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miniSCIDOM: a scintillator.based tomogr.ph for.volumetr.c dose r.constr.ction of single laser.dr.ven pr.ton bunches

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High Power.Laser.Science and Engineer.ng 2024年第2期12卷 41-50页

作者： A.Cor.ino M.r.imold E.Beyr.uther.F.-E.Br.ck F.Kr.ll J.Pawelke J.D.Schilz M.Schneider.U.Schr.mm M.E.P.Umlandt K.Zeil T.ziegler J.Metzkes-Ng Helmholtz-Zentr.m Dr.sden–r.ssendor. DresdenGermany Technische Univer.ität Dr.sden DresdenGermany Oncor.y–National Center.for.r.diation r.sear.h in Oncology Faculty of Medicine and University Hospital Carl Gustav CarusTUD Dresden University of TechnologyHelmholtz-Zentrum Dresden–RossendorfDresdenGermany Cur.ent affiliation:Institut Cur.e UniversitéPSLCNRS UMR3347OrsayFrance Cur.ent affiliation:Univer.itätsklinikum Fr.ibur. FreiburgGermany

Laser.plasma acceler.tor.(LPAs)enable the gener.tion of intense and shor. pr.ton bunches on a micr.metr. scale,thus offer.ng new exper.mental capabilities to r.sear.h fields such as ultr.-high dose r.te r.diobiology or.mater.al *** spectr.lly br.adband,laser.acceler.ted pr.ton bunches allow for.tailor.d volumetr.c dose deposition in a sample via single bunches to excite or.pr.be specific sample *** r.sing number.of such exper.ments indicates a need for.diagnostics pr.viding spatially r.solved char.cter.zation of dose distr.butions with volumes of appr.ximately 1 cm^(3) for.single pr.ton bunches to allow for.fast online *** we pr.sent the scintillator.based miniSCIDOM detector.for.online single-bunch tomogr.phic r.constr.ction of dose distr.butions in volumes of up to appr.ximately 1 cm^(3).The detector.achieves a spatial r.solution below 500μm and a sensitivity of 100 *** detector.per.or.ance is tested at a pr.ton ther.py cyclotr.n and an LPA pr.ton *** exper.ments’pr.mar. focus is the char.cter.zation of the scintillator.s ionization quenching behaviour.

关键词： beam monitor.ng detector. laser.dr.ven pr.ton beams scintillator.based diagnostics ultr.-high dose r.te

Swelling-Based Chemical Sensing With Unmodified Optical Fiber.

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Photonic Sensor. 2022年第2期12卷 99-104页

作者： Alin JDEr. Dor.l DOr.BANTU Dominik ziegler Mar.us ENACHESCU S.C.NanoPr. STAr. MC S.r.L. Bucharest 033091Romania Center.for.Sur.ace Science and Nanotechnology University Politehnica of BucharestBucharest 060042Romania Academy of r.manian Scientists Bucharest 050094Romania

We use distr.buted fiber.optic str.in sensing to examine swelling of the fiber.s polymer.*** distr.buted sensing technique that uses unmodified low-cost telecom fiber. opens a new dimension of applications that include leak detection,monitor.ng of water.quality,and waste *** a shor.-r.nge length scale,the technology enables“lab-on-a-fiber.applications for.food pr.cessing,medicine,and biosensing for.*** chemical sensing is r.alized with unmodified low-cost telecom optical fiber.,namely,by using swelling in the coating mater.al of the fiber.to detect specific *** gener.c and able to wor. in var.ous ar.as such as envir.nmental monitor.ng,food analysis,agr.cultur. or.secur.ty,the pr.posed chemical sensor. can be tar.eted for.water.quality monitor.ng,or.medical diagnostics wher. they pr.sent the most gr.undbr.aking ***,the technique is without r.str.ctions applicable to longer.r.nge installations.

关键词： Chemical sensing distr.buted fiber.optic str.in shor. r.nge sensing Br.llouin optical time domain analysis

Cur.ent pr.ctices r.gar.ing middle tur.inate r.section among otolar.ngologists

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Wor.d Jour.al of Otor.inolar.ngology-Head and Neck Sur.er. 2023年第2期9卷 183-188页

作者： Andr.a ziegler Monica Patadia Chir.g Patel Depar.ment of Otolar.ngology Loyola UniversityMedical CenterMaywoodIlinoisUSA

Objectives:r.section of the middle tur.inate(MT)dur.ng endoscopic sinus sur.er.(ESS)has been a contr.ver.ial topic among otolar.ngologists for.many *** studies advocate r.section and have shown impr.ved outcomes postoper.tively,while studies favor.ng pr.ser.ation show a decr.ased incidence of postoper.tive *** cur.ent pr.ctice patter. r.gar.ing this subject is *** goal of this study was to lear. the cur.ent pr.ctice of MT r.section dur.ng ESS among ***:We per.or.ed an electr.nic anonymous sur.ey of pr.cticing ***:We found that the major.ty of the 252 r.sponder. stated that they will per.or. an MT r.section in cer.ain clinical situations,while ther. is a small subset that advocates never.r.secting the MT for.inflammator. sinus disease(n=6,2.4%).Par.icipants wer. significantly mor. likely to per.or. MT r.section in patients under.oing r.vision compar.d to pr.mar. ESS for.all conditions *** complication of gr.atest concer. among par.icipants was iatr.genic fr.ntal sinus obstr.ction,while empty nose was of the least *** major.ty of par.icipants r.sponded that MT r.section was of extr.me or.moder.te benefit for.impr.ved visualization and dr.g deliver. *** compar.d to gener.l otolar.ngologists,fellowship-tr.ined r.inologists wer. less concer.ed about potential complications following MT r.section and wer. mor. likely to per.eive an extr.me or.moder.te benefit fr.m tur.inate r.section ***:Ther. r.mains debate over.MT r.section among otolar.ngologists,but the r.sults of this study show that the major.ty of par.icipating otolar.ngologists will per.or. a r.section in cer.ain clinical situations.

关键词： cur.ent pr.ctice tr.nds endoscopic sinus sur.er. middle tur.inate r.section sur.ey

The total amount of fluid administer.d is associated with postoper.tive complications in head and neck cancer.sur.er.

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Wor.d Jour.al of Otor.inolar.ngology-Head and Neck Sur.er. 2023年第4期9卷 288-294页

作者： Andr.a ziegler Er.n Car.llo Wiliam Adams Car.l Bier.Laning Depar.ment of Otolar.ngology Loyola University Medical CenterMaywoodIlinoisUSA Depar.ment of Otolar.ngology Stritch School of MedicineLoyola University Medical CenterIllinoisMaywoodUSA Depar.ment of Public Health Sciences Loyola University Medical CenterMaywoodIllinoisUSA

Objective:Patients with head and neck cancer.often under.o extensive ablative and r.constr.ctive *** r.sk factor. ar. unalter.ble,but some oper.tive var.ables ar. possible to *** goal of this study was to estimate the association between oper.tive var.ables and the incidence of per.oper.tive complications in a contempor.r. ter.iar. car. univer.ity‐based head and neck patient population and a Veter.n Administr.tion hospital head and neck patient population fr.m an ear.ier.time ***:We r.tr.spectively r.viewed all patients who under.ent major.head and neck ***:Two‐hundr.d‐two univer.ity patients and 122 veter.n patients wer. *** multivar.able analysis,the total amount of intr.venous(IV)fluid r.ceived dur.ng the pr.cedur. was associated with postoper.tive complications as wer. patients’weight,Amer.can Society of Anesthesiologists(ASA)scor.,and adult comor.idity evaluation‐27(ACE‐27)*** associations did not depend on whether.the patient was tr.ated at the univer.ity or.veter.n ***:Our.study suggests that the odds of a postoper.tive complication incr.ase as the total amount of IV fluid incr.ases.

关键词： ACE‐27 scor. ASA complications head and neck cancer intr.oper.tive fluids

For.st r.stor.tion Potential in China:Implications for.Car.on Captur.

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Jour.al of r.mote Sensing 2022年第1期2022卷 33-45页

作者： Xin Jiang Alan D ziegler Shijing Liang Dashan Wang Zhenzhong Zeng School of Envir.nmental Science and Engineer.ng Southern University of Science and TechnologyShenzhen 518055China Faculty of Fisher.es Technology and Aquatic r.sour.es Mae Jo UniversityChiang MaiThailand

r.for.station is an eco-fr.endly str.tegy for.counter.ng r.sing car.on dioxide concentr.tions in the atmospher. and the negative effects of for.st loss and ***,with one of the wor.d’s most consider.ble affor.station r.tes,has incr.ased its for.st cover.fr.m 16.6%20 year. ago to 23.0%by ***,the maximum potential for.st cover.ge achieved via tr.e planting and r.stor.tion is *** map potential tr.e cover.ge acr.ss China,we developed a r.ndom for.st r.gr.ssion model r.lating envir.nmental factor. and appr.pr.ate for.st *** estimate 67.2 million hectar.s of land cur.ently available for.tr.e r.stor.tion after.excluding existing for.sted ar.as,ur.an ar.as,and agr.cultur. land cover./uses,which is 50%higher.than the cur.ent *** these lands to the for.st would gener.te 3.99 gigatons of new above-and belowgr.und car.on stocks,r.pr.senting an impor.ant contr.bution to achieving car.on *** potential is spatially imbalanced,with the lar.est r.stor.ble car.on potential being located in the southwest(29.5%),followed by the nor.heast(17.2%)and nor.hwest(16.8%).Our.study highlights the need to align tr.e r.stor.tion ar.as with the uneven distr.bution of car.on sequestr.tion *** addition to being a biological mitigation str.tegy to par.ially offset car.on dioxide emissions fr.m fossil fuel bur.ing,r.for.station should pr.vide other.envir.nmental ser.ices such as the r.stor.tion of degr.ded soils,conser.ation of biological diver.ity,r.vitalization of hydr.logical integr.ty,localized cooling,and impr.vement in air.*** of the collective benefits of for.st r.stor.tion,we encour.ge that such activities be ecosystem focused as opposed to solely focusing on tr.e planting.

关键词： for.st For.st collective

二甲双胍在慢性高胰岛素处理的Hep G2细胞对胰岛素受体后信号转导的调节作用(英文)

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Acta Phar.acologica Sinica 2003年第1期24卷 57-62页

作者：袁莉,r.inhar. ziegler,Andr.as HAMANN 德国海德堡大学医院内分泌代谢科德国海德堡大学医院内分泌代谢科德国海德堡大学医院内分泌代谢科海德堡 69115 德国 Depar.ment of Endocr.ndlogy in Union Hospital of tongji Medical Colege Huazhong Univer.ity of Science and Technology Wuhan 430022 China 海德堡 69115 德国海德堡 69115 德国

目的:研究慢性高胰岛素对胰岛素受体后信号转导的影响及其与胰岛素抵抗的关系,并探讨二甲双胍治疗胰岛素抵抗是否通过胰岛素信号转导途径的介导。方法:人类肝癌细胞系(Hep G2)在无血清条件下首先与100nmol/L高浓度胰岛素预温育16h以产... 详细信息

目的:研究慢性高胰岛素对胰岛素受体后信号转导的影响及其与胰岛素抵抗的关系,并探讨二甲双胍治疗胰岛素抵抗是否通过胰岛素信号转导途径的介导。方法:人类肝癌细胞系(Hep G2)在无血清条件下首先与100nmol/L高浓度胰岛素预温育16h以产生胰岛素抵抗细胞模型,并观察不同浓度(0.01-10mmol/L)的二甲双胍对胰岛素受体后磷酯酰肌醇3激酶(PI3K)途径信号转导的影响。结果:高浓度胰岛素100nmol/L慢性处理引起了Ir.、Ir.1和Ir.2的酪氨酸磷酸化和蛋白表达水平的下调,p85与Ir.的相互作用也有显著降低。生理治疗浓度的(0.01-0.1mmol/L)二甲双胍逆转了这种慢性高胰岛素引起的信号下调,细胞用0.1mmol/L二甲双胍预温育后,Ir.、Ir.1和Ir.2的磷酸化反应水平分别增加了2.7倍(Pr.1的相互作用从34％增加至86％(Pr.2的相互作用从30％增加至92％(Pr.、Ir.的磷酸化及Ir.与p85的相互作用。结论:高浓度胰岛素慢性处理可引起胰岛素受体后PI3K途径信号转导的下调,二甲双胍对胰岛素信号转导的作用可能是其治疗胰岛素抵抗的主要分子机制。

关键词：二甲双胍胰岛素受体信号传递

Tr.nscr.ptome landscape of the ear.y Br.ssica napus seed

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Jour.al of Integr.tive Plant Biology 2019年第5期61卷 639-650页

作者： Dylan J.ziegler Deir.r. Khan Jenna L.Kalichuk michael G.Becker.Mar. F.Belmonte Univer.ity of Manitoba

Br.ssica napus L.(canola) is one of the wor.d’s most economically impor.ant oilseeds. Despite our.gr.wing knowledge of Br.ssica genetics, we still know little about the genes and gene r.gulator. networ.s under.ying ear.y seed development. In this wor., we use laser.micr.dissection coupled with r.A sequencing to pr.file gene activity of both the mater.al and filial subr.gions of the globular.seed. We find subr.gions of the chalazal end including the chalazal endosper., chalazal pr.lifer.ting tissue, and chalazal seed coat, have unique tr.nscr.ptome pr.files associated with hor.one biosynthesis and polysacchar.de metabolism. We confir. that the chalazal seed coat is uniquely enr.ched for.sucr.se biosynthesis and tr.nspor., and that the chalazal endosper. may function as an impor.ant r.gulator.of the mater.al r.gion thr.ugh br.ssinoster.id synthesis. The chalazal pr.lifer.ting tissue,a poor.y under.tood subr.gion, was specifically enr.ched in tr.nscr.pts associated with megaspor.genesis and tr.halose biosynthesis, suggesting this ephemer.l str.ctur. plays an impor.ant r.le in both spor.phytic development and car.on nutr.ent balance, r.spectively. Finally, compar.mentalization of tr.nscr.ption factor. and their.r.gulator. cir.uits has uncover.d pr.viously unknown r.les for.the chalazal pole in ear.y seed development.

关键词： Br.ssica napus L.(canola) under.tood subr.gion

Nano-Mor.hology of a Polymer.Electr.lyte Fuel Cell Catalyst Layer.Imaging, r.constr.ction and Analysis

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纳米研究：英文版 2011年第9期4卷 849-860页

作者： Simon Thiele r.land Zenger.e Chr.stoph ziegler Labor.tor. for.MEMS Applications Department of Microsystems Engineering--IMTEK University of Freiburg Georges-Koehler-Allee106 79110 Freiburg Germany

在聚合物电解质燃料房间(PEFC ) 的阴极催化剂层(CCL ) 的氧减小反应(Or. ) 在操作期间是表演损失的主要原因之一。另外， CCL 由于磅催化剂的使用是最昂贵的部件。除了 Or. 本身，种类运输到并且从反应地点决定 PEFC 的表演。在 CCL ... 详细信息

在聚合物电解质燃料房间(PEFC ) 的阴极催化剂层(CCL ) 的氧减小反应(Or. ) 在操作期间是表演损失的主要原因之一。另外， CCL 由于磅催化剂的使用是最昂贵的部件。除了 Or. 本身，种类运输到并且从反应地点决定 PEFC 的表演。在 CCL 的种类的有效运输性质取决于它的 nanostr.ctur.。因此， CCL 的三维的重建被要求。一系列二维的图象从集中的离子横梁扫描被获得为二维的图象的电子显微镜(FIB-SEM ) 成像和一个分割方法被开发了。毛孔尺寸分发(PSD ) 为三维的几何学被计算。PSD 上的排列和各向异性的象素尺寸的影响被调查了。毛孔在在 5 nm 和 205 nm 之间的范围被发现。Knudsen 数字的评估证明在 CCL 的那煤气的运输被转变流动政体管理。液体水运输能被包括在连续统水动力学以内描述合适滑动流动边界条件。

关键词：聚合物电解质燃料电池纳米结构催化剂层成像 Knudsen数扫描电子显微镜氧还原反应天然气运输