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Dynamic graph exploration by interactively linked node-link diagrams and matrix visualizations

Visual Computing for Industry,Biomedicine,and Art 2021年第1期4卷 219-232页

作者： michael Burch Kiet Bennema ten Brinke Adrien Castella Ghassen Karray Sebastiaan Peters Vasil Shteriyanov rinse Vlasvinkel Eindhoven University of Technology 5600MB EindhovenThe Netherlands

The visualization of dynamic graphs is a challenging task owing to the various properties of the underlying relational data and the additional time-varying *** sparse and small graphs,the most efficient approach to such visualization is node-link diagrams,whereas for dense graphs with attached data,adjacency matrices might be the better *** graphs can contain both properties,being globally sparse and locally dense,a combination of several visual metaphors as well as static and dynamic visualizations is *** this paper,a visually and algorithmically scalable approach that provides views and perspectives on graphs as interactively linked node-link and adjacency matrix visualizations is *** the novelty of this technique,insights such as clusters or anomalies from one or several combined views can be used to influence the layout or reordering of the other ***,the importance of nodes and node groups can be detected,computed,and visualized by considering several layout and reordering properties in combination as well as different edge properties for the same set of *** an additional feature set,an automatic identification of groups,clusters,and outliers is provided over time,and based on the visual outcome of the node-link and matrix visualizations,the repertoire of the supported layout and matrix reordering techniques is extended,and more interaction techniques are provided when considering the dynamics of the graph ***,a small user experiment was conducted to investigate the usability of the proposed *** usefulness of the proposed tool is illustrated by applying it to a graph dataset,such as e co-authorships,co-citations,and a Comprehensible Perl Archive Network distribution.

关键词： Dynamic graph visualization Node-link diagrams Adjacency matrices Layouts reorderings

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Crustal reworking and orogenic styles inferred from zircon Hf isotopes:Proterozoic examples from the North Atlantic region

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Geoscience Frontiers 2019年第2期10卷 417-424页

作者： C.J.Spencer C.L.Kirkland A.r.Prave r.A.Strachan V.Pease Earth Dynamics research Group The Institute of Geoscience Research (TIGeR)Department of Applied GeologyCurtin University Centre for Exploration Targeting d Curtin Node Department of Applied GeologyCurtin University Department of Earth and Environmental Sciences University of St Andrews School of Earth and Environmental Sciences University of Portsmouth Department of Geological Sciences Stockholm University

Zircon Hf evolutionary patterns are powerful tools to investiage magma petrogenesis and crustal evolution. The ^(176)Hf/^(177)Hf isotopic signature of a rock is particularly informative and can be used to derive an estimation of the time when mantle extraction and diagnose closed system reworking where successive samples through time define an Hf evolution array dependant on the source Lu/Hf ratio. However, many magmatic events require new mantle addition as the thermal impetus for melting pre-existing crust. In this situation, rather than simply reflecting reworking, the isotopic signature indicates mixing with contributions from both reworked crust and new radiogenic input. Different geodynamic settings have different propensities for either reworking or addition of new mantle-derived magma. Hence, Hf-time trends carry within them a record, albeit cryptic, of the evolving geodynamic environment as different tectonic configurations recycle and add new crust at different rates, magnitudes, and from different sources. As an example of the difference in apparent Hf evolution slopes, we present Hf-time compilations from three geographically distinct Meso-to Neoproterozoic orogenic belts in the North Atlantic region whose geodynamic configurations remain a subject of debate. We use the εHf/Ma trajectory to assist in understanding their evolution. The εHf/Ma trajectory of the Sveconorwegian Orogen corresponds to a ^(176)Lu/^(177) Hf ratio of 0.012, which implies a process driven primarily by reworking of preexisting crust that is balanced with input from the depleted mantle resulting in a relatively shallowεHf/Ma slope. The Valhalla Orogen reveals a similar comparatively shallow εHf/Ma path. In stark contrast to these patterns is the steep εHf/Ma trajectory of the Grenville Orogen that requires a mixing process involving a greater contribution of old crust of at least ～ 1.8 Ga age. The degree of reworking required to produce the εHf/Ma trend of the Grenville Orogen is co

关键词： Zircon Hf Crustal evolution Grenville Sveconorwegian Valhalla

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Detection of flock movement and behaviour of broiler chickens at different feeders using image analysis

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Information Processing in Agriculture 2015年第3期2卷 177-182页

作者： Diego Pereira Neves Saman Abdanan Mehdizadeh Matthew Tscharke Irenilza de Alencar Nääs Thomas michael Banhazi Structure&Motion Laboratory Royal Veterinary CollegeUniversity of LondonLondonUnited Kingdom Department of Mechanics of Biosystems Engineering College of Agricultural Engineering and Rural DevelopmentRamin University of Agriculture and Natural Resources of KhuzestanMollasaniAhvazKhuzestanIran NCEA University of Southern QueenslandToowoomba CampusQLDAustralia Agricultural Engineering College State University of CampinasCampinasSPBrazil NCEA and Faculty of Health Engineering and ScienceUniversity of Southern QueenslandToowoomba CampusQLDAustralia

The behaviour of broiler chickens has been extensively studied as a function of stocking density and environmental conditions,but limited information was reported in the scientific literature about the effect of feeder type on birds’feeding *** main objective of this study was to assess the effects of three different feeder types in relation to the birds’behaviour in its *** analysed feeders were:tube-type with partition grid(F1);tube-type without partition grid(F2);and automatic type with partition grid(F3).The considered variables were:occupied area(OA);activity index(AI)(flock movement);total birds presented in the area(TB);and birds effectively eating(EE).OA and AI were calculated by computational image analysis while TB and EE were manually *** results indicated that the feeder type could have influenced the birds’behaviour regarding to OA(r2=0.56),TB(r2=0.48),and EE(r2=0.40),but AI(r2=0.01)was not found to be directly influenced by the feeder type.A higher percentage of birds effectively eating were found in F2(86.4%),which was the one with the largest free area to access the *** average number of total birds was found in F1,but with a lower percentage of individuals effectively eating(63.3%),which means that birds were nearby this feeder performing other *** the assessed feeders were in the same house under the same conditions,it can be suggested that not only the free area to access the feed but potentially the design of feeders could have influenced the birds’feeding *** real beneficial effect of the adoption of partition grid on feed trays is still uncertain,and it is also unclear whether the financial value of reduced wastage would compensate the possible reduction in feed intake.

关键词： Activity index Animal behaviour Feeding Image processing Motion Occupied area

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Draft genome of the Native American cold hardy grapevine Vitis riparia Michx.‘Manitoba 37’

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Horticulture research 2020年第1期7卷 1676-1688页

作者： Sagar Patel michael robben Anne Fennell Jason P.Londo Dilmini Alahakoon roberto Villegas-Diaz Padmapriya Swaminathan Agronomy Horticulture and Plant Science Department and BioSNTRSouth Dakota State UniversityBrookingsSD 57006USA Grape Genetics research Unit USDA ARSGenevaNY 14456USA

Vitis riparia,a critically important Native American grapevine species,is used globally in rootstock and scion breeding and contributed to the recovery of the French wine industry during the mid-19th century phylloxera *** species has abiotic and biotic stress tolerance and the largest natural geographic distribution of the North American grapevine *** we report an Illumina short-read 369X coverage,draft de novo heterozygous genome sequence of *** Michx.‘Manitoba 37’with the size of~495 Mb for 69,616 scaffolds and a N50 length of 518,740 *** rNAseq data,40,019 coding sequences were predicted and *** with Universal Single-Copy Orthologs(BUSCO)analysis of predicted gene models found 96%of the complete BUSCOs in this *** assembly continuity and completeness were further validated using *** ESTs,BACs,and three de novo transcriptome assemblies of three different *** genotypes resulting in>98%of respective sequences/transcripts mapping with this *** of the *** assembly and predicted CDS with the latest ***‘PN40024’CDS and genome assembly showed 99%CDS alignment and a high degree of *** analysis of plant transcription factors indicates a high degree of homology with the *** transcription *** mapping to ***‘Manitoba 37’and *** PN40024 has identified genetic relationships to phenotypic variation between *** assembly provides reference sequences,gene models for marker development and understanding ***’s genetic contributions in grape breeding and research.

关键词： continuity globally alignment

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Horizontal and vertical fluxes of particulate matter during wind erosion on arable land in the province La Pampa, Argentina

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International Journal of Sediment research 2022年第5期37卷 539-552页

作者： Nicole Siegmund roger Funk michael Sommer Fernando Avecilla Juan Esteban Panebianco Laura Antonela Iturri Daniel Eduardo Buschiazzo Leibniz Centre for Agricultural Landscape research (ZALF) Working Group Landscape Pedology Institute of Environmental Science and Geography University of Potsdam Institute of Earth and Environmental Sciences of La Pampa (INCITAP) 4. National University of La Pampa Faculty of Agronomy (UNLPam)

A detailed analysis of horizontal and vertical particulate matter(PM) fluxes during wind erosion has been done, based on measurements of PM smaller than 10, 2.5, and 1.0 μm, at windward and leeward positions on a measuring field. The three fractions of PM measurement are differently influenced by the increasing wind and shear velocities of the wind. The measured concentrations of the coarser fractions of the fine dust, PM10, and PM2.5, increase with wind and shear velocity, whereas the PM1.0concentrations show no clear correlation to the shear velocity. The share of PM2.5on PM10depends on the measurement height and wind speed and varies between 4 and 12 m/s at the 1 m height ranging from 25% to 7%(average 10%),and at the 4 m height from 39% to 23%(average 30%). Although general relationships between wind speed, PM concentration, and horizontal and vertical fluxes could be found, the contribution of the measuring field was very low, as balances of incoming and outgoing fluxes show. Consequently, the measured PM concentrations are determined from a variety of sources, such as traffic on unpaved roads,cattle drives, tillage operations, and wind erosion, and thus, represent all components of land use and landscape structure in the near and far surroundings of the measuring field. The current results may reflect factors from the landscape scale rather than the influence of field-related variables. The measuring devices used to monitor PM concentrations showed differences of up to 20%, which led to considerable deviations when determining total balances. Differences up to 67% between the calculated fluxes prove the necessity of a previous calibration of the devices used.

关键词： PM 10 , PM 2.5 , and PM 1.0 concentrations Field measurements Horizontal flux Vertical flux PM balances

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直度及位置偏差的高精确度测量

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国外计量 1985年第5期 13-15页

作者： P.hoffmann 纪正昆

直度及位置偏差对金属加工工业产品元件和部件的性能,具有决定性的影响。考虑到日益提高的精度要求,掌握其测量技术是计量学的重要任务之一。其中,必要的测量与检验技术的正确性,对保证产品质量具有决定性的意义。在工业中,检定直度测... 详细信息

直度及位置偏差对金属加工工业产品元件和部件的性能,具有决定性的影响。考虑到日益提高的精度要求,掌握其测量技术是计量学的重要任务之一。其中,必要的测量与检验技术的正确性,对保证产品质量具有决定性的意义。在工业中,检定直度测量仪器要使用专用

关键词：平面度测量测量装置气浮干涉条纹位置偏差测量滑架直度自准直仪平直度量仪测量不确定度高精确度

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Homologous recombination mediates stable Fah gene integration and phenotypic correction in tyrosinaemia mouse-model

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World Journal of Hepatology 2018年第2期10卷 277-286页

作者： Norman Junge Qinggong Yuan Thu Huong Vu Simon Krooss Christien Bednarski Asha Balakrishnan Toni Cathomen michael P Manns Ulrich Baumann Amar Deep Sharma michael Ott Department of Pediatric Gastroenterology and Hepatology Hannover Medical School Department of Gastroenterology Hepatology and Endocrinology Hannover Medical School TWINCOrE Centre for Experimental and Clinical Infection Research Medical Center University of Freiburg Institute for Cell and Gene Therapy research Group Micro rNA in Liver regeneration Cluster of Excellence REBIRTH Hannover Medical School

AIM To stably correct tyrosinaemia in proliferating livers of fumarylacetoacetate-hydrolase knockout(Fah-/-) mice by homologous-recombination-mediated targeted addition of the Fah *** C57 BL/6 Fah?exon5 mice served as an animal model for human tyrosinaemia type 1 in our study. The vector was created by amplifying human Fah c DNA including the TTr promoter from a lentivirus plasmid as described. The Fah expression cassette was flanked by homologous arms(620 bp and 749 bp long) of the rosa26 gene locus. Mice were injected with 2.1 × 108 VP of this vector(r ***) via the tail vein. Mice in the control group were injected with 2.1 × 108 VP of a similar vector but missing the homologous arms(r ***). Primary hepatocytes from Fah-/-recipient mice, treated with our vectors, were isolated and 1 × 106 hepatocytes were transplanted into secondary Fah-/-recipient mice by injection into the spleen. Upon either vector application or hepatocyte transplantation NTBC treatment was stopped in recipient mice. rESULTS Here, we report successful Hr-mediated genome editing by integration of a Fah gene expression cassette into the "safe harbour locus" rosa26 by recombinant AAV8. Both groups of mice showed long-term survival, weight gain and FAH positive clusters as determined by immunohistochemistry analysis of liver sections in the absence of NTBC treatment. In the group of C57 BL/6 Fah?exon5 mice, which have been transplanted with hepatocytes from a mouse injected with r *** 156 d before, 6 out of 6 mice showed long-term survival, weight gain and FAH positive clusters without need for NTBC treatment. In contrast only 1 out 5 mice, who received hepatocytes from r *** treated mice, survived and showed few and smaller FAH positive clusters. These results demonstrate that homologous recombinationmediated Fah gene transfer corrects the phenotype in a mouse model of human tyrosinaemia type 1(Fah-/-mice) and

关键词： Gene therapy AAV8 Liver based metabolic disease Targeted integration rOSA26 Paediatric liver disease

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竭染加工的匀染性——理论和实践上的进展

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国外纺织技术（化纤．染整．环境保护分册） 1992年第1期 16-23页

作者： fredgar.hoffmann 马雅娟胡逊

竭染加工的费用大部分是花费在为取得匀染效果方面的,所以应选择恰当的染色处方、工艺及设备以避免染色不匀。许多文章已从理论上分析了染色条件(加热、计量加料、染液流动)

关键词：染色竭染匀染性

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real-world treatment patterns of gastrointestinal neuroendocrine tumors: A claims database analysis

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World Journal of Gastroenterology 2017年第33期23卷 6128-6136页

作者： Al B Benson III michael S Broder Beilei Cai Eunice Chang Maureen P Neary Elya Papoyan Northwestern University Partnership for Health Analytic research Novartis Pharmaceuticals

AIM To describe real-world treatment patterns of gastrointestinal neuroendocrine tumors(GI NET).METHODS In this retrospective cohort study,we used 2009-2014 data from 2 United States commercial claims databases to examine newly pharmacologically treated patients using tabular and graphical techniques. Treatments included somatostatin analogues(SSA),cytotoxic chemotherapy(CC),targeted therapy(TT),interferon(IF) and combinations. We identified patients at least 18 years of age,with ≥ 1 inpatient or ≥ 2 outpatient claims for GI NET who initiated pharmacologic treatment from 7/1/09-6/30/14. A 6 mo clean period prior to first treatment ensured patients were newly treated. Patients were followed until end of enrollment or the study end date,whichever was *** We identified 2258 newly treated GI NET patients: mean(SD) age was 55.6 years(SD = 9.7),47.2% of the patients were between 55 and 64 years,and 48.8% were female. All regions of the United States were represented. 59.6% started first-line therapy with SSA monotherapy(964 with octreotide LAr,380 with octreotide SA,and 1 with lanreotide),33.3% CC,3.6% TT,and 0.5% IF. The remainder received combinations. Mean follow up was 576 d. Overall mean first-line therapy duration was 361 d(449 d for SSA,215 for CC,267 for TT). 58.9% of patients had no pharmacological treatment beyond first line. The most common secondline was combination therapy with SSA. In graphical pattern analysis,there was no clear pattern visible after first line *** In this study,60% of patients initiated treatment with SSA alone or in combination. The relatively long time to discontinuation suggests possible sustained effectiveness and tolerability.

关键词： Gastrointestinal neuroendocrine tumors Treatment patterns Insurance claims Somatostatin analogue Targeted therapy Chemotherapy

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Subcutaneous fatty acid composition of steers finished as weanlings or yearlings with and without growth promotants

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Journal of Animal Science and Biotechnology 2014年第1期5卷 98-105页

作者： Cletos Mapiye Tyler D Turner John A Basarab Vern S Baron Jennifer L Aalhus michael Er Dugan Agriculture and Agri-Food Canada Lacombe Research Centre 6000 C & E Trail Lacombe Alberta T4L 1 W1 Canada Alberta Agriculture and rural Development Lacombe Research Centre 6000 C & E Trail Lacombe Alberta T4L 1 W1 Canada

Background： The current study evaluated the subcutaneous fatty acid （FA） composition of calf- and yearling-fed steer with or without growth promoting implants. Crossbred steers （n = 112; 267 ± 5.0 kg） of the same contemporary group were allocated to one of four production system and implant strategy based treatments in a completely randomized design with a 2 × 2 factorial arrangement of treatments. results： There were no interactions （P 〉 0.05） between production systems and growth promoting implants for the total and individual subcutaneous FA. Yearling as opposed to calf finishing reduced （P 〈 0.05） subcutaneous proportions of C20：3n-6, trans （t）l 2-18：1, C14：0, several minor cis-monounsaturated FA （c-MUFA; c9-14：1, c11-16：1, cl 1-18：1, cl 2-18：1, cl 3-18：1, c9-20：1 and cl 1-20：1）, and increased （P 〈 0.05） subcutaneous proportions of tl 1 cl 5-18：2, total and individual branched-chain FA. Subcutaneous fat from steers implanted with growth promotants had higher （P 〈 0.05） proportions of total polyunsaturated FA （PUFA）, total n-6 PUFA, C18：2n-6 and individual t-18：1 isomers （t6 to tl0） compared to non-implanted steers. Conclusions： Overall, current findings show that production systems and growth promotants led to only minor differences in subcutaneous FA composition of beef steers.

关键词： Age at feedlot entry Beef Fatty acids Growth implant Steers

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