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Antecedents and sex/gender differences in youth suicidal behavior

World Journal of Psychiatry 2014年第4期4卷 120-132页

作者： Anne E Rhodes michael h boyle Jeffrey A Bridge Mark Sinyor Paul S Links Lil Tonmyr Robin Skinner Jennifer M Bethell Corine Carlisle Sarah Goodday Travis Salway hottes Amanda Newton Kathryn Bennett Purnima Sundar Amy h Cheung Peter Szatmari Institute for Clinical Evaluative Sciences Toronto M4N 3M5 Ontario Canada Department of Psychiatry University of Toronto Toronto M5T 1R8 Ontario Canada Suicide Studies Unit St. Michael’s Hospital Toronto M5B 1W8 Ontario Canada Dalla Lana School of Public health University of Toronto Toronto M5T 3M7 Ontario Canada Department of Psychiatry and Behavioural Neurosciences Mc Master University Hamilton L8N 3K7 Ontario Canada The Offord Centre for Child Studies Hamilton L8S 4K1 Ontario Canada The Research Institute at Nationwide Children’s hospital Columbus OH 43205 United States The Ohio State University College of Medicine Columbus OH 43210 United States Sunnybrook health Sciences Centre Toronto M4N 3M5 Ontario Canada Department of Psychiatry University of Western Ontario London N6A 5W9 Ontario Canada The Injury and Child Maltreatment Section Public Health Agency of Canada Ottawa K1A 0K9 Ontario Canada The Centre for Addiction and Mental health Toronto M6J 1H4 Ontario Canada Department of Pediatrics University of Alberta Edmonton Alberta T6G 1C9 Canada The Department of Clinical Epidemiology and Biostatistics Mc Master University Hamilton L8S 4K1 Ontario Canada The Ontario Centre of Excellence for Child and Youth Mental health Ottawa K1G 0Z1 Ontario Canada The hospital for Sick Children Toronto M5G 1X8 Ontario Canada

Suicide is the second leading cause of death in youth globally; however, there is uncertainty about how best to intervene. Suicide rates are typically higher in males than females, while the converse is true for suicide attempts. We review this "gender paradox" in youth, and in particular, the age-dependency of these sex/gender differences and the developmental mechanisms that may explain them. Epidemiologic, genetic,neurodevelopmental and psychopathological research have identified suicidal behaviour risks arising from genetic vulnerabilities and sex/gender differences in early adverse environments, neurodevelopment, mental disorder and their complex interconnections. Further, evolving sex-/gender-defined social expectations and norms have been thought to influence suicide risk. In particular, how youth perceive and cope with threats and losses(including conforming to others' or one's own expectations of sex/gender identity) and adapt to pain(through substance use and helpseeking behaviours). Taken together, considering brain plasticity over the lifespan, these proposed antecedents to youth suicide highlight the importance of interventions that alter early environment(s)(e.g., childhood maltreatment) and/or one's ability to adapt to them. Further, such interventions may have more enduring protective effects, for the individual and for future generations, if implemented in youth.

关键词： Suicide Attempted suicide Sex Gender Child Adolescent Review

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hydrogeochemistry of toxic metals in Au-As-hg-Tl mineralized area in southwest Guizhou Province, China

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Chinese Science Bulletin 1999年第S2期44卷 171-172页

作者： boyle Dan Guha Jayanta Mineral Resources Division Geological Survey of Canada Ottawa K1A OE8 Canada Science de la Terre Departement des Sciences Aplliquees Universite du Quebec a Chicoutimi Quebec G7H2B1 Canada

ThE environmental geochemistry problems during the processes of mining activities are intensively considered by scientists worldwide, and the hydrogeochemistry presents an important implication of toxic metalcontamination related to mining activities. The hydrogeochemistry due to mining activities and naturalmineralized processes present some differences whose comparison can indicate a good understanding of theinfluence of mining on the environment. This ongoing study aims at the hydrogeochemistry of toxic metals in the Au-As-hg-Tl metallogenicbelt of huijiabao anticline in southwest Guizhou, China. The presently-mined Lanmuchang mercury-thallium deposit with a hg-mining history of about 350 years containing one of the world’s highest concentration of thallium and the to-be-mined Yanshang gold deposit enriching high concentration of toxic metals have been chosen to study the hydrogeochemistry of toxic metals. The groundwater samples werecollected from the shallow aquifer in terms of spring, domestic well and karstic cave whereas the surfacewater was only sampled downside the surface drainage leaching the mine waste at Lanmuchang. All

关键词： toxic metals hydrogeochemistry Au-As-hg-TI mineralized area southwest Guizhou Province.

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First large scale application of novel Si stripixel detector in real large experiment: Si VTX in PhENIX upgrade at RhIC

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中国有色金属学会会刊：英文版 2006年第B1期16卷 141-145页

作者： LI Zheng h. ENYO Y. GOTO J. TOJO Y. AKIBA R. NOUICER A. L. DEShPANDE K. boyle V. CIANCIOLO RIKEN BNL Research Center and BNL Instrumentation Division Upton NY 11973-5000 USA RIKEN Wako Saitama 351-0198 Japan BNL Chemistry Department Upton NY 11973-5000 USA Stony Brook University Department of Physics and Astronomy Stony Brook NY 11794 USA Oak Ridge National Laboratory Oak Ridge TN 37831 USA

2D position sensitive, single-sided Si stripixel detector was selected as the one of the two main components of the Si vertex tracker (Si SVX) in the upgraded PhENIX detector at RhIC (relativistic heavy ion collider) in Brookhaven National Laboratory (BNL). This is the first large scale application of the novel Si stripixel detector in a real large experiment after many years of research and development at BNL. The first and second prototype fabrication runs of the SVX stripixel detectors were carried out successfully in BNL’s Si detector development and processing Lab. The processing of these stripixel detectors is similar to that for the standard single-sided strip detectors: one-sided processing, single implant for the pixel (strip) electrodes, etc. The only additional processing step is the double metal process, a technology that is simple and well matured by many Si detector processing industries and labs, including BNL. The laser and beam tests on those prototype detectors show the 2D position sensitivity and good position resolution in both X and U coordinates (about 25 μm for 80 μm pitch). For the mass production of 400 sensors needed for the Si SVX, the processing technology has been successfully transferred to the industrial: hamamatsu Photonics (hPK). hPK has produced a pre-production run of stripixel sensors with the full PhENIX SVX specification on 150 mm diameter wafers. The laser tests on these pre-production wafers show good signal to noise ratio (about 20∶1).

关键词：相对论性重离子碰撞 PhENIX探测器天顶跟踪器硅顶点探测器硅条探测器应用

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Non-Assembly Walking Mechanism Utilizing a hexapod Gait

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Journal of Artificial Intelligence and Technology 2022年第4期2卷 158-163页

作者： George Jackson-Mills Andrew R.Barber Andrew Blight Andrew Pickering Jordan h.boyle Bilal Kaddouh Robert C.Richardson REAL Robotics Lab Institute of DesignRoboticsand Optimisation(iDRO)Mechanical EngineeringUniversity of LeedsLeeds LS29DYWest YorkshireUK Faculty of Industrial Design Engineering Delft University of TechnologyDelftNetherlands

Small inspection robots allow for the optimal exploration of environments and the collection of data from challenging areas,particularly where there may be small access points or tight and fragile *** robots can be custom-built for specific tasks,but the design and assembly process for this can be costly,both in resources and assembly *** use of 3D printing to create Non-Assembly mechanisms can assist in saving time and resources by reducing the number of different components required and removing the necessity for complex assembly *** iterating on previous work performed in the institute,this paper introduces a novel robot design to push the capabilities of Non-Assembly *** building on previous knowledge,this new walking robot improves on the previous iteration by creating a more robust and reliable system,more capable of effectively exploring challenging environments accurately,while still using practices designed to save on cost and production *** tests were performed to provide an accurate comparison against the previous design and highlight the robots marked improvements in positional accuracy over its predecessor.

关键词： robot 3D printing walking hexapod

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加拿大的博士培养及启示——访谈加拿大Phelim、Mary、Ralph三位教授

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研究生教育研究 2019年第5期 83-88页

作者：刘秀霞严孟帅 Phelim boyle Mary hARDY Ralph E.h.SMITh 华东师范大学教育学部上海200062 劳瑞尔大学滑铁卢N2L3C5 滑铁卢大学滑铁卢N2L3J1

加拿大的博士生培养机制和体系在百余载的发展历程中臻于完善,其培养质量业已位居世界前列。而我国的博士教育,尽管在四十年的发展历程中取得了长足进步,但在国际范围内而言,博士生教育在竞争力、创新力以及行业领导力等方面与加拿大等... 详细信息

加拿大的博士生培养机制和体系在百余载的发展历程中臻于完善,其培养质量业已位居世界前列。而我国的博士教育,尽管在四十年的发展历程中取得了长足进步,但在国际范围内而言,博士生教育在竞争力、创新力以及行业领导力等方面与加拿大等欧美高等教育强国之间还存有一定差距。因此,从博士生选择、培养过程、博士教育目标等三个方面阐述加拿大的博士教育经验,以期能为我国博士教育提供一定的借鉴价值。

关键词：加拿大博士教育中期管理培养目标

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生物物理经济学及其理论的能源研究

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国际石油经济 2018年第11期26卷 91-101页

作者：闫君冯连勇 Garvin h boyle 中国石油大学(北京)工商管理学院 Orrery软件公司(加拿大)

生物物理经济学重视经济主体和经济行为的生物物理基础,其思想一度被传统经济学发展浪潮淹没,随着20世纪以来日益严峻的生态危机,这一学说得以复兴。2008年金融危机之后,全球经济长期处于震荡调整期,并呈现中低速发展的新态势。传统西... 详细信息

生物物理经济学重视经济主体和经济行为的生物物理基础,其思想一度被传统经济学发展浪潮淹没,随着20世纪以来日益严峻的生态危机,这一学说得以复兴。2008年金融危机之后,全球经济长期处于震荡调整期,并呈现中低速发展的新态势。传统西方经济理论在解释新经济现象时遇到了困难。目前,生物物理经济学正在成长之中,并试图弥补新古典经济学的不足。文章梳理了不同时代的经济发展理论,探讨了生物物理经济学的起源、发展、研究内容和理论框架,从自然科学的角度,以能源为落脚点,寻求能源环境约束下经济发展的可持续之路。

关键词：生物物理经济学传统经济学能源研究经济学理论研究综述

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极低出生体重新生儿特护的经济估价

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国外医学(卫生经济分册) 1984年第4期 27-31页

作者： boyle M h 丁传记

新生儿特护既使极低出生体重新生儿的成活率增长,也使费用增长。由于高额的经济费用,经济上如何估价——这种估价因为新生儿特护的效益与费用增加是相关的——尚无报告。我们对极低出生体重新生儿(体重低于1500克者)规定在指定地区医院... 详细信息

新生儿特护既使极低出生体重新生儿的成活率增长,也使费用增长。由于高额的经济费用,经济上如何估价——这种估价因为新生儿特护的效益与费用增加是相关的——尚无报告。我们对极低出生体重新生儿(体重低于1500克者)规定在指定地区医院住院特护并进行经济估价。我们限制婴儿的靶人群的体重在1500克以下是因为从推广特护的报告来

关键词：估价经济贴现率资本成本新生儿

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中日战争时期的通敌内幕

中日战争时期的通敌内幕

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作者： J.h.·博伊尔(J.h. boyle)

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Essential Gene(s) Targeted by Peptide Nucleic Acids Kills <i>Mycobacterium smegmatis</i>in Culture and in Infected Macrophages

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Advances in Infectious Diseases 2021年第2期11卷 156-164页

作者： Md. Ariful Islam Mst. Minara Khatun Nammalwar Sriranganathan Stephen M. boyle Center for One health Research Virginia-Maryland College of Veterinary Medicine Virginia Tech Blacksburg VA USA Department of Microbiology & hygiene Bangladesh Agricultural University Mymensingh Bangladesh

Background: Antisense peptide nucleic acids (PNAs) exhibit growth inhibitory effects on bacteria by inhibiting the expression of essential genes and could be promising therapeutic agents for treating bacterial infections. A study was carried out to determine the efficacy of several antisense PNAs in inhibiting extracellular and intracellular growth of Mycobacterium smegmatis. Methods: Six PNAs obtained from a commercial supplier were tested to evaluate the inhibitory effect on bacterial growth by inhibiting the expression of the following essential genes: inhA (a fatty acid elongase), rpsL (ribosomal S12 protein), gyrA (DNA gyrase), pncA (pyrazinamidase), polA (DNA polymerase I) and rpoC (RNA polymerase β subunit) of M. smegmatis. Each PNA was tested at 20 μM, 10 μM, 5 μM and 2.5 μM concentrations to determine whether they caused a dose dependent killing of M. smegmatis cultured in Middlebrook 7h9 broth or in a J774A.1 murine macrophage cell line. Results: In Middlebrook broth, the strong growth inhibitory effect against M. smegmatis was observed by PNAs targeting the inhA and rpsL genes at all four concentrations. The PNAs targeting the pncA, polA and rpoC genes were found to exhibit strong growth inhibition against M. smegmatis but only at 20 μM concentration. No growth inhibition of M. smegmatis was seen in pure culture when treated with PNAs targeting gyrA and a mismatch PNA targeting dnaG (DNA primase). All six PNAs showed killing of M. smegmatis in J774A.1 macrophage cell line that were statistically significant (p Conclusion: It may be concluded from this study that PNAs could be potential therapeutics for mycobacterial infections.

关键词： Middlebrook 7h9 Broth Culture J774A.1 Murine Macrophage Cell Line Antisense Therapy Peptide Nucleic Acid Cell Penetrating Peptide Mycobacterium

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Extraterrestrial Life in the Thermosphere: Plasmas, UAP, Pre-Life, Fourth State of Matter

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Journal of Modern Physics 2024年第3期15卷 322-376页

作者： R. Joseph C. Impey O. Planchon R. del Gaudio M. Abu Safa A. R. Sumanarathna E. Ansbro D. Duvall G. Bianciardi C. h. Gibson R. Schild Astrobiology Research Center California USA Department of Astronomy University of Arizona Tucson USA Biogéosciences Laboratory University of Burgundy Dijon France Department of Biology University of Naples Federico II Naples Italy Department of Applied Physics Palestine Polytechnic University Hebron Palestine Department of Research and Innovation Eco Astronomy International Research Center Tetouan Morocco Space Exploration Ltd. Boyle County Roscommon Ireland Department of Zoology Oklahoma State University (Emeritus) Stillwater USA Department of Science and Medicine Università Degli Studi di Siena Tuscany Italy Center for Astrophysics and Space Sciences University of California (Emeritus) San Diego USA Center for Astrophysics Harvard-Smithsonian (Emeritus) Cambridge USA

“Plasmas” up to a kilometer in size and behaving similarly to multicellular organisms have been filmed on 10 separate NASA space shuttle missions, over 200 miles above Earth within the thermosphere. These self-illuminated “plasmas” are attracted to and may “feed on” electromagnetic radiation. They have different morphologies: 1) cone, 2) cloud, 3) donut, 4) spherical-cylindrical;and have been filmed flying towards and descending from the thermosphere into thunderstorms;congregating by the hundreds and interacting with satellites generating electromagnetic activity;approaching the Space Shuttles. Computerized analysis of flight path trajectories documents these plasmas travel at different velocities from different directions and change their angle of trajectory making 45°, 90°, and 180° shifts and follow each other. They’ve been filmed accelerating, slowing down, stopping, congregating, engaging in “hunter-predatory” behavior and intersecting plasmas leaving a plasma dust trail in their wake. Similar life-like behaviors have been demonstrated by plasmas created experimentally. “Plasmas” may have been photographed in the 1940s by WWII pilots (identified as “Foo fighters”);repeatedly observed and filmed by astronauts and military pilots and classified as Unidentified Aerial—Anomalous Phenomenon. Plasmas are not biological but may represent a form of pre-life that via the incorporation of elements common in space, could result in the synthesis of RNA. Plasmas constitute a fourth state of matter, are attracted to electromagnetic activity, and when observed in the lower atmosphere likely account for many of the UFO-UAP sightings over the centuries.

关键词： Extraterrestrials Plasmas Dusty Plasmas Extremophiles Life in Space Abiogenesis Origins of Life RNA World

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