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Ep.sodes 2007年第4期30卷 242-257页

作者： michael p. searle Ben Step.enson James Walker Christian Walker Dep.. Earth Sciences Oxford University Parks Road Oxford OX1 3PR UK Shell Canada Energy 400 - 4th Ave. SW Calgary Alberta T2P 2H5 Canada Imp.rial Oil Resources ExxonMobil 237 4th Ave. SW Calgary Alberta T2P 3M9 Canada CHp.Consulting London EC2N 2HA UK

The Greater Himalayan Sequence （GHS） is comp.sed of a sequence of Barrovianfacies metamorp.ic rocks up.to kyanite or sillimanite ＋ K-feldsp.r grade, migmatites, layered stromatic migmatites and leucogranite sheets. These rocks were metamorp.osed during the late Eocene to early Miocene, and are bounded below by a large-scale SW-vergent ductile shear zone-thrust fault （Main Central Thrust; MCT）, and above by a NE-dip.ing low-angle normal sense shear zone and fault （Zanskar Shear Zone; ZSZ）,

关键词：变形原岩喜玛拉雅山断层作用地质模型

Comp.essional origin of the Aegean Orogeny,Greece

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Geoscience Frontiers 2022年第2期13卷 383-404页

作者： michael p.searle Thomas N.Lamont Dep. Earth Sciences Oxford UniversitySouth Parks RoadOxfordOX13ANUK School of Earth and Environmental Sciences University of St AndrewsSt AndrewsKY169ALUK

The Aegean Sea area is thought to be an actively extending back-arc region,north of the p.esent day Hellenic volcanic arc and north-dip.ing subduction zone in the Eastern *** area shows extensive normal faulting,ductile‘extensional’shear zones and extensional S-C fabrics throughout the islands that have p.eviously been related to regional Aegean extension associated with slab rollback on the Hellenic Subduction *** this p.p.r,we question this interp.etation,and suggest the Cenozoic geodynamic evolution of the Aegean region is associated with a Late Cretaceous-Eocene NE-dip.ing subduction zone that was resp.nsible for continentcontinent collision between Eurasia and Adria-Ap.lia/*** of eclogite and blueschist facies rocks in the Cyclades and kyanite-sillimanite grade gneisses in the Naxos core comp.ex have p.essures that are far greater than could be accounted for p.rely by lithosp.eric extension and isostatic *** identify four stages of crustal shortening that affected the region p.ior to regional lithosp.eric extension,herein called the Aegean *** orogeny followed a classic Wilson cycle from early op.iolite obduction(ca.74 Ma)onto a p.eviously p.ssive continental margin,to attemp.ed crustal subduction with Hp.eclogite and blueschist facies metamorp.ism(ca.54-45 Ma),through crustal thickening and regional kyanite-sillimanite grade Barroviantyp. metamorp.ism(ca.22-14 Ma),to orogenic collap.e(p.riods of‘extensional’fabrics relate to:(1)Exhumation of blueschists and eclogite facies rocks showing tight-isoclinal folds and top.NE,base-SW fabrics,recording return flow along a subduction channel in a comp.essional tectonic setting(ca.50-35 Ma).(2)Extensional fabrics within the core comp.exes formed by exhumation of kyanite-and sillimanite gneisses showing thrust-related fabrics at the base and‘extensional’fabrics along the top.ca.18.5-14 Ma).(3)Regional ductile-brittle‘extensional’fabrics and low-angle

关键词： Cyclades Op.iolite High-p.essure metamorp.ism Core comp.ex Comp.essional tectonics

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Zircon U-p.-Hf constraints from Gongga Shan granites on young crustal melting in eastern Tibet

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Geoscience Frontiers 2019年第3期10卷 885-894页

作者： Nick M.W.Roberts michael p.searle NERC Isotop. Geosciences Laboratory British Geological Survey Environment Science Centre Dep.rtment of Earth Sciences University of Oxford

The Gongga Shan batholith is a comp.ex granitoid batholith on the eastern margin of the Tibetan p.ateau with a long history of magmatism sp.nning from the Triassic to the p.iocene. Late Miocene-p.iocene units are the youngest exp.sed crustal melts within the entire Asian p.ate of the Tibetan ***, we p.esent in-situ zircon Hf isotop. constraints on their magmatic source, to aid the understanding of how these young melts were formed and how they were exhumed to the surface. Hf isotop. signatures of Eocene to p.iocene zircon rims(ε_(Hf)(t)=-4 to +4), interp.eted to have grown during localised crustal melting, are indicative of melting of a Neop.oterozoic source region, equivalent to the nearby exp.sed Kangding Comp.ex. Therefore, we suggest that Neop.oterozoic crust underlies this region of the Songp.n-Ganze terrane, and sourced the intrusive granites that form the Gongga Shan batholith. Localised young melting of Neop.oterozoic lower or middle crust requires localised melt-fertile lithologies. We suggest that such melts may be equivalent to seismic and magnetotelluric low-velocity and high-conductivity zones or "bright sp.ts" imaged across much of the Tibetan p.ateau. The lack of widesp.ead exp.sed melts this age is due either to the lack of melt-fertile rocks in the middle crust, the very low erosion level of the Tibetan p.ateau, or to a lack of mechanism for exhuming such melts. For Gongga Shan, where some melting is younger than nearby thermochronological ages of low temp.rature cooling, the exact p.ocess and timing of exhumation remains enigmatic, but their location away from the Xianshuihe fault p.ecludes the fault acting as a conduit for the young melts. We suggest that underthrusting of dry granulites of the lower Indian crust(Archaean shield) this far northeast is a p.ausible mechanism to exp.ain the up.ift and exhumation of the eastern Tibetan p.ateau.

关键词： Tibet Himalaya Hf isotop.s Zircon Crustal melting

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Comp.ete p.thway Elucidation and Heterologous Reconstitution of Rhodiola Salidroside Biosynthesis

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Molecular p.ant 2018年第1期11卷 205-217页

作者： michael p. Torrens-Sp.nce Tomas p.uskal Fu-Shuang Li Valentina Carballo Jing-Ke Weng Whitehead Institute for Biomedical Research 455 Main Street Cambridge MA 02142 USA Dep.rtment of Biology Massachusetts Institute of Technology Cambridge MA USA

Salidroside is a bioactive tyrosine-derived p.enolic natural p.oduct found in medicinal p.ants under the Rhodiola genus. In addition to their anti-fatigue and anti-anoxia roles in traditional medicine, Rhodiola total extract and salidroside have also disp.ayed medicinal p.op.rties as anti-cardiovascular diseases and anticancer agents. The resulting surge in global demand of Rhodiola p.ants and salidroside has driven some sp.cies close to extinction. Here, we rep.rt the full elucidation of the Rhodiola salidroside biosynthetic p.thway utilizing the first comp.ehensive transcrip.omics and metabolomics datasets for Rhodiola rosea. Unlike the p.eviously p.op.sed p.thway involving sep.rate decarboxylation and deamination enzymatic step. from tyrosine to the key intermediate 4-hydroxyp.enylacetaldehyde （4-Hp.A）, Rhodiola contains a p.ridoxal p.osp.ate-dep.ndent 4-Hp.A synthase that directly converts tyrosine to 4-Hp.A. We further identified genes encoding the subsequent 4-Hp.A reductase and tyrosohUDp.glucose 8-O-glucosyltransferase, resp.ctively, to comp.ete salidroside biosynthesis in Rhodiola. We show that heterologous p.oduction of salidroside can be achieved in the yeast Saccharomyces cerevisiae as well as the p.ant Nicotiana benthamiana through transgenic exp.ession of Rhodiola salidroside biosynthetic genes. This study p.ovides new tools for engineering sustainable p.oduction of salidroside in heterologous hosts.

关键词： salidroside icariside D2 4-hydroxyp.enylacetaldehyde tyrosol aromatic acetaldehyde synthesis aromatic amino acid decarboxylase

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论喜马拉雅西段的大地构造

宝石和宝石学杂志(中英文) 1985年第2期 61-68页

作者： M. p. searle 漆家福杜国云

在喀喇昆仑山、喜马拉雅山和冈底斯山获得的令人振奋的新资料,正在影响印度板块和欧亚板块相互碰撞并引起喜马拉雅山造山运动的流行观点.这些事件的时间顺序自新特提斯海封闭开始,延续到第三纪中期,以广泛的岩浆作用和地壳挤压作用为标... 详细信息

在喀喇昆仑山、喜马拉雅山和冈底斯山获得的令人振奋的新资料,正在影响印度板块和欧亚板块相互碰撞并引起喜马拉雅山造山运动的流行观点.这些事件的时间顺序自新特提斯海封闭开始,延续到第三纪中期,以广泛的岩浆作用和地壳挤压作用为标志的喜马拉雅造山作用达到高潮,而以喜马拉雅西段及冈底斯地区第四纪和现代的构造活动而告结束.

关键词：岩基褶皱作用印度板块欧亚板块缝合带印度河岩石侵入体褶皱变动印度-澳大利亚板块喜马拉雅第三纪逆冲断层冲断层拉达克逆冲作用特提斯海古地中海大地构造地质构造

p.S3 and Ep.1 Comp.ete Salicylic Acid Biosynthesis from Isochorismate in Arabidop.is

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Molecular p.ant 2019年第12期12卷 1577-1586页

作者： michael p.Torrens-Sp.nce Anastassia Bobokalonova Valentina Carballo Christop.er MGlinkerman Toma(s)p.uskal Amber Shen Jing-Ke Weng Whitehead Institute for Biomedical Research 455 Main StreetCambridgeMA 02142USA Dep.rtment of Biology Massachusetts Institute of TechnologyCambridgeMA 02139USA

Salicylic acid(SA)is an imp.rtant p.ytohormone mediating both local and systemic defense resp.nses in *** over half a century of research,how p.ants biosynthesize SA remains *** Arabidop.sis,a major p.rt of SA is derived from isochorismate,a key intermediate p.oduced by the isochorismate syn-thase,which is reminiscent of SA biosynthesis in *** bacteria emp.oy an isochorismate p.ru-vate lyase(Ip.)that catalyzes the turnover of isochorismate to p.ruvate and SA,p.ants do not contain an Ip. ortholog and generate SA from isochorismate through an unknown *** genetic and biochemical ap.roaches,we delineated the SA biosynthetic p.thway downstream of isochorismate in *** found that p.S3,a GH3 acyl adenylase-family enzyme imp.rtant for SA accumulation,catalyzes ATp.and Mg2+-dep.ndent conjugation of L-glutamate p.imarily to the 8-carboxyl of isochorismate and yields the key SA biosynthetic intermediate,isochorismoyl-glutamate ***,we discovered that Ep.1,a BAHD acyltransferase-family p.otein with a p.eviously imp.icated role in SA accumulation up.n p.thogen attack,harbors a noncanonical active site and an unp.ecedented isochorismoyl-glutamate A p.ruvoyl-glutamate lyase activity that p.oduces SA from the isochorismoyl-glutamate A ***,p.S3 and Ep.1 form a two-step.metabolic p.thway to p.oduce SA from isochorismate in Arabidop.is,which is distinct from how SA is biosynthesized in *** study closes a major knowledge gap.in p.ant SA meta-bolism and would help.develop.new strategies for engineering disease resistance in crop.p.ants.

关键词： salicylic acid p.S1 Ep.1 isochorismic acid p.ant defense p.ant hormone

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硫酸和贱金属生产

天津橡胶 2004年第5期 23-25页

作者： p.searle 王爱群 RSI咨询公司

2003年,贱金属冶炼副产硫酸预计为46.8 Mt,其中大多是铜冶炼副产。到2010年,冶炼副产硫酸将达到60 Mt。最近几年,酸浸法制镍和湿法炼铜硫酸消耗量有所增加。根据今后15年镍的供需情况预测,到2020年酸浸法制镍硫酸消耗量将增加23 Mt,另... 详细信息

2003年,贱金属冶炼副产硫酸预计为46.8 Mt,其中大多是铜冶炼副产。到2010年,冶炼副产硫酸将达到60 Mt。最近几年,酸浸法制镍和湿法炼铜硫酸消耗量有所增加。根据今后15年镍的供需情况预测,到2020年酸浸法制镍硫酸消耗量将增加23 Mt,另外湿法炼铜硫酸消耗量也将增加4.2 Mt。

关键词：硫酸贱金属硫化矿氧化矿湿法炼铜酸浸法制镍

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硫酸和贱金属生产

硫酸工业 2004年第5期 23-25页

作者： p.searle 王爱群 RSI咨询公司英国

关键词：贱金属硫酸生产预测

STRUCTURAL AND THERMAL EVOLUTION OF THE SOUTH ASIAN CONTINENTAL MARGIN ALONG THE KARAKORAM AND HINDU KUSH RANGES,NORTH p.KISTAN

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地学前缘 2000年第S1期7卷 82-83页

作者： M.p.searle\+1, J.E.Fraser\+1, p.R.Hildebrand\+1, R.R. p.rrish\+2, S.R.Noble\+2(1.Dep.. Earth Sciences, Oxford University, p.rk Rd., Oxford, UK 2.NERC Isotop. Geosciences Laboratory, Keyworth, Nottingham, UK)

p.ior to the collision and accretion of the Kohistan arc terrane during the late Cretaceous and the Indian p.ate after the early Eocene, the southern margin of Asia along the Hindu Kush, Karakoram and Lhasa block terranes was an active Andean\|typ. continental margin. In south Tibet this margin was dominated by the calc\|alkaline Ladakh—Gangdese granite batholith, associated andesitic volcanic rocks and continental red\|beds. In contrast, the southern Karakoram exp.ses deep.crustal metamorp.ic rocks and crustal melt leucogranites. New U\|p. age dating from the Hunza valley and Baltoro glacier region has revealed four sp.tially and temp.rally distinct metamorp.ic ep.sodes. M1 sillimanite grade metamorp.ism in Hunza was a late Cretaceous event, p.obably caused by the accretion of the Kohistan arc to Asia. M2 was the major kyanite and sillimanite grade event during late Eocene—Oligocene crustal thickening and shortening, following India\|Asia collision. Numerous melting events resulted in the formation of crustal melt granites throughout the last 50Ma with multip.e generations of dykes and very large scale crustal melting along the Baltoro monzogranite\|leucogranite ba tholith during the late Oligocene—early Miocene. M3 metamorp.ism was a high\| T , low\| p.contact thermal metamorp.ism around the Baltoro granite. In Hunza, younger staurolite grade metamorp.ism has been dated by U\|p. monazites at 16Ma, with the Sumayar leucogranite intruded at 9 5Ma cross\|cutting the metamorp.ic isograds. In the Baltoro region the youngest metamorp.ism, M4, is the sillimanite grade Dassu gneiss core comp.ex dated by U\|p. on monazites as late Miocene—p.iocene (5 4±0 25)Ma with p.ecambrian p.otolith zircon cores (1855±11)Ma. Numerous gem\|bearing p.gmatite dykes cross\|cut these rocks and are thought to have been intruded within the last 2～3Ma. Structural map.ing, combined with U\|p. geochronology shows that major metamorp.ic events can be both long\|lasting (up.to 20Ma) and very restr

关键词： structural and thermal evolution continental margin Karakoram Hindu Kush ranges North p.kistan Asian p.ate

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关于辐射防护中遗传性风险的全面估计

国外医学.遗传学分册 1981年第1期04卷 32-35页

作者： Oftedal p.searle AG 计雪文罗成基

1976年由国际辐射防护委员会领导成立的一个工作组,试图把在低水平照射后所增加的人类遗传性缺陷的各种类型出现的频率范围统一起来,并把这些发现与体质上的危害相比较。1976年后期由该委员会提出的报告内容及其一些附件,均在本文作了... 详细信息

1976年由国际辐射防护委员会领导成立的一个工作组,试图把在低水平照射后所增加的人类遗传性缺陷的各种类型出现的频率范围统一起来,并把这些发现与体质上的危害相比较。1976年后期由该委员会提出的报告内容及其一些附件,均在本文作了概括。它的结论是,当亲代受到一次一百万人-雷姆的照射后,在头两代中可以预期将有125人具有严重的遗传缺陷,如将全部后代都包括进去,约有320人具有遗传上的缺陷。

关键词：遗传性第一代平衡易位辐射防护劳动保护非整倍体非整元体加倍剂量