.and methane ***,the application of s.mplified models.provides.a reliable bas.s.for the proces. s.mulation and optimization of full-s.ale agricultural biogas.plants.

关键词： ADM1 Agricultural feeds.ocks Biogas.technology Input variability Parameter es.imation

Fetal Head Compres.ion: Its.Pos.ible Role in Neurologic Inj.ry

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Open j.urnal of Obs.etrics.and Gynecology 2024年第1期14卷 124-143页

作者： Barry s. s.hifrin Brian j. Koos.Wayne R. Cohen Department of Obs.etrics.and Gynecology The Western University of Health Sciences Pomona USA The David Geffen s.hool of Medicine at UCLA Los Angeles USA The Univers.ty of Arizona College of Medicine Tucson USA

It is.widely as.umed that fetal is.hemic brain inj.ry during labor derives.almos. exclus.vely from s.vere, s.s.emic hypoxemia with marked neonatal depres.ion and acidemia. s.vere as.hyxia, however, is.one of s.veral caus.s.of perinatal neurological inj.ry and may not be the mos. common;mos. neonates.diagnos.d with hypoxic-is.hemic encephalopathy do not have evidence of s.vere as.hyxia. s.ps.s. direct brain trauma, and drug or toxin expos.re account for s.me cas.s. while mechanical forces.of labor and delivery that increas. fetal intracranial pres.ure s.fficiently to impair brain perfus.on may als. contribute. Becaus. of bony compliance and mobile s.ture lines. the fetal s.ull changes.s.ape and redis.ributes.cerebros.inal fluid during labor according to cons.raints.impos.d by contractions. and bony and s.ft tis.ue elements.of the birth canal as.the head des.ends. Thes. accommodations. including the increas. in intracranial pres.ure, are adaptive and neces.ary for efficient des.ent of the head while s.feguarding cerebral blood flow. Autonomic reflexes.mediated through central receptors.normally provide ample protection of the brain from the cons.derable pres.ure exerted on the s.ull. On occas.on, thos. forces. which are trans.itted intracranially, may overcome the various.adaptive anatomical, cardiovas.ular, metabolic, and neurological mechanis.s.that maintain cerebral perfus.on and oxygen availability, res.lting in is.hemic brain inj.ry. Accepting the notion of a potentially advers. impact of fetal head compres.ion s.gges.s.that avoidance of exces.ive uterine activity and of relentles. pus.ing without s.eady progres. in des.ent may offer protection for the fetal brain during parturition. Exces.ive head compres.ion s.ould be cons.dered in the differential diagnos.s.of is.hemic encephalopathy.

关键词： Fetal Brain Inj.ry Fetal Head Compres.ion Is.hemic Encephalopathy Neonatal Encephalopathy

Us. of donepezil for neurocognitive recovery after brain inj.ry in adult and pediatric populations.a s.oping review

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Neural Regeneration Res.arch 2024年第8期19卷 1686-1695页

作者： Avery L.Miller Nathan K.Evans.n j.michael Taylor Univers.ty of Cincinnati College of Medicine CincinnatiOHUSA Department of Pediatrics University of CincinnatiCincinnatiOHUSA Department of Neurology and Rehabilitation Medicine University of CincinnatiCincinnatiOHUSA Divis.on of Pediatric Rehabilitation Medicine Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA Divis.on of Neurology Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA

There are few pharmacologic options.for the treatment of cognitive deficits.as.ociated with traumatic brain inj.ry in pediatric *** inhibitors.s.ch as.donepezil have been evaluated in adult patients.after traumatic brain inj.ry,but relatively les. is.known about the effect in pediatric *** goal of this.review is.to identify knowledge gaps.in the efficacy and s.fety of acetylcholines.eras. inhibito rs.as.a potential a dj.vant treatment fo r neurocognitive decline in pediatric patients.with traumatic brain *** queried PubMed to identify literature publis.ed from databas. inception thro ugh j.ne 2023 des. ribing the us. of donepezil in young adult traumatic brain inj.ry and pediatric patients.with predefined *** on pres.lected s.arch criteria,340 unique papers.we re s.lected for title and abs.ra ct ***-two reco rds.were reviewed in full after eliminating preclinical s.udies.and pape rs.outs.de the s.ope of the *** adult traumatic brain inj.ry,we review res.lts.from 14 papers.detailing 227 s.bj.cts.where evidence s.gges.s.donepezil is.well tole rated and s.ows.both obj.ctive and patient-reported efficacy for reducing cognitive *** children,3 pape rs.report on 5 children recovering from traumatic brain inj.ry,s.owing limited *** additional 15 pediatric s.udies.conducted in populations.at ris. for cognitive dys.unction provide a broader look at s.fety and efficacy in 210 patients.in the pediatric age *** its.promis. for efficacy in adults.with traumatic brain inj.ry and tole rability in pediatric patients.we believe further s.udy of donepezil for children and adoles.ents.with traumatic brain inj.ry is.warranted.

关键词： acetylcholines.eras. inhibitor adult cognition donepezil pediatrics traumatic brain inj.ry

Meas.rement,as.ociations.patterns.and promotion:Unveiling vital areas.in phys.cal activity epidemiology

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j.urnal of s.ort and Health s.ience 2024年第5期13卷 605-607页

作者： Kara M.Whitaker Gues. editor michael j.LaMonte Department of Health&Human Phys.ology University of IowaIowa CityIA 52242USA Department of Epidemiology and Environmental Health University of BuffaloBuffaloNY 14214 USA

Phys.cal activity(PA)epidemiology firs. emerged as.a new field of s.udy around the 1950s.with publication of s.minal inves.igations.on London civil s.rvants. and has.continued to evolve as.a s.ientific dis.ipline to pres.nt *** s.bdis.ipline of epidemiology s.udies.the frequencies.dis.ributions.and dynamics.of PA and its.impact on human health,morbidity,and *** over the pas. 75 years.has.demons.rated numerous.health benefits.of *** on thes. res.arch findings.the World Health Organization recommends.adults.aged 18-64 years.engage in at leas. 150-300 min of moderate-intens.ty aerobic PA per week,or at leas. 75-150 min of vigorous.intens.ty aerobic PA per week,or a combination of both intens.ties.

关键词： epidemiology promotion continued

Buechel Pappas.Res.rfacing s.oulder Replacement: Evolution and over 40 Years.of Clinical Experience

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Open j.urnal of Orthopedics 2024年第5期14卷 218-228页

作者： Frederick F. Buechel michael j. Pappas Rutgers.Nj.Medical s.hool Newark NJ USA s.uth Mountain Orthopaedic As.ociates South Orange NJ USA New j.rs.y Ins.itute of Technology Newark NJ USA

Background: Early exploration of the s.mi cons.rained “Floating-s.cket” total s.oulder replacement (Ts.) in 1974 led to a proliferation of various.uncons.rained des.gns.that allowed res.ction or retention of the humeral head, depending upon the pathological proces. involved. Degenerative glenohumeral arthritis.with mild to moderate involvement of s.bchondral bone allowed for a res.rfacing option, while s.vere humeral head involvement required a partial or full humeral head replacement attached to an intramedullary s.em for fixation. All components.evolved from cemented to cementles. application by 1982. The purpos. of this.paper is.to des.ribe the progres.ion of Buechel-Pappas.(B-P) s.oulder replacement development from the early 1970’s.in both cemented and cement les. applications. Methods. Clinical evaluations.of “Floating-s.cket” Ts., followed by B-P s.em-type, res.rfacing types. bipolar-type and revis.on components. all of which compris. the B-P s.oulder Replacement s.s.em, were performed over a 49-year period. Res.lts. “Floating-s.cket” implants.improved the res.lts.of s.mple, cons.rained ball-in-s.cket des.gns. but generally failed by glenoid component loos.ning in both chimpanzee and human applications. Uncons.rained res.rfacing-type components. both anatomical humeral head and full proximal humeral components. were quite s.cces.ful, with minimal failures.obs.rved in long-term s.udies. Bipolar s.lvage implants. us.d for s.vere proximal deficiencies. revis.ons.and mas.ive rotator cuff arthropathy, were als. very s.cces.ful;providing overhead range of motion in many patients. Conclus.ons. Res.rfacing hemiarthroplas.y, in patients.with intact or repairable rotator cuff mechanis.s. gave the mos. s.tis.actory res.lts.and were the leas. technically complicated to perform, requiring minimal ins.rumentation. Res.rfacing of full proximal humeral deficiencies. us.ng femoral res.rfacing components. gave s.milar clinical res.lts.to more complex s.mi-cons.rained devices.

关键词： Total s.oulder Replacement Res.rfacing s.oulder Replacement