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Frontiers of Architectural Research 2022年第6期11卷 1092-1103页

作者： michael j.dawes ju Hyun Lee michael j.Ostwald Faculty of Arts Design&ArchitectureSchool of Built EnvironmentUniversity of New South WalesSydney2052Australia

The famous modernist architect Richard Neutra argued that movement through,and understanding of a building could be choreographed by controlling the visual stimuli that is available to a *** claims are tested by quantifying the lines of sight and intelligibility of five of Neutra’s residential designs.A computational method,weighted axial line analysis,is used to investigate lines of sight and movement in five of Neutra’s house *** cumulative lengths of axial lines required to reach public and private spaces are compared,and centrality measures are calculated for each design that are weighted with line length *** metrics are calculated from these centrality *** first hypothesis,that visual stimuli in Neutra’s architecture is greater when accessing public rather than private spaces is supported by the *** second hypothesis,that Neutra’s architecture is highly intelligible,is not supported by the *** research tests two theories used to explain the works of a famous architect and it develops a new variation of well-known Space Syntax technique,to account for axial line lengths.

关键词： Richard Neutra Modernism Space syntax Weighted axial map Centrality measures

Examining control,centrality and flexibility in Palladio’s villa plans using space syntax measurements

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Frontiers of Architectural Research 2021年第3期10卷 467-482页

作者： michael j.dawes michael j.Ostwald ju Hyun Lee UNSW Built Environment The University of New South WalesSydneyNSW 2052Australia

Andrea Palladio’s Renaissance villas are amongst the most famous and widely studied examples of domestic architecture ever *** majority of past research about Palladio’s architecture employed historical,mathematical and computational methods to analyse their complex proportional systems and *** contrast,this paper examines three of Palladio’s arguments about his villas plans which relate to their spatial properties and topological ***,this paper uses a computational method e the justified plan graph(jPG)e to test two arguments about the location and significance of the primary salon on the plan,and a third about the extent to which the rooms in Palladio’s plans are,as he claims,flexible enough to contain alternative *** ten of Palladio’s piano nobile(main floor)plans from I Quattro Libri Dell’Architettura as cases,this paper develops mathematical data to test three hypotheses framed around Palladio’s plans and theories.

关键词： Andrea palladio Palladian villa Renaissance architecture Space syntax justified plan graph(jPG)

NECAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno michael K.E.Schafer Sudena Wang michael j.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane trafficking and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, key regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is akin to atypical heme oxygenases in prokaryotes but is not wellcharacterized in vertebrates. Prokaryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is known about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

抗人凝血酶及其与抗凝血酶Ⅲ复合物的鼠单克隆抗体

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细胞与分子免疫学杂志 1986年第3期 129-130页

作者： j.dawes 马林 MRC/SNBTS Blood Components Assay Group Edinburgh UK

人类α-凝血酶是丝氨酸蛋白酶,它对血液凝固极为重要,它引起了纤维蛋白原的凝聚。凝血酶由凝血酶原产生,并在活体内由于凝血酶与抗凝血酶Ⅲ(ATⅢ)形成了一种共价化合物而很快失活。凝血酶的活性可以通过结合一些不同的分子而减弱。单... 详细信息

人类α-凝血酶是丝氨酸蛋白酶,它对血液凝固极为重要,它引起了纤维蛋白原的凝聚。凝血酶由凝血酶原产生,并在活体内由于凝血酶与抗凝血酶Ⅲ(ATⅢ)形成了一种共价化合物而很快失活。凝血酶的活性可以通过结合一些不同的分子而减弱。单克隆抗体在研究复合调解蛋白的控制中是很有价值的探针,例如在凝血酶的研究中就是如此。尽管人α-凝血酶对

关键词：抗凝血酶Ⅲ 人凝血酶鼠单克隆抗体血液凝固共价化合物活体内丝氨酸蛋白酶活性点免疫原性夹心法

Bugs beneath the surface： the functional significance of soil macroinvertebrates to landscape health in Australia＇s tropical savannas

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Insect Science 2005年第4期12卷 307-312页

作者： TRACY ZOE dawes-GROMADZKI CSIRO Sustainable Ecosystems and Tropical Savannas Cooperative Research Centre Australia

Soil macroinvertebrates play an important role in sustaining production and biodiversity in Australia＇ s tropical savannas. For example, termites, through their foraging and nesting activities, recycle nutrients and carbon and produce soil pores that facilitate water infiltration. The challenge ahead is to quantitatively understand the relationships and processes that drive this. What roles do different species and functional groups of macroinvertebrates play in various landscape processes？ What are the effects of different land management practices （e.g., domestic cattle grazing, fire） on these relationships, and the consequences for landscape health？ This paper presents preliminary results from studies in northern Australia, that examine the effects of land condition and domestic cattle grazing on soil macroinvertebrates, and the potential for termites to be used as a tool to restore soil function in degraded areas. In northern Australia, increased degradation seems to be associated with declines in the diversity and activity of macroinvertebrates. Termites appear to be one of the most resilient groups, with some species capable of maintaining activity in degraded landscapes.

关键词： Australia landscape health land management soil function soil macroinvertebrates tropical savanna

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

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Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher j.O’Connell Matthew j.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA james L.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

Modelling internal air systems ingas turbine engines

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航空动力学报 2007年第4期22卷 505-520页

作者： j michael Owen Department of Mechanical Engineering University of Bath

Rotating-disc systems can be used to model,experimentally and computationally,the flow and heat transfer that occur inside the internal cooling-air systems of gas turbine *** rotating-disc systems have been used successfully to simplify and understand some of the complex flows that occur in internal-air systems,and designers have used this insight to improve the cooling effectiveness,thereby increasing the engine efficiency and reducing the *** this review paper,three important cases are considered:hot-gas ingress;the pre-swirl system;and buoyancy-induced ***,or ingestion,occurs when hot gas from the mainstream gas path is ingested into the wheel-space between the turbine disc and its adjacent *** seals are fitted at the periphery of the system,and sealing flow is used to reduce or prevent ***,too much sealing air reduces the engine efficiency,and too little can cause serious overheating,resulting in damage to the turbine rim and blade *** the flow is three-dimensional and unsteady,there are encouraging signs that simple ‘orifice models’ could be used to estimate the amount of ingress into the *** a pre-swirl system,the cooling air for the gas-turbine blades is swirled by stationary nozzles,and the air is delivered to the blades via receiver holes in the rotating turbine *** the air reduces its temperature relative to the rotating blades,and the designer needs to calculate the air temperature and pressure drop in the *** designer also needs to calculate the effect of this swirling flow on the heat transfer from the turbine disc to the air,as this has a significant effect on the temperature distribution and stresses in the *** experimental and computational studies have given a better understanding of the flow and heat transfer in these ***-induced flow occurs in the cavity between two co-rotating compressor discs when the temperature of the discs is higher than

关键词：燃气涡轮机车空气动力学数学模型旋转式圆盘系统

Water transport to the core–mantle boundary

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National Science Review 2021年第4期8卷 13-16页

作者： michael j.Walter Earth and Planets Laboratory Carnegie Institution for Science

Water can have remarkable effects when exposed to rocks at high pressures and temperatures. It can form new minerals with unique properties and often profoundly affects the physical, transport and rheological properti...

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Temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries on magnetic resonance imaging

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Neural Regeneration Research 2025年第11期20卷 3144-3150页

作者： Holly Flyger Samantha j.Holdsworth Alistair j.Gunn Laura Bennet Hamid Abbasi Mātai Medical Research Institute Tairāwhiti GisborneNew Zealand Department of Anatomy&Medical Imaging Faculty of Medical and Health SciencesThe University of AucklandAucklandNew Zealand Center for Brain Research The University of AucklandAucklandNew Zealand Auckland Bioengineering Institute The University of AucklandAucklandNew Zealand

Moderate to severe perinatal hypoxic-ischemic encephalopathy occurs in~1 to 3/1000 live births in high-income countries and is associated with a significant risk of death or neurodevelopmental *** assessment is important to help identify highrisk infants,to help families,and to support appropriate interventions.A wide range of monitoring tools is available to assess changes over time,including urine and blood biomarkers,neurological examination,and *** present,magnetic resonance imaging is unique as although it is expensive and not suited to monitoring the early evolution of hypoxic-ischemic encephalopathy by a week of life it can provide direct insight into the anatomical changes in the brain after hypoxic-ischemic encephalopathy and so offers strong prognostic information on the long-term outcome after hypoxic-ischemic *** review investigated the temporal dynamics of neonatal hypoxic-ischemic encephalopathy injuries,with a particular emphasis on exploring the correlation between the prognostic implications of magnetic resonance imaging scans in the first week of life and their relationship to long-term outcome prediction,particularly for infants treated with therapeutic hypothermia.A comprehensive literature search,from 2016 to 2024,identified 20 pertinent *** review highlights that while the optimal timing of magnetic resonance imaging scans is not clear,overall,it suggests that magnetic resonance imaging within the first week of life provides strong prognostic *** challenges limit the timing consistency,particularly the need for intensive care and clinical ***,although most reports examined the prognostic value of scans taken between 4 and 10 days after birth,there is evidence from small numbers of cases that,at times,brain injury may continue to evolve for weeks after *** suggests that in the future it will be important to explore a wider range of times after hypo

关键词： magnetic resonance imaging neonatal hypoxic-ischemic encephalopathy neurodevelopmental outcomes prognostic biomarkers in neuroimaging scan timing therapeutic hypothermia

Pico-washing:simultaneous liquid addition and removal for continuous-flow washing of microdroplets

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Microsystems & Nanoengineering 2022年第2期8卷 249-261页

作者： michael j.Siedlik David Issadore Department of Bioengineering University of PennsylvaniaPhiladelphiaPA 19104United States

Droplet microfluidics is based on a toolbox of several established unit operations,including droplet generation,incubation,mixing,pico-injection,and *** the last two decades,the development of droplet microfluidic systems,which incorporate these multiple unit operations into a workflow,has demonstrated unique capabilities in fields ranging from single-cell transcriptomic analyses to materials *** unit operation that is sorely underdeveloped in droplet microfluidics is washing,exchange of the fluid in a droplet with a different ***,we demonstrate what we name the"pico-washer,"a unit operation capable of simultaneously adding fluid to and removing fluid from droplets in flow while requiring only a small footprint on a microfluidic *** describe the fabrication strategy,device architecture,and process parameters required for stable operation of this technology,which is capable of operating with kHz droplet ***,we provide an image processing workflow to characterize the washing process with microsecond and micrometer ***,we demonstrate the potential for integrated droplet workflows by arranging two of these unit operations in series with a droplet generator,describe a design rule for stable operation of the pico-washer when integrated into a system,and validate this design rule *** anticipate that this technology will contribute to continued development of the droplet microfluidics toolbox and the realization of novel droplet-based,multistep biological and chemical assays.

关键词： operations simultaneous removing