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Real-world treatment attrition rates in advanced esophagogastric cancer

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World journal of Gastroenterology 2020年第39期26卷 6027-6036页

作者： Erica S Tsang Howard j Lim Daniel j Renouf janine M Davies jonathan M Loree Sharlene Gill Department of Medicine BC CancerVancouver V5Z 4E6Canada Division of Medical Oncology University of British ColumbiaVancouver V5Z 4E6Canada

BACKGROUND Over the last decade,multiple agents have demonstrated efficacy for advanced esophagogastric cancer(EGC).Despite the availability of later lines of therapy,there remains limited real-world data about the treatment attrition rates between lines of *** To characterize the use and attrition rates between lines of therapy for patients with advanced *** We identified patients who received at least one cycle of chemotherapy for advanced EGC between july 1,2017 and july 31,2018 across six regional centers in British Columbia(BC),***,treatment,and outcomes data were *** Of 245 patients who received at least one line of therapy,median age was 66 years(IQR 58.2-72.3)and 186(76%)were male,Eastern Cooperative Oncology Group(ECOG)performance status 0/1(80%),gastric vs GEj(36%vs 64%).Histologies included adenocarcinoma(78%),squamous cell carcinoma(8%),and signet ring(14%),with 31%HER2 positive.72%presented with de novo disease,and 25%had received previous *** was a high level of treatment attrition,with patients receiving only one line of therapy n=122,50%),two lines n=83,34%),three lines n=34,14%),and four lines n=6,2%).Kaplan-Meier analysis demonstrated improved survival with increasing lines of therapy(median overall survival 7.7 vs 16.6 vs 22.8 vs 40.4 mo,P<0.05).On multivariable Cox regression,improved survival was associated with better baseline ECOG and increased lines of therapy(P<0.05).CONCLUSION The steep attrition rates between therapies highlight the unmet need for more efficacious early-line treatment options for patients with advanced EGC.

关键词： Esophagogastric cancer Gastric cancer Treatment attrition Systemic therapy Treatment outcomes Real-world evidence

Exploiting multi-channels deep convolutional neural networks for multivariate time series classification

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Frontiers of Computer Science 2016年第1期10卷 96-112页

作者： Yi ZHENG QiLIU Enhong CHEN Yong GE j. Leon ZHAO School of Computer Science and Technology University of Science and Technology of China Hefei 230027 China Department of Computer Science University of North Carolina at Charlotte Charlotte 28223 USA Department of Information Systems City University of Hong Kong Hong Kong China

Time series classification is related to many dif- ferent domains, such as health informatics, finance, and bioinformatics. Due to its broad applications, researchers have developed many algorithms for this kind of tasks, e.g., multivariate time series classification. Among the classifi- cation algorithms, k-nearest neighbor （k-NN） classification （particularly 1-NN） combined with dynamic time warping （DTW） achieves the state of the art performance. The defi- ciency is that when the data set grows large, the time con- sumption of 1-NN with DTW will be very expensive. In con- trast to 1-NN with DTW, it is more efficient but less ef- fective for feature-based classification methods since their performance usually depends on the quality of hand-crafted features. In this paper, we aim to improve the performance of traditional feature-based approaches through the feature learning techniques. Specifically, we propose a novel deep learning framework, multi-channels deep convolutional neu- ral networks （MC-DCNN）, for multivariate time series classi- fication. This model first learns features from individual uni- variate time series in each channel, and combines information from all channels as feature representation at the final layer. Then, the learnt features are applied into a multilayer percep- tron （MLP） for classification. Finally, the extensive experi- ments on real-world data sets show that our model is not only more efficient than the state of the art but also competitive in accuracy. This study implies that feature learning is worth to be investigated for the problem of time series classification.

关键词： convolutional neural networks time series clas-sification feature learning deep learning

Magnetic labeling of primary murine monocytes using very small superparamagnetic iron oxide nanoparticles

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Neural Regeneration Research 2022年第10期17卷 2311-2315页

作者： Martin Pohland Christoph Pohland jürgen Kiwit jana Glumm Institute of Cell Biology and Neurobiology Center for AnatomyCharité-Universitätsmedizin BerlinBerlinGermany Department of Neurosurgery Helios Klinikum Berlin BuchBerlinGermany

Due to their very small size,nanoparticles can interact with all cells in the central nervous *** of the most promising nanoparticle subgroups are very small superparamagnetic iron oxide nanoparticles(VSOP)that are citrate coated for electrostatic *** determine their influence on murine blood-derived monocytes,which easily enter the injured central nervous system,we applied VSOP and carboxydextran-coated superparamagnetic iron oxide nanoparticles(Resovist).We assessed their impact on the viability,cytokine,and chemokine secretion,as well as iron uptake of murine blood-derived *** found that(1)the monocytes accumulated VSOP and Resovist,(2)this uptake seemed to be nanoparticle-and time-dependent,(3)the decrease of monocytes viability was treatment-related,(4)VSOP and Resovist incubation did not alter cytokine homeostasis,and(5)overall a 6-hour treatment with 0.75 mM VSOP-R1 was probably sufficient to effectively label monocytes for future *** homeostasis is not altered,it is safe to label blood-derived monocles with *** labeled monocytes can be used to study injured central nervous system sites further,for example with drug-carrying VSOP.

关键词： CD11b,cytokine Ferucarbotran Mac1 MPS MRI Resovist superparamagnetic iron oxide nanoparticles(SPIO) very small superparamagnetic iron oxide nanoparticles(VSOP) viability

Parkinson's disease: From genetics to molecular dysfunction and targeted therapeutic approaches

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Genes & Diseases 2023年第3期10卷 786-798页

作者： Yue Huang jun Wei Antony Cooper Margaret j.Morris China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China Department of Pharmacology School of Medical SciencesFaculty of Medicine&HealthUNSWSydneyNSW 2052Australia The Garvan Institute of Medical Research SydneyNSW 2010Australia St Vincent's Clinical School Faculty of Medicine&Healthand School of Biotechnology and Biomolecular SciencesFaculty of ScienceUNSWSydneyNSW 2052Australia

Parkinson's disease (PD) is the most common neurodegenerative movement disorder in the elderly. As the pathogenesis of PD is still not fully understood, medications with the capacity of halting the disease progression are currently unavailable. The discovery of genes that are causative for, or increase susceptibility to PD is pivotal for the development of novel therapeutic approaches, as they are critical for the onset of PD and the molecular pathways underlying its pathogenesis. By reviewing relevant data, we discuss causative genes, and those associated with PD susceptibility and quantitative traits. Through Gene Ontology database and STRING analysis, we emphasize the roles of inorganic cation transmembrane transport pathways and hypothalamic pituitary thyroid axis, in addition to the established roles of inflammation/oxidative stress and mitochondrial dysfunction in the pathogenesis of PD. It is hoped these insights 1) untangle the clinical complex presentations of PD, 2) reveal the interwoven molecular network leading to PD, and 3) identify critical molecular targets to facilitate novel PD drug discovery, with a view to providing improved consultation and personalized medicine for patients with PD in the future.

关键词： Drug discovery Genetics Molecular function Parkinson's disease Quantitative traits

Germination strategies of annual and short-lived perennial species in the Arabian Desert

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journal of Arid Land 2020年第6期12卷 1071-1082页

作者： Arvind BHATT David j GALLACHER Paulo R M SOUZA-FILHO Lushan Botanical Garden Chinese Academy of SciencesJiujiang 332900China School of Life and Environmental Sciences The University of SydneyNarrabri NSW 2390Australia Multidisciplinary Center of Barra Federal University of Western BahiaBarra 47100-000Brazil

Germination timing is highly regulated in short-lived plant species since it strongly influences recruitment success of *** deserts,the spatiotemporal distribution of plant-available water is highly episodic and unpredictable,making winter months more favorable for seed germination when other abiotic conditions *** hypothesized that changes in photoperiod and thermoperiod would impact germination more in seeds that had undergone in situ *** assessed 21 annual and short-lived perennial species in the Arabian Desert to find(1)if seeds were dormant at maturity,(2)if in situ seed storage increased germination percentage compared with no storage,(3)if photoperiod and thermoperiod germination requirements were influenced by in situ storage,and(4)if a phylogenetic association in seed germination could be *** of each species collected in early 2017 were divided into two *** was tested for germination within one week(fresh seeds).The other was stored in situ at the maternal location(stored seeds)until October 2017 and tested for seed germination in the first week of *** germination was conducted in incubators at two thermoperiods(15℃/20℃ and 20℃/30℃;12 h/12 h),and two photoperiods(12 and 0 h light per day).Results indicated that seed germination percentages of 13 species were significantly enhanced by in situ storage.A thermoperiod response was exhibited by stored,but not fresh *** exposure increased germination of fresh seeds but had only a minimal effect on stored *** traits exhibited no phylogenetic *** result indicated that selection pressure for germination strategy was stronger than that for taxonomic traits of these desert species.

关键词： desert species dormancy germination light temperature phylogeny

Frictionally excited thermoelastic dynamic instability of functionally graded materials

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Acta Mechanica Sinica 2019年第1期35卷 99-111,I0004页

作者： j.Liu L.L.Ke Y.S.Wang College of Engineering Huazhong Agricultural UniversityWuhan 430070China Institute of Engineering Mechanics Beijing JiaotongUniversity Beijing 100044China

The perturbation method is applied to investigate the frictionally excited thermoelastic dynamic instability (TEDI) of a functionally graded material (FGM) coating in half-plane sliding against a homogeneous half-plane. We assume that the thermoelastic properties of the FGM vary exponentially with thickness. We also examine the effects of the gradient index, sliding speed, and friction coefficient on the TEDI for various material combinations. The transverse normal stress for two different coating structures is calculated. Furthermore, the frictional sliding stability of two different coating structures is analyzed. The obtained results show that use of FGM coatings can improve the TEDI of this sliding system and reduce the possibility of interfacial failure by controlling the interfacial tensile stress.

关键词： Thermoelastic dynamic instability Frictional heat Functionally graded materials Stress analysis

Why European Universities and Funding Agencies are Committing to Open Access

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图书情报工作 2006年第1期50卷 24-27页

作者： Frederick j Friend OSI Open Access Advocate JISC Consultant

New opportunities presented by technological developments are being realised but more can be achieved in opening access to scientific reports and data. Funding agencies and universities are beginning to realise the benefits from an open access model for the dissemination of research results. European funding agencies and universities are following two strategies towards open access, the deposit of research reports in repositories and the conversion of journals to an open access business model. Various public statements have been made in support of open access, and several organizations-such as jISC in the UK-are undertaking work to assist all stakeholders in scholarly communication in introducing beneficial changes.

关键词： open access jISC OSI

Gas separation using porous cement membrane

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journal of Environmental Sciences 2014年第1期26卷 140-146页

作者： Weiqi Zhang Maria Gaggl Gregor j.G.Gluth Frank Behrendt Berlin Institute of Technology Department of Energy Engineering Chair EVUR Chinese Research Academy of Environmental Sciences Berlin Institute of Technology Chair of Building Materials BAM Federal Institute for Materials Research and Testing Division 7.4 Technology of Construction Materials

Gas separation is a key issue in various industrial fields. Hydrogen has the potential for application in clean fuel technologies. Therefore, the separation and purification of hydrogen is an important research subject. CO2 capture and storage have important roles in ＂green chemistry＂. As an effective clean technology, gas separation using inorganic membranes has attracted much attention in the last several decades. Membrane processes have many applications in the field of gas separation. Cement is one type of inorganic material, with the advantages of a lower cost and a longer lifespan. An experimental setup has been created and improved to measure twenty different cement membranes. The purpose of this work was to investigate the influence of gas molecule properties on the material transport and to explore the influence of operating conditions and membrane composition on separation efficiency. The influences of the above parameters are determined, the best conditions and membrane type are found, it is shown that cementitious material has the ability to separate gas mixtures, and the gas transport mechanism is studied.

关键词： gas separation porous membrane clean fuel cement membrane inorganic membranes

Revealing pion and kaon structure via generalised parton distributions

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Chinese Physics C 2022年第1期46卷 80-101页

作者： K.Raya Z-F.Cui L.Chang j.M.Morgado C.D.Roberts j.Rodríguez-Quintero School of Physics Nankai UniversityTianjin 300071China Departamento de Física Teórica y del Cosmos Universidad de GranadaE-18071GranadaSpain Instituto de Ciencias Nucleares Universidad Nacional Autónoma de MéxicoApartado Postal 70-543CDMX 04510México School of Physics Nanjing UniversityNanjingJiangsu 210093China Institute for Nonperturbative Physics Nanjing UniversityNanjingJiangsu 210093China Department of Integrated Sciences and Center for Advanced Studies in Physics Mathematics and ComputationUniversity of HuelvaE-21071 HuelvaSpain

Clear windows onto emergent hadron mass(EHM)and modulations thereof by Higgs boson interactions are provided by observable measures of pion and kaon structure,many of which are accessible via generalised parton distributions(GPDs).Beginning with algebraic GPD Ansätze,constrained entirely by hadron-scaleπand K valence-parton distribution functions(DFs),in whose forms both EHM and Higgs boson influences are manifest,numerous illustrations are *** include the properties of electromagnetic form factors,impact parameter space GPDs,gravitational form factors and associated pressure profiles,and the character and consequences of allorders *** analyses predict that mass-squared gravitational form factors are stiffer than electromagnetic form factors;reveal that K pressure profiles are tighter than profiles,with both mesons sustaining near-core pressures at magnitudes similar to that expected at the core of neutron stars;deliver parameter-free predictions for and K valence,glue,and sea GPDs at the resolving scale l=2GeV;and predict that at this scale the fraction of meson mass-squared carried by glue and sea combined matches that lodged with the valence degrees-of-freedom,with a similar statement holding for mass-squared radii.

关键词： continuum Schwinger function methods emergence of hadron mass Nambu-Goldstone modes-pions and kaons nonperturbative quantum field theory parton distributions strong interactions