检索结果-南通市图书馆

Use of donepezil for neurocognitive recovery after brain injury in adult and pediatric populations:a scoping review

Neural Regeneration Research 2024年第8期19卷 1686-1695页

作者： Avery L.Miller Nathan K.Evanson J.michael taylor University of Cincinnati College of Medicine CincinnatiOHUSA Department of Pediatrics University of CincinnatiCincinnatiOHUSA Department of Neurology and Rehabilitation Medicine University of CincinnatiCincinnatiOHUSA Division of Pediatric Rehabilitation Medicine Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA Division of Neurology Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA

There are few pharmacologic options for the treatment of cognitive deficits associated with traumatic brain injury in pediatric *** inhibitors such as donepezil have been evaluated in adult patients after traumatic brain injury,but relatively less is known about the effect in pediatric *** goal of this review is to identify knowledge gaps in the efficacy and safety of acetylcholinesterase inhibito rs as a potential a djuvant treatment fo r neurocognitive decline in pediatric patients with traumatic brain *** queried PubMed to identify literature published from database inception thro ugh June 2023 desc ribing the use of donepezil in young adult traumatic brain injury and pediatric patients with predefined *** on preselected search criteria,340 unique papers we re selected for title and abstra ct ***-two reco rds were reviewed in full after eliminating preclinical studies and pape rs outside the scope of the *** adult traumatic brain injury,we review results from 14 papers detailing 227 subjects where evidence suggests donepezil is well tole rated and shows both objective and patient-reported efficacy for reducing cognitive *** children,3 pape rs report on 5 children recovering from traumatic brain injury,showing limited *** additional 15 pediatric studies conducted in populations at risk for cognitive dysfunction provide a broader look at safety and efficacy in 210 patients in the pediatric age *** its promise for efficacy in adults with traumatic brain injury and tole rability in pediatric patients,we believe further study of donepezil for children and adolescents with traumatic brain injury is warranted.

关键词： acetylcholinesterase inhibitor adult cognition donepezil pediatrics traumatic brain injury

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

I Don’t Peer-Review for Non-Open Journals,and Neither Should You

引用

Journal of Data and Information Science 2022年第2期7卷 1-3页

作者： michael P.taylor Department of Earth Sciences University of BristolBristol BS81RJEngland

“The reasonable man adapts himself to the world;the unreasonable one persists in trying to adapt the world to *** all progress depends on the unreasonable man.”-Maxims for Revolutionists,George Bernard Shaw(1903).In the twenty years since the Budapest Open Access Initiative(BOAI,2002)defined the term“open access”(OA)and laid out the unanswerable case in its favour,the growth of OA has been *** publishers,dependent on the revenue stream provided by subscriptions,have repeatedly attempted to stem this tide,and have certainly succeeded in delaying it-to no-one’s benefit but their *** OA progresses despite this rearguard action,especially in recent years through the adoption by many major research funders of the Plan S declaration(Plan S,2018),that open-access publication is a condition of grant *** the time of writing,over half of all newly published papers are open access either immediately or within a few months(Piwowar,Priem,&Orr,2019),and the proportion continues to increase rapidly.

关键词： Open repeatedly continue

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Treatment implications of posterior fossa ependymoma subgroups

引用

Chinese Journal of Cancer 2016年第11期35卷 563-566页

作者： Vijay Ramaswamy michael D.taylor Division of Haematology/Oncology Hospital for Sick Children Division of Neurosurgery Hospital for Sick Children

Posterior fossa ependymoma comprises two distinct molecular entities,ependymoma_posterior fossa A(EPN_PFA)and ependymoma_posterior fossa B(EPN_PFB),with differentiable gene expression *** yet,the response of the two entities to treatment is *** determine the relationship between the two molecular subgroups of posterior fossa ependymoma and treatment,we studied a cohort of 820 patients with molecularly profiled,clinically annotated posterior fossa *** found that the strongest predictor of poor outcome in patients with posterior fossa ependymoma across the entire age spectrum was molecular subgroup EPN_PFA,which was recently reported in the paper entitled "Therapeutic impact of cytoreductive surgery and irradiation of posterior fossa ependymoma in the molecular era:a retrospective multicohort analysis" in the Journal ofClinical *** with incompletely resected EPN_PFA tumors had a very poor outcome despite receiving adjuvant radiation therapy,whereas a substantial proportion of patients with EPN_PFB tumors can be cured with surgery alone.

关键词： Posterior fossa ependymoma Genomics Radiation PFA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

IOSCO《证券监管目标和原则》述评

引用

证券市场导报 2004年第8期 70-75页

作者： michael taylor 张文国际货币基金组织

1998年5月28日国际证券事务委员会(IOSCO)发布了《证券监管的目标和原则》的咨询文件,该文阐述了证券监管的三大目标和三十条原则,与同年巴塞尔委员会颁布的《核心原则》相仿。当年9月《证券监管的目标和原则》正式对外颁布。该文分别在... 详细信息

1998年5月28日国际证券事务委员会(IOSCO)发布了《证券监管的目标和原则》的咨询文件,该文阐述了证券监管的三大目标和三十条原则,与同年巴塞尔委员会颁布的《核心原则》相仿。当年9月《证券监管的目标和原则》正式对外颁布。该文分别在2002年2月和2003年5月两度更新,但更新内容全部在附录部分。这篇评述文章试图探讨、挖掘该文件背后的动机,评估其对国际证券监管可能产生的影响。本刊刊发此译文,期望对国内证券监管有所启迪。

关键词： IOSCO 国际证券事务委员会《证券监管目标和原则》咨询文件证券监管者国际金融市场

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mouse models of medulloblastoma

引用

Chinese Journal of Cancer 2011年第7期30卷 442-449页

作者： Paul A.Northcott Sidney Croul michael D.taylor Arthur and Sonia Labatt Brain Tumor Research Center Hospital for Sick Children

Medulloblastoma is the most common malignant pediatric brain tumor. Despite its prevalence and importance in pediatric neuro-oncology, the genes and pathways responsible for its initiation, maintenance, and progression remain poorly understood. Genetically engineered mouse models are an essential tool for uncovering the molecular and cellular basis of human diseases, including cancer, and serve a valuable role as preclinical models for testing targeted therapies. In this review, we summarize how such models have been successfully applied to the study of medulloblastoma over the past decade and what we might expect in the coming years.

关键词：小鼠模型母细胞遗传工程人类疾病脑肿瘤发病率小儿神经

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Molecular genetics of ependymoma

引用

Chinese Journal of Cancer 2011年第10期30卷 669-681页

作者： Yuan Yao Stephen C. Mack michael D. taylor Division of Neurosurgery Arthur and Sonia LabattBrain Tumour Research Centre Hospital for Sick Children TorontoOntario Canada Department of Laboratory Medicine and Pathobiology University of Toronto Toronto Ontario Canada.

Brain tumors are the leading cause of cancer death in children,with ependymoma being the third most common and posing a significant clinical *** mechanism of pathogenesis,reliable prognostic indicators,and effective treatments other than surgical resection have all remained *** recently,ependymoma research was hindered by the small number of tumors available for study,low resolution of cytogenetic techniques,and lack of cell lines and animal *** heterogeneity,which manifests as variations in tumor location,patient age,histological grade,and clinical behavior,together with the observation of a balanced genomic profile in up to 50% of cases,presents additional challenges in understanding the development and progression of this *** these difficulties,we have made significant headway in the past decade in identifying the genetic alterations and pathways involved in ependymoma tumorigenesis through collaborative efforts and the application of microarray-based genetic(copy number) and transcriptome profiling *** characterization of ependymoma unraveled distinct mRNA-defined subclasses and led to the identification of radial glial cells as its cell type of *** review summarizes our current knowledge in the molecular genetics of ependymoma and proposes future research directions necessary to further advance this field.

关键词：分子遗传学室管膜肿瘤发生发病机制手术切除动物模型遗传变异遗传特性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Conjugate strike-slip faulting along the Bangong-Nujiang suture zone accommodates coeval east-west extension and north-south shortening in the interior of the Tibetan Plateau

Conjugate strike-slip faulting along the Bangong-Nujiang sut...

引用

中国科学院地质与地球物理研究所2003学术年会

作者： michael taylor Frederick J.Ryerson Paul Kapp Department of Earth and Space Sciences University of California and Institute of Geophysics and Planetary PhysicsLos AngelesCaliforniaUSA Institute of Geophysics and Planetary Physics.Lawrence Livermore National Laboratory LivermoreCaliforniaUSA Department of Geosciences University of ArizonaTucson.ArizonaUSA

Geologic investigations of how the Tibetan plateau is currently deforming have focused primarily on its boundary ***,how the interior of the plateau deforms remains poorly *** fill this gap in knowledge,we conducted field mapping,analysis of remote sensing and digital topographic data,and reinterpretation of existing geologic maps in central *** study reveals a 200-300 km wide and 1500-1800 km long east trending zone of conjugate strike-slip faults across central *** central Tibet conjugate fault zone is comprised of northeast striking left-slip faults north of the Bangong-Nujiang suture and northwest striking right-slip faults(?)uth of the suture *** strike-slip faults are k(?)matically linked with north trending Tibetan rifts located north and south of the conjugate fault *** exception,all conjugate faults intersect or merge toward one another along the Bangong-Nujiang suture *** on these faults accommodates coeval east-west extension and north-south *** determine the fault kinematics and the magnitude of fault slip,we investigated three conjugate fault sets in the central Tibet fault zone. These include from east to vest,the Dong *** Co,and Aishi Co c(?)gate mult systems,which are adjacent to the Bangong-Nujiang suture zone and separated by a distance of 400 and 70 km, *** average magnitude of fault motion on individual strike-slip faults is～12 km as determined by offsets of Tertiary thrusts and Paleozoic-Mesozoic lithologic *** conjugate fault configuration requires 12 km of north-south contraction across the 200-300 km fault zone since its *** the conjugate strike-slip faults are kinematically linked with the north trending Tibetan rifts which initiated between 14 and 8 Ma,our estimated magnitude of north-south contraction implies a contraction rate of～1-2 mm/yr across central *** relatively closely spaced(<150 km) basins may result from a ser

关键词： conjugate strike-slip faults Tibet neotectonics extrusion tectonics

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

刍动驾驶汽车测试

引用

汽车制造业 2017年第20期 42-44页

作者： michael taylor

自动驾驶汽车要想获得公开路段的测试许可执照，是个非常困难但也非常重要的事情，与此同时，租用专用测试场地，或者在自己拥有的专用测试区域内，对自动驾驶汽车进行测试也是重中之重。

关键词：自动驾驶汽车汽车测试测试场地测试区路段

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

BMW的燃料电池汽车原型开发

引用

汽车制造业 2017年第7期 38-40页

作者： michael taylor

宝马公司（BMW）在氢动力技术上进行了大量投资，除了备受关注的最新两代的燃料电池5系GT原型车，探秘这家公司的一些早期原型，竟然还有装备了燃料电池的一款i8秘密车型。根据宝马公司的长期计划，纯电动车（BEV）会用于较小的轿车，... 详细信息

宝马公司（BMW）在氢动力技术上进行了大量投资，除了备受关注的最新两代的燃料电池5系GT原型车，探秘这家公司的一些早期原型，竟然还有装备了燃料电池的一款i8秘密车型。根据宝马公司的长期计划，纯电动车（BEV）会用于较小的轿车，而燃料电池将用于更长续驶里程的汽车。

关键词：燃料电池汽车原型开发 BMW 宝马公司动力技术长期计划纯电动车续驶里程

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

影子银行的中西对比

引用

首席财务官 2015年第Z1期 24-27页

作者： Richard Cantor michael taylor 穆迪穆迪亚太区

西方影子银行体系的风险在于短期商业票据和回购市场提供的资金无法展期,而中国影子银行体系的风险则是理财产品投资者会撤回其资金。合理设计期限的资产证券化可能会消除多数理财产品所固有的期限错配情况。虽然中国与西方的非银行信... 详细信息

西方影子银行体系的风险在于短期商业票据和回购市场提供的资金无法展期,而中国影子银行体系的风险则是理财产品投资者会撤回其资金。合理设计期限的资产证券化可能会消除多数理财产品所固有的期限错配情况。虽然中国与西方的非银行信贷中介体系通常都被称为"影子银行",但实际上其差异至少与其相似处一样显著。主要的区别在于西方的影子银行体系集中在资本市场实体和活动方面,而中国的影子银行涉及金融中介,其经济职能(若非法定形式)与银行在最重要的方面相似("类银行")。这些差异具有重大信用影

关键词：影子银行撤资影子银行体系借款人理财产品

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：