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Use of donepezil for neurocognitive recovery after brain injury in adult and pediatric populations:a scoping review

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Neural Regeneration Research 2024年第8期19卷 1686-1695页

作者： Avery L.miller Nathan K.Evanson J.michael Taylor University of Cincinnati College of Medicine CincinnatiOHUSA Department of Pediatrics University of CincinnatiCincinnatiOHUSA Department of Neurology and Rehabilitation Medicine University of CincinnatiCincinnatiOHUSA Division of Pediatric Rehabilitation Medicine Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA Division of Neurology Cincinnati Children’s Hospital Medical CenterCincinnatiOHUSA

There are few pharmacologic options for the treatment of cognitive deficits associated with traumatic brain injury in pediatric *** inhibitors such as donepezil have been evaluated in adult patients after traumatic brain injury,but relatively less is known about the effect in pediatric *** goal of this review is to identify knowledge gaps in the efficacy and safety of acetylcholinesterase inhibito rs as a potential a djuvant treatment fo r neurocognitive decline in pediatric patients with traumatic brain *** queried PubMed to identify literature published from database inception thro ugh June 2023 desc ribing the use of donepezil in young adult traumatic brain injury and pediatric patients with predefined *** on preselected search criteria,340 unique papers we re selected for title and abstra ct ***-two reco rds were reviewed in full after eliminating preclinical studies and pape rs outside the scope of the *** adult traumatic brain injury,we review results from 14 papers detailing 227 subjects where evidence suggests donepezil is well tole rated and shows both objective and patient-reported efficacy for reducing cognitive *** children,3 pape rs report on 5 children recovering from traumatic brain injury,showing limited *** additional 15 pediatric studies conducted in populations at risk for cognitive dysfunction provide a broader look at safety and efficacy in 210 patients in the pediatric age *** its promise for efficacy in adults with traumatic brain injury and tole rability in pediatric patients,we believe further study of donepezil for children and adolescents with traumatic brain injury is warranted.

关键词： acetylcholinesterase inhibitor adult cognition donepezil pediatrics traumatic brain injury

Cardiovascular disease:A global problem extending into the developing world

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World Journal of Cardiology 2009年第1期1卷 3-10页

作者： Temilolu Olayinka Aje michael miller Division of Cardiology Department of MedicineUniversity of Maryland School of MedicineRm S3B0622 South Greene St.BaltimoreMD 21201United States

This article reviews the current status of cardiovascular disease(CVD) on the international *** viewed as an epidemic that has migrated from westernized societies to developing countries,several important issues are elaborated *** include the basis for the increasing prevalence of CVD and the associated societal *** challenges related to lack of resources and infrastructure support may also impede successful implementation of proven strategies to reduce *** addition to traditional risk factors such as cigarette smoking,hypertension,obesity,hyperlipidemia,diabetes mellitus and insulin resistance,many developing countries must also contend with other risk *** in this grouping are human immunodeficiency virus/acquired immunodeficiency syndrome and other infectious/inflammatory processes as well as nutritional and vitamin deficiencies that make preventive measures more difficult to *** together,greater partnering between local governments,affiliated hospitals and international societies is needed to enhance and facilitate efforts aimed at optimizing standard of care measures in developing countries in order to reduce cardiovascular risk.

关键词： Heart disease Developing world Epidemic Risk factors Urbanization Prevention

Mars Probe Maintains Deafening Silence

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当代外语研究 2000年第1期 1-3页

作者： michael miller 许梦湖

随着1999年12月6日最后一次同Mars Polar Lander(火星极地着陆者)联系的失败,美国宇航局科学家寻找Mars Polar Lander下落的努力宣告失败。这是美国字航局在不到3个月的时间里损失的第二个火星探测器。今年1月从美国卡纳维拉尔角发射升... 详细信息

随着1999年12月6日最后一次同Mars Polar Lander(火星极地着陆者)联系的失败,美国宇航局科学家寻找Mars Polar Lander下落的努力宣告失败。这是美国字航局在不到3个月的时间里损失的第二个火星探测器。今年1月从美国卡纳维拉尔角发射升空的Mars Polar Lander,经过11个月的飞行按计划应于12月3日在火星着陆,并在90天的时间里对火星的气候变迁、地质状况、水和冰以及大气构成进行考察,并获取土壤样品携带回地球,为人类最终飞往火星打下基础。已在火星轨道上运行的“火星环球勘探者”一直在寻找Mars Polar Lander和两个Deep Space 2 microprobes(探空二号微型探测器),但也都毫无收获,无法向地面发回有关它们下落的信息。这说明美国宇航局已失去了耗资1.65亿美元的Mars Polar Lander和将近3000万美元的Deep Space 2 microprobes。1999年9月23日,美国宇航局的另一个火星探测器在进入火星大气层时被烧毁。这次失败必将影响到美国宇航局2001年对火星的考察计划。这一计划已进入研制和测试的最后阶段,按原计划美国宇航局将于2001年3月从加州的范登堡空军基地发射一个火星轨道器,4月从卡纳维拉尔角发射一个火星着陆器,对火星进行全面的探测。人类登上火星的道路是漫长的。

关键词：火星大气层宇航局 Mars Probe Maintains Deafening Silence 火星探测器卡纳维拉尔角

Data and Network Communications 英文影印

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The Challenges of Assessing the Output of EmergentEconomies： The Case of Bahrain

丛书名：国外高校电子信息类优秀教材

2002年

作者： michael A.miller

本书介绍了数据通信技术和电话系统、错误检测和修正的通用方法、两种开放系统网络层模型——osi和sna，重点是osi模型的物理层和数据链接层、网络和传输层，并介绍了集成服务数字网络和路径协议、光纤网络及各种无线通信系统。　　本... 详细信息

ISBN: (数字)7030101278

ISBN: (纸本)9787030101273

本书介绍了数据通信技术和电话系统、错误检测和修正的通用方法、两种开放系统网络层模型——osi和sna，重点是osi模型的物理层和数据链接层、网络和传输层，并介绍了集成服务数字网络和路径协议、光纤网络及各种无线通信系统。　　本书可作为通信专业的本科生教材，也可供相关专业技术人员参考。

关键词：数据通信

来源：畅想之星图书光盘版（南... 评论

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Chinese Business Review 2011年第12期10卷 1138-1147页

作者： michael S. miller Seth Epstein DePaul University Chicago USA

Business analysts worldwide use the standard theories and tools of macroeconomics and finance to determine the investment, trade or production possibilities in foreign markets. These evaluations are generally supported by three sources： estimations of using country-specific macroeconomic data on which they can determine patterns of growth, inflation, unemployment, productivity, income per capita, etc.; timely data on current conditions and developments in production, income and spending; and institutional information on policy makers, business practices and financial markets. This paper focuses on the first two where we examine the publically available macroeconomic data for the Kingdom of Bahrain to determine their reliability. Among our findings are：（1） creating a reliable data base of macroeconomic data is difficult due to data revision and incomplete data gathering; （2） the movement of standard macro-variables is often unusual, leading one to question further the reliability of the data; （3） based on available data it appears that the growth in Bahrain has been driven almost solely by an increase in the number of people working, with little to no apparent rise in productivity; and （4） the growth of GDP will eventually be constrained by physical limits on population growth, and can be improved only if ways can be found to increase the productivity of the workforce.

关键词： Bahrain macroeconomic data reliability GDP labor force productivity

For Sale On The Web:Ovarian Eggs Of Beautiful Women

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当代外语研究 1999年第11期 8-10页

作者： michael miller 柳延延

英国时装模特摄影师Ron Harris从10月25日起开辟了名模出售卵子的网页,以吸引世界上还没有孩子的富翁购买名模的卵子,为自己生下“美丽”的后代。有意者通过“哈里斯安琪儿”网页就能获得愿意出卖卵子的名模的详细信息,然后用信用卡就... 详细信息

英国时装模特摄影师Ron Harris从10月25日起开辟了名模出售卵子的网页,以吸引世界上还没有孩子的富翁购买名模的卵子,为自己生下“美丽”的后代。有意者通过“哈里斯安琪儿”网页就能获得愿意出卖卵子的名模的详细信息,然后用信用卡就能购买到他们心中的“安琪儿”的卵子,从而得到为自己生下“完美”后代的良机。据哈里斯的统计,世界上有数百万男子,其中不少十分富有,希望他们的基因能与最美丽、遗传基因最好的女子相结合,从而把“美”传给后代。这些名模的卵子投标的最低起点价为1.5万美元。哈里斯的这一做法遭到了一些组织的指责。国际生育组织谴责哈里斯将人的生命商品化的做法,认为他的行为有辱不孕夫妇的人格。英国不孕夫妇的最大慈善机构的主任赫杰莱认为,哈里斯的做法破坏了公众对不孕症进行治疗的观念。他警告哈里斯说,开辟“美丽”卵子市场是危险之经,有可能导致犯罪团伙劫持名模、以更高的价格出售她们的卵子。本文还提供了另一种反面的声音。这条理由还颇使人尴尬:Just look at allthe beautiful women in the world whose children look nothing like them.看来,这项“改造人的伟大事业”还需要保险公司的大力扶持。

关键词：哈里斯 For Sale On The Web:Ovarian Eggs Of Beautiful Women

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万物互联

The role of intangible capital in wage inequality between skilled and unskilled workers in China

作者： (美)michael miller

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Chinese Business Review 2010年第2期9卷 13-20,26页

作者： Qi Hong Dong michael S. miller Department of Economics DePaul University Chicago IL 60604 USA

Wage inequality between skilled and unskilled workers has increased rapidly in China, right along with its major trading partner--the United States. Trade liberalization and technological improvement have been proposed as causes for the inequality, yet trade liberalization and technological improvement have set the stage for another, possibly more important, cause of the inequality： the movement of intangible capital to China. Intangible capital works synergistically with other inputs to make skilled-workers and tangible capital more valuable. Once the accumulated tangible capital reaches a certain level, its lower unit cost will attract the inflow of intangible capital, which will further expand the demand for skilled workers. As a result, wage inequality becomes larger in China. This paper takes the first step in an attempt to understand the role that the movement of intangible capital plays in the increasing wage inequality in China, and sets out several possible policy prescriptions for China to deal with this inequality.

关键词： intangible assets skilled workers wage inequality

Molecular Computational Anatomy:Unifying the Particle to Tissue Continuum via Measure Representations of the Brain

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Biomedical Engineering Frontiers 2022年第1期3卷 453-468页

作者： michael miller Daniel Tward Alain Trouvé Department of Biomedical Engineering&Kavli Neuroscience Discovery Institute&Center for Imaging Science Johns Hopkins UniversityBaltimoreUSA Departments of Computational Medicine&Neurology University of California Los AngelesLos AngelesUSA Centre Giovanni Borelli(UMR 9010) Ecole Normale Supérieure Paris-SaclayUniversitéParis-SaclayGif-sur-YvetteFrance

*** objective of this research is to unify the molecular representations of spatial transcriptomics and cellular scale histology with the tissue scales of computational anatomy for brain *** *** present a unified representation theory for brain mapping based on geometric varifold measures of the microscale deterministic structure and function with the statistical ensembles of the spatially aggregated tissue *** across coordinate systems in computational anatomy allows us to understand structural and functional properties of the brain at the millimeter *** measurement technologies in digital pathology and spatial transcriptomics allow us to measure the brain molecule by molecule and cell by cell based on protein and transcriptomic functional *** currently have no mathematical representations for integrating consistently the tissue limits with the molecular particle *** formalism derived here demonstrates the methodology for transitioning consistently from the molecular scale of quantized particles—using mathematical structures as first introduced by Dirac as the class of generalized functions—to the tissue scales with methods originally introduced by Euler for *** introduce two mathematical methods based on notions of generalized functions and statistical *** use geometric varifolds,a product measure on space and function,to represent functional states at the micro-scales—electrophysiology,molecular histology—integrated with a Boltzmann-like program to pass from deterministic particle descriptions to empirical probabilities on the functional states at the tissue *** space-function varifold representation provides a recipe for traversing from molecular to tissue scales in terms of a cascade of linear space scaling composed with nonlinear functional feature *** the cascade implies every scale is a geometric measure so that a universal fam

关键词： anatomy unified function