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Genetic diversity of food-medicinal Lycium *** China:Insights from chloroplast genome

Chinese Herbal Medicines 2024年第3期16卷 401-411页

作者： Ruyu Yao Bin Wang michael heinrich Qiuling Wang Peigen Xiao Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100193China Hainan Provincial Key Laboratory of Resources Conservation and Development of Southern Medicine Hainan Branch of the Institute of Medicinal Plant DevelopmentChinese Academy of Medical Sciences and Peking Union Medical CollegeHaikou 570311China Research Group‘Pharmacognosy and Phytotherapy’ UCL School of PharmacyUniversity of LondonLondon WC1N1AXUnited Kingdom Kunming Institute of Botany Chinese Academy of SciencesKunming 650201China

Objective:Goji(fruits of Lycium spp.)is commonly consumed as food and *** increasing market demand for goji has led to its wide cultivation and broad breeding,which might cause loss of genetic *** study aims to uncover the genetic diversity of the cultivated and wild ***:The chloroplast genome(CPG)of 34 accessions of Chinese food-medicinal Lycium spp.,including the popular cultivars and their wild relatives,was re-sequenced and assembled,based on which the genetic diversity was ***:Sequence structural comparison shows that CPG is comparatively conserved within *** analysis indicates that CPG is sufficient for the discrimination of Lycium species;combined with nuclear ribosomal internal transcribed spacer(Nr ITS)sequences,materials with mixed genetic backgrounds can be *** diversity analysis reveals that the modern cultivars are probably with a common maternal parent,while the wild accessions are with higher level of genetic ***:For the first time this study reveals the intraspecies genetic diversity of Lycium *** CPG,highlighting the urgent conservation demand of wild genetic resources of *** study also demonstrates that CPG provides crucial evidence for identification of Lycium species with mixed genetic backgrounds and highlights the importance of the wild relatives in genetic diversity *** CPG-based technology will contribute to the sustainable development of medicinal plants broadly.

关键词： chloroplast genome cultivar food-medicine genetic diversity goji wild relative

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‘Food and medicine continuum’–Why we should promote cross-cultural communication between the global East and West

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Chinese Herbal Medicines 2022年第1期14卷 3-4页

作者： michael heinrich Ruyu Yao Peigen Xiao Research Group 'Pharmacognosy and Phytotherapy' UCL School of PharmacyUniversity College London CHM Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical College

It is estimated that by 2030 one sixth of the global population will be aged over 60(WHO,2021).Aging leads to functional decline,which triggers many chronic diseases and *** is reported that the elderly often suffer from geriatric syndromes such as frailty,sarcopenia,weight loss and dementia(Sanford et al.,2020);for those aged over 85,conditions of hearing and vision loss,decline in immune function,cardiovascular diseases,osteoporosis and dementia are in high prevalence(Jaul&Barron,2017).Therefore,aging has been an important risk for chronic diseases and geriatrics globally.

关键词： diseases cardiovascular

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Alkaloids as Drug Leads-A Predictive Structural and Biodiversity-based Analysis

Alkaloids as Drug Leads-A Predictive Structural and Biodiver...

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第十四届全国中药和天然药物学术研讨会

作者： Vafa Amirkia michael heinrich University College London

＜正＞The process of drug discovery and development particularly that of natural products,has evolved markedly over the last 30 years into increasingly formulaic *** a major class of natural products initially discovered and used as early as 4000 years ago,alkaloids and the species they are derived from have been used worldwide as a source of remedies to

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SALVIA MILTIORRHIZA BUNGE——~1H-NMR METABOLOMICS APPROACH IN TCM QUALITY CONTROL

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World Journal of Traditional Chinese Medicine 2016年第2期 80-81页

作者： Ka Yui Kum Anthony Booker Christine Leon José Prieto García michael heinrich Biodiversity and Medicines Research Cluster UCL School of Pharmacy Royal Botanic Gardens

Introduction:Many Danshen(DS-Radix Salviae miltiorrhizae-SM)products are found on the global market albeit without suitable quality *** substitutes including Salvia przewalskii Maxim,*** *** Salvia sinica *** similar ... 详细信息

关键词： NMR METABOLOMICS APPROACH IN TCM QUALITY CONTROL TCM SALVIA MILTIORRHIZA BUNGE

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不妨做一次长时间曝光

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设计家 2009年第6期 62-69页

作者： Andreas Hild Dionys Ottl michael heinrich 余丹 Hild und K Architekten BDA

距离慕尼黑北部约40千米的Hohenkammer古堡,是一座典型的文艺复兴时期建筑,城堡的周围是森林、农场、庄园和别墅区,几年前由一家世界知名的再保险公司买下,委托慕尼黑HildundK建筑事务所对其进行改造整修,目的是将它打造成一个国际性的... 详细信息

距离慕尼黑北部约40千米的Hohenkammer古堡,是一座典型的文艺复兴时期建筑,城堡的周围是森林、农场、庄园和别墅区,几年前由一家世界知名的再保险公司买下,委托慕尼黑HildundK建筑事务所对其进行改造整修,目的是将它打造成一个国际性的会议中心。

关键词：长时间文艺复兴时期会议中心建筑事务所历史建筑保护再保险公司建筑师曝光别墅区世界知名

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Cytotoxicity and Aristolochic Acid Content of Medicinally Used Asarum Species

Cytotoxicity and Aristolochic Acid Content of Medicinally Us...

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第十四届全国中药和天然药物学术研讨会

作者： Johanna Michl Olusheyi Bello Geoffrey C.Kite Monique S.J.Simmonds michael heinrich UCL School of Pharmacy London Royal Botanical Gardens KewSurrey

＜正＞Asarum species are used as herbal medicines in many parts of the world,including Europe and *** Asarum species are listed in the Chinese Pharmacopeia under the Pin Yin name Xixin（1）.Similar to Aristolochia species,they contain aristolochic acid（AA）analogues,compounds known for their nephrotoxic and carcinogenic effects（2）.So far,little is known

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A novel method of quantifying the coating progress in a three-dimensional prismatic spouted bed

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Particuology 2019年第1期17卷 137-145页

作者： Swantje Pietscha Finn Ole Poppinga Stefan heinrich michael Müller michael Schonherr Frank Kleine Jager Hamburg University of Technology Institute of Solids Process Engineering and Particle TechnologyDenickestraβe 1521073 HamburgGermany BASF SE RCP/TT67056 LudwigshafenGermany

An optical method of experimentally quantifying the coating progress in a laboratory prismatic spouted bed is presented. Microcrystalline cellulose particles with size dp = 0.57 mm are used as core material. Waterborne coating suspensions with methylene blue as a dye are used and sprayed via a two-fluid nozzle in bottom-spray configuration. A high-speed camera with a color filter is positioned in front of the observation window of the three-dimensional plant and records the flow pattern in the process chamber with a certain frequency. With increasing surface coverage, the particles become bluer and darker. The change in brightness is detected by digital image analysis. In the implemented algorithm, the spherical particles are detected, cut from the background and normalized regarding their lighting and area. The detection of coated pixels on the single particles allows the calculation of the coating fraction and coating uniformity after a Kalman filter has been applied to reduce noise. It is shown that the method can be used to determine the time needed to reach the maximum blue value indicating a complete coating of the particle bed. Besides the minimum coating duration, information on the spraying performance (e.g., the time point of a possibly occurring blockage of the nozzle) can be obtained from the data. Two exemplary experiments are presented, showing a connection of the slope of the coating fraction and the uniformity of the coating of the particles in the apparatus that results in the recommendation of a slow liquid injection for obtaining consistent coating layers as desired in many applications.

关键词： Spouted bed Particle coating Granulation Digital image analysis

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货币价值论——马克思论货币和危机

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当代国外马克思主义评论 2023年第1期 129-159页

作者： [德]米夏埃尔·海因里希王一惠(译) 李乾坤(译) 不详黑龙江大学哲学学院南京大学马克思主义学院

西方马克思主义对传统马克思主义的反思过程中,更多将批判集中于哲学和历史理论之上,而缺少对传统马克思主义的政治经济学的审视。传统马克思主义政治经济学并未脱离古典政治经济学所设定的经济学理论论域,而没有认识到马克思对古典政... 详细信息

西方马克思主义对传统马克思主义的反思过程中,更多将批判集中于哲学和历史理论之上,而缺少对传统马克思主义的政治经济学的审视。传统马克思主义政治经济学并未脱离古典政治经济学所设定的经济学理论论域,而没有认识到马克思对古典政治经济学范畴做出的革命性超越。传统马克思主义政治经济学的缺陷集中体现在对价值的理解上,它停留在了古典政治经济学的劳动量的理论之上,因此也无法看到货币对马克思的价值理解所具有的关键作用。对于马克思来说,价值的本质是交换的社会关系,它以货币为存在形式,货币是原子化的商品生产者进行社会化的必要中介,它不必以货币商品为基础。因此,马克思的价值理论可以被理解为货币价值论。货币价值论也为理解资本主义流通的信用体系提供了基础。与均衡理论的解释相反,危机正是资本主义的动力机制。马克思的政治经济学批判也因此更适合于解释当代的资本主义。

关键词：货币价值论马克思货币危机

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Synthesis and thermal behavior of [Li(thf)3(μ-Cl)La{N(SiMe3)2}3] and its investigation as spin-coating precursor for lanthanum-based layer formation

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Journal of Rare Earths 2018年第5期36卷 537-543页

作者： Andrea Preuβ Elaheh Pousaneh Julian Noll Tobias Rüffer Alexaner Jakob Lutz Mertens michael Mehring heinrich Lang Technische Universitat Chemnitz Faculty of Natural Sciences Institute of Chemistry Inorganic Chemistry 09107 Chemnitz Germany Technische Universitat Chemnitz Faculty of Natural Sciences Institute of Chemistry Coordination Chemistry 09107 Chemnitz Germany

The lanthanum（Ⅲ） complex [Li（thf）3（μ-CI）La{N（SiMe3）2}3]（3） was obtained by the reaction of LaCl3 with three equiv of Li[N（SiMe3）2]3 in a tetrahydrofuran solution. The molecular structure of 3 in the solid state was characterized by a tetracoordinated anionic lanthanide（Ⅲ） amide in form of an adduct with LiCl（thf）3 as evidenced by single crystal X-ray structure analysis. In order to study the suitability of 3 as a precursor for the deposition of La2O3/LiLaSiO4 by thin layer deposition techniques,its thermal behavior was investigated by thermogravimetry（TG） and TG-MS-coupled studies. TG studies show a two-step decomposition process, whereby volatile decomposition products can be detected during the second decomposition step. TG measurements under an atmosphere of oxygen produced La2O3, Calcination processes of 3 under ambient atmosphere for 10 h at 1000 ℃ gave La2O3 and LiLaSiO4,which was confirmed by PXRD studies. Metal-organic 3 was applied as spin-coating precursor for La2O3 thin film formation giving the as-deposited layers nearly crack-free.

关键词： Lanthanum Amide Thermogravimetry Solid state structure Spin-coating Rare earths

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Long-term follow-up after complete ablation of Barrett's esophagus with argon plasma coagulation

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World Journal of Gastroenterology 2005年第8期11卷 1182-1186页

作者： Ahmed Madisch Stephan Miehike Ekkehard Bayerdoerffer Birgit Wiedemann David Antos Anke Sievert michael Vieth Manfred Stolte heinrich Schulz Medical Department Ⅰ Department of Hematology and Oncology Institute of Medical Statistics and Biometry Clinic for Pediatric Diseases Gastroenterologist in private practice Institute of Pathology

AIM: To report the long-term outcome of patients after complete ablation of non-neoplastic Barrett's esophagus (BE) with respect to BE relapse and development of intraepithelial neoplasia or esophageal adenocarcinoma. METHODS: In 70 patients with historically proven non neoplastic BE, complete BE ablation was achieved by argon plasma coagulation (APC) and high-dose proton pump inhibitor therapy (120 mg omeprazole daily). Sixty-six patients (94.4%) underwent further surveillance endoscopy. At each surveillance endoscopy four-quadrant biopsies were taken from the neo-squamous epithelium at 2 cm intervals depending on the pre-treatment length of BE mucosa beginning at the neo-Z-line, and from any endoscopically suspicious lesion. RESULTS: The median follow-up of 66 patients was 51 mo (range 9-85 mo) giving a total of 280.5 patient years. A mean of 6 biopsies were taken during surveillance endoscopies. In 13 patients (19.7%) tongues or islands suspicious for BE were found during endoscopy. In 8 of these patients (12.1%) non-neoplastic BE relapse was confirmed histologically giving a histological relapse rate of 3% per year. In none of the patients, intraepithelial neoplasia nor an esophageal adenocarcinoma was detected. Logistic regression analysis identified endoscopic detection of islands or tongues as the only positive predictor of BE relapse (P= 0.0004). CONCLUSION: The long-term relapse rate of non neoplastic BE following complete ablation with high-power APC is low (3% per year).

关键词： Barrett's esophagus Argon plasma coagulation Esophageal adenocarcinoma

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