检索结果-南通市图书馆

Liquid biopsy for gastric cancer:Techniques,applications,and future directions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第12期30卷 1680-1705页

作者： Cristina díaz del Arco m Jesús Fernández Aceñero Luis Ortega m.d.na department of Surgical pathology Health Research Institute of the Hospital Clínico San CarlosHospital Clínico San CarlosMadrid 28040Spain department of Legal m.d.cine Psychiatry and PathologyUniversidad Complutense de MadridMadrid 28040Spain

After the study of circulating tumor cells in blood through liquid biopsy(LB),this technique has evolved to encompass the analysis of multiple materials originating from the tumor,such as nucleic acids,extracellular vesicles,tumor-educated platelets,and other ***,research has extended to include the examination of samples other than blood or plasma,such as saliva,gastric juice,urine,or *** techniques are diverse,intricate,and *** must be highly sensitive,and pre-analytical,patient,and tumor-related factors significantly influence the detection threshold,diagnostic method selection,and potential ***,the implementation of LB in clinical practice still faces several *** potential applications of LB range from early cancer detection to guiding targeted therapy or immunotherapy in both early and advanced cancer cases,monitoring treatment response,early identification of relapses,or assessing patient *** the other hand,gastric cancer(GC)is a disease often diagnosed at advanced *** recent advances in molecular understanding,the currently available treatment options have not substantially improved the prognosis for many of these *** application of LB in GC could be highly valuable as a non-invasive method for early diagnosis and for enhancing the management and outcomes of these *** this comprehensive review,from a pathologist’s perspective,we provide an overview of the main options available in LB,delve into the fundamental principles of the most studied techniques,explore the potential utility of LB application in the context of GC,and address the obstacles that need to be overcome in the future to make this innovative technique a game-changer in cancer diagnosis and treatment within clinical practice.

关键词： Liquid biopsy Gastric cancer Circulating tumor cells Cell-free dNA Circulating tumor dNA molecular

Antibacterial hA-coatings on bioresorbable mg alloy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of magnesium and Alloys 2024年第5期12卷 1965-1985页

作者： K.V.Nadaraia d.V.mashtalyar m.A.piatkova A.I.pleshkova I.m.Imshinetskiy m.S.Gerasimenko E.A.Belov V.V.Kumeiko d.N.Kozyrev K.A.Fomenko V.V.mostovaya B.R.Torpanov A.R.Biktimirov I.S.Osmushko S.L.Sinebryukhov S.V.Gnedenkov Institute of Chemistry FEB RAS 159 Pr.100-letiya VladivostokaVladivostok 690022Russia Far Eastern Federal University 10 Ajax BayRussky IslandVladivostok 690922Russia A.V.Zhirmunsky National Scientific Center of marine Biology FEB RAS 17 St.PalchevskogoVladivostok 690041Russia Regional Clinical dermatovenerological dispensary 18 V St.GamarnikaVladivostok 690033Russia NmIC“Treatment and Rehabilitation Center” 3 Ivankovskoe highwayMoscow 125367Russia

In this study,a calcium-phosphate coating was form.d.on a mg-mn-Ce alloy by the plasma electrolytic oxidation(pEO).The antibiotic vancomycin,widely used in the treatment of infections caused by Staphylococcus aureus(***),was impregnated into the *** with vancomycin showed high bactericidal activity against *** mechanical and electrochemical properties of the form.d.coatings were studied,as well as in vitro cytotoxicity tests and in vivo tests on mature male rats were *** to SEm,EdS,XRd and XpS data,coatings had a developed morphology and contained hydroxyapatite,which indicates high *** analysis of roughness of coatings without and with vancomycin did not reveal any differences,confirming the high roughness of the *** electrochemical tests,an increase in corrosion resistance by more than two times after the application of pEO coatings was *** to the results of an in vivo study,after 28 days of the implantation of samples with calcium phosphate pEO coating and vancomycin,no signs of inflammation were observed,while an inflammatory reaction developed in the area of implantation of bare alloy,followed by *** release tests from the coatings show a sharp decrease in the concentration of the released antibiotic on day 7 and then a gradual decrease until day *** the experiment,no significant deviations in the condition and behavior of the animals were observed;clinical tests did not reveal a systemic toxic reaction.

关键词： Bioactive coatings Biocompatibility mg alloy plasma electrolytic oxidation hydroxyapatite Vancomycin

Comparison of the Anatomy and Adaptability of Reconstructed Teeth with Natural Teeth:An Innovative Approach in Forensic dentistry

在线全文

学校读者我要写书评

暂无评论

Journal of Forensic Science and m.d.cine 2024年第1期10卷 47-54页

作者： Supraja S p m Tejaswi Ravikanth manyam mohan Kumar pasupuleti Swetha p Ramesh Kumar Budumuru department of Oral and maxillofacial pathology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia Vishnu dental College BhimavaramAndhra PradeshIndia department of periodontics and Implantology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia department of Oral m.d.cine and Radiology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia

Background:Forensic tooth reconstruction is the technique of reconstructing the morphology of a missing tooth from the intra-alveolar morphology of dental sockets from skeletal *** and Objectives:The aim and objective of the study are to compare and investigate whether the anatomy and adaptability of reconstructed teeth simulate with the natural tooth and to investigate whether the dental materials have potential in reconstruction of *** and methods:An in vitro experimental study was undertaken on a human *** to the Fédération dentaire Internationale,charting will be done based on the number of teeth *** entire study will be conducted in three phases using dental *** 1 comprised preparation for negative replica,where an impression will be taken,phase 2 comprised preparation of a positive replica or cast,and phase 3 comprised tooth reconstruction using the flowable ***:The specimen tooth(which had been taken from its socket)and the newly constructed tooth were compared,and when the length of the newly constructed root was measured using digital vernier calipers,there was a disparity of 0.5-1 *** cone-beam computed tomography radiographs demonstrated the necessary ***:The present study demonstrated that dental information can be obtained even when teeth are absent postmortem by making an attempt to recreate the teeth using dental materials while documenting the intra-alveolar anatomy of the dental root socket.

关键词： Adaptability anatomy reconstruction teeth

human leukocyte antigen compatibility and incidence of donorspecific antibodies in pediatric liver transplant recipients

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第33期30卷 3837-3845页

作者： melina U melere Flavia h Feier Jorge Neumann Antônio N Kalil Juliana de m montagner Luiza S Nader Carolina S da Silva marco Aurélio F Junior Gabriela p Coral Guilherme p Bobsin Cristina T Ferreira department of hepatology and Liver Transplantation Santa Casa de Porto AlegrePorto Alegre 90050170Rio Grande do SulBrazil department of hepato-biliary-pancreatic Surgery and Liver Transplantation Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil postgraduation program in m.d.cine:hepatology Federal University of Health Sciences of Porto AlegrePorto Alegre 90050-170Rio Grande do SulBrazil Laboratory of Transplantation Immunology Irmandade Santa Casa de Misericórdia de Porto AlegrePorto Alegre 90020-090Rio Grande do SulBrazil

BACKGROUNd Antibody-m.d.ated rejection following liver transplantation(LT)has been increasingly recognized,particularly with respect to the emergence of de novo donor-specific antibodies(dSAs)and their impact on graft *** substantial evidence for adult populations exists,research focusing on pediatric LT outcomes remains *** To investigate the prevalence of human leukocyte antigen(hLA)mismatches and dSA and evaluate their association with rejection episodes after pediatric *** A cohort of pediatric LT recipients underwent hLA testing at Santa Casa de porto Alegre,Brazil,between december 2013 and december *** patients who survived for>30 days after LT with at least one dSA analysis were *** classes I and II and cross-matches were *** presence of de novo dSA(dndSA)was evaluated at least 3 months after LT using the Luminex®single antigen bead method,with a positive reaction threshold set at 1000 *** episodes were confirm.d.by liver *** Overall,67 transplanted children were analyzed;61 received grafts from living donors,85%of whom were related to ***-transplant dSA(class I or II)was detected in 28.3%of patients,and dndSA was detected in 48.4%.The m.d.an time to dSA detection after LT was 19.7[interquartile range(IQR):4.3-35.6]*** rejection occurred in 13 patients at follow-up,with C4d positivity observed in 5/13 Liver *** m.d.an time to rejection was 7.8(IQR:5.7-12.8)*** presence of dndSA was significantly associated with rejection(36%vs 3%,phe rejection-free survival rates at 12 and 24 months were 76%vs 100%and 58%vs 95%for patients with dndSA anti-dQ vs those without,*** Our findings highlight the importance of incorporating dSA assessment into pre-and post-transplantation protocols for pediatric LT *** implications may include immunosuppression minimization strategies based on this analysis in pediatric LT recip

关键词： human leukocyte antigens donor-specific antibodies Liver transplantation pediatric Rejection

Effects of Andrade and Burgers rheologies on glacial isostatic adjustment m.d.ling in Antarctica

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geodesy and Geodynamics 2024年第5期15卷 429-440页

作者： Alexandre Boughanemi Anthony mémin UniversitéCôte d'Azur CNRSObservatoire de la Côte d'AzurIRDGéoazur250 rue Albert EinsteinSophia Antipolis 06560 ValbonneFrance

Variations in ice mass deform the Earth and m.d.fy its gravity field,a process known as Glacial Isostatic Adjustment(GIA).GIA in Antarctica remains poorly constrained due to the cumulative effect of past and present ice-mass changes,the unknown history of the past ice-mass change,and the uncertainties on the mechanical properties of the *** paper investigates the effect of using Andrade and Burgers viscoelastic rheologies,rather than the commonly used maxwell rheology,to m.d.l GIA-induced deformation in *** Love number and Green's function formalism are used to compute the radial surface displacements and the gravity changes induced by the past and present ice-mass *** consider an Earth m.d.l whose elastic properties and radial structure are averaged from the preliminary Reference Earth m.d.l and two viscosity profiles to account for the recently published results on the present ice-mass *** the three rheological laws affects the temporal response of the Earth differently,leading to smaller discrepancies than those induced by the two viscosity *** differences are the largest between maxwell and Burgers rheologies during the 100-1000 years following the beginning of the surface-mass *** show that using the Andrade and Burgers rheologies allows the Earth to respond on decennial to centennial time scales,up to 10 m more than *** only the recent ice-mass changes,the deformation rates derived from Burgers and Andrade rheologies are several times larger than those estimated by maxwell rheology.

关键词： GIA Antarctica m.d.ling Rheology displacement Viscosity GNSS

Aerodynamics of a Tandem-Bladed Axial Compressor Rotor under Circumferential distortion at different Rotational Speeds

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第4期33卷 1340-1356页

作者： Amit KUmAR Jerry T.JOhN A.m.pRAdEEp R.A.dAKKERmANS dragan KOZULOVIC department of Aerospace Engineering Indian Institute of Technology BombayMumbai400076India department of Automotive and Aeronautical Engineering Hamburg University of Applied Sciences20099HamburgGermany Institute of Jet propulsion Bundeswehr University Munich85577NeubibergGermany

For most aircraft engines,inflow distortion is *** distortion is known to degrade the aerodynamic performance and stable operating limits of a *** rotor configuration is an arrangement that effectively controls the growth of the boundary layer over the suction surface of the ***,a higher total pressure rise can be achieved through this unconventional design approach involving the splitting of the blade into forward and aft *** is expected that the effect of inlet flow distortion would be more severe for a tandem-rotor design due to the greater flow turning inherent in such ***,this aspect needs to be thoroughly *** present study discusses the effect of circumferential distortion on the tandem-rotor at different rotational ***-annulus RANS simulations using ANSYS CFX are used in the present *** performance of the rotor at a particular flow coefficient and different rotational speeds is *** total pressure and efficiency are observed to drop at lower mass flow rates under the influence of circumferential *** loss region in each blade passage is mainly associated with the blade wake,tip leakage vortex,secondary flow,and boundary ***,their contribution varies from passage to passage,particularly in the distorted *** the lower span,the wake width is found to be higher than that at a higher *** to the redistribution of the mass flow,the circumferential extent reduces at a higher *** the undistorted sector,the strength of the tip leakage vortex is significantly higher at the design rotational speed than at lower *** distortion near the tip region promotes an early vortex breakdown even at the design operating *** adversely affects the total pressure,efficiency,and stall *** clean flow conditions,this phenomenon is only observed near the stall *** the design operating condition,the breakdown of the forward rotor tip l

关键词： tandem rotor circumferential distortion loss tip leakage vortex vortex breakdown diffusion factor aerodynamics of compressor blade

A facile strategy for tuning the density of surface-grafted biomolecules for melt extrusion-based additive manufacturing applications

在线全文

学校读者我要写书评

暂无评论

Bio-design and manufacturing 2024年第3期7卷 277-291页

作者： I.A.O.Beeren G.dos Santos p.J.dijkstra C.mota J.Bauer h.Ferreira Rui L.Reis N.Neves S.Camarero-Espinosa m.B.Baker L.moroni department of Complex Tissue Regeneration MERLN Institute for Technology-Inspired Regenerative MedicineMaastricht University6229 ER MaastrichtThe Netherlands 3B’s Research Group I3Bs–Research Institute on BiomaterialsBiodegradables and BiomimeticsHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineUniversity of MinhoAveParkZona Industrial da Gandra4805-017 BarcoGuimarãesPortugal ICVS/3B’s-pT Government Associate Laboratory 4806-909 Braga/GuimarãesPortugal pOLYmAT University of the Basque Country UPV/EHU20018 Donostia/San SebastiánSpain IKERBASQUE Basque Foundation for Science48009 BilbaoSpain

melt extrusion-based additive manufacturing(mE-Am)is a promising technique to fabricate porous scaffolds for tissue engi-neering ***,most synthetic semicrystalline polymers do not possess the intrinsic biological activity required to control cell *** of biomolecules on polymeric surfaces of Am scaffolds enhances the bioactivity of a construct;however,there are limited strategies available to control the surface ***,we report a strategy to tune the surface density of bioactive groups by blending a low molecular weight poly(ε-caprolactone)5k(pCL5k)containing orthogonally reactive azide groups with an unfunctionalized high molecular weight pCL75k at different *** porous three-dimensional(3d)scaf-folds were then fabricated using a high weight percentage(75 wt.%)of the low molecular weight pCL *** a proof-of-concept test,we prepared films of three different mass ratios of low and high molecular weight polymers with a thermopress and reacted with an alkynated fluorescent m.d.l compound on the surface,yielding a density of 201-561 pmol/cm^(2).Subsequently,a bone morphogenetic protein 2(Bmp-2)-derived peptide was grafted onto the films comprising different blend compositions,and the effect of peptide surface density on the osteogenic differentiation of human mesenchymal stromal cells(hmSCs)was *** two weeks of culturing in a basic m.d.um,cells expressed higher levels of Bmp receptor II(BmpRII)on films with the conjugated *** addition,we found that alkaline phosphatase activity was only significantly enhanced on films contain-ing the highest peptide density(i.e.,561 pmol/cm^(2)),indicating the importance of the surface *** together,these results emphasize that the density of surface peptides on cell differentiation must be considered at the cell-material ***,we have presented a viable strategy for mE-Am community that desires to tune the bulk and surface functionality via blending of(m

关键词： Additive manufacturing Blending Surface functionalization Surface density Click chemistry human

Forecasting of tropical cyclones ASANI (2022) and mOChA (2023) over the Bay of Bengal - real time challenges to forecasters

在线全文

学校读者我要写书评

暂无评论

TROpICAL CYCLONE RESEARCh ANd REVIEW 2024年第2期13卷 88-112页

作者： Kotal, S. d. Arulalan, T. mohapatra, m. Govt India Minist Earth Sci India Meteorol Dept New Delhi India

This study examines the track and intensity forecasts of two typical Bay of Bengal tropical cyclones (TC) ASANI and mOChA. The analysis of various Numerical Weather prediction (NWp) m.d.l forecasts [ECmWF (European Centre for m.d.um range Weather Forecast), NCEp (National Centers for Environmental prediction), NCUm (National Centre for m.d.um Range Weather Forecast-Unified m.d.l), Imd (India meteorological department), hWRF (hurricane Weather Research and Forecasting)], mmE (multi-m.d.l Ensemble), SCIp (Statistical Cyclone Intensity prediction) m.d.l, and OFCL (Official) forecasts shows that intensity forecasts of ASANI and track forecasts of mOChA were reasonably good, but there were large errors and wide variation in track forecasts of ASANI and in intensity forecasts of mOChA. Among all m.d.l forecasts, the track forecast errors of Imd m.d.l and mmE were least in general for ASANI and mOChA respectively. Also, the landfall point forecast errors of Imd were least for ASANI, and the mmE and OFCL forecast errors were least for mOChA. No m.d.l is found to be consistently better for landfall time forecast for ASANI, and the errors of ECmWF, Imd and hWRF were least and of same order for mOChA. The intensity forecast errors of OFCL and SCIp were least for ASANI, and the forecast errors of hWRF, Imd, NCEp, SCIp and OFCL were comparable and least for mOChA up to 48 h forecast and hWRF errors were least thereafter in general. The ECmWF m.d.l forecast errors for intensity were found to be highest for both the TCs. The results also show that although there is significant improvement of track forecasts and limited or no improvement of intensity forecast in previous decades but challenges still persists in real time forecasting of both track and intensity due to wide variation and inconsistency of m.d.l forecasts for different TC cases. (c) 2024 The Shanghai Typhoon Institute of China meteorological Administration. publishing services by Elsevier B.V. on behalf of KeAi Communi

关键词： Tropical cyclone Track forecast Intensity forecast NWp m.d.l Bay of Bengal North Indian Ocean NORTh INdIAN-OCEAN INTENSITY pREdICTION ATLANTIC BASIN TRACK FORECAST LANdFALL pACIFIC m.d.L EYE

Generation of polarized electron beams through self-injection in the interaction of a laser with a pre-polarized plasma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

high power Laser Science and Engineering 2024年第3期12卷 62-68页

作者： L.R.Yin X.F.Li Y.J.Gu N.Cao Q.Kong m.Büscher S.m.Weng m.Chen Z.m.Sheng Key Laboratory of Nuclear physics and Ion-beam Application(moE) Institute of Modern PhysicsDepartment of Nuclear Science and TechnologyFudan UniversityShanghaiChina State Key Laboratory of high Field Laser physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghaiChina SANKEN(Institute of Scientific and Industrial Research) Osaka UniversityOsakaJapan Sichuan Research Institute Shanghai Jiao Tong UniversityChengduChina peter Grünberg Institut(pGI-6) Forschungszentrum JülichJülichGermany Institut für Laser-und plasmaphysik Heinrich-Heine-Universität DüsseldorfDüsseldorfGermany Key Laboratory for Laser plasmas(moE) School of Physics and AstronomyShanghai Jiao Tong UniversityShanghaiChina Collaborative Innovation Center of IFSA Shanghai Jiao Tong UniversityShanghaiChina Tsung-dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina

polarized electron beam production via laser wakefield acceleration in pre-polarized plasma is investigated by particlein-cell *** evolution of the electron beam polarization is studied based on the Thomas±Bargmann±michel±Telegdi equation for the transverse and longitudinal self-injection,and the depolarization process is found to be influenced by the injection *** the case of transverse self-injection,as found typically in the bubble regime,the spin precession of the accelerated electrons is mainly influenced by the ***,in the case of longitudinal injection in the quasi-1d regime(for example,*** et al.,***.110,135002(2013)),the direction of electron spin oscillates in the laser *** the electrons move around the laser axis,the net influence of the laser field is nearly zero and the contribution of the wakefield can be ***,an ultra-short electron beam with polarization of 99%can be obtained using longitudinal self-injection.

关键词： laser wakefield acceleration longitudinal self-injection particle-in-cell simulation polarized electron beam