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3d-printed Mechanically Strong Calcium Phosphate Cement Scaffold with Metformin/Stem Cell-encapsulating Alginate Microbeads for Bone Tissue Engineering

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Journal of Bionic Engineering 2022年第6期19卷 1658-1670页

作者： Xiong Xiong Yuanyuan Chen Rupan Yuan Gengtao Qiu michael d.weir Hockin H.K.Xu Jin Liu Jianping Ruan Xiaofeng Chang Shuxin Qu School of Life Science and Engineering Southwest Jiaotong UniversityChengdu610031China Sichuan Engineering Research Center for Biomimetic Synthesis of Natural drugs School of Life Science and EngineeringSouthwest Jiaotong UniversityChengdu610031China Key Lab of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu610031China department of Advanced Oral Sciences and Therapeutics University of Maryland School of DentistryBaltimoreMD21201USA Center for Stem Cell Biology and Regenerative Medicine University of Maryland School of MedicineBaltimoreMD21201USA University of Maryland Marlene and Stewart Greenebaum Cancer Center University of Maryland School of MedicineBaltimoreMD21201USA Key Laboratory of Shannxi Province for Craniofacial Precision Medicine Research Clinical Research Center of Shannxi Province for Dental and Maxillofacial DiseasesCollege of StomatologyXi’an Jiaotong UniversityXi’anShannxi710004China

The utilization of Calcium Phosphate Cement(CPC)is limited due to its low mechanical strength and difficulty to seed cells deep into the *** objectives of this study were to:(1)develop a 3d-printed CPC-dopamine-metformin scaffold encapsulating human periodontal ligament stem cells(hPdLSCs),(2)investigate the effect of dopamine on the performance of CPC,and(3)evaluate the effect of microbead degradation and metformin release on the osteogenic differentiation of the released *** mechanical property of the CPC scaffolds was elevated by adding dopamine,and the CPC scaffold with 7 wt.%dopamine had the highest compressive strength(7.35 MPa).Four types of microbeads with different content of alginate(oxidized alginate),hPdLSCs,and 2%metformin were *** and cell counting kit tests confirm that the hPdLSCs are protected by microbeads encapsulation during the CPC setting *** alkaline phosphatase test indicates that the osteogenic differentiation of hPdLSCs was enhanced by the fast release of cells and *** microbeads consisting of 2%oxidized alginate and 2%metformin were optimal for cell delivery due to favorable cell release and osteogenic *** CPC scaffold is promising used for bone regeneration in dental,craniofacial,and orthopedic applications.

关键词： Calcium phosphate cement 3d Printing Bionic Alginate microbeads Metformin

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Effects of water-aging for 6 months on the durability of a novel antimicrobial and protein-repellent dental bonding agent

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International Journal of Oral Science 2018年第3期10卷 160-167页

作者： Ning Zhang Ke Zhang michael d.weir david J.Xu Mark A.Reynolds Yuxing Bai Hockin H.K.Xu department of Orthodontics School of StomatologyCapital Medical UniversityBeijingChina Biomatexrials&Tissue Engineering division Department of EndodonticsPeriodontics and ProsthodonticsUniversity of Maryland Dental SchoolBaltimoreMDUSA Center for Stem Cell Biology&Regenerative Medicine University of Maryland School of MedicineBaltimoreMDUSA Marlene and Stewart Greenebaum Cancer Center University of Maryland School of MedicineBaltimoreMDUSA department of Mechanical Engineering University of MarylandBaltimore CountyMDUSA

Biofilms at the tooth-restoration bonded interface can produce acids and cause recurrent caries. Recurrent caries is a primary reason for restoration failures. The objectives of this study were to synthesize a novel bioactive dental bonding agent containing dimethylaminohexadecyl methacrylate(dMAHdM) and 2-methacryloyloxyethyl phosphorylcholine(MPC) to inhibit biofilm formation at the tooth-restoration margin and to investigate the effects of water-aging for 6 months on the dentin bond strength and protein-repellent and antibacterial durability. A protein-repellent agent(MPC) and antibacterial agent(dMAHdM) were added to a Scotchbond multi-purpose(SBMP) primer and adhesive. Specimens were stored in water at 37 °C for 1, 30, 90, or 180 days(d).At the end of each time period, the dentin bond strength and protein-repellent and antibacterial properties were evaluated. Protein attachment onto resin specimens was measured by the micro-bicinchoninic acid approach. A dental plaque microcosm biofilm model was used to test the biofilm response. The SBMP + MPC + dMAHdM group showed no decline in dentin bond strength after water-aging for 6 months, which was significantly higher than that of the control(P dMAHdM group had protein adhesion that was only 1/20 of that of the SBMP control(P d dMAHdM into SBMP provided a synergistic effect on biofilm reduction. The antibacterial effect and resistance to protein adsorption exhibited no decrease from 1 to 180 d(P > 0.1). In conclusion, a bonding agent with MPC and dMAHdM achieved a durable dentin bond strength and long-term resistance to proteins and oral bacteria. The novel dental bonding agent is promising for applications in preventive and restorative dentistry to reduce biofilm formation at the tooth-restoration margin.

关键词： MPC Effects of water-aging for 6 months on the durability of a novel antimicrobial and protein-repellent dental bonding agent

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Toward dental caries: Exploring nanoparticle-based platforms and calcium phosphate compounds for dental restorative materials

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Bioactive Materials 2019年第1期4卷 43-55页

作者： Abdulrahman A.Balhaddad Anmar A.Kansara denise Hidan michael d.weir Hockin H.K.Xu Mary Anne S.Melo Ph.d.Program in Biomedical Sciences University of Maryland School of DentistryBaltimoreMD21201USA division of Biomaterials&Tissue Engineering Department of Advanced Oral Sciences and TherapeuticsUniversity of Maryland School of DentistryBaltimoreMD21201USA department of Restorative dental Sciences Imam Abdulrahman Bin Faisal UniversityCollege of DentistryDammamSaudi Arabia department of Restorative dentistry Umm Al-Qura UniversityCollege of DentistryMakkahSaudi Arabia division of Operative dentistry Dept.of General DentistryUniversity of Maryland School of DentistryBaltimoreMD21201USA

Millions of people worldwide suffer from a toothache due to tooth cavity,and often permanent tooth *** caries,also known as tooth decay,is a biofilm-dependent infectious disease that damages teeth by minerals loss and presents a high incidence of clinical restorative polymeric fillings(tooth colored fillings).Until now,restorative polymeric fillings present no *** complexity of oral biofilms contributes to the difficulty in developing effective novel dental *** has been explored in the development of bioactive dental materials to reduce or modulate the activities of caries-related ***-structured platforms based on calcium phosphate and metallic particles have advanced to impart an anti-caries potential to restorative *** bioactivity of these platforms induces prevention of mineral loss of the hard tooth structure and antibacterial activities against caries-related *** has been suggested that this bioactivity could minimize the incidence of caries around restorations(CARS)and increase the longevity of such filling *** last few years witnessed growing numbers of studies on the preparation evaluations of these novel ***,the caries disease process and the role of pathogenic caries-related biofilm,the increasing incidence of CARS,and the recent efforts employed for incorporation of bioactive nanoparticles in restorative polymer materials as useful strategies for prevention and management of caries-related-bacteria are *** highlight the status of the most advanced and widely explored interaction of nanoparticle-based platforms and calcium phosphate compounds with an eye toward translating the potential of these approaches to the dental clinical reality.

关键词： dental materials Bioactive Nanoparticles dental caries

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dental remineralization via poly(amido amine) and restorative materials containing calcium phosphate nanoparticles

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International Journal of Oral Science 2019年第3期11卷 180-191页

作者： Kunneng Liang Suping Wang Siying Tao Shimeng Xiao Han Zhou Ping Wang Lei Cheng Xuedong Zhou michael d.weir Thomas W.Oates Jiyao Li Hockin H.K.Xu State Key Laboratory of Oral diseases & National Clinical Research Center for Oral diseases & department of Cariology and Endodontics West China Hospital of StomatologySichuan UniversityChengduChina department of Advanced Oral Sciences and Therapeutics University of Maryland School of DentistryBaltimoreMDUSA department of Operative dentistry and Endodontics & Stomatology Center The First Affiliated Hospital of Zhengzhou UniversityZhengzhouChina Center for Stem Cell Biology & Regenerative Medicine University of Maryland School of MedicineBaltimoreMDUSA Marlene and Stewart Greenebaum Cancer Center University of Maryland School of MedicineBaltimoreMDUSA

Tooth decay is prevalent,and secondary caries causes restoration failures,both of which are related to *** is an urgent need to develop new therapeutic materials with remineralization *** article represents the first review on the cutting edge research of poly(amido amine)(PAMAM) in combination with nanoparticles of amorphous calcium phosphate (NACP).PAMAM was excellent nucleation template,and could absorb calcium (Ca) and phosphate (P) ions via its functional groups to activate *** composite and adhesive showed acid-neutralization and Ca and P ion release *** +NACP together showed synergistic effects and produced triple benefits: excellent nucleation templates,superior acidneutralization,and ions ***,the PAMAM+NACP strategy possessed much greater remineralization capacity than using PAMAM or NACP ***+NACP achieved dentin remineralization even in an acidic solution without any initial Ca and P ***,the long-term remineralization capability of PAMAM+NACP was *** prolonged fluid challenge,the immersed PAMAM with the recharged NACP still induced effective dentin mineral ***,the hardness of predemineralized dentin was increased back to that of healthy dentin,indicating a complete ***,the novel PAMAM+NACP approach is promising to provide long-term therapeutic effects including tooth remineralization,hardness increase,and caries-inhibition capabilities.

关键词： an urgent need calcium phosphate dentin

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Advanced smart biomaterials and constructs for hard tissue engineering and regeneration

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Bone Research 2018年第4期6卷 316-330页

作者： Ke Zhang Suping Wang Chenchen Zhou Lei Cheng Xianling Gao Xianju Xie Jirun Sun Haohao Wang michael d.weir Mark A.Reynolds Ning Zhang Yuxing Bai Hockin H.K.Xu department of Orthodontics School of Stomatology Capital Medical University department of Advanced Oral Sciences and Therapeutics University of Maryland Dental School State Key Laboratory of Oral diseases & National Clinical Research Center for Oral diseases & deptartment of Cariology and Endodonics West China Hospital of Stomatology Sichuan University department of Operative dentistry and Endodontics Guanghua School of Stomatology Sun Yat-sen University Guangdong Provincial Key Laboratory of Stomatology Volpe Research Center American Dental Association Foundation National Institute of Standards and Technology Center for Stem Cell Biology & Regenerative Medicine University of Maryland School of Medicine Marlene and Stewart Greenebaum Cancer Center University of Maryland School of Medicine

Hard tissue repair and regeneration cost hundreds of billions of dollars annually worldwide, and the need has substantially increased as the population has aged. Hard tissues include bone and tooth structures that contain calcium phosphate *** biomaterial-based tissue engineering and regenerative medicine methods have the exciting potential to meet this urgent need. Smart biomaterials and constructs refer to biomaterials and constructs that possess instructive/inductive or triggering/stimulating effects on cells and tissues by engineering the material’s responsiveness to internal or external stimuli or have intelligently tailored properties and functions that can promote tissue repair and regeneration. The smart material-based approaches include smart scaffolds and stem cell constructs for bone tissue engineering; smart drug delivery systems to enhance bone regeneration; smart dental resins that respond to pH to protect tooth structures; smart pH-sensitive dental materials to selectively inhibit acid-producing bacteria; smart polymers to modulate biofilm species away from a pathogenic composition and shift towards a healthy composition; and smart materials to suppress biofilms and avoid drug resistance. These smart biomaterials can not only deliver and guide stem cells to improve tissue regeneration and deliver drugs and bioactive agents with spatially and temporarily controlled releases but can also modulate/suppress biofilms and combat infections in wound sites. The new generation of smart biomaterials provides exciting potential and is a promising opportunity to substantially enhance hard tissue engineering and regenerative medicine efficacy.

关键词： regeneration engineering minerals

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Novel dental implant modifications with two-staged double benefits for preventing infection and promoting osseointegration in vivo and in vitro

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Bioactive Materials 2021年第12期6卷 4568-4579页

作者： Xiaoyu Huang Yang Ge Bina Yang Qi Han Wen Zhou Jingou Liang Mingyun Li Xian Peng Biao Ren Bangcheng Yang michael d.weir Qiang Guo Haohao Wang Xinxuan Zhou Xugang Lu Thomas W.Oates Hockin H.K.Xu dongmei deng Xuedong Zhou Lei Cheng State Key Laboratory of Oral diseases West China Hospital of StomatologyNational Clinical Research Center for Oral DiseasesSichuan UniversityChengdu610041China department of Operative dentistry and Endodontics West China School of StomatologySichuan UniversityChengdu610041China Stomatological Hospital Southern Medical UniversityGuangzhou510280China department of Pathology West China School of StomatologySichuan UniversityChengdu610041China department of Pediatrics West China School of StomatologySichuan UniversityChengdu610041China department of Advanced Oral Sciences and Therapeutics University of Maryland School of DentistryBaltimoreMD21201USA department of Preventive dentistry Academic Center for Dentistry Amsterdam(ACTA)University of Amsterdam and VU University AmsterdamAmsterdamthe Netherlands National Engineering Research Center for Biomaterials Sichuan UniversityChengdu610041China

Peri-implantitis are a major problem causing implant failure these ***,anti-infection during the early stage and subsequent promotion of osseointegration are two main key factors to solve this ***-arc oxidation(MAO)treatment is a way to form an oxidation film on the surface of metallic *** method shows good osteogenic properties but weak antibacterial ***,we developed combined strategies to combat severe peri-implantitis,which included the use of a novel compound,Pd,comprising dendrimers poly(amidoamine)(PAMAM)loading dimethylaminododecyl methacrylate(dMAddM)as well as MAO ***,we explored the chemical properties of the novel compound Pd,and proved that this compound was successfully synthesized,with the loading efficiency and encapsulation efficiency of 23.91%and 31.42%,*** further report the two-stage double benefits capability of Pd+MAO:(1)in the first stage,Pd+MAO could decrease the adherence and development of biofilms by releasing dMAddM in the highly infected first stage after implant surgery both in vitro and in vivo;(2)in the second stage,Pd+MAO indicated mighty anti-infection and osteoconductive characteristics in a rat model of peri-implantitis in *** study first reports the two-staged,double benefits of Pd+MAO,and demonstrates its potential in clinical applications for inhibiting peri-implantitis,especially in patients with severe infection risk.

关键词： Peri-implantitis dimethylaminododecyl methacrylate Animal model Osseointegration Bioactive and therapeutic

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新型可充电磷酸钙树脂的研究初探——离子释放与离子充电

新型可充电磷酸钙树脂的研究初探——离子释放与离子充电

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第十一次全国口腔修复学学术会议

作者：张凌 michael d.weir Hockin H.K.Xu 陈吉华第四军医大学口腔医院修复科 dept.of Endodontics Prosthodontics and Operative DentistryUniversity of Maryland Dental School

具有钙、磷离子释放功能的新型纳米磷酸钙(Nano nanoparticles of amorphous calcium phosphate,NACP)树脂具有抑制龋病和促进牙齿再矿化的作用,成为可有效提高修复效果的一类新型功能性树脂。但是,这类树脂材料的钙和磷离子释放会随着...

具有钙、磷离子释放功能的新型纳米磷酸钙(Nano nanoparticles of amorphous calcium phosphate,NACP)树脂具有抑制龋病和促进牙齿再矿化的作用,成为可有效提高修复效果的一类新型功能性树脂。但是,这类树脂材料的钙和磷离子释放会随着时间衰减,关于可持续充电的磷酸钙树脂的研究尚属空白。目的:研制一种新型的可充电的磷酸钙树脂,探讨其钙、磷离子的充电和再释放的效能。方法:NACP颗粒(平均直径约116 nm)通过静电吸附技术进行制备。按照不同的树脂基质,制备了三

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含纳米银和季铵盐纳米复合物的抑制生物膜作用的研究

含纳米银和季铵盐纳米复合物的抑制生物膜作用的研究

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2014年第九次全国牙体牙髓病学学术会议

作者：葛阳周学东 Hockin H.K.Xu michael d.weir 王素苹王浩浩程磊四川大学口腔疾病研究国家重点实验室四川大学华西口腔医院牙体牙髓科美国马里兰大学牙学院

目的:本实验的目的:一是研制含有纳米无定形磷酸钙(NACP)、季铵二甲基丙烯酸(QAdM)和纳米银颗粒(NAg)的新型纳米复合材料;二是研究纳米复合材料的机械和抗菌性能。方法:制备三种纳米复合树脂材料:(1)NanoACP+QAdM复合树脂,(2)NanoACP+NA... 详细信息

目的:本实验的目的:一是研制含有纳米无定形磷酸钙(NACP)、季铵二甲基丙烯酸(QAdM)和纳米银颗粒(NAg)的新型纳米复合材料;二是研究纳米复合材料的机械和抗菌性能。方法:制备三种纳米复合树脂材料:(1)NanoACP+QAdM复合树脂,(2)NanoACP+NAg复合树脂,(3)NanoACP+QAdM+NAg复合树脂。以一种不含氟的商品化复合树脂材料为对照组。复合树脂材料经不同时间段的水老化处理后,检测机械性的改变(包括抗弯强度和弹性模量);同时在其表面构建多菌种生物膜,进行了生物膜活性,乳酸代谢和菌落计数(CFU)的研究,以及死活菌染色分析纳米复合树脂对牙菌斑生物膜的抑制作用。结果:经12个月的水老化,在抗弯强度和弹性模数方面,含有QAdM和NAg的NACP纳米复合材料与对照组相比无统计学意义(P>0.1)。在NACP纳米材料中添加QAdM或NAg都可以显著降低生物膜活力、代谢活性、CFU和乳酸代谢。添加QAdM和NAg两种的纳米复合材料的抗菌能力要强于单独添加QAdM或NAg的纳米复合材料(PdM纳米复合材料具有多方面的优势:能显著减少生物膜的形成,并且与无抗菌性的商品化的复合材料有相同的机械性能。NACP-QAdM复合材料具有强效持久的抗菌性能,并能释放Ca-PO,可用于防龋性充填材料的使用。

关键词：抗菌复合树脂生物膜机械性能

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Microscale shaping and rounding of ridge arrays and star pattern features on nickel mould via electrochemical polishing

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Advances in Manufacturing 2024年第2期12卷 207-226页

作者： Sana Zaki Nan Zhang michael d.Gilchrist School of Mechanical and Materials Engineering University College DublinBelfieldDublin 4Ireland

High quality micro mould tools are critical for ensuring defect-free production of micro injection moulded *** demoulding stage of the micro injection moulding can adversely affect the surface integrity due to friction,adhesion and thermal stresses between the metallic mould and polymeric replicated *** the present work,we propose the use of precision electropolishing(EP)as a shaping and polishing process to control the draft angle and fillet radius of micro features in order to ease *** defects that occur in replicated polymer parts include cracks,burrs and distorted features.A nickel mould having multiple linear ridges and star shape patterns was designed for the present investigation to have characteristic dimensions ranging from 10μm to 150μm and with various aspect ratios to study the effect of electropolishing on modifying the shape of micro features and surface morphology.A transient 2d computational analysis has been conducted to anticipate the effect of shaping on the Ni mould after electrochemical polishing with non-uniform material removal rates,based on the distribution of current *** experimental results indicate that after shaping using EP,the draft angle of star-patterns and linear patterns can be effectively increased by approximately 3.6°,while the fillet radius increases by up to 5.0μ*** controlling the electropolishing process,the surface roughness can be maintained under 50 *** work uses a green and environmental friendly nickel sulfamate electrolyte which can be effective for shaping of nickel micro features without causing any surface deposition.

关键词： Micro feature shaping and electropolishing Micro mould tools Green electrolyte demoulding micro patterns

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BMPRⅡ^(+)neural precursor cells isolated and characterized from organotypic neurospheres:an in vitro model of human fetal spinal cord development

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Neural Regeneration Research 2024年第2期19卷 447-457页

作者： michael W.Weible II michael d.Lovelace Hamish d.Mundell Tsz Wai Rosita Pang Tailoi Chan-Ling Bosch Institute Discipline of Anatomy and Histology(F13)University of SydneySydneyNSWAustralia School of Environment and Science Griffith UniversityNathanQLDAustralia discipline of Medicine Nepean Clinical SchoolFaculty of Medicine and HealthUniversity of SydneyKingswoodNSWAustralia New South Wales Brain Tissue Resource Centre School of Medical SciencesFaculty of Medicine and HealthUniversity of SydneyCharles Perkins Centre(D17)SydneyNSWAustralia

Roof plate secretion of bone morphogenetic proteins(BMPs)directs the cellular fate of sensory neurons during spinal cord development,including the formation of the ascending sensory columns,though their biology is not well ***-ⅡBMP receptor(BMPRⅡ),the cognate receptor,is expressed by neural precursor cells during embryogenesis;however,an in vitro method of enriching BMPRⅡ^(+)human neural precursor cells(hNPCs)from the fetal spinal cord is *** was undertaken on intact second-trimester human fetal spinal cord using antibodies to BMPRⅡand leukemia inhibitory factor(LIF).Regions of highest BMPRⅡ^(+)immunofluorescence localized to sensory *** and meningeal-associated BMPRⅡ^(+)vascular cells were identified in both intact fetal spinal cord and cortex by co-positivity with vascular lineage markers,Cd34/*** immunostaining identified a population of somas concentrated in dorsal and ventral horn interneurons,mirroring the expression of LIF receptor/Cd118.A combination of LIF supplementation and high-density culture maintained culture growth beyond 10 passages,while synergistically increasing the proportion of neurospheres with a stratified,*** neurospheres were characterized by BMPRⅡ^(+)/MAP2ab^(+/–)/βⅢ-tubulin^(+)/nestin^(–)/vimentin^(–)/GFAP^(–)/NeuN^(–)surface hNPCs surrounding a heterogeneous core ofβⅢ-tubulin^(+)/nestin^(+)/vimentin^(+)/GFAP^(+)/MAP2ab^(–)/NeuN^(–)multipotent *** cultures from tripotential neurospheres contained neuronal(βⅢ-tubulin^(+)),astrocytic(GFAP+),and oligodendrocytic(O4+)lineage ***-activated cell sorting-sorted BMPRⅡ^(+)hNPCs were MAP2ab^(+/–)/βⅢ-tubulin^(+)/GFAP^(–)/O4^(–)in *** is the first isolation of BMPRⅡ^(+)hNPCs identified and characterized in human fetal spinal *** data show that LIF combines synergistically with high-density reaggregate cultures to support the organotypic reorganization of neurospheres,characterize

关键词： BMPRⅡ bone morphogenetic protein histotypic human spinal cord development leukemia inhibitory factor neurosphere organotypic reaggregate sensory columns

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