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Pancreatic hardness: Correlation of surgeon's palpation, durometer measurement and preoperative magnetic resonance imaging features

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World Journal of Gastroenterology 2017年第11期23卷 2044-2051页

作者： Tae Ho Hong Joon-Il Choi michael Yong park Sung Eun Rha Young Joon Lee Young Kyoung You Moon Hyung Choi Department of Surgery Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Cancer Research Institute Seoul St.Mary’s HospitalCollege of Medicinethe Catholic University of Korea Department of Radiology Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea

AIM To evaluate the correlation between subjective assessments of pancreatic hardness based on the palpation, objective measurements using a durometer, and magnetic resonance imaging(MRI) findings for assessing pancreatic *** Eighty-three patients undergoing pancreatectomies were enrolled. An experienced surgeon subjectively evaluated the pancreatic hardness in the surgical field by palpation. The pancreatic hardness was also objectivelyevaluated using a durometer. Preoperative MRI findings were evaluated by a radiologist in terms of the apparent diffusion coefficient(ADC) values, the relative signal intensity decrease(RSID) of the pancreatic parenchyma, and the diameter of the pancreatic parenchyma and duct. Durometer measurement results, ADC values, RSID, pancreatic duct and parenchyma diameters, and the ratio of the diameters of the duct and parenchyma were compared between pancreases judged to be soft or hard pancreas on the palpation. A correlation analysis was also performed between the durometer and MRI *** The palpation assessment classified 44 patients as having a soft pancreas and 39 patients as having a hard pancreas. ADC values were significantly lower in the hard pancreas group. The ductal diameter and duct-to-pancreas ratio were significantly higher in the hard pancreas group. For durometer measurements, a correlation analysis showed a positive correlation with the ductal diameter and the duct-to-pancreas ratio and a negative correlation with ADC values. CONCLUSION Hard pancreases showed lower ADC values, a wider pancreatic duct diameter and a higher duct-to-pancreas ratio than soft pancreases. Additionally, the ADC values, diameter of the pancreatic duct and duct-to-pancreas ratio were closely correlated with the durometer results.

关键词： Pancreas Texture Hardness Magnetic resonance imaging Fistula

MINAR1 is a Notch2-binding protein that inhibits angiogenesis and breast cancer growth

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Journal of Molecular Cell Biology 2018年第3期10卷 195-204页

作者： Rachel Xi-Yeen Ho Rosana D. Meyer Kevin B. Chandler Esma Ersoy michael park Philip A. Bondzie Nima Rahimi Huihong Xu Catherine E. Costello Nader Rahimi Department of Pathology School of Medicine Boston University Medical Campus Boston MA 02118 USA Department of Biochemistry and Center for Biomedical Mass Spectrometry School of Medicine Boston University Medical Campus Boston MA 02118 USA

Intrinsically disordered proteins （IDPs）/intrinsicaUy unstructured proteins are characterized by the lack of fixed or stable tertiary structure, and are increasingly recognized as an important class of proteins with major roles in signal transduction and transcriptional regulation. In this study, we report the identification and functional characterization of a previously uncharacterized protein （UPFO258/KIAA1024）, major intrinsically disordered Notch2-associated receptor 1 （MINAR1）. While MINAR1 carries a single transmembrane domain and a short cytoplasmic domain, it has a large extraceUular domain that shares no similarity with known protein sequences. Uncharacteristically, MINAR1 is a highly IDP with nearly 70% of its amino acids sequences unstructured. We demonstrate that MINAR1 physically interacts with Notch2 and its binding to Notch2 increases its stability and function. MINAR1 is widely expressed in various tissues including the epithelial cells of the breast and endothelial cells of blood vessels. MINAR1 plays a negative role in angioganesis as it inhibits angioganesis in cell culture and in mouse matrigal plug and zebraflsh anglo- genesis models. Furthermore, while MINAR1 is highly expressed in the normal human breast, its expression is significantly down- regulated in advanced human breast cancer and its re-expression in breast cancer cells inhibited tumor growth. Our study demonstrates that MINAR1 is an IDP that negatively regulates angioganesis and growth of breast cancer cells.

关键词： intrinsically disordered proteins Notch2 angiogenesis breast cancer MINAR1

Computed tomography and magnetic resonance imaging evaluation of lymph node metastasis in early colorectal cancer

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World Journal of Gastroenterology 2015年第2期21卷 556-562页

作者： Joonsung Choi Soon Nam Oh Dong-Myung Yeo Won Kyung Kang Chan-Kwon Jung Sang Woo Kim michael Yong park Department of Radiology Seoul St.Mary’s HospitalThe Catholic University of KoreaSeoul 137-701South Korea Department of Surgery Seoul St.Mary’s HospitalThe Catholic University of KoreaSeoul 137-701South Korea Department of Hospital Pathology Seoul St.Mary’s HospitalThe Catholic University of KoreaSeoul 137-701South Korea Department of Internal Medicine Seoul St.Mary’s HospitalThe Catholic University of KoreaSeoul 137-701South Korea

AIM: To assess the role of computed tomography(CT) and magnetic resonance imaging(MRI) and establish imaging criteria of lymph node metastasis in early colorectal ***: One hundred and sixty patients with early colorectal cancer were evaluated for tumor location, clinical history of polypectomy, depth of tumor invasion, and lymph node metastasis. Two radiologists assessed preoperative CT and/or MRI for the primary tumor site detectability, the presence or absence of regional lymph node, and the size of the largest lymph node. Demographic, imaging, and pathologic findings were compared between the two groups of patients based on pathologic lymph node metastasis and optimal size criterion was ***: The locations of tumor were ascending, transverse, descending, sigmoid colon, and rectum. One hundred and sixty early colorectal cancers were classified into 3 groups based on the pathological depth of tumor invasion; mucosa, submucosa, and depth unavailable. A total of 20(12.5%) cancers with submucosal invasion showed lymph node metastasis. Lymph nodes were detected on CT or MRI in 53 patients. The detection rate and size of lymph nodes were significantly higher(P = 0.000, P = 0.044, respectively) in patients with pathologic nodal metastasis than in patients without nodal metastasis. Receiver operating curve analysis showed that a cut-off value of 4.1 mm is optimal with a sensitivity of 78.6% and specificity of 75%.CONCLUSION: The short diameter size criterion of≥ 4.1 mm for metastatic lymph nodes was optimal for nodal staging in early colorectal cancer.

关键词： Early colon cancer Lymph node metastasis Computed

Digital twin modeling method for lithium-ion batteries based on data-mechanism fusion driving

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Green Energy and Intelligent Transportation 2024年第5期3卷 52-69页

作者： Chao Lyu Shaochun Xu Junfu Li michael Pecht School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin 150001HeilongjiangChina School of Automotive Engineering Harbin Institute of TechnologyWeihai 264209ShandongChina Center for Advanced Life Cycle Engineering(CALCE) University of MarylandCollege ParkMD 20742USA

Lithium-ion batteries have been rapidly developed as clean energy sources in many industrial fields,such as new energy vehicles and energy *** core issues hindering their further promotion and application are reliability and safety.A digital twin model that maps onto the physical entity of the battery with high simulation accuracy helps to monitor internal states and improve battery *** work focuses on developing a digital twin model via a mechanism-data-driven parameter updating algorithm to increase the simulation accuracy of the internal and external characteristics of the full-time domain battery under complex working *** electrochemical model is first developed with the consideration of how electrode particle size impacts battery *** adding the descriptions of temperature distribution and particle-level stress,a multi-particle size electrochemical-thermal-mechanical coupling model is ***,considering the different electrical and thermal effect among individual cells,a model for the battery pack is constructed.A digital twin model construction method is finally developed and verified with battery operating data.

关键词： Lithium-ion battery Multi-particle size electrochemical-thermalmechanical coupling model Online model parameter updating algorithm Digital twin

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适合中国企业的商务解决方案

程序员 2010年第2期 8-8页

作者： michael park 微软商务解决事业部

随着行业信息化领域应用的不断深入，客户对信息化也有了更高的需求。满足行业自身特点、满足流程再造的产品方案成为当今客户新的需求。不仅如此，越来越多的客户需要厂商为自己开发出个性化需求的产品，越来越多的厂商需要具备这种随... 详细信息

随着行业信息化领域应用的不断深入，客户对信息化也有了更高的需求。满足行业自身特点、满足流程再造的产品方案成为当今客户新的需求。不仅如此，越来越多的客户需要厂商为自己开发出个性化需求的产品，越来越多的厂商需要具备这种随需应变的能力和可移植的平台架构技术。近几年来，MBS（Microsoft Business Solution，微软企业解决方案）作为业内专注于面向成长型企业的管理软件供应商，一直致力于打造出更加适合国内企业的商务解决方案。

关键词：中国企业商务 Business 行业信息化企业解决方案产品方案个性化需求流程再造

Nonparametric Feature Screening via the Variance of the Regression Function

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Open Journal of Statistics 2024年第4期14卷 413-438页

作者： Won Chul Song michael G. Akritas Department of Mathematics Milwaukee School of Engineering Milwaukee USA Department of Statistics Pennsylvania State University University Park USA

This article develops a procedure for screening variables, in ultra high-di- mensional settings, based on their predictive significance. This is achieved by ranking the variables according to the variance of their respective marginal regression functions (RV-SIS). We show that, under some mild technical conditions, the RV-SIS possesses a sure screening property, which is defined by Fan and Lv (2008). Numerical comparisons suggest that RV-SIS has competitive performance compared to other screening procedures, and outperforms them in many different model settings.

关键词： Sure Independence Screening Nonparametric Regression Ultrahigh-Dimensional Data Variable Selection

Hom-derivations in C^*-ternary Algebras

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Acta Mathematica Sinica,English Series 2020年第9期36卷 1025-1038页

作者： Yuan Feng JIN Choonkil park michael ThRASSIAS Department of Mathematics Yanbian UniversityYanji 133001P.R.China Research Institute for Natural Sciences Hanyang UniversitySeoul 04763Republic of Korea Institute of Mathematics University of ZurichCH-8057ZurichSwitzerland

In this paper,we introduce and solve the following additive(ρ1,ρ2)-functional inequalities‖f(x+y+z)-f(x)-f(y)-f(z)‖≤‖ρ1(f(x+z)-f(x)-f(z))‖+‖ρ2(f(y+z)-f(y)-f(z))‖,whereρ1 andρ2 are fixed nonzero complex numbers with|ρ1|+|ρ2|<*** the fixed point method and the direct method,we prove the Hyers–Ulam stability of the above additive(ρ1,ρ2)-functional inequality in complex Banach ***,we prove the Hyers–Ulam stability of hom-derivations in C^*-ternary algebras.

关键词： Hyers–Ulam stability additive (ρ1 ρ2)-functional inequality fixed point method direct method hom-derivation on C^*-ternary algebra

后疫情时代要避免危机,领导者亟需做好这四件事

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中外管理 2020年第8期 26-26页

作者： Daniel Pacthod michael park 赵嘉怡(译) 不详

第一,大胆任用后起之秀。在新冠疫情之前,一家欧洲汽车和卡车制造商发现:公司最重要的50个价值贡献者当中,有2/3的人并非来自最高管理层,他们的职位通常比最高管理层低一到三个等级。而疫情的出现,让这一类中层管理者更快速地出现在了... 详细信息

第一,大胆任用后起之秀。在新冠疫情之前,一家欧洲汽车和卡车制造商发现:公司最重要的50个价值贡献者当中,有2/3的人并非来自最高管理层,他们的职位通常比最高管理层低一到三个等级。而疫情的出现,让这一类中层管理者更快速地出现在了领导面前,所以,企业管理者应该学会奖励并大胆任用他们。

关键词：最高管理层卡车制造商中层管理者企业管理者贡献者疫情领导者任用

Are the release characteristics of Erzhi pills in line with traditional Chinese medicine theory?A quantitative study

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Journal of Integrative Medicine 2021年第1期19卷 50-55页

作者： Jie-yu Zuo Chulhun park michael Doschak Raimar Lobenberg Faculty of Pharmacy and Pharmaceutical Sciences University of AlbertaEdmontonAlberta T6G 2E1Canada

Objective:Traditional Chinese medicine(TCM)has been widely used throughout China to prevent and cure diseases for thousands of years,and now it is a part of the integrative medicine field that is available in Western *** ensure the safety and quality of the herbal medicines that are a major part of the TCM tradition,they must be held to modern pharmaceutical *** pill(EZP)is a Chinese Pharmacopeia-listed herbal preparation that is used in the long-term clinical management of postmenopausal symptoms,osteoporosis and menstrual *** now,whether the drug release mechanism of EZP is in line with its intended TCM usage has not been ***:The release of specnuezhenide from three EZPs(self-made,Leiyunshang and Renhe)in simulated gastric fluid(SGF),acetate buffer(p H 4.5 buffer)and simulated intestinal fluid(SIF)was investigated in a dissolution *** water uptake capacity and erosion extent of the three EZPs were investigated using swelling and erosion *** drug release mechanism was further assessed through statistical model fitting,using DDSolver ***:The release of specnuezhenide from all three EZPs in SGF was less than 50%within a 4 h ***,over 70%of the specnuezhenide was released from each EZP in both p H 4.5 buffer and SIF in the same *** of the swelling and erosion behaviors and the drug release mechanism of the three EZPs confirmed that the release rate from EZP followed a sustained release profile,which was an interactive combination of swelling and ***:This study showed that the release pattern from the pills was in line with the intended TCM use of *** had not only theoretically considered sustained release from the pills,but also formulated them to achieve this release *** establishing quality control standards for pills,the theoretical TCM usage and the actual release patterns need to be considered.

关键词： Traditional Chinese medicine Dosage form Herbal preparation Dissolution Drug release mechanism Erzhi pill