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Fabrication of sub-20 nm MoS_(2) horizontal nanowire on silicon substrates by inclusion of precursors into polystyrene-bpolyethylene oxide nanopatterns: Detailed structural investigation

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Nano Research 2024年第3期17卷 2145-2153页

作者： Tandra Ghoshal michael A.Morris School of Chemistry AMBER and CRANNTrinity College DublinDublinIrelandD02 AK60

Herein,we demonstrate the fabrication of sub-20 nm MoS_(2) horizontal nanowire arrays on silicon substrates using a self-assembled block copolymer assisted in situ inclusion *** separated long-range ordered polystyrene-b-polyethylene oxide(PS-b-PEO)block copolymer(BCP)line-space nanopatterns were achieved through thermo-solvent *** patterns produced had long-range order and domain sizes>1μ*** BCP structures were lightly etched and modified by anhydrous ethanol to facilitate insertion of molybdenum precursor within the film maintaining the parent BCP *** ordered molybdenum oxide nanowire arrays were then fabricated by ultraviolet(UV)/ozone treatment at room *** oxides were converted to sulphides by thermal evaporation at different temperatures in Ar/H_(2) environment.X-ray photoelectron spectroscopy revealed the composition and phases of the molybdenum oxide and sulphide *** mapping was performed to investigate the interfaces between the oxide and sulphide nanowires with the substrate *** formation and stability of the sulphide nanowires were studied at different *** photoluminescence and Raman properties were studied at different formation temperatures to investigate defects and estimate the number of layers.

关键词： MoS_(2) block copolymer nanowires inclusion X-ray photoelectron spectroscopy(XPS) mapping photoluminescence

Ultra-fine grinding and mechanical activation of mine waste rock using a high-speed stirred mill for mineral carbonation

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International Journal of Minerals,Metallurgy and Materials 2015年第10期22卷 1005-1016页

作者： Jia-jie Li michael Hitch Norman B.Keevil Institute of Mining Engineering University of British ColumbiaVancouver V6T 1Z4Canada

CO2sequestration by mineral carbonation can permanently store CO2and mitigate climate change. However, the cost and reaction rate of mineral carbonation must be balanced to be viable for industrial applications. In this study, it was attempted to reduce the carbonation costs by using mine waste rock as a feed stock and to enhance the reaction rate using wet mechanical activation as a pre-treatment method. Slurry rheological properties, particle size distribution, specific surface area, crystallinity, and CO2 sequestration reaction efficiency of the initial and mechanically activated mine waste rock and olivine were characterized. The results show that serpentine acts as a catalyst, increasing the slurry yield stress, assisting new surface formation, and hindering the size reduction and structure amorphization. Mechanically activated mine waste rock exhibits a higher carbonation conversion than olivine with equal specific milling energy input. The use of a high-speed stirred mill may render the mineral carbonation suitable for mining industrial practice.

关键词： mineral carbonation mine wastes mechanical activat

Poststroke seizure:optimising its management

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Stroke & Vascular Neurology 2019年第1期4卷 48-56页

作者： michael Y Xu Department of Neurology OSF Illinois Neurological InstituteUniversity of Illinois College of MedicinePeoriaIllinoisUSA

Seizure after stroke or poststroke seizure (PSS) is a common and very important complication of stroke. It can be divided into early seizure and late seizure, depending on seizure onset time after the stroke. It has been reported that ischaemic and haemorrhagic stroke accounts for about 11% of all adult epilepsy cases and 45% of epilepsy cases over 60 years of age. However, there are no reliable guidelines in clinical practice regarding most of the fundamental issues of PSS management. In recent years there has been an increased interest in the study of PSS which may give clinical practitioners a better picture of how to optimise PSS management. Studies have indicated two peaks in PSS occurrence-the first day and 6-12 months after a stroke. Haemorrhagic stroke, cortical involvement, severity of initial neurological deficit, younger patients (<65 years of age), family history of seizures and certain genetic factors carry a higher risk of PSS. The use of continuous electroencephalogram has demonstrated significant benefits in capturing interictal or ictal abnormalities, especially in cases of non-convulsive seizures and non-convulsive status epilepticus. Current available data indicated that there was no significant difference in antiepileptic efficacy among most of the antiepileptic drugs (AEDs) in PSS. Levetiracetam and lamotrigine are the most studied newer generation AEDs and have the best drug tolerance. The purpose of this review is to summarise the recent advances in PSS research and focus on the most important practice issues of PSS management.

关键词： seizure epilepsy involvement

Some Open Problems in Parameterized Complexity Related to the Work of Jianer Chen

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Tsinghua Science and Technology 2014年第4期19卷 325-328页

作者： michael Ralph Fellows Engineering and IT Charles Darwin UniversityDarwin 0909 Northern TerritoryAustralia

This short paper highlights some open problems related to the work of Jianer Chen in the area of parameterized/multivariate algorithmics.

关键词： parameterized complexity multivariate algorithmics open problems

Building geospatial infrastructure

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Geo-Spatial Information Science 2020年第1期23卷 1-9页

作者： Jack Dangermond michael F.Goodchild Esri RedlandsCAUSA Department of Geography University of CaliforniaSanta BarbaraCAUSA

Many visions for geospatial technology have been advanced over the past half *** researchers saw the handling of geospatial data as the major problem to be *** vision of geographic information systems arose as an early international *** visions included spatial data infrastructure,Digital Earth,and a nervous system for the *** accelerating advances in information technology,a new vision is needed that reflects today’s focus on open and multimodal access,sharing,engagement,the Web,Big Data,artificial intelligence,and data *** elaborate on the concept of geospatial infrastructure,and argue that it is essential if geospatial technology is to contribute to the solution of problems facing humanity.

关键词： Spatial data handling National Spatial Data Infrastructure Digital Earth Big Data citizen engagement

The ubiquitin ligase Siah2 is revealed as an accomplice of the androgen receptor in castration resistant prostate cancer

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Asian Journal of Andrology 2013年第4期15卷 447-448页

作者： michael R Freeman Research Division of Cancer Biology and Therapeutics Departments of Surgery Medicine and BiomedicalSciences Cancer Biology Program Samuel OschinComprehensive Cancer Institute Los Angeles CA90048 USA

The androgen receptor （AR） remains the primary molecular target forprostate cancer （PCa） treatment and for development of novel therapies. Profiling and other analyses of human prostate adenocarcinoma have shown that the AR is still functional during latestage disease in the absence of circulating hormone fol lowing castration therapy. The molecular mechanisms that operate during this ＇cas tration resistant＇ phase are still not well understood. Qi et al. have now implicated the ubiquitin ligase Siah2 as an important mediator of AR action in castration resis tant prostate cancer （CRPC）. Siah2 was found to target repressed AR chromatin complexes for degradation, resulting in activation of ARregulated genes involved in tumor cell proliferation, cell motility and lipid metabolism. The authors show a requirement for Siah2 activity for PCa cell growth under conditions of low androgen, and also that targeting Siah2 results in tumor growth suppression under castrate conditions. These findings identify a new mechanism of AR regulation in progressing disease as well as a novel enzymatic target for therapeutic intervention. The AR is a wellstudied hormone receptor that belongs to the large nuclear receptor gene superfamily. AR is activated by androgen binding （principally 5：~dihydrotestosterone, 5DHT）, which elicits changes in AR resident cytosolic complexes, translocation of the receptor to cell nuclei, formation of multiprotein transcriptional complexes onchromatin, and activation or repression of gene expression. Experiments with in vivo model systems have provided evidence that virtually all physiologic processes affected by androgens require the AR as a mediator of molecular effects at the gene level.1 AR is widely expressed beyond the reproductive systems and is believed to play important roles in several nonreproductive tissues, including muscle and brain. The fact that PCa growth is initially dependent on the pre sence of androgens in the circulation, and that prostat

关键词： ligase revealed accomplice

Two-dimensional near-infrared photonic crystal fabrication by generation of void channels in solid resin

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Chinese Optics Letters 2003年第12期1卷 719-721页

作者： michael James Ventura Centre for Micro-Phtonics and the Centre for Ultrahigh-Highwidth Devices for Optical Systems School of Biophysical Sciences and Electrical Engineering Swinburne University of Technology PO Box 218 Hawthorn Victoria 3122 Australia

Two-dimensional (2D) triangular void channel photonic crystals with different lattice constants stacked in two different directions were fabricated by using femtosecond laser micro-explosion in solid polymer material. Fundamental and higher-order stop gaps were observed both in the infrared transmission and reflection spectra. There is an approximately linear relationship between the gap position and the lattice constant. The suppression of the fundamental gap is as high as 70% for 24-layer structures stacked in the T-M direction.

关键词： of as Two-dimensional near-infrared photonic crystal fabrication by generation of void channels in solid resin by that were for with

A Retrospect and Prospect of Urban Models: Reflections after Interviewing michael Batty

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China City Planning Review 2015年第4期24卷 8-14页

作者： Liu Lun Long Ying michael Batty Department of Land Economy University of Cambridge Beijing Institute of City Planning Beijing Key Lab of Capital Spatial Planning and Studies Bartlett School of Planning University College London

Based on an interview with Prof. michael Batty, a leading scholar in urban modeling, this paper reviews the history of urban models, comments on their present developments and pictures their prospects. The first section briefly overviews the family tree of urban models and then looks further into the causes for their failure in planning application in the first upsurge of related research in the 1960 s and 1970 s. The second section summarizes the current development of urban models, which can be counted as the second upsurge of related research. It is estimated that more research attention will be paid to building dynamic, disaggregate, micro and problem-oriented models, with a combination of top-down and bottomup modeling methods. This can be more capable of tackling the growing urban complexity and uncertainty. Meanwhile, the "big data era" also poses more opportunities for the development of urban models. The last section introduces three new trends in the theoretical, educational and research development of urban models, which compose the idea of "new science of cities" from michael Batty, the start-up of quantitative urban research education and the establishment of Beijing City Lab.

关键词： urban model quantitative urban research big data Beijing City Lab China

Pico-washing:simultaneous liquid addition and removal for continuous-flow washing of microdroplets

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Microsystems & Nanoengineering 2022年第2期8卷 249-261页

作者： michael J.Siedlik David Issadore Department of Bioengineering University of PennsylvaniaPhiladelphiaPA 19104United States

Droplet microfluidics is based on a toolbox of several established unit operations,including droplet generation,incubation,mixing,pico-injection,and *** the last two decades,the development of droplet microfluidic systems,which incorporate these multiple unit operations into a workflow,has demonstrated unique capabilities in fields ranging from single-cell transcriptomic analyses to materials *** unit operation that is sorely underdeveloped in droplet microfluidics is washing,exchange of the fluid in a droplet with a different ***,we demonstrate what we name the"pico-washer,"a unit operation capable of simultaneously adding fluid to and removing fluid from droplets in flow while requiring only a small footprint on a microfluidic *** describe the fabrication strategy,device architecture,and process parameters required for stable operation of this technology,which is capable of operating with kHz droplet ***,we provide an image processing workflow to characterize the washing process with microsecond and micrometer ***,we demonstrate the potential for integrated droplet workflows by arranging two of these unit operations in series with a droplet generator,describe a design rule for stable operation of the pico-washer when integrated into a system,and validate this design rule *** anticipate that this technology will contribute to continued development of the droplet microfluidics toolbox and the realization of novel droplet-based,multistep biological and chemical assays.

关键词： operations simultaneous removing