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富谷屋

建筑创作 2016年第6期 42-53页

作者： Zaha Hadid michael wolfson Brenda MacKneson Signy Svalastoha Paul Brislin Nicola Cousins David Gomersal Edgar Gonzaiez Erik Hemingway Simon Koumijan Palvi Jaaskelainen Patrik Schumacher Edgar Gonzalez

在这个拥挤的城市中,这座建筑与场地和街道的关系很特殊。轻质的玻璃亭在凌乱拥挤的社区肌理中拔地突起,创造了一个小小的舒缓的城市空间。这个升起的亭子,尽管是一个完全独立的空间,但却是整体建筑概念的一个组成部分。这个只有一层的... 详细信息

在这个拥挤的城市中,这座建筑与场地和街道的关系很特殊。轻质的玻璃亭在凌乱拥挤的社区肌理中拔地突起,创造了一个小小的舒缓的城市空间。这个升起的亭子,尽管是一个完全独立的空间,但却是整体建筑概念的一个组成部分。这个只有一层的轻型结构架置于开放的首层之上,曲线屋面,三个立面均是通高的玻璃,可以灵活地用作工作室或零售店面。

关键词：轻型结构城市空间建筑概念 clutter 地下层光通路 providing 西巴 street 漫射光

From 2-dimensional to 3-dimensional: Overcoming dilemmas in intestinal mucosal interpretation

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World Journal of Gastroenterology 2019年第20期25卷 2402-2415页

作者： Richard PG Charlesworth michael N Marsh School of Science and Technology University of New EnglandArmidaleNSW 2351Australia wolfson College University of OxfordOxford OX2 6UDUnited Kingdom

The purpose of this review is to provide a definitive account of small intestinal mucosal structure and interpretation. The coeliac lesion has been well known, but not well described to date and this review aims to identify the interpretative difficulties which have arisen over time with the histological assessment of coeliac disease. In early coeliac interpretation, there were significant inaccuracies, particularly surrounding intraepithelial lymphocyte counts and the degree of villous flattening which occurred in the tissue. Many of these interpretive pitfalls are still encountered today, increasing the potential for diagnostic errors. These difficulties are mostly due to the fact that stained 2-dimensional sections can never truly represent the 3-dimensional framework of the intestinal tissue under investigation. Therefore, this review offers a critical account occasioned by these 2-dimensional interpretative errors and which, in our opinion, should in general be jettisoned. As a result, we leave a framework regarding the true 3-dimensional knowledge of mucosal structure accrued over the 70-year period of study, and one which is available for future reference.

关键词： Coeliac disease Histology Diagnosis 2-dimensional 3-dimensional

Reinvigorating the Wiener-Hopf technique in the pursuit of understanding processes and materials

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National Science Review 2021年第2期8卷 11-13页

作者： David Abrahams Xun Huang Anastasia Kisil Gennady Mishuris michael Nieves Sergei Rogosin Ilya Spitkovsky IsaacNewtonInstituteforMathematicalSciences CollegeofEngineering PekingUniversity DepartmentofMathematics UniversityofManchester DepartmentofMathematics AberystwythUniversity SchoolofComputingandMathematics KeeleUniversity FacultyofEconomics BelarusianStateUniversity ScienceandMathematics NewYorkUniversityAbuDhabi

The Wiener-Hopf(WH) method was created in 1931, by Norbert Wiener and Eberhard Hopf, to deliver exact solutions to integral equations with convolutiontype kernels on a half-line. It appears that this problem is closely related to that posed by Riemann in 1857 on the problem concerning the construction of a Fuchsian system of differential equations with given singular points and a prescribed monodromy group. This later became known as the 21 st Hilbert problem. The WH method is a powerful and long-standing tool that served as a catalyst in broadening the applicability of Fourier analysis, owing to the essential characteristics of analytic functions. Employing the Fourier transform(FT) to the integral equation leads to a RiemannHilbert(RH) problem on the real axis:

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Pattern analysis of schistosomiasis prevalence by exploring predictive modeling in Jiangling County,Hubei Province,***

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Infectious Diseases of Poverty 2017年第1期6卷 791-800页

作者： Shang Xia Jing-Bo Xue Xia Zhang He-Hua Hu Eniola michael Abe David Rollinson Robert Bergquist Yibiao Zhou Shi-Zhu Li Xiao-Nong Zhou National Institute of Parasitic Diseases Chinese Center for Disease Control and PreventionKey Laboratory of Parasite and Vector BiologyMinistry of HealthWHO Collaborating Center for Tropical DiseasesShanghai 200025People’s Republic of China Jiangling Institute of Schistosomiasis Control and Prevention Jiangling 434100People’s Republic of China Department of Zoology Natural History MuseumWolfson Wellcome Biomedical LaboratoriesCromwell RoadLondon SW75BDUK Ingerod BrastadSweden Department of Epidemiology School of Public HealthFudan UniversityShanghai 200032People’s Republic of China.

Background:The prevalence of schistosomiasis remains a key public health issue in *** County in Hubei Province is a typical lake and marshland endemic *** pattern analysis of schistosomiasis prevalence in Jiangling County is of significant importance for promoting schistosomiasis surveillance and control in the similar endemic ***:The dataset was constructed based on the annual schistosomiasis surveillance as well the socio-economic data in Jiangling County covering the years from 2009 to 2013.A village clustering method modified from the K-mean algorithm was used to identify different types of endemic *** these identified village clusters,a matrix-based predictive model was developed by means of exploring the one-step backward temporal correlation inference algorithm aiming to estimate the predicative correlations of schistosomiasis prevalence among different *** sampling of faeces from domestic animals,as an indicator of potential schistosomiasis prevalence,was carried out and the results were used to validate the results of proposed models and ***:The prevalence of schistosomiasis in Jiangling County declined year by *** total of 198 endemic villages in Jiangling County can be divided into four clusters with reference to the 5 years’occurrences of schistosomiasis in human,cattle and snail *** each identified village cluster,a predictive matrix was generated to characterize the relationships of schistosomiasis prevalence with the historic infection level as well as their associated impact ***,the results of sampling faeces from the front field agreed with the results of the identified clusters of endemic ***:The results of village clusters and the predictive matrix can be regard as the basis to conduct targeted measures for schistosomiasis surveillance and ***,the proposed models and methods can be modified to investigate the schistosomiasis pre

关键词： Schistosomiasis Clustering Predictive modelling

食品行业粉体材料流动性研究的新仪器——PFT

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农产品加工（下） 2012年第11期 146-150页

作者：丁晓炯刘柳莉 michael S A Bradley 广州市博勒飞粘度计质构仪技术服务有限公司广东广州510075 wolfson Centre for Bulk Solids Handling Technology University of GreenwichLondon SE10 9LS

奶粉、面粉、糖、盐、调味品等原料和添加剂粉体的流动性研究是目前很多材料行业的难点,现有常见的一些方法不能满足实际的需求。简单介绍了Brookfield公司根据ASTM D 6128推出的PFT粉体流体测试仪的基本功能,介绍了粉体流动函数、壁面... 详细信息

奶粉、面粉、糖、盐、调味品等原料和添加剂粉体的流动性研究是目前很多材料行业的难点,现有常见的一些方法不能满足实际的需求。简单介绍了Brookfield公司根据ASTM D 6128推出的PFT粉体流体测试仪的基本功能,介绍了粉体流动函数、壁面摩擦、松装密度、时间固结、拱架、鼠孔、料斗半角的测量和计算。

关键词：粉体流动性流动函数壁面摩擦松装密度时间固结

为规范处方行为开个处方——一些医学生并不具备熟练开处方的能力

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英国医学杂志中文版 2007年第1期10卷 5-6页

作者： Jeffrey K Aronson Graeme Henderson David J Webb michael D Rawlins 肖月（译） British Pharmacological Society London EC1V 2SC Chairman of the committee of heads and professors of clinical pharmacology wolfson Unit of Clinical Pharmacology University of NewcastleNewcastle upon Tyne NE2 4HH 不详

每年的这个时候，新分配来的医生上岗了，老的担心又出现了——他们受过良好的培训了吗？特别令人担忧的是：他们在临床药物治疗和开处方方面是否受过合格的培训？我们认为培训未必合格。

关键词：处方行为医学生能力药物治疗新分配培训

外周神经病理性疼痛的病理生理学：免疫细胞和分子机制

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麻醉与镇痛 2008年第5期4卷 78-88页

作者： michael A. Thacker Anna K. Clark Fabien Marchand Stephen B. McMahon 娄景盛(译) 徐波(译) 邓小明(校) Neurorestoration group Wolfson Centre for Age Related Diseases Academic Department of Physiotherapy Kings College London London Pain Consortium London UK 不详

外周神经系统损伤常常导致慢性神经病理性疼痛，其特征表现为自发痛、痛觉过敏以及痛觉异常。这种疼痛状态常使患者极度虚弱且难以治疗。虽然人们一般认为炎性疼痛和神经病理性疼痛综合征的本质是不同的，但是显现出来的一些现象却与这... 详细信息

外周神经系统损伤常常导致慢性神经病理性疼痛，其特征表现为自发痛、痛觉过敏以及痛觉异常。这种疼痛状态常使患者极度虚弱且难以治疗。虽然人们一般认为炎性疼痛和神经病理性疼痛综合征的本质是不同的，但是显现出来的一些现象却与这一严格的分类不符。炎症极具特征性，涉及一系列不同的免疫细胞，如肥大细胞、中性粒细胞、巨噬细胞以及T淋巴细胞。此外，这些细胞还释放多种致痛复合物。最近研究表明，免疫细胞在外周神经病理性疼痛中起到了一定作用。本综述阐述了不同类型免疫细胞在外周神经病理性疼痛中的作用，及其致痛过程中释放出来的一些关键因子。

关键词：慢性神经病理性疼痛免疫细胞病理生理学分子机制神经系统损伤疼痛综合征中性粒细胞 T淋巴细胞

双对吻挤压与经典挤压技术治疗冠状动脉分叉病变的前瞻性、随机、多中心研究

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中华心血管病杂志 2008年第2期36卷 100-107页

作者：陈绍良张俊杰叶飞陈韵岱吕树铮 Tan Huaycheem Tejas Patel Kawajiri Kenji Israel Tamari 单守杰朱中生林松田乃亮李晓波刘志忠 michael Lee 魏盟徐亚伟袁争白钱均孙学文杨松陈金国何奔 Sumitsuji 南京医科大学附属南京第一医院心内科 210006 首都医科大学附属北京安贞医院新加坡国立大学医院印度Kraishina心脏中心日本德州会医学中心以色列wolfson医学中心中国香港皇家玛丽医院上海交通大学附属第六人民医院上海同济大学附属第十人民医院上海交通大学附属仁济医院日本大阪国立循环器中心

目的比较双对吻挤压（DK crush）和经典挤压技术治疗冠状动脉分叉病变的临床效果。方法311例真性分叉病变患者随机分入DK crush组（n=155）和经典挤压组（n=156），随访时间8个月。一级及二级终点分别为主要心脏不良事件（MACE，包括心... 详细信息

目的比较双对吻挤压（DK crush）和经典挤压技术治疗冠状动脉分叉病变的临床效果。方法311例真性分叉病变患者随机分入DK crush组（n=155）和经典挤压组（n=156），随访时间8个月。一级及二级终点分别为主要心脏不良事件（MACE，包括心肌梗死、心原性死亡和靶病变血运重建）和血管直径再狭窄及晚期丢失。结果DK crush组糖尿病患者较多。经典挤压组及DK crush组最终对吻扩张（FKBI）成功率分别为76％和100％（P〈0．001）。DK crush术式的不足包括造影剂用量大（P=0．04）、球囊数量多（P〈0．01）、手术时间长（P〈0．001），但是对吻扩张不满意率显著减少（27．6％比6．3％，P〈0．01）。临床随访率为100％，冠状动脉造影随访率为82％。经典挤压组累计再狭窄率为32．3％，而DK crush组为20．3％（P=0．01），经典挤压组分支血管再狭窄率高（24．4％比12．3％，P=0．01），而两组间主干血管再狭窄率差异无统计学意义。经典挤压组术后8个月时的累计MACE发生率为24．4％（FKBI失败组为35．9％，FKBI成功组为19．7％），显著高于DK crush组（11．4％，P=0．02）。经典挤压组血栓栓塞率为3．2％（FKBI失败组为5．1％，FKBI成功组为1．7％），而DK crush组为1．3％（P〉0．05）。经典挤压组术后8个月时无靶病变血运重建生存率为75．4％（FKBI失败组为71．2％，FKBI成功组为77．6％），而DK crush组为89．5％（P=0．002）。结论DKcrush可能是治疗冠状动脉分又病变的较佳术式。

关键词：冠状动脉疾病支架冠状动脉分叉病变 DK crush 最终对吻扩张

Microscopic enteritis:Bucharest consensus

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World Journal of Gastroenterology 2015年第9期21卷 2593-2604页

作者： Kamran Rostami David Aldulaimi Geoffrey Holmes Matt W Johnson Marie Robert Amitabh Srivastava Jean-Francois Fléjou David S Sanders Umberto Volta Mohammad H Derakhshan James J Going Gabriel Becheanu Carlo Catassi Mihai Danciu Luke Materacki Kamran Ghafarzadegan Sauid Ishaq Mohammad Rostami-Nejad A Salvador Pe?a Gabrio Bassotti michael N Marsh Vincenzo Villanacci Department of Gastroenterology Alexandra HospitalWorcestershire B98 7UBUnited Kingdom Department of Gastroenterology Royal Derby HospitalDerby DE22 3NEUnited Kingdom Gastroenterology Unit Luton Dunstable University FT Hospital LU4 0DZUnited Kingdom Department of Pathology and Medicine Yale University School of MedicineNew HavenCT 06520United States Department of Pathology Staff PathologistBrigham and Women’s HospitalHarvard Medical School BostonBostonMA 02115United Sates Department of Pathology Serviced’Anatomie PathologiqueHopital Saint-AntoineAP-HPUniversité Pierre et Marie Curie75005 ParisFrance Department of Gastroenterology University of SheffieldSouth Yorkshire S10 2TNUnited Kingdom Department of Gastroenterology Department of Medical and Surgical SciencesUniversity of Bologna40126 BolognaItaly Section of Gastroenterology Institute of Cardiovascular and Medical SciencesUniversity of GlasgowGlasgow G12 8QQUnited Kingdom Department of Pathology Southern General HospitalLanarkshire G51 4TFUnited Kindom Department of Pathology Carol Davila Univerity of Medicine and PharmacyBucharest 050474Romania Università Politecnica delle Marche AnconaItalyPresidente Società Italiana di GastroenterologiaEpatologia e Nutrizione PediatricaCo-DirectorCenter For Celiac Research University of Maryland School of Medicine BaltimoreMD 21201United States Grigore T Popa" University of Medicine and Pharmacy Iasi 747800Romania Laboratory Department Mashad Razavi HospitalKhorasan Razavi ***Iran Dudley group of Hospitals Birmingham City UniversityBirmingham B42 2SUUnited Kindom Gastroenterology and Liver Diseases Research Institute Shahid Beheshti University of Medical SciencesTehran ***Iran Laboratory of Immunogenetics Department of Medical Microbiology and Infection ControlVrije Universiteit medical centre (VUmc)1081 HZ AmsterdamThe Netherlands Gastroenterology Section Department of MedicineUniversity of Perugia Medical School06100 PerugiaItaly wolfson College University of OxfordOxford

Microscopic enteritis(ME) is an inflammatory condition of the small bowel that leads to gastrointestinal symptoms,nutrient and micronutrient *** is characterised by microscopic or sub-microscopic abnormalities such as microvillus changes and enterocytic alterations in the absence of definite macroscopic changes using standard modern *** work recognises a need to characterize disorders with microscopic and submicroscopic features,currently regarded as functional or non-specific entities,to obtain further understanding of their clinical *** consensus working party reviewed statements about the aetiology,diagnosis and symptoms associated with ME and proposes an algorithm for its investigation and *** the 5th International Course in Digestive Pathology in Bucharest in November 2012,an international group of 21 interested pathologists and gastroenterologists formed a working party with a view to formulating a consensus statement on ME.A five-step agreement scale(from strong agreement to strong disagreement) was used to score 21 statements,*** was strong agreement on all statements about ME histology(95%-100%).Statements concerning diagnosis achieved 85% to 100% agreement.A statement on the management of ME elicited agreement from the lowest rate(60%) up to 100%.The remaining two categories showed general agreement between experts on clinical presentation(75%-95%) and pathogenesis(80%-90%) of *** was strong agreement on the histological definition of *** agreement on management indicates a need for further investigations,better definitions and clinical trials to produce quality guidelines for *** ME consensus is a step toward greater recognition of a significant entity affecting symptomatic patients previously labelled as non-specific or functional enteropathy.

关键词： Microscopic enteritis Enteropathy Gluten Malabsorption Non-celiac gluten Bucharest consensus