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A pan-cancer fingerprint:common molecular denominators of the human tumor microenvironment

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Signal Transduction and Targeted Therapy 2021年第12期6卷 3371-3372页

作者： Susanna S.ng Sonia Leonardelli michael Hölzel Institute of Experimental Oncology University Hospital BonnUniversity of Bonn53127 BonnGermany

In a recent study published in Cancer Cell,Bagaev et *** a pan-cancer tumor microenvironment(TME)classification that can be predictive of response to immune check.oint inhibitor(ICI)therapy.1 The authors presented a detailed visualization that can be generated for each tumor,which combines the 29 functional gene expression signatures(Fges)used to subtype the TME with targetable genomic *** the compartments and pathways within the TME could aid decision-mak.ng in patient-specific treatment of cancer,especially in the context of immunotherapies.2 The increasing use of ICIs have shown promising clinical outcomes in several cancer ***,response to treatment is heterogenous and often results in immune-related adverse events.3 Therefore,efforts are focused on the development of prognostic tools to predict response to *** analysis of 468 melanoma patients resulted in grouping of the TME into four major subsets based on manually curated Fges.

关键词： cancer alterations

金融秩序维护与企业ESG表现——来自金融司法审判的证据

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经济学动态 2024年第7期 92-110页

作者：魏建王慧敏薛启航山东大学人文社科期刊社山东大学中泰证券金融研究院 250100 山东大学经济学院 250100

司法行为的社会影响备受关注,但对该问题的研究缺乏充足的经验证据。从金融秩序维护的角度,利用中国裁判文书网公布的破坏金融管理秩序刑事一审判决书构建地级市层面的金融司法审判指标,探讨金融司法审判对企业ESG表现的影响。研究结果... 详细信息

司法行为的社会影响备受关注,但对该问题的研究缺乏充足的经验证据。从金融秩序维护的角度,利用中国裁判文书网公布的破坏金融管理秩序刑事一审判决书构建地级市层面的金融司法审判指标,探讨金融司法审判对企业ESG表现的影响。研究结果显示:企业所在地的金融司法审判效率越高、上诉率越低,企业的ESG表现越好。机制分析表明,金融司法审判主要通过降低信息不对称程度、缓解企业融资约束以及增强企业风险管理意识来提高企业的ESG表现水平。进一步分析发现,对于那些拥有较多法律背景高管的企业以及处于银行机构密集城市的企业,金融司法审判的影响更加显著;而且,金融司法审判的改善还有助于降低ESG不确定性程度,以及强化ESG对企业价值的提升效应。因此,应当持续加强金融司法审判的专业化和严格化,鼓励企业主动承担ESG责任,从而实现企业和社会的“双赢”局面。

关键词：金融秩序维护审判效率上诉率 ESG

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EPEG型聚羧酸保坍剂的制备及性能研究

四川建材 2024年第6期50卷 13-15页

作者：汪咏梅赵明敏倪涛宋欣 Serina ng 石家庄市长安育才建材有限公司河北石家庄051430 河北省混凝土用功能性材料工程技术研究中心河北石家庄051430

以乙二醇单乙烯基聚乙二醇醚(EPEG)、丙烯酸羟丙酯(HPA)、丙烯酸(AA)为主要原料,在常温条件下通过自由基聚合合成聚羧酸保坍剂。通过试验考察了釜底浓度、反应温度、引发剂、链转移剂用量及酸醚比对产品性能的影响。最佳反应条件:HPA∶A... 详细信息

以乙二醇单乙烯基聚乙二醇醚(EPEG)、丙烯酸羟丙酯(HPA)、丙烯酸(AA)为主要原料,在常温条件下通过自由基聚合合成聚羧酸保坍剂。通过试验考察了釜底浓度、反应温度、引发剂、链转移剂用量及酸醚比对产品性能的影响。最佳反应条件:HPA∶AA∶EPEG=3.5∶1.5∶1.0,引发剂占单体质量百分比为1.2%,滴加时间为60 min,保温30 min,反应结束。通过对EPEG和TPEG大单体核磁对比分析,以及EPGE与TPEG型保坍剂进行凝胶渗透色谱(GPC)、总有机碳分析仪(TOC)微观分析,证实了EPEG型保坍剂具有更优性能的微观原因。在达到相同保坍性能条件下,EPEG型保坍剂只占TPEG型保坍剂用量的80%,大幅降低了保坍剂用量,显著节约成本,大幅提高市场竞争力,同时EPEG型保坍剂常温、短时间、高效率的生产特点,使其具有良好的经济价值及广泛的应用前景。

关键词： EPEG 保坍剂常温合成微观分析保坍性能

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释放生长潜力：利用合生元的力量加强侧耳属植物种植（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第4期 293-307页

作者： Reshma PATIL Aizi Nor Mazila RAMLI Ang Shu XUAN ng Zhi XIN Nur Izyan Wan AZELEE Prak.sh BHUYAR 马来西亚彭亨苏丹阿卜杜拉大学工业科学与技术学院(UMPSA) 2. Bio芳香卓越研究中心马来西亚彭亨苏丹阿卜杜拉大学马来西亚工艺大学工程学院生物工艺与聚合物工程系梅州大学国际学院有机农业管理(MJU-IC) 梅州大学国际学院国际工农业创新研究中心(IIAR)

平菇（Pleurotus spp.）是全球最广泛栽培的蘑菇品种之一。本研究旨在探讨合生元对Pleurotus ostreatus和Pleurotus pulmonarius生长和品质的影响。通过每日对蘑菇样品喷洒不同浓度的合生元，测量其生长参数、产量、生物效率、近似成分... 详细信息

平菇（Pleurotus spp.）是全球最广泛栽培的蘑菇品种之一。本研究旨在探讨合生元对Pleurotus ostreatus和Pleurotus pulmonarius生长和品质的影响。通过每日对蘑菇样品喷洒不同浓度的合生元，测量其生长参数、产量、生物效率、近似成分、矿物质含量、总酚含量和二苯基-1-三硝基苯肼（DPPH）自由基清除活性。结果表明，使用喷洒菊粉和干酪乳杆菌的合生元，平菇的产量最高（56.92克），生物效率也最高（12.65%）。菊粉和干酪乳杆菌的组合最为高效，可以同时提高两种样品蘑菇的生长性能和营养成分。此外在白平菇（***）中，菊粉和干酪乳杆菌组合的合生元可产生最高的总酚含量（20.550 mg GAE/g DE），而在灰蘑菇（P. pulmonarius）中产生最高总酚含量的是干酪乳杆菌（1.098 mg GAE/g DE），其次是菊粉和干酪乳杆菌（1.079 mg GAE/g DE）。DPPH结果表明，平菇可以作为一种有效的抗氧化剂。综上，合生元可通过增加酚类化合物的含量来提高蘑菇的抗氧化能力，并通过增加矿物质元素的含量来提供更好的健康益处，从而提高了蘑菇的品质。上述研究证明了合生元作为一种生物肥料用于蘑菇栽培的应用潜力，是帮助蘑菇种植者解决质量不稳定的一个有效方案。

关键词：抗氧化剂生物肥料成长表现蘑菇种植侧耳属合生元

Philippine retinoblastoma initiative multi-eye center study 2010-2020

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 144-156页

作者： Roland Joseph D.Tan Gary John V.Mercado Patricia E.Cabrera Paulita Pamela P.Astudillo Rolando Enrique D.Domingo Josept Mari S.Poblete Charmaine Grace M.Cabebe Adriel Vincent R.Te Melissa Anne S.Gonzales Jocelyn G.Sy Beltran Alexis A.Aclan Jayson T.So Fatima G.Regala k.mberley Amanda k.Comia Josemaria M.Castro Mara Augustine S.Galang Aldous Dominic C.Cabanlas Benedicto Juan E.Aguilar Gabrielle S.Evangelista Jo michael Maniwan Andrei P.Martin Calvin Y.Martinez John Alfred H.Lim Rena Ivy Bascuna Rachel M.ng k.vin B.Agsaoay k.is Zanna A.Acluba-Arao Ellaine Rose V.Apostol Beatriz M.Prieto Department of Ophthalmology and Visual Sciences Philippine General HospitalManila 1000Philippines Department of Ophthalmology Baguio General Hospital and Medical CenterBaguio City 2600Philippines Department of Ophthalmology Manila Doctors HospitalManila 1000Philippines Department of Ophthalmology Rizal Medical CenterPasig City 1600Philippines Department of Ophthalmology Jose B.Lingad Memorial Regional HospitalPampanga 2000Philippines Department of Ophthalmology Southern Philippines Medical CenterDavao City 8000Philippines Department of Ophthalmology East Avenue Medical CenterQuezon City 1100Philippines Department of Ophthalmology Northern Mindanao Medical CenterCagayan de Oro City 9000Philippines Department of Ophthalmology Cebu Velez General HospitalCebu City 6000Philippines Legazpi Eye Center Legazpi City 4500Philippines Department of Ophthalmology Cagayan Valley Medical CenterTuguegarao City 3500Philippines

AIM:To provide a comprehensive and more representative national data on the disease,especially on treatment options and outcomes,and to determine access of retinoblastoma patients from Luzon,Visayas and Mindanao to eye care,and determine if access is associated with delay in consultation,staging and ***:Cohort study of retinoblastoma patients seen in eleven institutions located in the three major areas of the Philippines namely Luzon,Vizayas and Mindanao from ***:Totally 636 patients,involving 821 eyes,were ***(57%)were from Luzon and were seen in institutions in Luzon(72%).Annually,58±10 new cases were seen with 71%having unilateral *** delay of consultation remained long at 9(3,17)mo,longest in patients with unilateral disease(Png System,only 35%of patients had Stage 1 while 47%already had extraocular *** was the most common treatment received by 484 patients while intravenous chemotherapy was received by *** were 250(39%)patients alive,195(31%)dead,85(13%)abandoned,17(3%)refused and 89(14%)with no ***:This study presents the largest cohort of retinoblastoma patients in the Philippines in terms of patients’and participating institutions’number and geographical location and type of institution(private and public).It also presents more comprehensive data on the treatments used and outcomes(survival,globe salvage,and vision retention rates).Delay in consultation was still long among patients leading to advanced disease stage and lower survival *** increasing capacity to diagnose and manage retinoblastoma in the country,the delay of consultation remains long primarily due to accessibility issues to eye care institutions especially in the Visayas and financial *** delay was still significant that overall survival rate remain low.

关键词： retinoblastoma Philippines clinical profile

Rank.ng parameters in urban energy models for various building forms and climates using sensitivity analysis

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建筑模拟(英文) 2023年第9期16卷 1587-1600页

作者： Aysegul Demir Dilsiz k.itlynn ng Jérôme k.mpf Zoltan Nagy Department of Civil and Architectural Engineering and Construction Management University of WyomingLaramie WYUSA Intelligent Environments Lab Department of CivilArchitectural and Environmental EngineeringThe University of Texas at AustinAustin TXUSA Energy Informatics Group Idiap Research Institute1920 MartignySwitzerland

Urban Building Energy Modelling(UBEM)allows us to simulate buildings’energy performances at a larger ***,creating a reliable urban-scale energy model of new or existing urban areas can be difficult since the model requires overly detailed input data,which is not necessarily publicly *** calibration is a necessary step to reduce the uncertainties and simulation results in order to develop a reliable and accurate *** to the concerns over computational resources and the time needed for calibration,a sensitivity analysis is often required to identify the k.y parameters with the most substantial impact before the calibration is deployed in ***,we study the sensitivity of uncertain input parameters that affect the annual heating and cooling energy demand by employing an urban-scale energy model,*** goal is to determine the relative influence of each set of input parameters and their interactions on heating and cooling loads for various building forms under different ***,we conduct a global sensitivity analysis for annual cooling and heating consumption under different climate *** upon this,we investigate the changes in input sensitivity to different building forms,focusing on the indices with the largest Total-order ***,we determine First-order indices and Total-order effects of each input parameter included in the urban building energy *** also provide tables,showing the important parameters on the annual cooling and heating demand for each climate and each building *** find that if the desired calibration process require to decrease the number of the inputs to save the computational time and cost,calibrating 5 parameters;temperature set-point,infiltration rate,floor U-value,*** U-value and roof U-value would impact the results over 55%for any climate and any building form.

关键词： global sensitivity analysis Sobol’method urban energy modeling building stock. energy modelling parameter screening Sobol’indices sustainable urban planning

Enhanced activity and durability of FeCoCrMoCBY nanoglass in acidic hydrogen evolution reaction

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Journal of Materials Science & Technology 2024年第3期170卷 212-220页

作者： Mengyang Yan Shuangqin Chen Shangshu Wu Xuechun Zhou Shu Fu Di Wang Christian k.bel Horst Hahn Si Lan Tao Feng Herbert Gleiter Institute of Nanoscience School of Material Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China Institute of Nanotechnology Karlsruhe Institute of TechnologyKarlsruhe 76021Germany

In the present work.a multi-element nanoglass(m-ng)of FeCoCrMoCBY is obtained first time by the laser ablation combined with inert gas condensation(laser-IGC)*** with the conventional rapid-quenched metallic glass(MG)with identical composition,the Fe-based m-ng demonstrates a superior performance as a self-supported electrocatalyst for hydrogen evolution reaction(HER)in acidic *** enhanced HER activity of m-ng is proposed to be closely related to its high en-ergy states,which is originated from the unique inhomogeneous nanostructures with a high density of low-coordinated ***,the Fe-based m-ng exhibits an outstanding comprehensive catalytic performance even beyond the commercial Pt/C catalyst in long-term test due to its self-optimization *** work.not only opens the way to the preparation of m-ngs by the novel laser-IGC technique,but also mak.s a great contribution to developing low-cost,high-efficient,and super-durable HER electrocat-alysts in acidic environment.

关键词： Nanoglass Inert gas condensations High energy states Hydrogen evolution reactions

The RNA Pol Ⅱ sub-complex hsRpb4/7 is required for viability of multiple human cell lines

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Protein & Cell 2012年第11期3卷 846-854页

作者： Yang Zhao k.m k.C.Li k.ng Pan ng Chi Ho ng k.vin A.W.Lee Division of Life Science The Hong Kong University of Science and TechnologySai KungHong Kong S.A.R.China

The evolutionarily conserved RNA Polymerase Ⅱ Rpb4/7 sub-complex has been thoroughly studied in yeast and impacts gene expression at multiple levels including transcription,mRNA processing and *** addition Rpb4/7 exerts differential effects on gene expression in yeast and Rpb4 is not obligatory for yeast(***)*** roles for human(hs)Rpb4/7 have not been extensively described and we have probed this question by depleting hsRpb4/7 in established human cell lines using RNA *** find that Rpb4/7 protein levels are inter-dependent and accordingly,the functional effects of depleting either protein are ***4/7 exhibits gene-specific effects and cells initially remain viable upon hsRpb4/7 *** prolonged hsRpb4/7 depletion is cytotoxic in the range of cell lines *** cell death occurs by an unk.own mechanism and in some cases is accompanied by a pronounced elongated cell *** conclusion we provide evidence for a gene-specific role of hsRpb4/7 in human cell viability.

关键词： RNA PolymeraseⅡ hsRpb4/7 sub-complex gene expression cell viability cell shape

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Residential building performance analysis at near extreme weather conditions in Hong k.ng through a thermal-comfort-based strategy

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Building Simulation 2023年第1期16卷 13-25页

作者： k.F.Fong C.k.Lee k.vin k.-Lun Lau Edward Yan Yung ng Division of Building Science and Technology College of EngineeringCity University of Hong KongHong KongChina Department of Civil Engineering and Natural Resources Lulea University of TechnologySweden School of Architecture The Chinese University of Hong KongHong KongChina

The precise building performance assessment of residential housings in subtropical regions is usually more difficult than that for the commercial premises due to the much more complicated behavior of the occupants with regard to the change in indoor *** conventional use of a fixed schedule for window opening,clothing insulation and cooling equipment operation cannot reflect the real situation when the occupants respond to the change in thermal comfort,thus affecting the appropriateness of the assessment *** rectify the situation,a new modeling strategy in which the modification of the various operation schedules was based on the calculated thermal comfort(TC),was developed in this *** this new TC-based strategy,the realistic building performances under different cooling provision scenarios applied to a high-rise residential building under the near extreme weather conditions were investigated and *** was found that sole provision of ventilation fans could not meet the zone thermal comfort by over 68%of the time,and air-conditioning was *** optimal use of ventilation fans for cooling could only help reduce the total cooling energy demand by less than 12%at best which could only be realistically evaluated by adopting the present *** studies were conducted which revealed that some design factors could offer opportunities for reducing the total cooling energy under the near extreme weather conditions.

关键词： predicted mean vote thermal comfort ventilation potential building performance simulation residential housings