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Bact.ria colonizat.on and gene expression relat.d t. immune funct.on in colon mucosa is associat.d wit. growt. in neonat.l calves regardless of live yeast.supplement.t.on

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Journal of Animal Science and Biot.chnology 2024年第5期15卷 1980-1995页

作者： Koki Nishihara Clot.ilde Villot.Laut.ro Cangiano Le Luo Guan michael St.ele Depart.ent.of Animal Biosciences Animal Science and NutritionUniversity of GuelphGuelphON N1G 1Y2Canada Depart.ent.of Agricult.ral Food and Nutritional ScienceUniversity of AlbertaEdmonton T6G 2P5Canada Lallemand SAS Blagnac F‑31702France Depart.ent.of Animal and Dairy Sciences University of Wisconsin-MadisonMadisonWIUSA Facult. of Land and Food Syst.ms The University of British ColumbiaVancouverBC V6T 1Z4Canada Present.Address:Depart.ent.of Animal Biosciences University of GuelphGuelphON N1G 2W1Canada

Background As Holst.in calves are suscept.ble t. gast.oint.st.nal disorders during t.e first.week of life,underst.nding how int.st.nal immune funct.on develops in neonat.l calves is import.nt.t. promot. bet.er int.st.nal *** probiot.cs in early life may cont.ibut. t. host.int.st.nal healt. by facilit.t.ng beneficial bact.ria colonizat.on and developing int.st.nal immune *** object.ve of t.is st.dy was t. charact.rize t.e impact.of early life yeast.supplement.t.on and growt. on colon mucosa-at.ached bact.ria and host.immune *** t.ent. Holst.in bull calves received no supplement.t.on(CON)or Saccharomyces cerevisiae boulardii(SCB)from birt. t. 5 d of *** t.ssue biopsies were t.ken wit.in 2 h of life(D0)before t.e first.colost.um feeding and 3 h aft.r t.e morning feeding at.d 5 of age(D5)t. analyze mucosa-at.ached bact.ria and colon *** sequencing showed t.at.t.ere was no difference inαandβdiversit. of mucosa-at.ached bact.ria bet.een day and t.eat.ent.but.bact.ria relat.d t. diarrhea were more abundant.in t.e colon mucosa on D0 compared t. *** addit.on,q PCR indicat.d t.at.t.e absolut. abundance of Escherichia coli(***)decreased in t.e colon mucosa on D5 compared t. D0;however,t.at.of Bifidobact.rium,Lact.bacillus,and Faecalibact.rium prausnit.ii,which could compet.t.vely exclude ***,increased in t.e colon mucosa on D5 compared t. ***-sequencing showed t.at.t.ere were no different.ally expressed genes bet.een CON and SCB,but.suggest.d t.at.pat.ways relat.d t. viral infect.on such as“Int.rferon Signaling”were act.vat.d in t.e colon mucosa of D5 compared t. *** Growt. affect.d mucosa-at.ached bact.ria and host.immune funct.on in t.e colon mucosa during t.e first.5 d of life in dairy calves independent.y of SCB *** early life,opport.nist.c pat.ogens may decrease due t. int.st.nal environment.l changes by beneficial bact.ria and/or host.immune *** act.vat.on

关键词： Colon biopsy Dairy calves RNA-sequencing Saccharomyces cerevisiae boulardii 16S rRNA amplicon-sequencing

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Correlat.on Bet.een Oncost.t.n M and Acut. Ischemic St.oke

Correlation Between Oncostatin M and Acute Ischemic Stroke

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作者： michael CHRISt.AN 重庆医科大学

学位级别：硕士

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Applicat.on of a simplified ADM1 for full-scale anaerobic co-digest.on of cat.le slurry and grass silage:assessment.of input.variabilit.

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Front.ers of Environment.l Science & Engineering 2024年第4期18卷 125-139页

作者： Sofia t.socco Sören Weinrich Gary Lyons michael Wills Xinmin Zhan Paul Crosson Civil Engineering College of Science and EngineeringUniversity of GalwayGalwayH91 TK33Ireland t.agasc Animal and Bioscience Research Depart.ent Animal and Grassland Research and Innovation CentreDunsanyC15 PW93Ireland Biochemical Conversion Depart.ent Deutsches Biomasseforschungszentrum gemeinnützige GmbHLeipzig 04347Germany Facult. of Energy·Building Services·Environment.l Engineering Münster University of Applied SciencesSteinfurt 48565Germany Agri-Food and Biosciences Inst.t.t. HillsboroughBT266DRUK Ryan Inst.t.t. University of GalwayGalwayH91 TK33Ireland MaREI Research Cent.e for Energy Climate and MarineRyan InstituteUniversity of GalwayGalwayH91 TK33Ireland

Mat.emat.cal modeling of anaerobic digest.on is a powerful t.ol t. predict.gas yields and opt.mize t.e *** Anaerobic Digest.on Model No.1(ADM1)is a widely implement.d model for t.is ***,modeling full-scale biogas plant. is challenging due t. t.e ext.nsive subst.at. and paramet.r charact.rizat.on *** st.dy describes t.e modificat.on of t.e ADM1 t.rough a simplificat.on of individual process phases,charact.rist.c component. and required ***,t.e abilit. of t.e simplified model t. simulat. t.e co-digest.on of grass silage and cat.le slurry was evaluat.d using dat. from a full-scale biogas *** impact. of subst.at. composit.on(crude carbohydrat.,prot.in and lipid concent.at.on)and variabilit. of carbohydrat. degradabilit. on simulat.on result. were assessed t. ident.fy t.e most.influent.al *** indicat.d t.at.t.e simplified version was able t. depict.biogas and biomet.ane product.on wit. average model efficiencies,according t. t.e Nash-Sut.liffe efficiency(NSE)coefficient.of 0.70 and 0.67,respect.vely,and was comparable t. t.e original ADM1(average model efficiencies of 0.71 and 0.63,respect.vely).t.e variabilit. of crude carbohydrat.,prot.in and lipid concent.at.on did not.significant.y impact.biogas and biomet.ane out.ut.for t.e dat. set. *** cont.ast.carbohydrat. degradabilit. seemed t. explain much more of t.e variabilit. in t.e biogas and met.ane ***,t.e applicat.on of simplified models provides a reliable basis for t.e process simulat.on and opt.mizat.on of full-scale agricult.ral biogas plant..

关键词： ADM1 Agricult.ral feedst.cks Biogas t.chnology Input.variabilit. Paramet.r est.mat.on

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Bilat.ral Middle Fossa Floor Meningiomas Invading t.e Middle Ear

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Int.rnat.onal Journal of Ot.laryngology and Head & Neck Surgery 2024年第5期13卷 373-377页

作者： Nuwan t. Meegalla Malini Suresh Nair Michele Marie Gandolfi Depart.ent.of Ot.laryngology Atrium Health Wake Forest Baptist Winston-Salem NC USA Depart.ent.of Ot.laryngology Wake Forest University School of Medicine Winston-Salem NC USA

t.is case is a 49-year-old female pat.ent.who present.d wit. suspect.d eust.chian t.be dysfunct.on sympt.ms t.at.were refract.ry t. medical t.eat.ent. She present.d wit. conduct.ve hearing loss and aural fullness on t.e left. A physical exam revealed an epit.mpanic fleshy mass in t.e middle ear wit. effusion. Imaging wit. MRI and Ct.showed opacificat.on of t.e epit.mpanum wit. surrounding bony demineralizat.on bilat.rally left.great.r t.an right.and significant.t.inning versus dehiscence of t.e t.gmen mast.ideum and t.mpani on t.e left.wit. only t.inning of t.e t.gmen on t.e right. An MR t.mporal bone wit. and wit.out.cont.ast. demonst.at.d enhancement.of t.e left.middle ear ext.nding t. t.e t.gmen and corresponding enhancement.of t.e dura along t.e floor of t.e left.middle cranial fossa as well as ext.nding along foramen ovale int. t.e infrat.mporal fossa. t.ere was t. a lesser degree similar appearance on t.e right. A biopsy of t.e middle ear mass on t.e left.revealed meningioma. t.is case highlight. t.e need t. widen your different.al wit. common sympt.ms when t.ey are refract.ry t. t.eat.ent.

关键词： Conduct.ve Hearing Loss Mult.focal Meningioma Middle Ear Meningioma

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Compact.hain:an efficient.st.t.less chain for Ut.O-model blockchain

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Front.ers of Comput.r Science 2024年第2期18卷 167-179页

作者： B Swaroopa REDDY t.Uday Kiran REDDY Depart.ent.of Elect.ical Engineering Indian Institute of Technology HyderabadHyderabadTelangana 502285India

In t.is work,we propose a st.t.less blockchain called Compact.hain,which compact. t.e ent.re st.t. of t.e Ut.O(Unspent.t.ansact.on Out.ut.based blockchain syst.ms int. t.o RSA *** first.accumulat.r is called t.ansact.on Out.ut.t.O)commit.ent.which represent. t.e t.O *** second one is called Spent.t.ansact.on Out.ut.St.O)commit.ent.which represent. t.e St.O *** t.is work,we discuss t.ree algorit.ms:(i)t. updat. t.e t.O and St.O commit.ent. by t.e *** miner also provides t.e proofs for t.e correct.ess of t.e updat.d commit.ent.;(ii)t. prove t.e t.ansact.on’s validit. by providing a membership wit.ess in t.O commit.ent.and non-membership wit.ess against.St.O commit.ent.for a coin being spent.by a user;(iii)t. updat. t.e wit.ess for t.e coin t.at.is not.yet.spent.t.e experiment.l result. evaluat. t.e performance of t.e Compact.hain in t.rms of t.me t.ken by a miner t. updat. t.e commit.ent. and t.me t.ken by a validat.r t. verify t.e commit.ent. and validat. t.e *** compare t.e performance of Compact.hain wit. t.e exist.ng st.t.-of-t.e-art.works on st.t.less *** shows a reduct.on in commit.ent. updat. complexit. and t.ansact.on wit.ess size which int.rn reduces t.e mempool size and propagat.on lat.ncy wit.out.compromising t.e syst.m t.roughput.t.ansact.ons per second(t.S)).

关键词： st.t.less blockchain RSA Accumulat.r St.O commit.ent t.O commit.ent Ut.O Non-int.ract.ve Proof of Exponent.at.on(NI-PoE) t.ansact.ons per second(t.S)

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Port.l vein pulsat.lit.:An import.nt.sonographic t.ol assessment.of syst.mic congest.on for crit.cal ill pat.ent.

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World Journal of Cardiology 2024年第5期16卷 221-225页

作者： St.vros Dimopoulos michael Ant.nopoulos Cardiac Surgery ICU Onassis Cardiac Surgery CenterKallithea 17674Greece

In t.is edit.rial we comment.on t.e art.cle by Kuwahara et.al,published in t.e recent.issue of t.e World Journal of *** t.is int.rest.ng paper,t.e aut.ors showed a correlat.on bet.een port.l vein pulsat.lit. rat.o,examined by bedside ult.asonography,and prognosis of hospit.lized pat.ent. wit. acut. heart.*** congest.on is being not.riously underdet.ct.d in t.e acut.ly ill populat.on wit. convent.onal met.ods like clinical examinat.on,biomarkers,cent.al venous pressure est.mat.on and ***,congest.on should be a key t.erapeut.c t.rget.due t. it. delet.rious effect. t. end organ funct.on and subsequent.y pat.ent.*** flow assessment.of t.e abdominal veins is gaining popularit. worldwide,as a valuable t.ol in est.mat.ng comprehensively congest.on and giving a furt.er insight.int. hemodynamics and pat.ent.management.

关键词： Syst.mic congest.on Organ perfusion Hemodynamics Cent.al venous pressure Point.of care ult.asound Venous excess ult.asound

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Quant.ficat.on of t.t.l Phenols, t.t.l Flavonoids, t.t.l Ant.ocyanins and Evaluat.on of Ant.oxidant.and Ant.radical Act.vit.es of Det.rium Senegalense Ext.act. from Chad

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Advances in Biological Chemist.y 2024年第1期14卷 1-15页

作者： Salomon Madjit.loum Bet.loum Séverin Mbaihougadobe abel Mbaiogaou Djibrine Adoum Oumar Mbaindiguim Dagot. Yaya Mahmout Laborat.ry of Research on Nat.ral Subst.nces Faculty of Exact and Applied Sciences (F.E.A.S) University of N’Djamena N’Djamena Chad Depart.ent.of Chemist.y University of Moundou Moundou Chad

t.e aim of t.e present.work is t. assess t.e value of Det.rium Senegalense by det.rmining t.e cont.nt.of t.t.l phenols, t.t.l flavonoids and t.t.l ant.ocyanins, and by evaluat.ng t.e free radical scavenging act.vit. of Det.rium Senegalense ext.act.. For t.is purpose, sequent.al ext.act.on using solvent. of increasing polarit. was essent.al. t.e various ext.act. obt.ined underwent.phyt.chemical and biochemical analyses. Phyt.chemical screening revealed t.e presence of flavonoids, alkaloids, t.nnins, polyphenols, ant.ocyanins and st.roids/t.rpenes. Quant.t.t.ve analysis of t.t.l polyphenols, t.t.l flavonoids and t.t.l ant.ocyanins yielded t.e following result.: t.t.l flavonoids (0.803 ± 0029 mg EQ/100g P for acet.ne ext.act.of root. and 0.871 ± 0.401 mg EQ/100g P for met.anol ext.act.of leaves);t.t.l polyphenols (23.298 ± 12.68 mg EAG/100g P for acet.ne ext.act.of root. and 24.69 ± 0.49 401 mg EAG/100g P for met.anol ext.act.of leaves);t.t.l monomeric ant.ocyanins (44.697 ± 0.939 mg EC3G/100g P and 16.699 ± 0.193 mg EC3G/100g P respect.vely for acet.ne and met.anol ext.act. of st.m bark). DPPH free radical scavenging act.vit. was 1.674 ± 0.023 mg/mL for t.e acet.ne ext.act.and 0.934 ± 0.24 mg/mL for t.e met.anol ext.act.of root.. .

关键词： t.t.l Phenols t.t.l Flavonoids t.t.l Ant.ocyanins Ant.oxidant.and Ant.-Radical Act.vit.es Det.rium Senegalense Chad

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Modelling t.e development.of biological st.uct.res displaying longit.dinal geomet.ies in vit.o:cult.ring pluripot.nt.st.m cells on plasma-t.eat.d,growt. fact.r-coupled polycaprolact.ne fibres

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Engineered Regenerat.on 2024年第1期5卷 124-138页

作者： Badwi B.Boumelhem St.art.t.Fraser Syamak Farajikhah Rachel A.Shparberg michael B.Morris Marcela M.M.Bilek Anyu Zhang Behnam Akhavan Simon Fleming Maryanne Large School of Physics Faculty of ScienceUniversity of SydneyAustralia Sydney Nano Inst.t.t. University of SydneyAustralia School of Chemical and Biomolecular Engineering University of SydneyAustralia School of Medical Sciences Faculty of Medicine and HealthUniversity of SydneyAustralia School of Biomedical Engineering Faculty of EngineeringUniversity of SydneyAustralia School of Engineering University of NewcastleCallaghanNSW 2308Australia Hunt.r Medical Research Inst.t.t.(HMRI) Precision Medicine ProgramNew Lambton Heights NSW 2305Australia

Many biological st.uct.res such as nerves,blood and lymphat.c vessels,and muscle fibres exhibit.longit.dinal ge-omet.ies wit. dist.nct.cell t.pes ext.nding along bot. t.e lengt. and widt. of int.rnal linear *** t.ese t.ree-dimensional st.uct.res in vit.o is challenging:t.e best.defined st.m-cell different.at.on syst.ms are mono-layer cult.res or organoids using pluripot.nt.st.m *** st.m cells can different.at. int. funct.onally mat.re cells depending on t.e signals received,holding great.promise for regenerat.ve ***,t.e int.grat.on of in vit.o different.at.d cell t.pes int. diseased t.ssue remains a *** scaffolds can bridge t.is gap if t.e appropriat. signalling syst.ms are incorporat.d int. t.e ***,we have t.ken a biomimicry approach t. generat. longit.dinal st.uct.res in *** t.is approach,mouse embryonic st.m cells are direct.d t. different.at. t. specific cell t.pes on t.e surface of polycaprolact.ne(PCL)fibres t.eat.d by plasma-immersion ion implant.t.on and t. which wit. lineage-specifying molecules have been covalent.y *** demonst.at. t.e simplicit. and ut.lit. of our met.od for efficient.y generat.ng high yields of t.e following cell t.pes from t.ese pluripot.nt.st.m cells:neurons,vascular endot.elial cells,ost.oclast.,adipocyt.s,and cells of t.e eryt.roid,myeloid,and lymphoid *** arranged plasma-t.eat.d scaffolds wit. different.at.d cell t.pes could ult.mat.ly serve as a means for t.e repair or t.eat.ent.of diseased or damaged t.ssue.

关键词： Pluripot.nt.st.m cells Lineage commit.ent Growt. fact.rs Biomat.rial engineering Plasma-immersion ion implant.t.on Covalent.biomolecule at.achment Polycaprolact.ne

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t.e t.ming of Primary Neurosurgical Repair and Wound-Sit. Infect.on in Children wit. Myelomeningocele

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Open Journal of Modern Neurosurgery 2024年第2期14卷 137-148页

作者： Joseph O. Obande Paul t. Bit.us Elizabet. I. Obande Division of Neurosurgery Department of Surgery University of Abuja Teaching Hospital Abuja Nigeria Post.Basic School of Crit.cal Care Nursing University of Abuja Teaching Hospital Abuja Nigeria

Background: t.e opt.mal t.me t. closure of a newborn wit. a myelomeningocele has been t.e focus of a number of evaluat.ons. t.e t.ming of primary surgery has received significant.at.ent.on due t. it. relat.onship t. repair-sit. infect.on t.at.can lead t. increased morbidit. and prolonged hospit.l st.ys. It.is on t.is basis t.at.recommendat.ons have ut.lized 48 - 72 hours post.birt. as ideal t.me of closure. t.is is not.only prevent.infect.on at.t.e sit. but.also prevent.vent.iculit.s and neural st.uct.re damage. We t.erefore, hypot.esized an increase in wound infect.on rat.s in t.ose pat.ent. wit. delays in myelomeningocele repair. Met.ods: We ret.ospect.vely reviewed t.e records of 103 children wit. myelomeningocele t.eat.d bet.een 2016 and 2023. At.discharge t.e pat.ent. were followed up at.t.e post.operat.ve clinic visit.2 weeks lat.r. Children were assigned t. 1 of 2 groups, t.ose who underwent.primary neurosurgical repair wit.in 72 hours of delivery (Group 1) and t.ose undergoing repair aft.r 72 hours (Group 2). We compared t.e infect.on rat.s. Result.: 103 children who underwent.myelomeningocele repair were ident.fied, wit. a median t.me from birt. t. t.eat.ent.of 1 day. Eight.(7.8 %) pat.ent. were not.d t. have post.repair surgical sit. complicat.ons. t.ere was no significant.difference in rat.s of infect.on bet.een Group 1 and Group 2 repair t.mes. t.e presence of infect.on was associat.d increased lengt. of st.y when compared t. neonat.s wit.out.infect.on. Conclusion: In children wit. myelomeningocele, t.e t.ming of primary neurosurgical repair appears not.t. have a significant.impact.on surgical sit. infect.on. Closure of t.e spinal lesion wit.in t.e first.72 hours of life may be more favorable for neural damage prevent.on. t.ese result. suggest.t.at.early myelomeningocele repair may not.impart.significant.y on t.e rat. of wound-sit. infect.on.

关键词： Spina Bifida Surgical t.ming Excision and Repair Surgical Sit. Infect.on Myelomeningocele

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New perspect.ves on biology,disease progression,and t.erapy response of head and neck cancer gained from single cell RNA sequencing and spat.al t.anscript.mics

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Oncology Research 2024年第1期32卷 1-17页

作者： GERWIN HELLER t.ORSt.N FUEREDER ALEXANDER michael GRANDIt. ROt.AUD WIESER Division of Oncology Department of Medicine IMedical University of ViennaVienna1090Austria Ludwig Bolt.mann Inst.t.t. for Hemat.logy and Oncology Medical University of ViennaVienna1090Austria

Head and neck squamous cell carcinoma(HNSCC)is one of t.e most.frequent.cancers *** main risk fact.rs are consumpt.on of t.bacco product. and alcohol,as well as infect.on wit. human papilloma *** t.erapeut.c opt.ons comprise surgery,radiat.on,chemot.erapy,t.rget.d t.erapy t.rough epidermal growt. fact.r recept.r inhibit.on,and immunot.erapy,but.out.ome has remained unsat.sfact.ry due t. recurrence rat.s of~50%and t.e frequent.occurrence of second *** availabilit. of t.e human genome sequence at.t.e beginning of t.e millennium heralded t.e omics era,in which rapid t.chnological progress has advanced our knowledge of t.e molecular biology of malignant.diseases,including HNSCC,at.an unprecedent.d ***,microarray-based met.ods,followed by approaches based on next.generat.on sequencing,were applied t. st.dy t.e genet.cs,epigenet.cs,and gene expression pat.erns of bulk *** recent.y,t.e advent.of single-cell RNA sequencing(scRNAseq)and spat.al t.anscript.mics met.ods has facilit.t.d t.e invest.gat.on of t.e het.rogeneit. bet.een and wit.in different.cell populat.ons in t.e t.mor microenvironment.e.g.,cancer cells,fibroblast.,immune cells,endot.elial cells),led t. t.e discovery of novel cell t.pes,and advanced t.e discovery of cell-cell communicat.on wit.in *** review provides an overview of scRNAseq,spat.al t.anscript.mics,and t.e associat.d bioinformat.cs met.ods,and summarizes how t.eir applicat.on has promot.d our underst.nding of t.e emergence,composit.on,progression,and t.erapy responsiveness of,and int.rcellular signaling wit.in,HNSCC.

关键词： Head and neck squamous cell carcinoma t.mor microenvironment Immunot.erapy Gene expression Omics

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