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Landscape of global urban environmental resistome and its association with local socioeconomic and medical status

Science China(Life Sciences) 2024年第6期67卷 1292-1301页

作者： Jun Wu Yige hu michael h perlin David Danko Jun Lu Manuela Oliveira Johannes Werner Maria M Zambrano Maria A Sierra Olayinka O Osuolale Paweł Łabaj Nicolás Rascovan Nur hazlin hazrin-Chong Soojin Jang haruo Suzuki Marina Nieto-Caballero Bharath Prithiviraj Patrick K h Lee Agnieszka Chmielarczyk Anna Różańska Yongxiang Zhao Lan Wang Christopher E Mason Tieliu Shi Center for Bioinformatics and Computational Biology and the Institute of Biomedical SciencesSchool of Life SciencesEast China Normal UniversityShanghai 200241China Department of Biology Program on Disease EvolutionUniversity of LouisvilleLouisville 40292USA Weill Cornell Medicine New York 10065USA The Bin Talal Bin Abdulaziz Alsaud Institute for Computational Biomedicine New York 10065USA Department of Pulmonary Medicine Shanghai Chest HospitalShanghai Jiao Tong UniversityShanghai 200025China i3S-Instituto de Investiga玢o e Inova玢o em Saúde Universidade do PortoPorto 4050-290Portugal Ipatimup-Instituto de Patologia e Imunologia Molecular da Universidade do Porto Porto 4200-465Portugal Departamento de Biologia Faculdade de CiênciasUniversidade do PortoPorto 4050-290Portugal high Performance and Cloud Computing Group Zentrum für Datenverarbeitung(ZDV)Eberhard Karls University of TübingenW鋍hterstra遝7672074TübingenGermany Corporación Corpogen Research Center Bogotá110311Colombia Applied Environmental Metagenomics and Infectious Diseases Research(AEMIDR) Department of Biological SciencesElizade UniversityIlara-Mokin 340271Nigeria Maopolska Centre of Biotechnology Jagiellonian UniversityKraków 30-005Poland Aix-Marseille Université Mediterranean Institute of OceanologyUniversitéde ToulonCNRSIRDUM 110Marseille 83041France Department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 UKM BangiSelangor Institut Pasteur Korea Seoul 13488Republic of Korea Faculty of Environment and Information Studies Keio UniversityFujisawaKanagawa 252-0882Japan University of Colorado at Boulder CivilEnvironmental and Architectural DepartmentBoulder 80303USA Brooklyn College of the City University of New York Brooklyn 11210USA School of Energy and Environment City University of Hong KongHong Kong 999077China Department of Microbiology Faculty of MedicineJagiellonian UniversityKraków 30-005Poland Biological Targeting Diagnosis and The

Antimicrobial resistance(AMR)poses a critical threat to global health and development,with environmental factors—particularly in urban areas—contributing significantly to the spread of antibiotic resistance genes(ARGs).however,most research to date has been conducted at a local level,leaving significant gaps in our understanding of the global status of antibiotic resistance in urban *** address this issue,we thoroughly analyzed a total of 86,213 ARGs detected within 4,728 metagenome samples,which were collected by the Meta SUB International Consortium involving diverse urban environments in 60 cities of 27 countries,utilizing a deep-learning based *** findings demonstrated the strong geographical specificity of urban environmental resistome,and their correlation with various local socioeconomic and medical *** also identified distinctive evolutionary patterns of ARG-related biosynthetic gene clusters(BGCs)across different countries,and discovered that the urban environment represents a rich source of novel *** study provides a comprehensive overview of the global urban environmental resistome,and fills a significant gap in our knowledge of large-scale urban antibiotic resistome analysis.

关键词： urban environment metagenome antibiotic resistance resistance diversity biosynthetic gene clusters

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标准化的结构形式——一种简化数字电路设计的方法

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计算机研究与发展 1965年第11期 35-40页

作者： h.C.Stroupe A.I.perlin 杜业祥

引言为使晶体管化数字电路适合于多种应用可以有两种方法:为每种应用重新进行设计,这是一种费时而又很不经济的方法;或者采用一组标准的脱机电路,这会严重地限制应用的范围。有一种方法列出了公式,它具有使每种应用得出接近最佳电气设... 详细信息

引言为使晶体管化数字电路适合于多种应用可以有两种方法:为每种应用重新进行设计,这是一种费时而又很不经济的方法;或者采用一组标准的脱机电路,这会严重地限制应用的范围。有一种方法列出了公式,它具有使每种应用得出接近最佳电气设计的优点,而无需新的结构设计或制造新的产品。此处所介绍的技术采用一种标准电路结构。所描述的一种简单方法是:当采用任何数量及类型的半导体时,可以迅速确定电路元件的数值。问题逻辑系统的发展总是要求设计标准化单元

关键词：方程式所有二极管限制方程最大值漏电流

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Influence of substrate misorientation on the emission and waveguiding properties of a blue (In,Al,Ga)N laser-like structure studied by synchrotron radiation microbeam X-ray diffraction

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Photonics Research 2021年第3期9卷 299-307页

作者： A.Kafar A.Sakaki R.Ishii S.Stanczyk K.Gibasiewicz Y.Matsuda D.Schiavon S.Grzanka T.Suski P.perlin M.Funato Y.Kawakami Department of Electronic Science and Engineering Kyoto UniversityKyoto 615-8510Japan Institute of high Pressure Physics PAS Sokolowska 29/3701-142 WarsawPoland Nichia Corporation AnanTokushima 774-8601Japan TopGaN Ltd. Sokolowska 29/3701-142 WarsawPoland

In this work, we study how an epitaxial laser-like(or superluminescent diode-like) structure is modified by intentional changes of the substrate misorientation in the range of 0.5°–2.6°. The 40 μm × 40 μm test structure with misorientation profiling was fabricated using multilevel photolithography and dry-etching. The local structural parameters were measured by synchrotron radiation microbeam X-ray diffraction, with the sampling area of below 1 μm × 1 μm. We directly obtained the relation between the misorientation and indium content in the quantum well, changing from 9% to 18%, with a high resolution(small misorientation step). We also show a good agreement of local photoluminescence emission wavelength with simulation of transition energy based on synchrotron radiation microbeam X-ray diffraction(SR-XRD) data and estimated Stokes shift. We observe that the substrate misorientation influences also the In Ga N waveguide and Al Ga N cladding composition. Still, we showed through simulation of the optical confinement factor of a full laser diode structure that good light guiding properties should be preserved in the whole misorientation range studied here. This proves the usefulness of misorientation modification in applications like broadband superluminescent diodes or multicolor laser arrays.

关键词： structure microbeam blue

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