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P2X7 receptor signaling during adult hippocampal neurogenesis

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Neural Regeneration Research 2019年第10期14卷 1684-1694页

作者： Hannah C. Leeson Tailoi Chan-Ling michael d. Lovelace Jeremy C. Brownlie Ben J. Gu michael W. Weible II Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueenslandAustralia Griffith Institute for drug discovery Griffith UniversityBrisbaneQueenslandAustralia discipline of Anatomy and Histology School of Medical ScienceThe University of SydneySydneyNew South WalesAustralia Bosch Institute The University of SydneySydneyNew South WalesAustralia Applied Neurosciences Program Peter Duncan Neurosciences Research UnitSt. Vincent’s Centre for Applied Medical ResearchSydneyNew South WalesAustralia Faculty of Medicine St. Vincent’s Clinical SchoolUniversity of New South Wales SydneySydneyNew South WalesAustralia School of Environment and Science Griffith UniversityBrisbaneQueenslandAustralia Florey Institute of Neuroscience and Mental Health University of MelbourneMelbourneVictoriaAustralia

Neurogenesis is a persistent and essential feature of the adult mammalian *** neurons generated from resident pools of stem or progenitor cells provide a mechanism for the formation and consolidation of new *** of hippocampal neurogenesis is complex and multifaceted,and numerous signaling pathways converge to modulate cell proliferation,apoptosis,and clearance of cellular debris,as well as synaptic integration of newborn immature *** expression of functional P2X7 receptors in the central nervous system has attracted much interest and the regulatory role of this purinergic receptor during adult neurogenesis has only recently begun to be explored.P2X7 receptors are exceptionally versatile:in their canonical role they act as adenosine triphosphate-gated calcium channels and facilitate calcium-signaling cascades exerting control over the cell via calcium-encoded sensory proteins and transcription factor activation.P2X7 also mediates transmembrane pore formation to regulate cytokine release and facilitate extracellular communication,and when persistently stimulated by high extracellular adenosine triphosphate levels large P2X7 pores form,which induce apoptotic cell death through cytosolic ion ***,as a scavenger receptor P2X7 directly facilitates phagocytosis of the cellular debris that arises during neurogenesis,as well as during some disease *** how P2X7 receptors regulate the physiology of stem and progenitor cells in the adult hippocampus is an important step towards developing useful therapeutic models for regenerative *** review considers the relevant aspects of adult hippocampal neurogenesis and explores how P2X7 receptor activity may influence the molecular physiology of the hippocampus,and neural stem and progenitor cells.

关键词： P2X7 P2X7R adult neurogenesis neural stem cells neural progenitor cells hippocampus SGZ calcium signaling purinergic signaling

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2012年太阳能光伏产业的两种走势

低碳世界 2011年第8期1卷 18-19页

作者： michael barker

无可争辩,对于光伏制造商来说,2011年是艰难的一年。那么,在即将到来的2012年太阳能光伏产业会有机会翻身吗?我认为,也许下游产业才应该是很多制造商新的关注点。

关键词：太阳能光伏产业光伏低成本太阳能组件制造商出货量晶体硅

Systematic review of mixed cryoglobulinemia associated with hepatitis E virus infection:association or causation?

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Gastroenterology Report 2017年第3期5卷 178-184,I0001页

作者： Fateh Bazerbachi michael d.Leise Kymberly d.Watt MHassan Murad Larry J.Prokop Samir Haffar division of Gastroenterology and Hepatology Mayo ClinicRochesterMNUSA Robert d.and Patricia E.Kern Center for the Science of Health Care delivery Mayo ClinicRochesterMNUSA Library Public Services Mayo ClinicRochesterMNUSA digestive Centre for diagnosis and Treatment DamascusSyrian Arab Republic

Background and aim:Mixed cryoglobulinemia(MC)has been associated with several viral infections,and chronic hepatitis C is recognized as a major *** associated with hepatitis E virus(HEV)has been described and little is known about this rare *** aim of this study is to perform a systematic review of MC associated with HEV,and examine the presence of a causal ***:An experienced librarian conducted a search of databases from each database’s inception to 12 december 2016 based on a priori *** risk of bias was assessed,and Hill’s criteria were applied to determine ***:Five publications met inclusion criteria,with a total of 15 *** studies had low,one low to moderate and one moderate risk of *** age was 43 years,and all patients came from Western *** patients were immunocompetent,while 13 were immunosuppressed,post solid organ transplant and had chronic hepatitis *** involvement was observed in seven patients,mild to moderately severe cryoglobulinemic disease in one patient and severe cryoglobulinemic disease in three *** patient improved spontaneously,and another was treated with immunosuppressant reduction leading to viral *** patients treated with peg-interferon or ribavirin for 3 months achieved loss of cryoglobulinemia and end-of-treatment response,but sustained virologic response was reported and achieved in *** achieved loss of cryoglobulinemia in three *** case of chronic renal failure,three cases of end-stage renal disease and one death were *** of the nine Hill’s criteria were ***:MC has been described with HEV infection.A causal relationship between HEV infection and cryoglobulinemia is highly probable.

关键词： hepatitis E virus hepatitis virology mixed cryoglobulinemia systematic review

An infertile male with dilated seminal vesicles due to functional obstruction

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Asian Journal of Andrology 2017年第2期19卷 256-257页

作者： michael d Font Alexander W Pastuszak John R Case Larry I Lipshult Baylor College of Medicine Houston TX 77030 USA Center for Reproductive Medicine Baylor College of Medicine Houston TX 77030 USA Scott department of Urology Baylor College of Medicine Houston TX 77030 USA Urology San Antonio San Antonio TX 78229 USA

dear Editor, The patient is a 45-year-old male who presented to an outside clinic in 2014 for evaluation of painful ejaculation, infertility, and difficulty with urination for as long as he could remember. He reported no past significant medical or surgical history and no family history of infertility. He was given a trial of tamsulosin without improvement in his symptoms. Initial semen analysis demonstrated azoospermia.

关键词： infertile male dilated seminal vesicles due functional obstruction

Combination of repeated single-session percutaneous ethanol injection and transarterial chemoembolisation compared to repeated single-session percutaneous ethanol injection in patients with non-resectable hepatocellular carcinoma

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World Journal of Gastroenterology 2006年第23期12卷 3707-3715页

作者： Arne dettmer Timm d Kirchhoff michael Gebel Lars Zender Nisar P Malek Bernhard Panning Ajay Chavan Herbert Rosenthal Stefan Kubicka Susanne Krusche Sonja Merkesdal michael Galanski michael P Manns Joerg S Bleck department of Gastroenterology Hepatology and EndocrinologyHannover Medical SchoolGermany department of diagnostic Radiology Hannover Medical SchoolGermany department of Anaesthesiology Hannover Medical SchoolGermany department of diagnostic and Interventional Radiology Klinikum OldenburgGermany S Bleck Department of GastroenterologyHepatology and EndocrinologyHannover Medical SchoolGermany division of Rheumatology Hannover Medical SchoolGermany

AIM： To evaluate the treatment effect of percutaneous ethanol injection （PEI） for patients with advanced, non-resectable HCC compared with combination of transarterial chemoembolisation （TACE） and repeated single-session PEI, repeated single-session PEI alone, repeated TACE alone, or best supportive care. METHOdS： All patients who received PEI treatment during the study period were included and stratified to one of the following treatment modalities according to physical status and tumor extent： combination of TACE and repeated single-session PEI, repeated single-session PEI alone, repeated TACE alone, or best supportive care. Prognostic value of clinical parameters including Okuda-classification, presence of portal vein thrombosis, presence of ascites, number of tumors, maximum tumor diameter, and serum cholinesterase （CHE）, as well as Child-Pugh stage, α-fetoprotein （AFP）, fever, incidence of complications were assessed and compared between the groups. Survival was determined using Kaplan-Meier and multivariate regression analyses.

关键词： HCC Single-session PEI TACE Survival Prediction

Two decades of compositional and structural change in deciduous old-growth forests of Indiana,USA

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Journal of Plant Ecology 2016年第3期9卷 256-271页

作者： Christy A.Lowney Bradley d.Graham Martin A.Spetich Stephen R.Shifley michael R.Saunders michael A.Jenkins department of Forestry and Natural Resources and Hardwood Tree Improvement and Regeneration Center Purdue University715 West State StreetWest Lafayette IN 47907USA Arkansas Forestry Sciences Laboratory USDA Forest ServiceSouthern Research StationP.O.Box 1270Hot SpringsAR 71902USA USdA Forest Service Northern Research Station202 ABNR BuildingColumbiaMO 65201USA

Aims Using a network of permanent plots,we determined how multiple old-growth forests changed over an 18-19-year period at a state-wide *** examination of change allowed us to assess how the compositional and structural stability of each forest varied with site characteristics(topography,physiography and productivity)and stochastic *** In 2011,we resampled 150 plots distributed across five old-growth hardwood forests in Indiana,USA that were originally sampled in *** each plot,we relocated and remeasured the diameter at breast height(dbh)of all trees(≥10.0 cm)present during the 1992-1993 sample,which allowed us to track their individual fates through time for growth and mortality *** that grew to≥10.0 cm dbh since plot establishment were designated as *** dbh and species of all saplings(stems≥2.0 cm butdbh)were also *** each forest,we calculated density(stems ha^(−1)),basal area(BABA;m^(2)ha^(−1))and importance value(relative density+relative BABA)/2 of trees by *** saplings,density per ha was calculated by species for each *** also calculated annual mortality rate(AMR)for three diameter classes(10-29.9,30-59.9 and≥60 cm)and species richness(S),evenness(E)and Shannon-Weiner diversity(H')for the tree and sapling *** between years were compared for each forest using paired t-tests and Wilcoxon signed rank *** FindingsAlthough we observed commonality in changes across some sites,our results suggest that these forests differ in their rates and trajectories of *** in total stand BABA and density varied across sites and were influenced by past disturbance and mortality *** observed a general increase in the overstory dominance of Acer saccharum coupled with a general decrease in the dominance of Quercus section Lobatae(red oak group)*** of overstory trees present in 1992-1993 ranged from 27%to 49%over the study period(mean AM

关键词： forest remnants forest structure long-term data mortality species diversity stand development.

Monohalogenated acetamide-induced cellular stress and genotoxicity are related to electrophilic softness and thiol/thiolate reactivity

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Journal of Environmental Sciences 2017年第8期29卷 224-230页

作者： Justin A.Pals Elizabeth d.Wagner michael J.Plewa Menghang Xia Matias S.Attene-Ramos department of Crop Sciences University of Illinois at Urbana-Champaign Urbana IL United States department of Environmental and Occupational Health Milken Institute School of Public Health George Washington University Washington DC United States Safe Global Water Institute University of Illinois at Urbana-Champaign Urbana IL United States National Center for Advancing Translational Sciences National Institutes of Health (NIH) Department of Health and Human Services (DHHS) Bethesda MD United States

Haloacetamides（HAMs） are cytotoxic, genotoxic, and mutagenic byproducts of drinking water disinfection. They are soft electrophilic compounds that form covalent bonds with the free thiol/thiolate in cysteine residues through an S_N2 reaction *** of the monohalogenated HAMs（iodoacetamide, IAM; bromoacetamide, BAM;or chloroacetamide, CAM） varied depending on the halogen substituent. The aim of this research was to investigate how the halogen atom affects the reactivity and toxicological properties of HAMs, measured as induction of oxidative/electrophilic stress response and genotoxicity. Additionally, we wanted to determine how well in silico estimates of electrophilic softness matched thiol/thiolate reactivity and in vitro toxicological *** of the HAMs significantly induced nuclear Rad51 accumulation and ARE signaling activity compared to a negative control. The rank order of effect was IAM 〉 BAM 〉 CAM for Rad51, and BAM ≈ IAM 〉 CAM for ARE. In general, electrophilic softness and in chemico thiol/thiolate reactivity provided a qualitative indicator of toxicity, as the softer electrophiles IAM and BAM were more thiol/thiolate reactive and were more toxic than CAM.

关键词： drinking water disinfection byproducts Haloacetamide Toxicity Soft electrophile Oxidative stress dNA damage

Chloramination of wastewater effluent: Toxicity and formation of disinfection byproducts

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Journal of Environmental Sciences 2017年第8期29卷 135-145页

作者： Julien Le Roux michael J.Plewa Elizabeth d.Wagner Maolida Nihemaiti Azra dad Jean-Philippe Croué LEESU(UMR MA 102) Université Paris-Est–AgroParisTech department of Crop Sciences the Global Safe Water InstituteUniversity of Illinois at Urbana-Champaign Curtin Water Quality Research Centre Department of ChemistryCurtin University US Food and drug Administration National Center for Toxicological Research

The reclamation and disinfection of waters impacted by human activities（e.g., wastewater effluent discharges） are of growing interest for various applications but has been associated with the formation of toxic nitrogenous disinfection byproducts（N-dBPs）. Monochloramine used as an alternative disinfectant to chlorine can be an additional source of nitrogen in the formation of N-dBPs. Individual toxicity assays have been performed on many dBPs, but few studies have been conducted with complex mixtures such as wastewater effluents. In this work, we compared the cytotoxicity and genotoxicity of wastewater effluent organic matter（Ef OM） before and after chloramination. The toxicity of chloraminated Ef OM was significantly higher than the toxicity of raw Ef OM, and the more hydrophobic fraction（HPO）isolated on XAd-8 resin was more toxic than the fraction isolated on XAd-4 *** dBPs were also isolated on the XAd-8 resin. N-dBPs（i.e., haloacetonitriles or haloacetamides） were responsible for the majority of the cytotoxicity estimated from dBP concentrations measured in the XAd-8 and XAd-4 fractions（99.4% and 78.5%, respectively）.Measured dBPs accounted for minor proportions of total brominated and chlorinated products, which means that many unknown halogenated compounds were formed and can be responsible for a significant part of the toxicity. Other non-halogenated byproducts（e.g.,nitrosamines） may contribute to the toxicity of chloraminated effluents as well.

关键词： disinfection byproducts Chloramination Toxicity Wastewater XAd resins Haloacetonitriles Haloacetamides

Targeted therapy for capillary-venous malformations

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Signal Transduction and Targeted Therapy 2024年第7期9卷 3024-3039页

作者： Lola Zerbib Sophia Ladraa Antoine Fraissenon Charles Bayard Marina Firpion Quitterie Venot Sanela Protic Clément Hoguin Amandine Thomas Sylvie Fraitag Jean-Paul duong Sophie Kaltenbach Estelle Balducci Coline Lefevre Patrick Villarese Vahid Asnafi Christine Broissand Nicolas Goudin Ivan Nemazanyy Gwennhael Autret Bertrand Tavitian Christophe Legendre Nadia Arzouk Veronique Minard-Colin Caroline Chopinet michael dussiot denise MAdams Tristan Mirault Laurent Guibaud Paul Isenring Guillaume Canaud UniversitéParis Cité ParisFrance INSERM U1151 Institut Necker-Enfants MaladesParisFrance Service d’Imagerie Pédiatrique Hôpital Femme-Mère-EnfantHCLBronFrance CREATIS UMR 5220 Villeurbanne 69100France Service de Radiologie Mère-Enfant Hôpital NordSaint EtienneFrance Service d’Anatomie pathologique Hôpital Necker-Enfants MaladesAP-HPParisFrance Laboratoire d’Oncohématologie Hôpital Necker-Enfants MaladesAP-HPParisFrance Pharmacie Hôpital Necker-Enfants MaladesAP-HPParisFrance Necker Bio-Image Analysis INSERM US24/CNRS UMS 3633ParisFrance Platform for Metabolic Analyses Structure Fédérative de Recherche NeckerINSERM US24/CNRS UMS 3633ParisFrance Plateforme Imageries du Vivant Universitéde ParisPARCCINSERMParisFrance Service de Néphrologie Transplantation AdultesHôpital Necker-Enfants MaladesAP-HPParisFrance Service de Transplantation Hôpital La PitiéSalpétrièreAP-HPParisFrance department of Pediatric and Adolescent Oncology INSERM 1015Gustave RoussyUniversitéParis-SaclayVillejuifFrance Service de Physiologie&Explorations Fonctionnelles Cardiovasculaires CHU de LilleLille 59000France INSERM U1163 Laboratory of Cellular and Molecular Mechanisms of Hematological Disorders and Therapeutic ImplicationsLaboratoire d’Excellence GR-ExParisFrance division of Oncology Comprehensive Vascular Anomalies ProgramChildren’s Hospital of PhiladelphiaPhiladelphiaPAUSA Service de Médecine Vasculaire hôpital Européen Georges-PompidouParisFrance Nephrology Research Group L’Hôtel-Dieu de Québec Research CenterDepartment of MedicineFaculty of MedicineLaval UniversityQuebecQC G1R2J6Canada Unitéde médecine translationnelle et thérapies ciblées Hôpital Necker-Enfants MaladesAP-HPParisFrance CNRS UMR8253 Institut Necker-Enfants MaladesParisFrance

Sporadic venous malformations are genetic conditions primarily caused by somatic gain-of-function mutation of PIK3CA or TEK,an endothelial transmembrane receptor signaling through *** malformations are associated with pain,bleedings,thrombosis,pulmonary embolism,esthetic deformities and,in severe cases,life-threatening *** authorized medical treatment exists for patients with venous ***,we created a genetic mouse model of PIK3CA-related capillary venous malformations that replicates patient *** showed that these malformations only partially signal through AKT *** compared the efficacy of different drugs,including rapamycin,a mTORC1 inhibitor,miransertib,an AKT inhibitor and alpelisib,a PI3Kαinhibitor at improving the lesions seen in the mouse *** demonstrated the effectiveness of alpelisib in preventing vascular malformations’occurrence,improving the already established ones,and prolonging *** these findings,we were authorized to treat 25 patients with alpelisib,including 7 children displaying PIK3CA(n=16)or TEK(n=9)-related capillary venous malformations resistant to usual therapies including sirolimus,debulking surgical procedures or percutaneous *** assessed the volume of vascular malformations using magnetic resonance imaging(MRI)for each *** demonstrated improvement in all 25 *** malformations previously considered intractable were reduced and clinical symptoms were *** showed a decrease of 33.4%and 27.8%in the median volume of PIK3CA and TEK malformations respectively,over 6 months on *** conclusion,this study supports PI3Kαinhibition as a promising therapeutic strategy in patients with PIK3CA or TEK-related capillary venous malformations.

关键词： PIK3CA malformations venous