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Voxel Placement Precision for GABA-Edited Magnetic Resonance Spectroscopy

Open Journal of Radiology 2017年第1期7卷 35-44页

作者： Xue Bai Ashley D.Harris Tao Gong Nicolaas A.J.Puts Guangbin Wang michael schar Peter B.Barker Richard A.E.Edden Department of Radiology Qilu Hospital of Shandong UniversityJinanChina Russell H.Morgan Department of Radiology and Radiological Science The Johns Hopkins University School of MedicineBaltimoreMDUSA F.M.Kirby Research Center for Functional Brain Imaging Kennedy Krieger InstituteBaltimoreMDUSA Department of MR Shandong Medical Imaging Research InstituteShandong UniversityJinanChina

The purpose of the present study was to assess the reproducibility of voxel placement for GABA-edited MRS. GABA-edited MRS data were acquired in 13 healthy volunteers from (3 cm)3 voxel;and within the same session a second acquisition was independently prescribed. A three-dimensional voxel mask image was reconstructed in T1-image-space using the SVMask tool (in house software). Reproducibility of voxel placement was assessed using the Dice overlap coefficient, both within-subject and between-subject following co-registration of T1 images and transformation of voxel mask images to standard space. Within-subject overlap coefficients were 86% ± 5%. Between-subject overlap coefficients were 75% ± 10%. For the two voxel locations considered (occipital and sensorimotor), voxel overlap was very similar. Between-subject values are higher due to between-session effects, anatomical variability and volume mismatch in standard space. While surprisingly low in terms of volume overlap, the overlap coefficients correspond to acceptable linear displacements.

关键词： MRS Voxel Placement Precision Voxel Prescription Registration

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Identifying Novel Drug Targets by iDTPnd:A Case Study of Kinase Inhibitors

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Genomics, Proteomics & Bioinformatics 2021年第6期19卷 986-997页

作者： Hammad Naveed Corinna Reglin Thomas Schubert Xin Gao Stefan T.Arold michael L.Maitland Toyota Technological Institute at Chicago ChicagoIL 60637USA Department of Computer Science National University of Computer and Emerging SciencesIslamabad 44000Pakistan 2bind GmbH D-93053 RegensburgGermany King Abdullah University of Science and Technology(KAUST) Computational Bioscience Research Center(CBRC)ComputerElectrical and Mathematical Sciences and Engineering(CEMSE)DivisionThuwal 23955Saudi Arabia King Abdullah University of Science and Technology(KAUST) Computational Bioscience Research Center(CBRC)Biological and Environmental Sciences and Engineering(BESE)DivisionThuwal 23955Saudi Arabia Inova Center for Personalized Health and schar Cancer Institute Falls ChurchVA 22042USA University of Virginia Cancer Center AnnandaleVA 22003USA

Current FDA-approved kinase inhibitors cause diverse adverse effects,some of which are due to the me-chanism-independent effects of these *** these mechanism-independent interactions could improve drug safety and support drug ***,we develop iDTPnd(integrated Drug Target Predictor with negative dataset),a computational approach for large-scale discovery of novel targets for known *** a given drug,we construct a positive structural signature as well as a negative structural signature that captures the weakly conserved structural features of drug-binding *** facilitate assessment of unintended targets,iDTPnd also provides a docking-based interaction score and its statistical *** confirm the interactions of sorafenib,imatinib,dasatinib,sunitinib,and pazopanib with their known targets at a sensitivity of 52%and a specificity of 55%.We also validate 10 predicted novel targets by using in vitro *** results suggest that proteins other than kinases,such as nuclear receptors,cytochrome P450,and MHC class I molecules,can also be physiologically relevant targets of kinase *** method is general and broadly applicable for the identification of protein–small molecule interactions,when sufficient drug–target 3D data are *** code for constructing the structural signatures is available at https://***/Documents/***.

关键词： Protein-drug interaction iDTPnd Kinase inhibitor Drug-binding site signature Drug repurposing

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重申美国现实主义

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亚太安全与海洋研究 2017年第4期 1-12页

作者：泰德.R.布洛蒙德迈克尔.奥斯林科林.杜克美国传统基金会美国企业研究所美国乔治梅森大学

文章对冷战结束以来的美国外交政策提出了批评,认为它过于关注国际秩序本身而非美国的国家利益,忽视了美国民众普遍的不满情绪。文章认为,美国外交政策的最终目标是维护美国人民自由生活的能力,而所谓的"自由的国际秩序"只是实现这一外... 详细信息

文章对冷战结束以来的美国外交政策提出了批评,认为它过于关注国际秩序本身而非美国的国家利益,忽视了美国民众普遍的不满情绪。文章认为,美国外交政策的最终目标是维护美国人民自由生活的能力,而所谓的"自由的国际秩序"只是实现这一外交政策目标的手段。因此,文章主张美国的外交政策应回归到传统的现实主义中去,即在强调美国实力重要性的同时,也要认识到美国实力存在的有限性。因此,美国的最佳策略是推行威慑战略,提高对手行动的成本,而不是与之发生战争。

关键词：现实主义国际秩序国家利益

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