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Controls of fault geometry and thermal stress on fault slip modes:Implications for permeability enhancement and injection-induced seismicity

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Petroleum Research 2021年第4期6卷 392-407页

作者： Dorcas s.Eyinla michael A.Oladunjoye Department of Geology Pan African UniversityLife and Earth Sciences Institute(PAULESI)University of IbadanIbadanNigeria Department of Earth sciences Adekunle Ajasin UniversityAkungba AkokoNigeria Department of Geology and Petroleum Geology School of GeosciencesUniversity of AberdeenAberdeenScotlandUnited Kingdom

Fluid pressurization within the fault zone generates increasing pore pressure and stress change which is liable to create shear and/or brittle fractures within the reservoir volumes and subsequently generating earthquakes of varying ***,we explored time-dependent fault weakening processes in the fault zone which are dependent on several factors,including the rate of cold-water injection,modes of injection(hydromechanical(HM)and thermo-hydro-mechanical(THM)interactions),and changing fault spatial configurations using data from Niger Delta *** variation in the stability of different fault models in withstanding stresses induced by HM and THM fluid interactions is *** permeability enhancement and the behaviour of slip event under isothermal and non-isothermal conditions revealed that stress and pore pressure perturbations have a first order control on the rate of fault dilation and *** is observed that the progressive cooling of the reservoir induced thermal stress which induced the timing of slip by unloading the fault to earlier seismic rupture in the non-isothermal case,and accelerates the magnitude of the fault reactivation and the accompanied induced *** to increased tendency of shear failure during injection,fracture opening through shear dilation is more enhanced in THM simulation as the fracture permeability is significantly higher than in *** effect becomes increasingly more dominant with intermediate fault angle and joint *** fault/joint configurations which were resistant to shear failure under isothermal injection had their frictional resistance broken by thermal *** results also indicate that there is higher pore pressure build-up in THM than in HM as the injection rate increases and reservoir temperature drops during cold injections..This study has demonstrated the importance of fully characterizing the fracture geometries and configurations of normal faulting regime in additio

关键词： Fault spatial arrangement Thermal stress Cold injection Injection-induced seismicity stress variation slip delay

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Exotic parrots breeding in urban tree cavities: nesting requirements, geographic distribution, and potential impacts on cavity nesting birds in southeast Florida

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Avian Research 2019年第4期10卷 459-468页

作者： Joshua M.Diamond michael s.Ross Florida International University Earth & Environment

Background:Exotic parrots have established breeding populations in southeast Florida,including several species that nest in tree *** aimed to determine the species identity,nest site requirements,relative nest abundance,geographic distribution,and interactions of parrots with native cavity-nesting bird ***:We searched Miami-Dade County,Florida,and nearby areas for natural cavities and holes excavated by woodpeckers,recording attributes of potential nest *** inspected all cavities with an elevated video inspection system to determine occupancy by parrots or other *** mapped nearly 4000 citizen science observations of parrots in our study area corresponding to our study period,and used these to construct range maps,comparing them to our nesting ***:Not all parrots reported or observed in our study area were actively *** parrots were observed at tree cavities,which previous studies have suggested is evidence of reproduction,but our inspections with an elevated video inspection system suggest they never initiated nesting *** parrot species did successfully nest in tree cavities,Red-masked Parakeets(Psittacara erythrogenys)and Orange-winged Parrots(Amazona amazonica)being the most common(n=7 and 6 nests,respectively).These two parrots had similar nesting requirements,but Orange-winged Parrots use nests with larger entrance holes,which they often *** analysis of nests combined with citizen science data indicate that parrots are limited to developed *** most common parrots were less abundant cavity nesters than the native birds which persist in Miami’s urban areas,and far less abundant than the invasive European starling(sturnus vulgaris).Conclusions:Exotic parrots breeding elsewhere in the world have harmed native cavity-nesting birds through interference competition,but competitive interference in southeast Florida is minimized by the urban affinities of parrots in this ***

关键词： Amazona Cavity nest webs Invasive species Parakeets Psittacara Urban ecology

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Use of androgen deprivation therapy in prostate cancer： indications and prevalence

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Asian Journal of Andrology 2012年第2期14卷 177-186页

作者： Roisin M Connolly michael A Carducci Emmanuel s Antonarakis Prostate Cancer Research Program Department of Medical Oncology Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Baltimore MD 21231-1000 USA

Androgens play a prominent role in the development, maintenance and progression of prostate cancer. The introduction of androgen deprivation therapies into the treatment paradigm for prostate cancer patients has resulted in a wide variety of benefits ranging from a survival advantage for those with clinically localized or locally advanced disease, to improvements in symptom control for patients with advanced disease. Controversies remain, however, surrounding the optimal timing, duration and schedule of these hormonal approaches. Newer hormonal manipulations such as abiraterone acetate have also been investigated and will broaden treatment options for men with prostate cancer, This review highlights the various androgen-directed treatment options available to men with prostate cancer, their specific indications and the evidence supporting each approach, as well as patterns of use of hormonal therapies.

关键词： androgen deprivation therapy androgen synthesis anti-androgen prostate cancer

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Deep brain stimulation for Tourette’s syndrome

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Translational Neurodegeneration 2020年第1期9卷 20-38页

作者： Wenying Xu Chencheng Zhang Wissam Deeb Bhavana Patel Yiwen Wu Valerie Voon michael s.Okun Bomin sun Department of Functional Neurosurgery Ruijin HospitalShanghai Jiao Tong University School of MedicineRuijin Hospital197 Ruijin Er RoadShanghai 200025China Norman Fixel Institute for Neurological Diseases Department of NeurologyCollege of MedicineUniversity of FloridaGainesvilleFL 32608USA Department of Neurology&Institute of Neurology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghaiChina Department of Psychiatry University of CambridgeCambridgeUK

Tourette syndrome(Ts)is a childhood-onset neuropsychiatric disorder characterized by the presence of multiple motor and vocal *** usually co-occurs with one or multiple psychiatric *** behavioral and pharmacological treatments for Ts are available,some patients do not respond to the available *** these patients,Ts is a severe,chronic,and disabling *** recent years,deep brain stimulation(DBs)of basal ganglia-thalamocortical networks has emerged as a promising intervention for refractory Ts with or without psychiatric *** major challenges need to be addressed to move the field of DBs treatment for Ts forward:(1)patient and DBs target selection,(2)ethical concerns with treating pediatric patients,and(3)DBs treatment optimization and improvement of individual patient outcomes(motor and phonic tics,as well as functioning and quality of life).The Tourette Association of America and the American Academy of Neurology have recently released their recommendations regarding surgical treatment for refractory ***,we describe the challenges,advancements,and promises of the use of DBs in the treatment of *** summarize the results of clinical studies and discuss the ethical issues involved in treating pediatric *** aim is to provide a better understanding of the feasibility,safety,selection process,and clinical effectiveness of DBs treatment for select cases of severe and medically intractable Ts.

关键词： Tourette syndrome Deep brain stimulation Capsulotomy Adaptive close loop Connectivity

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sexual selection on color and behavior within and between cichlid populations： Implications for speciation

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Current Zoology 2012年第3期58卷 475-483页

作者： michael J.PAUERs Jeffrey s.MCKINNON section of Vertebrate Zoology The Milwaukee Public MuseumMilwaukeeWI 53233USA Department of Biology N108 Howell Science ComplexEast Carolina UniversityGreenvilleNC 27858-4353USA

sexual selection is widely viewed as playing a central role in haplochromine cichlid speciation. Hypothetically, once divergent mate preferences evolve among populations of these fishes, reproductive isolation follows and the populations begin to behave as different species. Various studies have examined patterns of assortative mating among species and sometimes populations, but few have examined variation in directional preferences, especially among populations of the same species. We investi- gated mate choice behavior in two populations of Labeotropheus fueUeborni, a Lake Malawi endemic. We test whether mating preferences between populations are based on the same traits and in the same direction as preferences within populations. We examine the potential contributions of two classes of trait, color patterns and behaviors, to reproductive isolation. When females chose between either two males of their own population, or two from another, female preferences were generally similar （for the female population） across the two contexts. Mate choice patterns differed between （female） populations for a measure of color, but only modestly for male behavior. In a separate experiment we simultaneously offered females a male of their own population and a male from a different population. In these trials, females consistently preferred males from their own population, which were also the males that displayed more frequently than their opponents, but not necessarily those with color traits suggested to be most attractive in the previous experiment. Thus directional preferences for chroma and related aspects of color may be important when females are presented with males of otherwise similar phenotypes, but may play little role in mediating assortative mating among populations with substantially different color patterns. A preference for male behavior could play some role in speciation if males preferentially court same-population females, as we have observed for the populations

关键词： Haplochromine cichlid sexual selection speciation Color Labeotropheus

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Evidence that all sorsby's fundus dystrophy mutations cause TIMP3 dimerization resulting in impaired inhibition of VEGFR2

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Genes & Diseases 2023年第1期10卷 45-47页

作者： Fatimah A.Alsaffar Ahmed H.Mujamammi Mohammed s.K.Aldughaim Martin J.H.Nicklin michael D.Barker Department of Oncology&Metabolism University of Sheffield Medical SchoolSheffield S102RXUK Department of Infection Immunity&Cardiovascular Disease University of Sheffield Medical SchoolSheffield S102RXUK

Tissue inhibitor of metalloproteinases 3(TIMP3)regulates turnover of the extracellular matrix(ECM)and is also a potent inhibitor of the vascular endothelial growth factor receptor 2(VEGFR2),a key mediator of *** in TIMP3 give rise to sorsby's fundus dystrophy(sFD),a dominantly inherited degenerative disease of the retina that leads to blindness,usually in middle age.

关键词： TIMP3 VEGFR2 impaired

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Machine learning for the discovery of molecular recognition based on single-walled carbon nanotube corona-phases

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npj Computational Materials 2022年第1期8卷 1265-1277页

作者： Xun Gong Nicholas Renegar Retsef Levi michael s.strano Massachusetts Institute of Technology Department of Chemical EngineeringCambridgeMAUSA Massachusetts Institute of Technology Operations Research CenterCambridgeMAUSA Massachusetts Institute of Technology Sloan School of ManagementCambridgeMAUSA

Nanoparticle corona phase(CP)design offers a unique approach toward molecular recognition(MR)for sensing ***-walled carbon nanotube(sWCNT)CPs can additionally transduce MR through its band-gap photoluminescence(PL).While DNA oligonucleotides have been used as sWCNT CPs,no generalized scheme exists for MR prediction de novo due to their sequence-dependent three-dimensional *** work generated the largest DNA-sWCNT PL response library of 1408 elements and leveraged machine learning(ML)techniques to understand MR and DNA sequence dependence through local(LFs)and high-level features(HLFs).Out-of-sample analysis of our ML model showed significant correlations between model predictions and actual sensor responses for 6 out of 8 experimental *** HLF combinations were found to be uniquely correlated with different ***,models utilizing both LFs and HLFs show improvement over that with HLFs alone,demonstrating that DNA-sWCNT CP engineering is more complex than simply specifying molecular properties.

关键词： walled carbon utilizing

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Ecology and Behaviour of Burton's Legless Lizard(Lialis burtonis,Pygopodidae) in Tropical Australia

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Asian Herpetological Research 2013年第1期4卷 9-21页

作者： michael WALL Richard sHINE school of Biological sciences A08 University of Sydney

The elongate, functionally limbless flap-footed lizards （family Pygopodidae） are found throughout Australia, ranging into southern New Guinea. Despite their diversity and abundance in most Australian ecosystems, pygopodids have attracted little scientific study. An intensive ecological study of one pygopodid, Burton＇s legless lizard （Lialis burtonis Gray 1835）, was conducted in Australia＇s tropical Northern Territory. L. burtonis eats nothing but other lizards, primarily skinks, and appears to feed relatively infrequently （only 20.8% of stomachs contained prey）. Ovulation and mating occur chiefly in the late dry-season （beginning around september）, and most egg-laying takes place in the early to middle wet-season （November-January）. Females can lay multiple clutches per year, some of which may be fertilised with stored sperm. Free-ranging L. burtonis are sedentary ambush foragers, with radio-tracked lizards moving on average 〈 5 m/day. Most foraging is done diurnally, but lizards may be active at any time of day or night. Radiotracked lizards were usually found in leaf-litter microhabitats, a preference that was also evident in habitat-choice experiments using field enclosures. Lizards typically buried themselves in 6-8 cm of litter; at this depth, they detect potential prey items while staying hidden from predators and prey and avoiding lethally high temperatures.

关键词： squamata habitat use wet-dry tropics thermoregulation movement activity patterns

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CD5:from antiquated T cell marker to immunotherapy’s new hope

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signal Transduction and Targeted Therapy 2023年第6期8卷 2442-2444页

作者： sandra schwarz michael Linnebacher Molecular Oncology and Immunotherapy Clinic of General SurgeryRostock University Medical Center18057RostockGermany

In a recent study published in science,He et *** the role of CD5 on dendritic cells(DCs)in priming effector T cells.^(1)By proving the importance of CD5 in engaging effective antitumor immune responses,they highlighte... 详细信息

关键词： immunotherapy al. CD5

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Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia Monteiro António J.salgado Nuno A.silva Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

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