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A retrospective analysis of pain and opioid usage in head and neck free flap reconstruction

World journal of Otorhinolaryngology-Head and Neck Surgery 2023年第2期9卷 153-159页

作者： Parhom Towfighi Alison Hill jason R.Crossley Amanda Walsh james A.Leonard jonathan P.Giurintano Matthew L.Pierce michael j.reilly Georgetown University School of Medicine WashingtonDistrict of ColumbiaUSA Department of Otolaryngology-Head and Neck Surgery Medstar GeorgetownWashingtonDistrict of ColumbiaUSA

Objectives:Investigate opioid usage and postoperative pain in patients undergoing head and neck free flap ***:A retrospective review of 100 consecutive patients undergoing head and neck free flap reconstruction at two academic centers was *** captured included demographics,postoperative inpatient pain,pain at postoperative visits,morphine equivalent doses(MEDs)administration,medication history,and *** were analyzed using regression models,χ2 tests,and student’’***:Seventy-three percent of patients were discharged with opioid medication,with over half(53.4%)continuing to take opioids at their second postoperative visit,and over one-third(34.2%)continuing to take them around 4-month *** out of every five(20.3%)opioid-na?ve patients chronically took opioids *** was a poor association between inpatient postoperative pain scores and daily MEDs administered(R2=0.13,0.17,and 0.22 in postoperative Days 3,5,and 7,respectively).Neither preoperative radiotherapy nor postoperative complications were associated with an increase in opioid ***:For patients undergoing head and neck free flap operations,opioid medications are commonly used for postoperative *** practice may increase the chance an opioid-na?ve patient uses opioids *** found a poor association between MEDs administered and patient-reported pain scores,which suggests that standardized protocols aimed at optimizing analgesia while reducing opioid administration may be *** of Evidence:3(Retrospective cohort study).

关键词： free flap reconstruction head and neck multimodal analgesia opioids postoperative pain

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Impact of early eyelid weight placement on the development of synkinesis and recovery in patients with idiopathic facial paralysis

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World journal of Otorhinolaryngology-Head and Neck Surgery 2021年第4期7卷 270-274页

作者： Keon M.Parsa Caroline Rieger Dara Khati jennifer R.White jodi Barth Chad C.Zatezalo michael j.reilly Department of Otolaryngology MedStar Georgetown University HospitalWashingtonDCUSA The Center for Facial Recovery RockvilleMDUSA The Zatezalo Group RockvilleMDUSA

Determine the impact of upper eyelid weight placement at 3 months post onset of idiopathic facial paralysis(IFP)on the recovery of facial function in patients with ***:This is a retrospective review of patients with incomplete recovery of IFPddefined as a Sunnybrook Facial Grading Scale(FGS)score of less than 100,3 months after *** patients with FGS and Facial Clinimetric Evaluation(FaCE)scores recorded at 3 and 12 months were *** were categorized into 3 groups:Group A,lagophthalmos with eyelid weight placement;Group B,lagophthalmos without eyelid weight placement;Group C,complete eye closure(CEC)without eyelid weight *** eye comfort domain and composite score of the FaCE questionnaire were *** eye closure,synkinesis with eye closure,overall synkinesis and the composite score of the FGS were also *** two-tailed t-test was used to evaluate the data comparing the 3 and 12 month FaCE and FGS scores within and between the 3 ***:The change in composite FGS score significantly increased from month 3 to month 12 in Group A as compared to Group B(37 vs 4.25,P=0.01).While Group A had significantly lower eye comfort(-12.5,P=0.01),voluntary eye closure(-1.75,P=0.05)and overall FGS scores(-28.75,P=0.04)at 3 months compared to those in Group C,there were no differences between these two groups at 12 month ***:For patients with lagophthalmos at 3 months,early eyelid weight placement may lead to improved facial function at 12 months.

关键词： Facial paralysis Synkinesis Eyelid weight

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*** Web应用程序开发新思维

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丛书名：微软.NET程序员系列

2002年

作者：（美）Douglas j.reilly 赵海等译

本书主要介绍了如何开发***应用程序，包括：创建Web窗体和自定义控件；开发和使用XML Web服务；创建使用XML和***的***应用程序。

ISBN: (数字)7900641688

ISBN: (纸本)7900641688

本书主要介绍了如何开发***应用程序，包括：创建Web窗体和自定义控件；开发和使用XML Web服务；创建使用XML和***的***应用程序。

关键词：互连网络程序设计

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基于服务器的应用程序技术内幕 G

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丛书名： Microsoft编程系列

2000年

作者：（美）Douglas j.reilly 潇湘工作室译

本书介绍基于服务器开发的基础知识、介绍了在Windows 2000平台上进行各种服务器应用程序的编写等内容。

ISBN: (数字)7900625690

ISBN: (纸本)7900625690

本书介绍基于服务器开发的基础知识、介绍了在Windows 2000平台上进行各种服务器应用程序的编写等内容。

关键词：网络服务器应用程序

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Delirium after emergency hip surgery-common and serious, but rarely consented for

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World journal of Orthopedics 2019年第6期10卷 228-234页

作者： Louis j Koizia Faye Wilson Peter reilly michael B Fertleman Geriatric Medicine Imperial College NHS TrustLondon W2 1NYUnited Kingdom Geriatric Medicine City Hospitals SunderlandSunderland SR4 7TPUnited Kingdom Department of Trauma and Orthopaedics Imperial College Healthcare NHS TrustLondon W2 1NYUnited Kingdom

A quarter of patients admitted with a proximal femoral fracture suffer from an acute episode of delirium during their hospital *** it is often unrecognised,poorly managed,and rarely discussed by *** is important not only to the affected individuals and their families,but also socioeconomically to the broader *** increases mortality and morbidity,leads to lasting cognitive and functional decline,and increases both length of stay and dependence on *** should be routinely and openly discussed by all members of the clinical team,including surgeons when gaining *** to do so may expose surgeons to claims of *** we present a concise review of the literature and discuss the epidemiology,causative factors,potential consequences and preventative strategies in the perioperative period.

关键词： Delirium Proximal femoral fractures Consent Hip surgery Montgomery Medicolegal

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Biopsy of solid liver tumors:adverse consequences

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Hepatobiliary & Pancreatic Diseases International 2008年第3期7卷 325-327页

作者： Dhya Al-Leswas Derek A O'reilly Graeme j Poston Department of Surgery University Hospital Aintree Lower LaneLiverpoolL9 7ALUK

BACKGROUND:Percutaneous radiologically-guided liver biopsy is used routinely worldwide in all secondary- level hospital *** it has an undoubted role in the investigation and management of acute and chronic inflammatory conditions of the liver,its role in hepatic oncology is doubtful and probably dangerous. METHOD:We report on two patients who underwent preoperative biopsy of potentially resectable liver tumors. RESULTS:At the time of surgery,there was evidence of seeding at the biopsy site in both *** case 1,potentially curative liver resection was rendered incurable because of gross peritoneal carcinomatosis lying adjacent to the site of liver *** case 2,the patient underwent curative liver resection,but there was histopathological evidence of peritoneal disease beyond the liver capsule along the falciform ligament at the site of the previous biopsy. CONCLUSIONS:No patient with a suspicious liver tumor which is thought to be malignant and has any possibility of being a potential candidate for liver surgery,should be subjected to pre-operative diagnostic biopsy in a non- specialist center.

关键词： liver biopsy colorectal liver metastases hepatocellular carcinoma

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Epigenetic N6-methyladenosine modification of RNA and DNA regulates cancer

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Cancer Biology & Medicine 2020年第1期17卷 9-19页

作者： Zhixian Liang reilly LKidwell Haijing Deng Qi Xie School of Life Sciences Westlake UniversityHangzhou 310024China Institute of Biology Westlake Institute for Advanced StudyHangzhou 310024China Division of Regenerative Medicine Department of MedicineUniversity of California San DiegoSan DiegoCA 92037USA University of California San Diego School of MedicineLa JollaCA 92037USA

The biological roles of N6 methylation of nucleic acids have been extensively *** methylation of RNA is the most prevalent RNA modification and has widespread effects on RNA splicing,translation,localization,and *** dynamic regulation of RNA N6-methyladenosine(m6 A)has been reported in numerous human diseases,including several *** recent years,eukaryotic DNA N6-methyladenosine(6 mA)has also been reported and implicated in cancer progression and *** this review,we summarize the contributions of N6-methyladenosine modification to cancer biology and pathogenesis in the context of both RNA and *** also highlight the clinical relevance of targeting these modifications as a therapeutic strategy for cancer.

关键词： N6-methyladenosine RNA methylation DNA methylation cancer therapeutic targets

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MicroRNA-let-7a promotes E2F-mediated cell proliferation and NFKB activation in vitro

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Cellular & Molecular Immunology 2014年第1期11卷 79-93页

作者： Cristen B Chafin Nicole L Regna David L Caudell Christopher M reilly Department of Biomedical Sciences & Pathobiology Virginia-Maryland Regional College of Veterinary Medicine Virginia Polytechnic Institute and StateUniversity Blacksburg VA USA Department of Pathology/Comparative Medicine Wake Forest University Primate Center Wake Forest School ofMedicine Winston-Salem NC USA Edward Via College of Osteopathic Medicine Blacksburg VA USA

Epigenetic factors, including altered microRNA （miRNA） expression, may contribute to aberrant immune cell function in systemic lupus erythematosus （SLE）. MiRNA-let-7a （let-7a） has been shown to directly alter cell cycle progression and proinflammatory cytokine production. Due to the crucial role of let-7a in cell division and inflammation, we investigated let-7a-mediated proliferation and NFKB translocation in j774A. 1 macrophages and MES 13 mesangial cells in vitro. In immune-stimulated cells transfected with let-7a, cell proliferation was significantly increased over time. There was a significant increase in the number of immune-stimulated cells in S and G2 phases. Immune-stimulated cells overexpressing let-7a had increased nuclear translocation of NFKB. Bioinformatical analysis revealed that the E2F family, critical regulators of the G1-S transition, has potential binding sites for let-7a in their mRNA transcripts. Let-7a overexpression significantly increased the expression of the cell cycle activator E2F2 and increased retinoblastoma protein （Rb） phosphorylation in immune-stimulated cells. The cell cycle inhibitor E2F5 was significantly decreased in let-7a-transfected cells that were immune-stimulated. Bioinformatical analysis revealed E2F2 and NFKB are transcription factors predicted to regulate the let-7a promoter. We analyzed transcriptional regulation of let-7a by real-time RT-PCR using chromatin immunoprecipitation with E2F2 and NFKB antibodies. There was an increase in E2F2 and NFKB binding in DNA enriched for the let-7a promoter in immune-stimulated cells. Silencing E2F2 or NFKB significantly decreased let-7a expression and IL-6 production in immune-stimulated cells. Taken together, our results suggest that overexpression of let-7a may contribute to hyperplasia and the proinflammatory response in SLE.

关键词： cell proliferation E2F microRNA-let-7a NF~:B systemic lupus erythematosus

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Complications arising in simple and polycystic liver cysts

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World journal of Hepatology 2012年第12期4卷 406-411页

作者： Christian Macutkiewicz Ricci Plastow Melissa Chrispijn Rafik Filobbos Basil A Ammori David j Sherlock joost PH Drenth Derek A O’reilly Department of HepatoPancreato-Biliary Surgery North Manchester General HospitalManchester M8 5RBUnited Kingdom Department of Gastroenterology and Hepatology Radboud University Nijmegen Medical CenterPO Box 9101Code 455 NijmegenThe Netherlands Department of Radiology North Manchester General HospitalManchester M8 5RBUnited Kingdom The University of Manchester Manchester Academic Health Science CentreManchesterUnited Kingdom

Liver cysts are common,affecting 5%-10% of the *** are asymptomatic,however 5% of patients develop symptoms,sometimes due to complications and will require *** is no consensus on their management because complications are so *** aim of this study was to perform a collected review of how a series of complications were managed at our *** different patients presenting with rare complications of liver cysts were obtained from Hepatobiliary Units in the United Kingdom and The *** and radiological imaging were obtained from case notes and computerised *** a result,1 patient admitted with inferior vena cava obstruction was managed by cyst aspiration and lanreotide;1 patient with common bile duct obstruction was first managed by endoscopic retrograde cholangiopancreatography and stenting,followed by open fenestration;1 patient with ruptured cysts and significant medical co-morbidities was managed by percutaneous drainage;1 patient with portal vein occlusion and varices was managed by open liver resection;1 patient with infected cysts was treated with intravenous antibiotics and is awaiting liver *** final patient with a simple liver cyst mimicking a hydatid was managed by open liver *** conclusion,complications of cystic liver disease are rare,and we have demonstrated in this series that both operative and non-operative strategies have defined roles in *** mainstays of treatment are either aspiration/sclerotherapy or,alternatively laparoscopic *** management with somatostatin analogues is a potentially new and exciting treatment option but requires further study.

关键词： Liver Cysts Complications Polycystic

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Three Stages of Zircon Growth in Magmatic Rocks from the Pingtan Complex,Eastern China

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Acta Geologica Sinica(English Edition) 2007年第1期81卷 68-80页

作者： WANG Xiang W. L. GRIFFIN S. Y. O＇reilly LI Wuxian State Key Laboratory for Mineral Deposit Research Department of Earth Sciences Nanjing University Nanjing Jiangsu 210093 China GEMOC ARC National Key Center Department of Earth and Planetary Sciences Macquarie University NSW 2109 Australia CSIRO Exploration and Mining North Ryde NSW 2113 Australia

Morphological and chemical studies on zircon grains from gabbro and granite of the Pingtan magmatic complex, Fujian Province, eastern China, show that there are three stages of zircon growth. The early stage of zircon growth is characterized by colorlessness, high transparence and birefringence, low and dispersive Ipr and Ipy, weak and homogeneous BSE brightness, lower Hf content and depletion of U, Th and Y; the middle stage is characterized by abruptly increasing lpy, progressively strong and sectoral-zoning BSE brightness, higher Hf content and enrichment of U, Th and Y with Th/U 〉 1; the late stage of growth is characterized by brownish color, poor transparence, low birefringence, highest Ipr and Ipy, middle and oscillatorily-zoning BSE brightness, highest contents of Hf, U and Y with Th/U 〈 1. The stages are considered to be formed in a deep magma chamber, ascent passage and emplacement site, respectively. Due to the more or less long residual time of the magma chamber, the difference in age between the early and late stages of zircon might be great enough to be distinguished, which can be attributed to tectonic constraint for the magnlatism.

关键词： zircon three stages of crystal growth typology trace element magmatic rock

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