检索结果-南通市图书馆

High Power Laser Science and Engineering 2019年第2期7卷 22-26页

作者： John Pasley Georgia Andrianaki Andreas Baroutsos Dimitri Batani Emmanouil P.Benis Marco Borghesi Eugene Clark Donna cook Emmanuel D'Humieres Vasilios Dimitriou Brendan Dromey michael Ehret Ioannis Fitilis Anastasios Grigoriadis Satya Kar Evaggelos Kaselouris Ondrej Klimo Michel Koenig Kyriaki Kosma George Koundourakis Milan Kucharik Aveen Lavery Jiri Limpouch Yannis Orphanos Nektarios A.Papadogiannis Stelios Petrakis Dave riley Maria Serena rivetta Laura Tejada Pascual Joao Jorge Santos Alexandros Skoulakis Ioannis Tazes Vladimir Tikhonchuk Jocelain Trela Calliope Tsitou Luca Volpe Steven White Mark Yeung michael Tatarakis York Plasma Institute University of York Technological Educational Institute of Crete School of Applied SciencesCentre for Plasma Physics and Lasers-CPPL Universitéde Bordeaux CNRSCEACELIA(Centre Lasers Intenses et Applications) Department of Physics University of Ioannina Centre for Plasma Physics School of Mathematics and PhysicsQueen’s University Belfast Faculty of Nuclear Sciences and Physical Engineering Czech Technical University in Prague LULI-CNrS Ecole Polytechnique CEA:UniversitéParis-Saclay UPMC Univ Paris 06:Sorbonne Universités CLPU Laser-Plasma Chair University of Salamanca Centro de Láseres Pulsados(CLPU) Edificio M5.Parque Cientfico.C/Adaja

The Erasmus Plus programme’Innovative Education and Training in high power laser plasmas’,otherwise known as PowerLaPs,is *** PowerLaPs programme employs an innovative paradigm in that it is a multi-centre programme where teaching takes place in five separate institutes with a range of different aims and styles of *** ’in class’ time is limited to four weeks a year,and the programme spans two *** aims to train students from across Europe in theoretical,applied and laboratory skills relevant to the pursuit of research in laserplasma interaction physics and inertial confinement fusion(ICF).Lectures are intermingled with laboratory sessions and continuous assessment *** programme,which is led by workers from the Technological Educational Institute(TEI)of Crete,and supported by co-workers from the Queen’s University Belfast,the University of Bordeaux,the Czech Technical-University in Prague,Ecole Polytechnique,the University of Ioannina,the University of Salamanca and the University of York,has just completed its first *** far three Learning Teaching Training(LTT)activities have been held,at the Queen’s University Belfast,the University of Bordeaux and the Centre for Plasma Physics and Lasers(CPPL)of TEI *** last of these was a two-week long Intensive Programme(IP),while the activities at the other two universities were each five days in *** far work has concentrated upon training in both theoretical and experimental work in plasma physics,high power laser-matter interactions and high energy density *** nature of the programme will be described in detail and some metrics relating to the activities carried out to date will be presented.

关键词： higher education inertial confinement fusion laser-plasma interactions post-graduate education

Linking science and decision making to promote an ecology for the city:practices and opportunities

在线全文

学校读者我要写书评

暂无评论

Ecosystem Health and Sustainability 2016年第9期2卷 18-27页

作者： J.Morgan Grove Daniel L.Childers michael Galvin Sarah Hines Tischa Muñoz-Erickson Erika S.Svendsen Baltimore Field Station USDA Forest ServiceBaltimoreMaryland 21228 USA School of Sustainability Arizona State UniversityTempeArizona 85287 USA Urban Field Station International Institute of Tropical ForestryUSDA Forest ServiceRío PiedrasPuerto Rico 00926-1119 USA New York City Field Station USDA Forest ServiceNew YorkNew York 10007 USA

To promote urban sustainability and resilience,there is an increasing demand for actionable science that links science and decision making based on social-ecological ***,frameworks,and practices for such actionable science are needed and have only begun to *** propose that approaches based on the co-design and co-production of knowledge can play an essential role to meet this *** the antecedents for approaches to the co-design and co-production of knowledge are decades old,the integration of science and practice to advance urban sustainability and resilience that we present is different in several *** differences include the disciplines needed,diversity and number of actors involved,and the technological infrastructures that facilitate local-to global *** this article,we discuss how the new requirements and possibilities for co-design,co-production,and practical use of social-ecological research can be used as an ecology for the city to promote urban sustainability and *** new technologies are part of the solution,traditional approaches also remain *** our urban experiences with long-term,place-based research from several ***-Term Ecological research sites and *** of Agriculture,Forest Service Urban Field Stations,we describe a dynamic framework for linking research with *** posit that this framework,coupled with a user-defined,theory-based approach to science,is instrumental to advance both practice and ***,cities are ideal places for integrating basic science and decision making,facilitating flows of information through networks,and developing sustainable and resilient solutions and futures.

关键词： Baltimore co-design co-production ecology for cities long-term ecological research New York City Phoenix San Juan social-ecological Special Feature:An Ecology in,of,and for the City transdisciplinary urban

在乳腺癌普查中临床乳腺检查可以取代乳腺X线照相吗?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

英国医学杂志中文版 2003年第1期6卷 57-59页

作者： Indraneel Mittra michael Baum Hazel Thornton Joan Houghton 王万祥 Department of Surgical Oncology Tata Memorial HospitalMumbai-400012India Department of Surgery University College Medical School London WIP 7LD Saionara 31 Regent Street.RowhedgeColchester CO5 7EA CrC and UCL Cancer Trials Centre Royal Free and University College London Medical SchoolLondon WIA 8AN

乳腺癌普查和乳腺X线照相在公众的理解中已成为同义词,但事实上却不一定是一回事。乳腺癌理想的普查方法应该是既能降低乳腺癌的病死率、假阳性率,花费又要相对便宜。进行普查需要费用,但不应该以降低对有症状患者的医疗服务为代价,也... 详细信息

乳腺癌普查和乳腺X线照相在公众的理解中已成为同义词,但事实上却不一定是一回事。乳腺癌理想的普查方法应该是既能降低乳腺癌的病死率、假阳性率,花费又要相对便宜。进行普查需要费用,但不应该以降低对有症状患者的医疗服务为代价,也不应该耗费国家医疗卫生服务体系(NHS)的有限资源,以便花在同样重要的、但是公众没有特别关注的一些领域。

关键词：乳腺癌普查临床乳腺检查诊断乳腺X线照相

New frontiers for the materials genome initiative

在线全文

学校读者我要写书评

暂无评论

npj computational Materials 2019年第1期5卷 776-798页

作者： Juan J.de Pablo Nicholas E.Jackson michael A.Webb Long-Qing Chen Joel E.Moore Dane Morgan ryan Jacobs Tresa Pollock Darrell G.Schlom Eric S.Toberer James Analytis Ismaila Dabo Dean M.DeLongchamp Gregory A.Fiete Gregory M.Grason Geoffroy Hautier Yifei Mo Krishna rajan Evan J.reed Efrain rodriguez Vladan Stevanovic Jin Suntivich Katsuyo Thornton Ji-Cheng Zhao Institute for Molecular Engineering University of ChicagoChicagoIL 60615USA Department of Materials Science and Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Physics University of CaliforniaBerkeleyBerkeleyCA 94720USA Department of Materials Science and Engineering University of Wisconsin-MadisonMadisonWI 53706USA Materials Department and Materials research Laboratory University of CaliforniaSanta BarbaraCA 93106USA Department of Materials Science and Engineering Cornell UniversityIthacaNY 14853USA Department of Physics Colorado School of MinesGoldenCO 80401USA Materials Measurement Laboratory National Institute of Standards and TechnologyGaithersburgMD 20899USA Department of Physics University of Texas at AustinAustinTX 78712USA Department of Polymer Science and Engineering University of MassachusettsAmherstMA 01003USA Institute of condensed Matter and Nanosciences UniversitéCatholique de Louvain1348 Louvain-la-NeuveBelgium Department of Materials Science and Engineering University of MarylandCollege ParkMD 20742USA Department of Materials Design and Innovation University of Buffalo–The State University of New YorkBuffaloNY 14260-5030USA Department of Materials Science and Engineering Stanford UniversityStanfordCA 94305USA Department of Chemistry and Biochemistry University of MarylandCollege ParkMD 20742USA Department of Metallurgical and Materials Engineering Colorado School of MinesGoldenCO 80401USA Department of Materials Science and Engineering University of MichiganAnn ArborMI 48109USA Department of Materials Science and Engineering The Ohio State UniversityColumbusOH 43210USA

The Materials Genome Initiative(MGI)advanced a new paradigm for materials discovery and design,namely that the pace of new materials deployment could be accelerated through complementary efforts in theory,computation,and *** with numerous successes,new challenges are inviting researchers to refocus the efforts and approaches that were originally inspired by the *** May 2017,the National Science Foundation sponsored the workshop“Advancing and Accelerating Materials Innovation Through the Synergistic Interaction among computation,Experiment,and Theory:Opening New Frontiers”to review accomplishments that emerged from investments in science and infrastructure under the MGI,identify scientific opportunities in this new environment,examine how to effectively utilize new materials innovation infrastructure,and discuss challenges in achieving accelerated materials research through the seamless integration of experiment,computation,and *** article summarizes key findings from the workshop and provides perspectives that aim to guide the direction of future materials research and its translation into societal impacts.

关键词： utilize frontier accomplishment

海洋-大气耦合模型对大气二氧化碳增加的响应

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

人类环境杂志 1994年第1期23卷 44-49页

作者： Syukuro Manabe ronald J.Stouffer michael J.Spelman 蒋逸航朱志辉美国国家海洋大气局地球物理流体动力学实验室 Geophysical Fluid Dynamics Laboratory/NOAA Princeton UniversityPO Box 308 Princeton New Jersey 08542 USA

本文研究一个气候模型对大气co_2每年增加1%的响应。该模型是耦合海洋-大气-陆面系统的大气环流模型,具有全球计算域,进行了地理上的修匀,并包含了日射的季节变化。模拟得到的海面增温在北大西洋北部和南半球的绕极海区非常缓慢,在这些... 详细信息

本文研究一个气候模型对大气co_2每年增加1%的响应。该模型是耦合海洋-大气-陆面系统的大气环流模型,具有全球计算域,进行了地理上的修匀,并包含了日射的季节变化。模拟得到的海面增温在北大西洋北部和南半球的绕极海区非常缓慢,在这些海区水体的垂直混合可以达到很深的深度,深层水的交换速度也较快。为将这一工作深入下去,我们研究了过去几百年间该耦合模型对大气co_2浓度增至2倍和4倍时的瞬时响应。在整个500年实验期间,当co_2增至2倍时,全球平均地面气温增加3.5C,当co_2增至4倍时升高7C。在后一项实验中,所研究的海洋的热力结构和动力特征都经历了剧烈的变化,例如,模型所选取的海洋大多数都发生了温盐环流的终止,斜温层也显著变深,在北大西洋,这些变化尤其明显。这些变化阻碍了深层海水的交换,如果这些变化实际发生,将对海洋-大气耦合系统的碳循环和生物地球化学过程产生深远影响。

关键词：气候模型海洋大气耦合模型二氧化碳

在线全文

学校读者我要写书评

暂无评论

交通运输在物流链中的作用

四川建材 2019年第4期45卷 173-177,179页

作者：蒋志华 Yung yu TSENG Wen Long YUE michael A P TAYLOr 中国中铁二院工程集团有限责任公司四川成都610031

物流运输的运转过程决定了货物运输的效率。改进运输技术和管理原则,提高了运输工具装载量,运输速度和运输服务质量,降低了运输成本,并进一步促进了运输设备的有效使用以及节能环保。交通运输在物流业中起着重要作用。就目前情况而言,... 详细信息

物流运输的运转过程决定了货物运输的效率。改进运输技术和管理原则,提高了运输工具装载量,运输速度和运输服务质量,降低了运输成本,并进一步促进了运输设备的有效使用以及节能环保。交通运输在物流业中起着重要作用。就目前情况而言,一个强大的物流系统需要一个清晰的物流框架,采用合理的运输工具和技术,实现物流沟通连接生产全过程的目的。本文目的在于清晰定义交通运输在物流系统中的作用,为进一步完善、规范物流业提供参考。此项研究致力于帮助物流管理者、研究人员、运输规划人员定义及理解物流的基本概念,其广泛应用以及物流及交通运输之间的关系。

关键词：物流交通运输城市物流

转染嵌合性T细胞受体基因小鼠T淋巴细胞的体外抗肿瘤作用

在线全文

学校读者我要写书评

暂无评论

中国肿瘤生物治疗杂志 2006年第4期13卷 243-248页

作者：杨建民 michael S Friedman 李峤 James J Mule Alfred E Chang Kevin T McDonagh 第二军医大学长海医院血液内科 University of Michigan Medical SchoolAnn Arbor MI 48109-0620 USA University of Kentucky College of Medicine Lexington Ky 40536-0293 USA

目的:研究小鼠T淋巴细胞在转染嵌合性T细胞受体基因后的体外抗肿瘤作用。方法:应用重组DNA技术,将HEr2特异性嵌合性T-细胞受体构建入逆转录病毒载体;转入包装细胞后,收集病毒上清,转染小鼠T淋巴细胞,转基因后的小鼠T淋巴细胞分别与HEr2... 详细信息

目的:研究小鼠T淋巴细胞在转染嵌合性T细胞受体基因后的体外抗肿瘤作用。方法:应用重组DNA技术,将HEr2特异性嵌合性T-细胞受体构建入逆转录病毒载体;转入包装细胞后,收集病毒上清,转染小鼠T淋巴细胞,转基因后的小鼠T淋巴细胞分别与HEr2阳性(SK-OV-3)或阴性(MCF-7)的肿瘤细胞系共培养,检测其细胞因子γ干扰素释放,51Cr释放法检测CTL评价其抗肿瘤效应。结果:所构建载体经酶切鉴定符合要求,乒乓法转染包装细胞系GP+E86,检测病毒滴度为1.2×106,retronectin结合离心法转染经抗CD3/CD28单抗活化的小鼠T淋巴细胞,转染效率可达50%以上;转染嵌合性T细胞受体基因的T淋巴细胞与HEr2阳性或阴性的肿瘤细胞系共培养后可检测到HEr2特异性的细胞因子γ干扰素释放,51Cr释放法测CTL可见转染嵌合性T细胞受体基因T淋巴细胞对HEr2阳性的肿瘤细胞具显著杀伤效应。结论:转染嵌合性T细胞受体基因的小鼠T淋巴细胞在体外可通过细胞因子释放和CTL效应发挥显著的抗肿瘤作用。

关键词：嵌合性T细胞受体基因转染免疫治疗小鼠 T淋巴细胞

Interaction of haptoglobin with hemoglobin octamers based on the mutation <i>α</i>Asn78Cys or <i>β</i>Gly83Cys

在线全文

学校读者我要写书评

暂无评论

American Journal of Molecular Biology 2012年第1期2卷 1-10页

作者： Thomas Brillet michael C. Marden Joanne I. Yeh Tong-Jian Shen Nancy T. Ho regina Kettering Shoucheng Du corinne Vasseur Elisa Domingues-Hamdi Chien Ho Véronique Baudin-Creuza Department of Biological Sciences Carnegie Mellon University Pittsburgh USA Department of Structural Biology School of Medicine University of Pittsburgh Pittsburgh USA Inserm U779 Université Paris XI et VII CHU Bicêtre Le Kremlin-Bicêtre France

Octameric hemoglobins have been developed by the introduction of surface cysteines in either the alpha or beta chain. Originally designed as a blood substitute, we report here the structure and ligand binding function;in addition the interaction with haptoglobin was studied. The recombinant Hbs (rHbs) with mutations alpha Asn78Cys or beta Gly83Cys spontaneously form octamers under conditions where the cysteines are oxidized. Oxygen binding curves and co kinetic studies indicate a co.rect allosteric transition of the tetramers within the octamer. Crystallographic studies of the two rHbs show two disulfide bonds per octamer. reducing agents may provoke dissociation to tetramers, but the octamers are stable when mixed with fresh human plasma, indicating that the reduction by plasma is slower than the oxidation by the dissolved oxygen, consistent with an enhanced stability. The octameric rHbs were also mixed with a solution of haptoglobin (Hp), which binds the dimers of Hb: there was little interaction for incubation times of 15 min;however, on longer timescales a complex was formed. Dynamic light scattering was used to follow the interaction of Hp with the alpha Asn78Cys octamer during 24 hours;a transition from a simple complex of 15 nm to a final size of 60 nm was observed. The results indicate a specific orientation of the αβ dimers may be of importance for the binding to haptoglobin.

关键词： Octamers Hemoglobin Haptoglobin Allosteric Transition Crystallography

Mobilizing Crop Biodiversity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular Plant 2020年第10期13卷 1341-1344页

作者： Susan Mccouch Zahra Katy Navabi michael Abberton Noelle L.Anglin rosa Lia Barbieri michael Baum Kirstin Bett Helen Booker Gerald L.Brown Glenn J.Bryan Luigi Cattivelli David Charest Kellye Eversole Marcelo Freitas Kioumars Ghamkhar Dario Grattipaglia robert Henry Maria Cleria Valadares Inglis Tofazzal Islam Zakaria Kehel Paul J.Kersey Graham J.King Stephen Kresovich Emily Marden Sean Mayes Marie Noelle Ndjiondjiop Henry T.Nguyen Samuel rezende Paiva roberto Papa Peter W.B.Phillips Awais rasheed Christopher richards Mathieu Flouard Maria Jose Amstalden Sampaio Uwe Scholz Paul D.Shaw Brad Sherman S.Evan Staton Nils Stein Jan Svensson Mark Tester Jose Francisco Montenegro Valls rajeev Varshney Stephen Visscher Eric von Wettberg robbie Waugh Peter Wenzl Loren H.rieseberg Plant Breeding and Genetics School of Integrated Plant SciencesCornell UniversityIthacaNY14853USA DivSeek Global Institute for Food Security110 Gymnasium PlaceUniversity of SaskatchewanSaskatoonSKS7N 0W9Canada lnternational Institute of Tropical Agriculture(IITA) PMB 5320Oyo RdIbadanNigeria International Potato Center(CIP)1895 Avenida La Molina Lima Peru 12Lima 15023Peru Embrapa Genetic resources and Biotechnology Parque Estacjao BiologicaFinal Av W5 NorteCaixa Postal 0237270770-917-Brasilia DFBrazil International Center for Agricultural research in the Dry Areas(I CAr DA) Station Exp.INRA-Quich.Rue Hafiane Cherkaoui.Agdal.Rabat-Instituts10111RabatMorocco Department of Plant Sciences University of Saskatchewan51 Campus Dr.SaskatoonSK S7N 5A8Canada Department of Plant Agriculture University of GuelphRm 316Crop Science Bldg50 Stone Rd EGuelphON N1G 2W1Canada Genome Prairie 111 Research DriveSuite 101SaskatoonSKS7N 3R2Canada The James Hutt on Institute Errol RoadInvergowrieDundeeDD25DAUK CrEA Research Centre for Genomics and Bioinformaticsvia San Protaso 302Fiorenzuola d'Arda29017Italy Genome British columbia 400-575 West 8th AvenueVancouverBCV5Z 0C4Canada International Wheat Genome Sequencing consortium 2841 NE Marywood CtLee's SummitMO.64086USA Forage Science Grasslands Research CentreAgResearchPalmerston North4410New Zealand Queensla nd Alliance for Agriculture and Food Inn ovation University of QueenslandBrisbaneQLD 4072Australia Institute of Biotechnology and Genetic Engineering(IBGE) Bangabandhu Sheikh Mujibur Rahman Agricultural UniversityGazipur 1706Bangladesh Southern Cross University PO Box 157LismoreNSW 2480Australia royal Botanic Gardens KewRichmondSurreyTW93AEUK Feed the Future Innovation Lab for Crop Improvement 431 Weill HallCornell UniversityIthacaNY14853USA Department of Botany and Biodiversity research Centre University of British ColumbiaVancouverBC V6R 2A5Canada Crops For the Future(UK)CIC 76-80 Baddow road ChelmsfordEs

Over the past 70 years,the world has witnessed extraordinary growth in crop productivity,enabled by a suite of technological advances,including higher yielding crop varieties,improved farm management,synthetic agrochemicals,and agricultural *** this"Green revolution"intensified crop production,and is credited with reducing famine and malnutrition,its benefits were accompanied by several undesirable collateral effects(Pingali,2012).These include a narrowing of agricultural biodiversity,stemming from increased monoculture and greater reliance on a smaller number of crops and crop varieties for the majority of our *** reduction in diversity has created vulnerabilities to pest and disease epidemics,climate variation,and ultimately to human health(Harlan,1972).

关键词： intensified crops agricultural