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The subgenual cingulate gyrus exhibits lower rates of bifurcation in schizophrenia than in controls, bipolar disorder and depression

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Open Journal of Psychiatry 2012年第4期2卷 253-257页

作者： Matthew R. Williams Ronald K. B. Pearce Steven R. Hirsch Olaf Ansorge Maria Thom michael maier Department of Neuropathology The Radcliffe Infirmary Oxford UK Institute of Neurology UCL London UK King’s College London Institute of Psychiatry De Crespigny Park London UK Neuropathology Unit Department of Clinical Neuroscience Division of Neuroscience & Mental Health Imperial College London Charing Cross Hospital London UK Trust HQ West London Mental Health NHS Trust Middlesex UK

The subgenual cingulate cortex has been found to be different in structure and function in mood and affective disorders compared to healthy individuals. Imaging studies have shown a decrease in function of the subgenual region in bipolar disorder and depression, with overall glial number shown to be decreased in these disorders. Decreases in subgenual grey matter in SZ have been observed also. In this neuropathological study upon formalin-fixed coronal brain sections we describe the morphological finding of de- creased frequency of subgenual cingulate crown bifurcation (p = 0.02) as compared to control, bipolar and depression cases. This suggests that the cingulate cortex in schizophrenia may be morphologically distinct in utero formation, potentially enabling an early identification of high-risk individuals.

关键词： Neuropathology Schizophrenia Cortical Flattening

Structure-function relationship comparison between retinal nerve fibre layer and Bruch's membrane opening-minimum rim width in glaucoma

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International Journal of Ophthalmology(English edition) 2017年第10期10卷 1534-1538页

作者： Lukas Reznicek Sophie Burzer Andrea Laubichler Ali Nasseri Chris P Lohmann Nikolaus Feucht michael Ulbig Mathias maier Department of Ophthalmology Technical University of Munich

AIM：To evaluate and compare structural optical coherence tomography（OCT）-based parameters,such as Bruch’s membrane opening-minimum rim width（BMO-MRW）,and retinal nerve fiber layer（RNFL）thickness in glaucoma patients with visual field（VF）defects,and to correlate both to mean deviation（MD）values of obtained standard achromatic perimetry（SAP）***：Patients with glaucoma and glaucomatous VF defects were enrolled in this prospective study and compared to age-matched healthy *** study participants underwent a full ophthalmic examination and VF testing with *** RNFL thickness and BMO-MRW were acquired with *** analyses between obtained global functional and global as well as sectorial structural parameters were ***：A consecutive series of 30 glaucomatous right eyes of 30 patients were included and compared to 36healthy right eyes of 36 individuals in the control *** MD of values correlated significantly with global RNFL（Pearson ***：0.632,P=0.001）and global BMO-MRW（Pearson ***：0.746,P〈0.001）values in the glaucoma *** MD and sectorial RNFL or BMO-MRW values correlated less *** the control group,MD values did not correlate with RNFL or BMO-MRW measurements.A subgroup analysis of myopic patients（〉4 diopters）within the glaucoma group（n=6）revealed a tendency for higher correlations between MD and BMO-MRW than MD and RNFL ***：In a clinical setting,RNFL thickness and BMO-MRW correlate similarly with global VF sensitivity in glaucoma patients with BMO-MRW showing higher correlations in myopic glaucoma patients.

关键词： glaucoma optical coherence tomography Bruch's membrane opening-minimum rim width retinal nerve fibre layer myopia standard automated perimetry visual field defects

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几种多功能护理液对镜片保湿效果的比较

中国眼镜科技杂志 2006年第2期 50-51页

作者： Stephen E.maier X.michael Liu

消费者在配戴隐形眼镜的过程中最常见的不适症状就是眼睛干燥,他们普遍认为:隐形眼镜多功能护理液对镜片表面的保湿作用能够极大地影响镜片配戴的舒适度、配戴全天的无干燥感、镜片的整体眼内表现。博士伦公司最新推出的润明水凝全护理... 详细信息

消费者在配戴隐形眼镜的过程中最常见的不适症状就是眼睛干燥,他们普遍认为:隐形眼镜多功能护理液对镜片表面的保湿作用能够极大地影响镜片配戴的舒适度、配戴全天的无干燥感、镜片的整体眼内表现。博士伦公司最新推出的润明水凝全护理液,特殊添加专利的水凝分子,可以与泪液协同作用,持久保持镜片表面湿润,令眼睛一整日舒适。下面这几组实验证明了润明水凝分子卓越的保湿效果。

关键词：保湿效果护理液多功能镜片隐形眼镜博士伦公司协同作用实验证明舒适度消费者

应用全血阻抗法和传统透光聚集度评估体外循环所致血小板聚集功能改变的试验性研究

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麻醉与镇痛 2011年第3期7卷 48-56页

作者： Corinna Velik-Salchner, MD Stephan maier, MD Petra Innerhofer, MD Christian Kolbitsch, MD Werner Streif, MD Markus Mittermayr, MD michael Praxmarer, MSc Dietmar Fries, MD 冯雪辛(译) Departments of Anesthesiology and Intensive Care Medicine Innsbrudk Medical University Innsbruck Austria Pediatrics Innsbruck Medical University Innsbrudk Medical University Innsbruck Austria Assign Data Management and Biostatistics lnnsbruck Austria Innsbrudk Medical University Innsbruck Austria Department of General and Surgical Critical Care Medicine Innsbrudk Medical University Innsbruck Austria 不详

背景本研究分别采用全血阻抗法与传统透光聚集度（LTA）测定血小板聚集率，以探讨抗血小板治疗药物是否会降低心脏手术或体外循环（CPB）后的血小板聚集功能。方法选择70例拟行择期冠状动脉旁路移植术的患者，分别于麻醉诱导前、诱导中... 详细信息

背景本研究分别采用全血阻抗法与传统透光聚集度（LTA）测定血小板聚集率，以探讨抗血小板治疗药物是否会降低心脏手术或体外循环（CPB）后的血小板聚集功能。方法选择70例拟行择期冠状动脉旁路移植术的患者，分别于麻醉诱导前、诱导中和肝素化后15分钟及3小时采取动脉血，应用Multiplate（M）测定随时间变化的电阻值作为聚集单位，同时使用以胶原（COL）、二磷酸腺苷（ADP）或花生四烯酸（AA）为激活剂的LTA（％聚集率）法进行检测。A组（n=48）为对照组，手术前停用抗血小板药物至少7天，B组（n=11）和C组（n=11）患者分别服用阿司匹林100mg／d或阿司匹林100mg／d与氯吡格雷75mg／d（双重抗血小板治疗）至手术前一天。结果未行抗血小板治疗的患者，给予鱼精蛋白15分钟及3小时后，应用3种激活剂及两种聚集方法均可观察到血小板聚集率明显降低。单纯使用阿司匹林的患者，LTA—COL、LTA—ADP及M—ADP随时间发生显著改变；接受双重抗血小板治疗的患者，两种方法的ADP检测均提示给予鱼精蛋白15分钟后血小板聚集显著减弱。通过计算受试者工作特征曲线（receiver-operatingcharacteristiccurves，ROC曲线）下面积来区分抗血小板药物，LTA-COL可以在CPB后15分钟和3小时区分出对照组与阿司匹林组或双重抗血小板治疗组，M—ADP则可在鱼精蛋白拮抗后3小时区分对照组和双重抗血小板治疗组。结论对于未经抗血小板治疗的患者，全血电阻抗法及使用了常用激活剂的传统LTA法均可检测出CPB所致的血小板聚集功能改变。而对于接受了抗血小板治疗的患者，ADP激活的抗血小板检测方法能更好地检测出CPB所致的血小板聚集功能减退。

关键词：血小板聚集功能电阻抗法体外循环试验性研究全血应用抗血小板药物抗血小板治疗

Therapeutic resistance training:proposal for an algorithm-based approach

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Translational Exercise Biomedicine

Translational Exercise Biomedicine 2024年第1期1卷 89-101页

作者： Frank Weber Christina Stark Wilhelm Bloch Jonas Böcker michael Drey Sebastian Gehlert Björn maier Kirsten Peters Ludwig Sachs Benedikt Schoser Eckhard Schönau Rolf Schröder Henning Wackerhage Peter Young Jörn Rittweger German Air Force Center of Aerospace Medicine CologneGermany Department of Neurology Medical Faculty and University HospitalUniversity of CologneCologneGermany Section Molecular and Cellular Sports Medicine German Sports University CologneCologneGermany Institute of Aerospace Medicine German Aerospace CenterCologneGermanyLinder Höhe51147 Department of Internal Medicine IV Ludwig-Maximilians-University of MunichMunichGermany Department for Biosciences of Sports Institute of Sports ScienceUniversity of HildesheimHildesheimGermany Duale Hochschule Baden Württemberg MannheimGermany Rijnstate Hospital Arnhemthe Netherlands Psychotherapie Praxis Sachs Prien a.ChiemseeGermany Friedrich-Baur-Institute Ludwig-Maximilians-UniversityMunichGermany Department of Pediatrics Medical Faculty and University HospitalUniversity of CologneCologneGermanyD-50937 Institute of Neuropathology Friedrich-Alexander UniversityErlangenGermany Department of Sport and Health Sciences Technical University MunichMunichGermany Medical Park Bad Feilnbach Bad FeilnbachGermany

Background Ageing,immobilization,sepsis or cachexia reduce muscle mass and *** age-related loss,***,contributes to frailty and results in a loss of mobility and autonomy in aging and *** individuals are often socially isolated,have a greater risk of metabolic disorders and psychosomatic *** a result,quality of life and life expectancy are *** and lack of adequate stimuli to the skeletal muscle seem to play a central part in these *** overcome them,resistance training(i.e.,weightlifting)is an effective *** of the problem Despite the efficacy of resistance training for increasing muscle mass and function,this treatment is underused in clinical *** argue that this is due to a lack of a generally applicable *** and framework To address this and related problems,we have formed the Network of Expertise for Immobilization-induced Muscle Disorders(KNIMS)to develop a potential algorithm for treating sarcopenia and other immobilization-related muscle *** important aspect of the proposed method is that it is defined as a formal algorithm that consists of two *** A aims to recover bed-ridden patients’ability to stand by applying vibration-tilt table *** B aims at rehabilitating compromised gait,using a combination of squats,lunges and single leg *** is anticipated that this algorithm-based approach will enhance the ability for standardization and documentation,whilst reducing resource efforts at the same time,which will be equally useful to clinical practice and to clinical research.

关键词： muscle training sarcopenia falls mobility immobilization physiotherapy muscle