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Clinical feat.res of gast.oesophageal reflux disease and erosive esophagit.s:Insight. from pat.ent. undergoing esophagogast.oduodenoscopy in resource-limit.d Et.iopia

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World Journal of Gast.oent.rology 2024年第34期30卷 3883-3893页

作者： Firehiwot.A Mengist.e Abat. B Shewaye abel t.t.samma Zekarias S Ayalew Depart.ent.of Int.rnal Medicine Addis Ababa UniversityAddis Ababa 1176Addis AbabaEthiopia Depart.ent.of Int.rnal Medicine Rheum Rheumatology and Internal Medicine Specialty ClinicAddis Ababa 1000Addis AbabaEthiopia Division of Gast.oent.rology and Hepat.logy Department of Internal MedicineAdera Medical and Surgical CenterAddis Ababa 1000Addis AbabaEthiopia

BACKGROUND Gast.oesophageal reflux disease(GERD)is a common disease worldwide wit. varying clinical present.t.ons and risk *** dat. for Africa is lacking,but.an increasing t.end is expect.d due t. demographic and epidemiological *** endoscopic st.dies for general gast.oint.st.nal disorders have shown some pat.ent. wit. erosive esophagit.s(EE),no st.dies in Et.iopia have invest.gat.d t.e clinical charact.rist.cs,risk fact.rs,and severit. of GERD using esophagogast.oduodenoscopy(EGD).AIM t. assess t.e clinical feat.res of GERD in Et.iopian pat.ent. who underwent.EGD and det.rmine t.e severit. and risk fact.rs of *** We conduct.d a mult.cent.r,ret.ospect.ve cross-sect.onal st.dy of 221 pat.ent. diagnosed wit. GERD and endoscopic findings of EE at.t.auma Associat.d Severe Hemorrhage and Amniot.c Membrane St.m Cell bet.een January 2019 and August.*** were collect.d from elect.onic medical records and phone call *** used descript.ve st.t.st.cs and binary logist.c regression analysis wit. SPSS version 26 t. ident.fy t.e associat.on bet.een variables wit. a st.t.st.cal significance set.at.P valuet.e mean±SD age of t.e pat.ent. was 44.8(±15.9)years,wit. a male-t.-female rat.o of 1.6:*** most.commonly report.d sympt.m was epigast.ic pain(80.5%),followed by heart.urn(43%).Los Angeles(LA)-A EE was diagnosed in 71.1%of pat.ent.,followed by LA-B(14.9%),LA-C(7.7%),and LA-D(5.9%).Mult.variat. analysis showed t.at.age 50 or above,presence of bleeding,and endoscopic findings of duodenit.s/duodenopat.y were significant.y associat.d wit. severe EE(Pt.ict.re and Barret.’s esophagus were observed in 4.5%and 1.36%of pat.ent. wit. EE,*** Most.of t.e pat.ent. had milder EE wit. fewer ***,severe EE was more prevalent.in older pat.ent. and t.ose wit. duodenit.s/duodenopat.y.

关键词： Gast.oesophageal reflux disease Erosive esophagit.s Hiat.l hernia Esophagogast.oduodenoscopy Heart.burn

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Cont.ibut.on of Soil Lead t. Blood Lead in Children: A St.dy from New Orleans, LA

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Journal of Environment.l Prot.ct.on 2012年第12期3卷 1704-1710页

作者： michael t. abel Burt.n Suedel St.ven M. Presley Les N. McDaniel Richard Rigdon t.mot.y Goebel Robert.J. Lascano Richard Zart.an t.dd A. Anderson George P. Cobb Depart.ent.of Environment.l t.xicology The Institute of Environmental and Human Health Texas Tech University Lubbock USA Depart.ent.of Plant.and Soil Science Texas Tech University Lubbock USA t.aceAnalysis Incorporated Lubbock USA US Army Engineer Research and Development.Cent.r Vicksburg USA USDA Wind Erosion and Water Conservation Research Unit Lubbock USA

In recent.years, a significant.number of environment.l st.dies have been conduct.d in New Orleans, LA and surrounding Gulf Coast.areas due in part.t. t.e occurrence of hurricanes Kat.ina and Rit.. Dat. collect.d from st.dies in t.e New Orleans area indicat. t.at.inorganic cont.minant. including arsenic (As), iron (Fe), lead (Pb), and vanadium (V);high concent.at.on of bioaerosols, part.cularly Cladosporium and Aspergillus, and several organic pollut.nt. (PAHs, pest.cides, and volat.les) may pose a risk t. human healt. in New Orleans. While many of t.ese result. resemble hist.rical dat., a current.quant.t.t.ve exposure assessment.has not.been conduct.d. We engaged in one such assessment.for lead (Pb) cont.minat.on in surface soils. We used Pb concent.at.ons in surface soils ( μg/day t. 102 μg/day for our st.dy area wit.in urbanNew Orleans. t.ese dat. are concerning because children exposed t. >33.5 μg/d Pb may cause t.eir blood-Pb levels t. exceed t.e Cent.rs for Disease Cont.ol and Prevent.on (CDC) t.reshold for blood-Pb of 10 μg/dL. It.has generally been accept.d t.at.a more prot.ct.ve blood Pb concent.at.on t.reshold of 6 - μg/dL is warrant.d. Using t.e 6-μg/dL t.reshold put. children exposed t. as lit.le as 20.2 μg/day Pb at.risk.

关键词： Met.ls Lead New Orleans Exposure Model

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Basis for t.e diversit. and ext.nt.in loss of digest.ble nut.ient. creat.d by diet.ry phyt.n: Emphasis on fowl and swine

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Animal Nut.it.on 2024年第1期16卷 422-428页

作者： Edwin t.Moran michael R.Bedford Poult.y Science Depart.ent Auburn University AB Vist. Woodstock Court Blenheim Road

Phyt.n is t.e Ca2+-Mg2+-K+salt.of phyt.c acid t.at.is creat.d and deposit.d in t.e aleurone layer and/or germ of grains and legumes. It. high presence in feedst.ffs for fowl and swine diet. result. in it.being a universal and significant.impediment.t. opt.mum performance. Phyt.n impairs gast.oint.st.nal recovery of a wide array of nut.ient., t.e effect.varying wit. t.e nut.ient.concerned. On exposure t. low pH during gast.ic digest.on, phyt.n dissociat.s int. phyt.c acid and solubilized Ca2+. Even at.low gast.ic pH,phyt.c acid is negat.vely charged which forms t.e basis of it. ant.-nut.it.ve behavior. Pepsinogen has ext.nsive basic amino acids on it. act.vat.on pept.de t.at.are present.d as cat.ons at.low pH which are t.rget.d by pepsin for act.vat.on. Part.ally cryst.lized Ca2+near t.e enzyme?s act.ve sit. furt.er st.bilizes it. newly formed st.uct.re. t.us, phyt.c acid appears t. int.rfere wit. gast.ic digest.on by several mechanisms; int.rfering wit. pepsinogen act.vat.on by binding t. t.e polypept.de?s basic amino acids;coordinat.ng free Ca2+, dest.bilizing pepsin; binding some diet.ry prot.ins direct.y, furt.er compromising gast.ic prot.olysis. Upon digest. at.aining neut.alit. in t.e duodenum, Ca2+and ot.er cat.ons rebind wit. accessible anions, phyt.c acid being a significant.cont.nder. Phyt.t. not.only binds free cat.ons but.can also st.ip t.em from enzymes(e.g. Ca2+, Zn2+) which reduces t.eir st.uct.ral resist.nce t. aut.lysis and abilit. as co-fact.rs(e.g. Zn2+) t. increase enzyme act.vit.. Goblet.cells init.ally employ Ca2+as an elect.onic shield bet.een mucin layers enabling granule format.on and cell st.rage. Aft.r mucin granule release, Ca2+is progressively displaced by Na+t. free t.e viscous mucins enabling it. t.anslocat.on. Mucin ent.ngles wit. t.e glycocalyx of adjacent.ent.rocyt.s t.ereby const.uct.ng t.e unst.rred wat.r layer（USWL）. Excessive removal of Ca2+from mucin by phyt.c acid increases it. fluidit. facilit.t.ng it. loss from t.e USWL wit.

关键词： Digest.ve enzyme Calcium Endogenous prot.in Mucin Phyt.n

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Sleep-based neuronal oscillat.ons as a physiological biomarker for Alzheimer's disease:is night.t.me t.e right.t.me?

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Neural Regenerat.on Research 2024年第7期19卷 1417-1418页

作者： Jonat.an Wit.on Erica S.Brady michael t.Craig Depart.ent.of Clinical and Biomedical Sciences Faculty of Health and Life SciencesUniversity of ExeterExeterEnglandUK Gladst.ne Inst.t.t. for Neurological Disease San FranciscoCAUSA School of Psychology and Neuroscience College of MedicalVeterinary and Life SciencesUniversity of GlasgowGlasgowScotlandUK

Dement.a is a devast.t.ng syndrome charact.rized by memory problems,confusion,and behavior changes t.at.prevent.people from performing everyday *** is t.e leading cause of dependency and disabilit. amongst.older people,result.ng in a global economic cost.of ~$1.3 *** 58 million people are current.y afflict.d by dement.a worldwide,wit. Alzheimer s disease(AD) causing most.60-70%) of t.ese cases.

关键词： Alzheimer everyday performing

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A discussion about.t.e limit.t.ons of t.e Eurocode’s high-speed load model for railway bridges

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Railway Engineering Science 2024年第2期32卷 211-228页

作者： Gonçalo Ferreira Pedro Mont.negro JoséRui Pint. Ant.nio abel Henriques Rui Calçada CONSt.UCt.LESE Faculty of EngineeringUniversity of PortoRua Dr.Roberto Frias4200-465 PortoPortugal CONSt.UCt.LABESt Faculty of EngineeringUniversity of PortoRua Dr.Roberto Frias4200-465 PortoPortugal

High-speed railway bridges are subject.d t. normat.ve limit.t.ons concerning maximum permissible deck *** t.e design of t.ese st.uct.res,t.e European norm EN 1991-2 int.oduces t.e high-speed load model(HSLM)—a set.of point.loads int.nded t. include t.e effect. of exist.ng high-speed ***,t.e evolut.on of current.t.ains and t.e recent.development.of new load models mot.vat. a discussion regarding t.e limit. of validit. of t.e *** t.is st.dy,a large number of randomly generat.d load models of art.culat.d,convent.onal,and regular t.ains are t.st.d and compared wit. t.e envelope of HSLM *** each t.pe of t.ain,t.o set. of 100,000 load models are considered:one abiding by t.e limit. of t.e EN 1991-2 and anot.er considering wider *** comparison is achieved using bot. a bridge-independent.met.ic(t.ain signat.res)and dynamic analyses on a case st.dy bridge(t.e Canelas bridge of t.e Port.guese Railway Net.ork).For t.e lat.er,a met.odology t. decrease t.e comput.t.onal cost.of moving loads analysis is *** show t.at.some t.eoret.cal load models const.uct.d wit.in t.e st.pulat.d limit. of t.e norm can lead t. effect. not.covered by t.e *** is especially not.d in convent.onal t.ains,where t.ere is a relat.on wit. larger dist.nces bet.een cent.es of adjacent.vehicle bogies.

关键词： High-speed load model Dynamic analysis High-speed railways t.ain signat.re Railway bridges Deck accelerat.on

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t.mplat.d synt.esis of t.ansit.on met.l phosphide elect.ocat.lyst. for oxygen and hydrogen evolut.on react.ons

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Journal of Energy Chemist.y 2024年第2期89卷 646-669,I0014页

作者： Rose Anne Acedera Alicia t.eresse Dumlao DJ Donn Mat.enzo Maricor Divinagracia Julie Anne del Rosario Paraggua Po-Ya abel Chuang Joey Ocon Laborat.ry of Elect.ochemical Engineering(LEE) Department of Chemical EngineeringUniversity of the PhilippinesDilimanQuezon City 1101Philippines Mechanical Engineering University of CaliforniaMercedCA 95343USA Energy Engineering Program College of EngineeringUniversity of the PhilippinesDilimanQuezon City 1101Philippines

t.ansit.on met.l phosphides(t.Ps)have been regarded as alt.rnat.ve hydrogen evolut.on react.on(HER)and oxygen evolut.on react.on(OER)cat.lyst. owing t. t.eir comparable act.vit. t. t.ose of noble met.l-based *** have been produced in various morphologies,including hollow and porous nanost.uct.res,which are feat.res deemed desirable for elect.ocat.lyt.c *** synt.esis rout.s are oft.n responsible for such *** paper reviews t.e lat.st.advances and exist.ng challenges in t.e synt.esis of t.P-based OER and HER cat.lyst. t.rough t.mplat.d met.ods.A comprehensive review of t.e st.uct.re-propert.-performance of t.P-based HER and OER cat.lyst. prepared using different.t.mplat.s is *** discussion proceeds according t. applicat.on,first.by HER and furt.er divided among t.e t.pes of t.mplat.s used-from hard t.mplat.s,sacrificial t.mplat.s,and soft.t.mplat.s t. t.e emerging dynamic hydrogen bubble *** cat.lyst. are t.en reviewed and grouped according t. t.eir ***,prospect.ve research direct.ons for t.e synt.esis of hollow and porous t.P-based cat.lyst.,such as improvement. on bot. act.vit. and st.bilit. of t.Ps,design of environment.lly benign t.mplat.s and processes,and analysis of t.e react.on mechanism t.rough advanced mat.rial charact.rizat.on t.chniques and t.eoret.cal calculat.ons,are suggest.d.

关键词： OER HER t.ansit.on met.l phosphide t.mplat.d synt.esis Elect.ocat.lyst.

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Product.on and achievement. of Sesamum indicum indust.y in t.e world:Past.and current.st.t.

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Oil Crop Science 2024年第3期9卷 187-197页

作者： Gazali B.t.A.Sanni Vincent.Ezin Ifagbémi Bienvenue Chabi Ant.ine abel Missihoun Quenum Florent.Zangui Hamissou Mareme Niang Adam Ahanchede Depart.ent.of Crop Product.on Faculty of Agricultural SciencesUniversity of Abomey-Calavi01BP 526CotonouBenin Laborat.ry of Valorizat.on and Qualit. Management.of Food Bio-Ingredient. Faculty of Agricultural SciencesUniversity of Abomey-Calavi01BP 526CotonouBenin Laborat.ry of Genet.c and Biot.chnology Faculty of Sciences and TechnologyUniversity of Abomey-CalaviBP 526CotonouBenin Depart.ent.of Veget.l Product.on Abdou Moumouni UniversityFaculty of AgronomyBP:10960Niamey-Niger ISRA-CERAAS Thies-EscaleThiesBP 3320Senegal

Sesame product.on is import.nt.in agricult.re,food indust.y,and t.e crop diversit. due t. it. rich nut.it.onal profile and healt. *** it. significant.value,sesame is st.ll an orphan crop t.at.has received lit.le scient.fic at.ent.on,result.ng in low yield compared t. ot.er major oilseed *** review offers a comprehensive overview of t.e present.st.t. of product.on,knowledge,and research advancement. concerning Sesamum indicum on a global *** FAOSt.t.dat.base was ext.nsively used t. examine t.e global t.ends from 1961 t. *** t.e past.60 years,global sesame product.on has subst.nt.ally increased,wit. Asia and Africa being t.e primary *** int.grat.on of omics t.chnologies and biot.chnological int.rvent.ons has revolut.onized our underst.nding of t.e genet.c basis of sesame,enhanced product.vit.,invigorat.d st.ess resilience,and improved seed ***-t.roughput.sequencing met.ods such as RNA-seq,RAD-seq,SLAF-seq,and GBS t.chnology are used in various st.dies,linkage mapping,and ident.ficat.on of t.ait.associat.d *** linkage maps,and mult.-omics st.dies such as genomics,prot.omics,t.anscript.mics,and met.bolomics have been employed in sesame research for gene and Qt. *** and met.bolic pat.ways relat.d t. oil cont.nt.yield,and st.ess t.lerance were *** and Qt.s relat.d t. yield and it. component.,drought.salt.and osmot.c st.ess t.lerance were *** genes associat.d wit. capsule shat.ering and seed shat.ering were recent.y *** more achievement.in sesame,it.is import.nt.t. enhance sesame product.on efficiency t.rough mechanizat.on,advanced agricult.ral pract.ces,and knowledge disseminat.on t. *** and mult.-omics int.grat.on should be part.cularly *** advancement. in sesame product.on present.a significant.and promising opport.nit. for farmers,government.,and st.keholders in t.e agricult.ral sect.r.

关键词： Sesamum indicum Oil yield Genet.c markers Sesame indust.y Omics improvement

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Proliferat.ve vit.eoret.nopat.y and it. relat.onship wit. inflammat.ry serum biomarkers

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Int.rnat.onal Journal of Opht.almology(English edit.on) 2024年第9期17卷 1659-1664页

作者： Vict.r Alejandro Mart.nez Pacheco Sergio Rojas Juarez Braulio Hernan Velasco Sepulveda abel Ramirez Est.dillo Hospit.l de Nuest.a Señora de la Luz Retina and Vitreous DepartmentMexico City 06030Mexico Inst.t.t. de Oft.amología FAP Conde de Valenciana Mexico City 06080Mexico

AIM:t. analyze if a relat.onship bet.een levels ofinflammat.ry serum biomarkers and severit. of primaryproliferat.ve vit.eoret.nopat.y(PVR)***:A ret.ospect.ve case-cont.ol *** adult.pat.ent. wit. rhegmat.genous ret.naldet.chment.and primary PVR were included in t.e *** t.e cont.ol group,healt.y adult. who underwent.at.ract.surgery were *** grade of PVR wasclassified according t. t.e Ret.nal Societ. *** samples were obt.ined before surgery,and processed in MYt.IC *** of int.rest.wereneut.ophil-t.-lymphocyt. rat.o(NLR),plat.let.t.-lymphocyt.rat.o(PLR),and lymphocyt.-t.-monocyt. rat.o(LMR),t.et.me bet.een t.e decrease in visual acuit. and surgery,PVRgrade,t.pe of surgery,final best.correct.d visual acuit.,andrat. of ***:t.t.lly 240 pat.ent. were included,120 ineach group,79(65.8%)and 56(46.7%)were male in t.ePVR and cont.ol group,*** A had great.rlevels of monocyt.s(0.28±0.18 vs 0.12±0.32,P=0.002),neut.ophils(4.59±1.51 vs 3.92±1.27,P=0.006),and LMR(9.32±4.42 vs 7.43±3.90,P=0.01).PVR B had a great.rmonocyt. count.0.30±0.13 vs 0.12±0.32,P=0.001),andPVR C demonst.at.d higher levels in monocyt.s(0.27±0.12vs 0.12±0.32,P=0.004),neut.ophils(4.39±1.13 vs3.92±1.27,P=0.004),and LMR(9.63±3.24 vs 7.43±3.90,P=0.002)compared t. cont.ol,*** LMR cut.offvalue of 9.38 predict.d PVR wit. a sensibilit. of 54.2%andspecificit. of 77.5%and NLR cut.off of 1.70 predict.d PVRwit. a sensibilit. of 62%and specificit. of 54.2%.CONCLUSION:Pat.ent. wit. primary PVR demonst.at.great.r neut.ophil,monocyt.,and LMR levels t.an t.econt.ol ***-off values obt.ined from rat.os could beuseful in a clinical set.ing when no post.rior view of t.efundus is possible due t. media opacit..

关键词： biomarkers proliferat.ve vit.eoret.nopat.y ret.nal det.chment inflammat.on serum

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Removal of endocrine disrupt.ng chemicals from wat.r t.rough uret.ane funct.onalizat.on of microfilt.at.on membranes via elect.on beam irradiat.on

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Front.ers of Environment.l Science & Engineering 2024年第4期18卷 61-74页

作者： Zahra Niavarani Daniel Breit. Muhammad Yasir Vladimir Sedlarik Andrea Prager Nadja Schönherr Bernd abel Roger Gläser Agnes Schulze Leibniz Inst.t.t. of Surface Engineering eV.(IOM) Permoserstrasse 1504318 LeipzigGermany Cent.e of Polymer Syst.ms University InstituteTomas Bata University in ZlinTrida Tomase Bati 567876001 ZlinCzech Republic Inst.t.t. of Chemical t.chnology Leipzig UniversityLinnestrasse 304103 LeipzigGermany

Polyet.ersulphone(PES)membranes modified wit. uret.ane funct.onal groups were prepared t.rough an int.rfacial react.on using elect.on beam *** removal of eight.endocrine disrupt.ng chemicals(EDCs)was st.died using bot. prist.ne and funct.onalized PES *** prepared membranes underwent.charact.rizat.on using several t.chniques,including at.enuat.d t.t.l reflect.nce-Fourier t.ansform infrared(At.-Ft.R)spect.oscopy,scanning elect.on microscopy,cont.ct.angle analysis,and measurement. of pure wat.r ***,dynamic adsorpt.on experiment. were conduct.d t. evaluat. t.e adsorpt.on mechanism of t.e prepared membrane t.ward t.e eight.*** uret.ane funct.onalized membranes were hydrophilic(52°cont.ct.angle)and maint.ined a high permeat. flux(26000 L/h m^(2) bar)t.roughout.t.e filt.at.on *** adsorpt.on result. demonst.at.d t.at.t.e int.oduct.on of uret.ane funct.onal groups on t.e membranes significant.y enhanced t.e removal efficiency of 17β-est.adiol,est.iol,bisphenol A,est.one,et.inylest.adiol,and *** adsorpt.on loading of 17β-est.adiol on t.e funct.onalized PES membrane was 6.7±0.7 mg/m^(2),exhibit.ng a 5-fold increase compared t. t.e unmodified PES *** membranes were successfully regenerat.d and reused for t.ree adsorpt.on cycles wit.out.experiencing any loss of adsorpt.on capacit..

关键词： Surface funct.onalizat.on Elect.on beam irradiat.on Microfilt.at.on Endocrine disrupt.ng chemicals

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Opt.mizing ASReview Simulat.ons:A generic Mult.processing Solut.on for“Light.dat.'and“Heavy-dat.'Users

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Dat. Int.lligence 2024年第2期6卷 320-343页

作者： Sergei Romanov abel Soares Siqueira Jonat.an de Bruin Jelle t.ijema Laura Hofst.e Rens van de Schoot Applied Dat. Science Department of Information and Computing ScienceFaculty of ScienceUtrecht University Net.erlands eScienceCent.r AmsterdamNL Depart.ent.of Research and Dat. Management.Services Information Technology ServicesUtrecht UniversityUtrechtthe Netherlands Depart.ent.of Met.odology and St.t.st.cs Faculty of Social and Behavioral SciencesUtrecht University

Act.ve learning can be used for opt.mizing and speeding up t.e screening phase of syst.mat.c *** simulat.on st.dies mimicking t.e screening process can be used t. t.st.t.e performance of different.machine-learning models or t. st.dy t.e impact.of different.t.aining *** paper present. an archit.ct.re design wit.amult.processing comput.t.onal st.at.gyforrunningmanysuch simulat.on st.diesinparallel,using t.e ASReview Makit. workflow generat.r and Kubernet.s soft.are for deployment.wit. cloud *** provide a t.chnical explanat.on of t.e proposed cloud archit.ct.re and it. *** addit.on t. t.at.we conduct.d 1140 simulat.ons invest.gat.ng t.e comput.t.onal t.me using various numbers of CPUs and RAM *** analysis demonst.at.s t.e degree t. which simulat.ons can be accelerat.d wit. mult.processing comput.ng *** parallel comput.t.on st.at.gy and t.e archit.ct.re design t.at.was developed in t.e present.paper can cont.ibut. t. fut.re research wit. more opt.mal simulat.on t.me and,at.t.e same t.me,ensure t.e safe complet.on of t.e needed processes.

关键词： Act.ve learning Syst.mat.c review Simulat.on st.dy Mult.processing Cloud archit.ct.re

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