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Antimicrobial susceptibility testing in veterinary medicine:performance,interpretation of results,best practices and pitfalls

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One Health Advances 2023年第1期1卷 62-77页

作者： Andrea t.Feßler Yang Wang Claire R.Burbick Dubraska Diaz-Campos Virginia RFajt Sara D.Lawhon Xian-Zhi Li Brian V.Lubbers Kelli Maddock Ron A.Miller Mark G.Papich Shabbir Simjee michael t.sweeney Jeffrey L.Watts Congming Wu Jianzhong Shen Stefan Schwarz Institute of Microbiology and Epizootics Centre for Infection MedicineSchool of Veterinary MedicineFreie Universität BerlinBerlinGermany Veterinary Centre for Resistance Research(tZR) Freie Universität BerlinBerlinGermany National Key Laboratory of Veterinary Public Health and Safety College of Veterinary MedicineChina Agricultural UniversityBeijingChina Key Laboratory of Animal Antimicrobial Resistance Surveillance Ministry of Agriculture and Rural AffairsCollege of Veterinary MedicineChina Agricultural UniversityBeijingChina Department of Veterinary Microbiology and Pathology College of Veterinary MedicineWashington State UniversityPullmanWAUSA Department of Clinical Sciences College of Veterinary MedicineThe Ohio State UniversityColumbusOHUSA texas A&M University School of Veterinary Medicine College StationTXUSA Veterinary Drugs Directorate Health CanadaOttawaONCanada Department of Clinical Sciences College of Veterinary MedicineKansas State UniversityManhattanKSUSA North Dakota State University Veterinary Diagnostic Laboratory FargoNDUSA U.S.Food and Drug Administration Center for Veterinary MedicineRockvilleMDUSA College of Veterinary Medicine North Carolina State UniversityRaleighNCUSA Elanco Animal Health HookUK Zoetis Inc.KalamazooMIUSA.

the performance of antimicrobial susceptibility testing(ASt)of bacteria and the interpretation of ASt results for bacteria isolated from animals are complex tasks which must be performed using standard published methodology and overseen by experts in clinical microbiology and in consultation with clinical ***,ASt has significant potential for errors and *** this review,we provide guidance on how to correctly perform ASt of bacteria isolated from animals and interpret the ASt *** emphasis is placed on the various approved or published methodologies for the different bacteria as well as the application of interpretive criteria,including clinical breakpoints and epidemiological cut-off values(ECVs/ECOFFs).Application of approved interpretive criteria and definitions of susceptible,susceptible dose-dependent,nonsusceptible,intermediate,and resistant for clinical breakpoints as well as wild-type and non-wildtype for ECVs,are explained and the difficulties resulting from the lack of approved clinical breakpoints for other bacteria,indications,and animal species is *** requirement of quality controls in any ASt approach is also *** addition,important parameters,often used in monitoring and surveillance studies,such as MIC50,MIC90,and testing range,are explained and criteria for the classification of bacteria as multidrug-resistant,extensively drug-resistant or pandrug-resistant are *** mistakes are presented and the means to avoid them are *** provide the most accurate ASt,one must strictly adhere to approved standards or validated methodologies,like those of the Clinical and Laboratory Standards Institute or other internationally accepted ASt documents and the detailed information provided therein.

关键词： Antimicrobial susceptibility testing Quality controls Clinical breakpoints Epidemiological cut-off values Multidrug resistance

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Effect of various aromatic compounds with different functional groups on enzymatic hydrolysis of microcrystalline cellulose and alkaline pretreated wheat straw

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Journal of Bioresources and Bioproducts 2024年第2期9卷 211-221页

作者： Yufeng Yuan Xinyu Guo Bo Jiang Wenjuan Wu tingwei Zhang michael sweeney Mehraj Ahmad Yongcan Jin Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources International Innovation Center for Forest Chemicals and MaterialsJiangsu Provincial Key Lab of Pulp and Paper Science and TechnologyNanjing Forestry UniversityNanjing 210037China School of Chemistry and Chemical Engineering Queen’s University BelfastBelfast BT71NNNorthern Ireland United Kingdom Department of Food Science and Engineering College of Light Industry and Food EngineeringNanjing Forestry UniversityNanjing 210037China

Low molecular aromatic compounds are detrimental to the enzymatic hydrolysis of ***,the specific role of their functional groups remains ***,a series of nine aromatic compounds as additives were tested to understand their effect on the hydrolysis yield of microcrystalline cellulose(MCC)and alkaline pretreated wheat *** on the results,the inhibition of aldehyde groups on MCC was greater than that of carboxyl groups,whereas for the alkaline pretreated wheat straw case,the inhibitory effect of aldehyde groups was lower than that of carboxyl *** methoxyl groups of aromatic compounds reduced the inhibitory ef-fect on enzymatic hydrolysis of both *** inhibition of aromatic compounds on MCC hydrolysis was detected in comparison with the alkaline pretreated wheat straw,indicating that the substrate lignin can offset the inhibition to a certain *** all aromatic com-pounds,syringaldehyde with one aldehyde group and two methoxyl groups improved the glucan conversion of the alkaline pretreated wheat straw.

关键词： Aromatic compound Functional group Enzymatic hydrolysis Alkaline pretreated wheat straw Microcrystalline cellulose

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REENGAGING tHE LAND At tHE GEORGE *** PRESIDENtIAL CENtER

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Journal of Green Building 2014年第3期9卷 3-22页

作者： Laura Solano Herb sweeney IV michael Van Valkenburgh Associates Landscape Architects Senior Associate Michael Van Valkenburgh AssociatesLandscape Architects

In planning the George *** Presidential Center in Dallas,texas,former First Lady Laura Bush presented a very clear vision of what the Center should epitomize:“Because George was the first president of the new millennium,I wanted it to be forward and modern.”1 For the president and *** this meant making the building and landscape environmentally responsible,beautiful,and *** particular,their love of native texas landscapes was an important framework for transforming the project’s urban site into a park that was sustainable and experientially rich for *** was addressed from the start with smart planning that privileged contiguous parkland over impermeable surfaces and *** consideration of every landscape component—-stormwater,plants,soil,topography,and more—netted cohesive natural systems that are better able to succeed with short-term establishment and provide enduring long-term health,the ultimate goals for a sustainable landscape.

关键词： presidential libraries parks sustainable landscapes stormwater management cistern irrigation tank forebay bioswale native ecologies native plants prairies meadows planting soil texas

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Waste-to-Fuel technology in Albania——How to Implement a Renewable Energy System in Europe’s Largest Onshore Oilfield

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Journal of Earth Science 2019年第6期30卷 1311-1325页

作者： Besmir Buranaj Hoxha Dael Dervishi Kyle sweeney PetroFluids LLC Houston TX 77084USA McCain Institute Washington D.C.20006USA Fulbright Program&UNDP PrishtinaThe Republic of Kosovo

Albania has historically been known to have an active but challenging drilling activity that demands the most innovative technology to develop,predominantly,medium-heavy oil *** recent efforts have been made by the government to stimulate and expand the largest onshore European oilfield,technical and economical obstacles are *** obstacles make it difficult to fully develop reliable and profitable hydrocarbon bearing zones in a downturn economy,especially since Albanian oil can be costly to produce and *** to these typical issues that affect many local energy sectors,many developed countries diversify their energy production to avoid strict dependency on crude *** emblematic and modern option that is extensively gaining popularity in Europe focuses on renewable energy from sophisticated recycling *** Albania is a relatively"green"country when it pertains to its electricity production(97%hydropower and 3%fossil fuels),it has yet to develop energy-recycling programs that it can salvage for self-sustainable energy *** past years have seen a conscious revitalization and stimulation in the mentality of green economy in ***,in comparison to the rest of"western Europe"that are leading world examples in efficient recycling,it is significantly lagging with initial strides just now focusing on aligning national legislations with current EU ***,two crucial reasons that should motivate Albania to investigate new applications for energy recycling are:(1)alternatives to crude oil and petroleum products that can be supplemental and provide stable access to fossil fuels;(2)industrial and municipal recycling via waste management to reprocess waste and produce industrial raw material-spawning the emergence of a"circular economy"to develop the backbone needed to strengthen the industrial and manufacturing markets for a self-sustaining ***,in this paper,the topic that will be addressed,giv

关键词： renewable energy pyrolysis waste-to-fuel technology circular economy plastic-to-fuel alternative energy

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Sensorimotor dysfunctions as primary features of autism spectrum disorders

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Science China(Life Sciences) 2015年第10期58卷 1016-1023页

作者： Matthew W.MOSCONI John A.sweeney Departments of Psychiatry and Pediatrics University of Texas Southwestern Medical Center

Motor impairments in autism spectrum disorders(ASD) have received far less research attention than core social- communication and cognitive features. Yet, behavioral, neurophysiological, neuroimaging and histopathological studies have documented abnormal motor system development in the majority of individuals with ASD suggesting that these deficits may be primary to the disorder. there are several unique advantages to studying motor development in ASD. First, the neurophysiological substrates of motor skills have been well-characterized via animal and human lesion studies. Second, many of the single-gene disorders associated with ASD also are characterized by motor dysfunctions. third, recent evidence suggests that the onset of motor dysfunctions may precede the emergence of social and communication deficits during the first year of life in ASD. Motor deficits documented in ASD indicate disruptions throughout the neuroaxis affecting cortex, striatum, the cerebellum and brainstem. Questions remain regarding the timing and development of motor system alterations in ASD, their association with defining clinical features, and their potential for parsing heterogeneity in ASD. Pursuing these questions through neurobiologically informed translational research holds great promise for identifying gene-brain pathways associated with ASD.

关键词： autism motor cerebellum dyspraxia oculomotor

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Comparison of the timing of spring phenological events between phenological garden trees and wild populations

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Journal of Plant Ecology 2024年第2期17卷 49-61页

作者： Calum J.sweeney Fidelma Butler Astrid Wingler School of Biological Earth&Environmental Sciences and Environmental Research InstituteUniversity College CorkDistillery FieldsNorth MallCork T23 TK30Ireland

Phenological research is engaged in monitoring the infuence of climate change on the natural *** International Phenological Gardens(IPG)network provides a valuable dataset of standardized tree phenology records dating back to the mid-20th *** make best use of this actively growing record,it is important to investigate how network data can be applied to predict the timing of phenological events in natural *** study compared clonally propagated IPG downy birch(Betula pubescens Ehrh.)and hazel(Corylus avellana L.)specimens of central European provenance to nearby wild populations at the western-most margin of the IPG network,in the south-west of *** addition to monitoring by trained scientists,observations by citizen scientists were *** order of the timing of phenological events among sites was consistent across 2 years,confrming reproducibility of the *** trees had the earliest *** leaf unfolding and *** fowering dates of the sites *** addition,leaf unfolding occurred later in the wild populations than expected from the temperature responses of the *** and *** IPG *** variation in phenology also exceeded the historical change observed at the IPG site,suggesting a potential genetic basis for climate *** circumference,refecting the age-dependent increase in tree size,was found to infuence *** phenology,with earlier timing of phenological events in larger *** fnding highlights tree size as an important consideration in the management of phenological gardens and tree phenology research in general.

关键词： citizen science downy birch(Betula pubescens) hazel(Corylus avellana) phenological garden spring phenology tree size

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the effects of dietary supplementation with mushroom or selenium enriched mushroom powders on the growth performance and intestinal health of post-weaned pigs

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Journal of Animal Science and Biotechnology 2023年第3期14卷 1167-1181页

作者： Alison Dowley torres sweeney Eadaoin Conway Stafford Vigors Marion t.Ryan Supriya Yadav Jude Wilson John V.O’Doherty School of Agriculture and Food Science University College DublinBelfieldDublin 4Ireland School of Veterinary Medicine University College DublinBelfieldDublin 4Ireland Mbio Monaghan Mushroom GroupTyhollandCo.MonaghanIreland

Background there is an urgent need to identify natural bioactive compounds that can enhance gastrointestinal health and promote pig growth performance in the absence of pharmacological levels of zinc oxide(ZnO).the objectives of this study were to:1)compare the effects of mushroom powder supplemented with inorganic selenium(inSeMP)to mushroom powder enriched with organic selenium(orgSeMP)to pharmacological levels of ZnO on growth performance and faecal scores(FS)for the first 21 d post-weaning(Period 1);and 2)compare the molecular and microbial effects of inSeMP and orgSeMP in these pigs on d 39 post-weaning(Period 2).Methods In Period 1,pigs(3 pigs/pen;8 pens/treatment)were assigned to:(1)basal diet(control);(2)basal diet+zinc oxide(ZnO)(3100 mg/kg d 1–14,1550 mg/kg d 15–21);(3)basal diet+mushroom powder supplemented with inorganic selenium(inSeMP)containing selenium(selenite)content of 0.3 mg/kg feed;(4)basal diet+mushroom powder enriched with organic selenium(orgSeMP)containing selenium(selenocysteine)content of 0.3 mg/kg *** powders were included at 6.5 g/kg of *** In Period 1,there was no effect of diets on average daily gain(ADG)and gain:feed(G:F)ratio(P>0.05).the orgSeMP supplemented pigs had a lower average daily feed intake(ADFI)compared to all other groups(Pthe ZnO supplemented pigs had reduced FS compared to the basal and mushroom group,while the orgSeMP supplemented pigs had lower FS compared to the basal group during the 21 d experimental period(Pthere was no effect of diets on ADFI,ADG and G:F ratio(P>0.05).the orgSeMP supplementation increased the caecal abundance of bacterial members of the Firmicutes and Bacteroidetes phylum,including Lactobacillus,Agathobacter,Roseburia,and Prevotella and decreased the abundance of Sporobacter compared to the basal group,while inSeMP increased the caecal abundance of Prevotella and decreased the caecal abundance of Sporobacter compared to the basal group(Ptary

关键词： Agaricus bisporus Gastrointestinal microbiota Mushroom powder Organic selenium Pig Zinc oxide

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AI-Based Modeling and Data-Driven Evaluation for Smart Manufacturing Processes

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IEEE/CAA Journal of Automatica Sinica 2020年第4期7卷 1026-1037页

作者： Mohammadhossein Ghahramani Yan Qiao Meng Chu Zhou Adrian O’Hagan James sweeney the University College Dublin BelfieldDublin 4Ireland the Institute of Systems Engineering Macao University of Science and TechnologyMacaoChina the Helen and John C.Hartmann Department of Electrical and Computer Engineering New Jersey Institute of TechnologyNewarkNJ 07102 USA the Royal College of Surgeons in Ireland Dublin 8Ireland

Smart manufacturing refers to optimization techniques that are implemented in production operations by utilizing advanced analytics approaches. With the widespread increase in deploying industrial internet of things(IIOt) sensors in manufacturing processes, there is a progressive need for optimal and effective approaches to data *** machine learning and artificial intelligence to take advantage of manufacturing data can lead to efficient and intelligent automation. In this paper, we conduct a comprehensive analysis based on evolutionary computing and neural network algorithms toward making semiconductor manufacturing *** propose a dynamic algorithm for gaining useful insights about semiconductor manufacturing processes and to address various challenges. We elaborate on the utilization of a genetic algorithm and neural network to propose an intelligent feature selection algorithm. Our objective is to provide an advanced solution for controlling manufacturing processes and to gain perspective on various dimensions that enable manufacturers to access effective predictive technologies.

关键词： Artificial intelligence(AI) cyber physical systems feature selection genetic algorithms(GA) industrial internet of things(IIOt) machine learning neural network(NN) smart manufacturing

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Sand dunes as potential sources of dust in northern China

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Science China Earth Sciences 2016年第4期59卷 760-769页

作者： Mark R sweeney LU HuaYu CUI MengChun Joseph A MASON FENG Han XU ZhiWei Department of Earth Sciences University of South Dakota Laboratory of Earth Surface Process and Environment School of Geographic and Oceanographic Sciences Nanjing University Department of Geography University of Wisconsin-Madison

While saltation bombardment of sand grains on a fine substrate can produce considerable dust, the well-sorted nature of sand dunes tends to preclude them from consideration as major dust sources. Recent research, however, has revealed that sand dunes can, in some cases, be large sources of dust. We used the PI-SWERL(Portable In-Situ Wind Erosion Laboratory) to measure in the field the potential of sand dunes and other desert landforms to emit particulate matter t in the tengger, Ulan Buh, and Mu Us deserts of northern China. Combined with high resolution particle size measurements of the dune sand, an assessment of sand dunes as a dust source can be made. Large active transverse dunes tend to contain little to no stored PM-10, yet they produce a low dust flux. Coppice dunes stabilized by vegetation contain appreciable PM-10 and have very high dust emission potential. there is a positive correlation between the amount of PM-10 stored in a dune and its potential dust flux. Saltation liberates loose fines stored in dunes, making them very efficient dust emitters compared to landforms such as dry lake beds and washes where dust particles are unavailable for aeolian transport due to protective crusts or sediment cohesion. In cases where large dunes do not store PM-10 yet emit dust when active, two hypotheses can be considered:(1) iron-oxide grain coatings are removed during saltation, creating dust, and(2) sand grains collide during saltation, abrading grains to create dust. Observations reveal that iron oxide coatings are present on some dune sands. PI-SWERL data suggests that low dust fluxes from dunes containing no stored dust may represent an estimate for the amount of PM-10 dust produced by removal of iron oxide coatings. these results are similar to results from dunes in the United States. In addition, PI-SWERL results suggest that dust-bearing coppice dunes, which cover vast areas of China's sandy deserts, may become major sources of dust in the f

关键词： Coppice dunes transverse dunes Dust PI-SWERL Desert

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Pilot study of a novel serum mRNA gene panel for diagnosis of acute septic arthritis

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World Journal of Orthopedics 2019年第12期10卷 424-433页

作者： Blake J Schultz timothy sweeney Malcolm R DeBaun Melissa Remmel Uros Midic Purvesh Khatri michael J Gardner Department of Orthopedic Surgery Stanford UniversityRedwood CityCA 94063United States Inflammatix Inc863 Mitten RoadSuite 104BurlingameCA 94010United States Institute for Immunity Transplantation and InfectionsCenter for Biomedical ResearchDepartment of MedicineStanford UniversityStanfordRedwood CityCA 94305United States

BACKGROUND Septic arthritis is an orthopedic emergency requiring immediate surgical *** diagnostic standard of care is an invasive joint *** provide information about the inflammatory cells in the sample within a few hours,but there is often ambiguity about whether the source is infectious(***)or non-infectious(***).Cultures can take days to result,so decisions about surgery are often made with incomplete *** diagnostics are thus ***“Sepsis MetaScore”(SMS)is an 11-mRNA host immune blood signature that can distinguish between infectious and noninfectious acute *** has been validated in multiple cohorts across heterogeneous clinical *** to study whether the SMS holds diagnostic validity in determining the etiology of acute *** We conducted a blinded,prospective,non-interventional clinical study of the *** patients undergoing work-up for a septic primary joint were *** proceeded through the normal standard-of-care pathway,including joint aspiration and inflammatory labs[white blood cell(WBC),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)].Venous blood was also drawn into PAX gene RNA-stabilizing tubes and mRNAs were measured using Nano String nCounter?.SMS was calculated blinded to clinical *** A total of 20 samples were included,of which 11 were infected based on aspiration or intra-operative *** SMS had an area under the ROC curve(AUROC)of 0.87 for separating infectious from non-infectious *** comparison,the AUROCs for ESR=0.58,CRP=0.6,and WBC=*** 100%sensitivity for infection,the specificity of the SMS was 40%,meaning nearly half of non-septic patients could have been ruled out for further *** In this pilot study,SMS showed a high level of diagnostic accuracy in predicting septic joints compared to other diagnostic *** quick blood test could be an important tool for earl

关键词： Biomarkers Bioinformatics Infection Septic arthritis Medical technology Diagnostics

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