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Metal-free acyl-directed electrophilic C–H borylation using just BBr3

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Science China Chemistry 2019年第12期62卷 1547-1548页

作者： michael j.Ingleson School of Chemistry University of Edinburgh

The considerable utility of organoboranes in synthesis is firmly established,which is in a large part due to the power of the Suzuki-Miyaura cross-coupling reaction for con・structing C-C ***,discovering simple new routes to form desirable organoboranes continues to be of significant *** that directly transform C-H into C-B are particularly desirable,especially if borylation occurs with excellent site selectivity and without precious metal catalysts due to their low crustal abundance,high cost and toxicity.

关键词： desirable organo bonds

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Simple Algorithms for Network Visualization:A Tutorial

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Tsinghua Science and Technology 2012年第4期17卷 383-398页

作者： michael j.McGuffin Department of Software and IT Engineering cole de technologie suprieureMontral H3C 1K3Canada

The graph drawing and information visualization communities have developed many sophisticated techniques for visualizing network data, often involving complicated algorithms that are difficult for the uninitiated to learn. This article is intended for beginners who are interested in programming their own network visualizations, or for those curious about some of the basic mechanics of graph visualization. Four easy-to-program network layout techniques are discussed, with details given for implementing each one： force-directed node-link diagrams, arc diagrams, adjacency matrices, and circular layouts. A java applet demonstrating these layouts, with open source code, is available at http：//***/research/simpleNetVis/. The end of this article also briefly surveys research topics in graph visualization, pointing readers to references for further reading.

关键词： network visualization graph visualization graph drawing node-link diagram force-directed layout arcdiagram adjacency matrix circular layout tutorial

How to make the "jump" on understanding the importance of the intrinsic foot muscles for propulsion

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journal of Sport and Health Science 2023年第5期12卷 648-650页

作者： michael j.Asmussen Department of Biology Faculty of Science&TechnologyMount Royal UniversityCalgaryAB T3E 6K6Canada

In this issue of the journal of Sport and Health Science,Smith and colleagues1addressed a unique aspect of human locomotion;they evaluated the effects of the intrinsic foot musculature on the mechanical properties and energetic function of the human *** performing a controlled jumping experiment to mimic components of human locomotion.

关键词： intrinsic muscles propulsion

Universal Hyperthermal Model for Mass Extinctions

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journal of Earth Science 2024年第2期35卷 704-707页

作者： michael j.Benton Paleobiology Research Group School of Earth SciencesUniversity of BristolLife Sciences BuildingTyndall AvenueBristolBS81TQUK

INTRODUCTION Earth scientists have long sought universal features of past extinction *** can be argued that each past extinction event was a singularity,caused by combinations of circumstances that are unique in each case,and therefore that the search for common causes is ***,a key feature of the uniformitarian approach to geology is that past processes are the same as modern-day processes and,with that in mind,earth scientists are keen to use their knowledge to contribute some understanding to the study of the present and future climate crisis.

关键词： extinction singularity Extinction

Understanding Performance for Two 802.11 Competing Flows

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journal of Computer Science & Technology 2008年第3期23卷 365-376页

作者： michael j.Feeley Brendan Cully Sharath j.George Department of Computer Science University of British ColumbiaVanconverCanada

It is well known that 802.11 suffers from both inefficiency and unfairness in the face of competition and interference. This paper provides a detailed analysis of the impact of topology and traffic type on network performance when two flows compete with each other for airspace. We consider both TCP and UDP flows and a comprehensive set of node topologies. We vary these topologies to consider all combinations of the following four node-to-node interactions：（1） nodes unable to read or sense each other, （2） nodes able to sense each other but not able to read each other＇s packets and nodes able to communicate with （3） weak and with （4） strong signal. We evaluate all possible cases through simulation and show that the cases can be reduced to 9 UDP and 10 TCP 802.11g models with similar efficiency/fairness characteristics. We also validate our simulation results with extensive experiments conducted in a laboratory testbed. These more detailed models improve on previous work such as hidden-/exposed-terminal categorization and are thus better suited as a basis for adaptive techniques to improve performance in 802.11 multi-hop WLAN or Mesh Networks.

关键词： 802.11 wireless unfairness two-flow competition network topology

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander j.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi james D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Distributed Control of Chemical Process Networks

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International journal of Automation and computing 2015年第4期12卷 368-381页

作者： michael j.Tippett jie Bao School of Chemical Engineering The University of New South Wales

In this paper,we present a review of the current literature on distributed(or partially decentralized) control of chemical process *** particular,we focus on recent developments in distributed model predictive control,in the context of the specific challenges faced in the control of chemical process *** paper is concluded with some open problems and some possible future research directions in the area.

关键词： Distributed process control chemical process systems process networks plantwide control distributed model predictive control.

Current strategies for the treatment of inborn errors of metabolism

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journal of Genetics and Genomics 2018年第2期45卷 61-70页

作者： michael j.Gambello Hong Li Department of Human Genetics Emory University School of Medicine

Inborn errors of metabolism（IEMs） are a large group of inherited disorders characterized by disruption of metabolic pathways due to deficient enzymes, cofactors, or transporters. The rapid advances in the understanding of the molecular pathophysiology of many IEMs, have led to significant progress in the development of many new treatments. The institution and continued expansion of newborn screening provide the opportunity for early treatment, leading to reduced morbidity and mortality. This review provides an overview of the diverse therapeutic approaches and recent advances in the treatment of IEMs that focus on the basic principles of reducing substrate accumulation, replacing or enhancing absent or reduced enzyme or cofactor, and supplementing product deficiency. In addition, the challenges and obstacles of current treatment modalities and future treatment perspectives are reviewed and discussed.

关键词： Inborn errors of metabolism Treatment Dietary therapy Enzyme replacement therapy Substrate reduction therapy Pharmacological chaperone therapy