检索结果-南通市图书馆

Harnessing innovation to help meet the needs of elders:field testing an electronic tool to streamline geriatric assessments across healthcare settings

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Family Medicine and Community Health 2024年第2期12卷 1-11页

作者： Limor Adler Zorian Radomyslsky Miri mizrahi Reuveni Eduardo Schejter Ilan Yehoshua Yakov Segal Sara Kivity Etti Naimi Mor Saban Maccabi Healthcare Services Tel AvivIsrael Department of Health system management Ariel UniversityArielIsrael Medical&Health Sciences Tel Aviv UniversityTel AvivIsrael

Background As populations age globally,effectively managing geriatric health poses challenges for primary *** geriatric assessments(CGAs)aim to address these challenges through multidisciplinary screening and coordinated care ***,most CGA tools and workflows have not been optimised for routine primary care *** This study aimed to evaluate the impact of a computerised CGA tool,called the Golden Age Visit,implemented in primary care in *** This study employed a quasiexperimental mixed-methods design to evaluate outcomes associated with the Golden Age electronic health assessment *** analysis used electronic medical records data from Maccabi Healthcare Services,the second largest health management organisation(HMO)in *** aged 75 and older were included in analyses from January 2017 to December 2019 and January 2021 to December *** patients,data were also collected on controls who did not participate in the Golden Age Visit programme during the same time period,to allow for comparison of *** physicians,qualitative data were collected via surveys and interviews with primary care physicians who used the Golden Age Visit SMARTEST e-assessment *** A total of 9022 community-dwelling adults aged 75 and older were included in the study:1421 patients received a Golden Age Visit CGA(intervention group),and 7601 patients did not receive the assessment(control group).After CGAs,diagnosis rates increased significantly for neuropsychiatric conditions and *** to physiotherapy,occupational therapy,dietetics and geriatric outpatient clinics also rose ***,no differences were found in rates of hip fracture or relocation to long-term care between *** among physicians(n=151)found high satisfaction with the *** Implementation of a large-scale primary care CGA programme was associated with improved diagnosis and management of geriatr

关键词： diagnosis routine Golden

Role of laparoscopy in rectal cancer:A review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第17期20卷 4900-4907页

作者： Ido mizrahi Haggi Mazeh Department of Surgery HadassahHebrew University Medical CenterMount ScopusJerusalem 91240Israel

Despite established evidence on the advantages of laparoscopy in colon cancer resection,the use of laparoscopy for rectal cancer resection is still *** initial concern was mainly regarding the feasibility of laparoscopy to achieve an adequate total mesorectal excision *** concerns have been raised following early studies demonstrating higher rates of circumferential margins positivity following laparoscopic resection,as compared to open *** to colon resection,patients undergoing laparoscopic rectal cancer resection are expected to benefit from a shorter length of hospital stay,less analgesic requirements,and a faster recovery of bowel *** the past decade there have been an increasing number of large scale clinical trials investigating the oncological and perioperative outcomes of laparoscopic rectal cancer *** this review we summarize the current literature available on laparoscopic rectal cancer surgery.

关键词： Rectal cancer Laparoscopy Open resection Review Comparison Outcomes Laparoscopic resection of gastrointestinal

Gastric stimulation for weight loss

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2012年第19期18卷 2309-2319页

作者： Meir mizrahi Ami Ben Ya'acov Yaron Ilan Gastroenterology and Liver Units Hebrew University-Hadassah Medical CenterEin-KaremJerusalemPOB1200Israel

The prevalence of obesity is growing to epidemic proportions,and there is clearly a need for minimally invasive therapies with few adverse effects that allow for sustained weight *** and lifestyle therapy are safe treatments for obesity in the short term,but the durability of the weight loss is *** promising obesity drugs are in development,the currently available drugs lack efficacy or have unacceptable side *** leads to long-term weight loss,but it is associated with morbidity and *** electrical stimulation(GES) has received increasing attention as a potential tool for treating obesity and gastrointestinal dysmotility *** is a promising,minimally invasive,safe,and effective method for treating *** gastric pacing is aimed at alteration of the motility of the gastrointestinal tract in a way that will alter absorption due to alteration of transit *** addition,data from animal models and preliminary data from human trials suggest a role for the gut-brain axis in the mechanism of *** may involve alteration of secretion of hormones associated with hunger or *** selection for gastric stimulation therapy seems to be an important determinant of the treatment's ***,we review the current status,potential mechanisms of action,and possible future applications of gastric stimulation for obesity.

关键词： Obesity Gastric stimulation Gastric motil-ity External pacing Gastric pacing Intestinal pacing

Hepatitis C infection and lymphoproliferative disease:Accidental comorbidities?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第43期20卷 16197-16202页

作者： Tawfik Khoury Shmuel Chen Tomer Adar E Ollech Jacob Meir mizrahi Department of Internal Medicine Hebrew University-Hadassah Medical CenterJerusalemIL 91120Israel Institute for Gastroenterology and Liver Disease Hebrew University-Hadassah Medical CenterJerusalemIL 91120Israel

Chronic hepatitis C virus(HCV)infection has been associated with liver cancer and cirrhosis,autoimmune disorders such as thyroiditis and mixed cryoglobulinema,and alterations in immune function and chronic inflammation,both implicated in B cell lymphoproliferative diseases that may progress to non-Hodgkin lymphoma(NHL).HCV bound to B cell surface receptors can induce lymphoproliferation,leading to DNA mutations and/or lower antigen response *** findings and epidemiological reports suggest an association between HCV infection and *** performed a systematic review of the literature to clarify this potential *** searched the English-language literature utilizing Medline,Embase,Paper First,Web ofScience,Google Scholar,and the Cochrane Database of Systematic Reviews,with search terms broadly defined to capture discussions of HCV and its relationship with NHL and/or lymphoproliferative *** were screened to further identify relevant studies and literature in the basic sciences.A total of 62 reports discussing the relationship between HCV,NHL,and lymphoproliferative diseases were *** studies suggest that at least a portion of NHL may be etiologically attributable to HCV,particularly in areas with high HCV *** that showed a lack of association between HCV infection and lymphoma may have been influenced by small sample size,short follow-up periods,and database *** association appears strongest with the B-cell lymphomas relative to other lymphoproliferative *** by which chronic HCV infection promotes lymphoproliferative disease remains *** is a multifactorial process involving genetic,environmental,and infectious *** most probably have a role in the lymphomagenesis but further study to clarify the association and underlying mechanisms is warranted.

关键词： Blood Hepatitis C infection Non-Hodgkin’ s lymphoma Pathogenesis Treatment

A prospective study assessing the efficacy of abdominal computed tomography scan without bowel preparation in diagnosing intestinal wall and luminal lesions in patients presenting to the emergency room with abdominal complaints

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2005年第13期11卷 1981-1986页

作者： Michal mizrahi Yoav Mintz Avraham Rivkind David Kisselgoff Eugene Libson Mayer Brezis Eran Goldin Oren Shibolet Gastroenterology Unit Department of General Surgery Department of Radiology School of Public Health

AIM: To evaluate the positive predictive value of abdominal non-prepared computed tomography (CT) for diagnosing intestinal lumen or wall lesions in patients presenting to the emergency room (ER) with abdominal ***: For 1-year we prospectively evaluated all ER patients hospitalized after abdominal CT scan detected either intraluminal or intestinal wall lesions. These patients underwent colonoscopy serving as gold standard. Patients with prior abdominal pathology or CT findings of appendicitis or diverticulitis were ***: Five hundred and sixty-eight abdominopelvic CT scans were performed in the ER, 96 had positive colonic findings. Sixty-two patients were excluded, 46 because of diverticulitis or appendicitis, 16 because of prior abdominal pathology. Of the remaining 34 patients, 14 did not undergo colonoscopy during *** eligible patients were included in the study. The positive predictive value of the CT scans performed in the ER was calculated to be 45% (95% CI 25-67).CONCLUSION: CT findings correlated with colonoscopic findings only in approximately half of the cases. Relying on non-prepared CT scan findings in planning patient management and colonoscopy may lead to unnecessary diagnostic work-ups.

关键词： Abdominal computed tomography Intestinal lesions Emergency room

Multi-institutional retrospective analysis of FOLFIRI in patients with advanced biliary tract cancers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2020年第1期12卷 83-91页

作者： Jonathan D mizrahi Valerie Gunchick Kabir Mody Lianchun Xiao Phanikeerthi Surapaneni Rachna T Shroff Vaibhav Sahai Division of Cancer Medicine The University of Texas MD Anderson Cancer CenterHoustonTX 77005United States Department of Internal Medicine University of MichiganAnn ArborMI 48109United States Division of Medical Oncology Mayo Clinic Cancer CenterJacksonvilleFL 32224United States University of Arizona Cancer Center University of ArizonaTucsonAZ 85724United States

BACKGROUND Gemcitabine plus platinum is the standard of care first-line treatment for advanced biliary tract cancers(BTC).There is no established second-line therapy,and retrospective reviews report median progression-free survival(PFS)less than 3 mo on second-line therapy.5-Fluorouracil plus irinotecan(FOLFIRI)is a commonly used regimen in patients with BTC who have progressed on gemcitabine plus platinum,though there is a paucity of data regarding its efficacy in this *** To assess the efficacy of FOLFIRI in patients with biliary tract *** We retrospectively identified patients with advanced BTC who were treated with FOLFIRI at MD Anderson,University of Michigan and Mayo Clinic in *** were collected on patient demographics,BTC subtype,response per RECIST v1.1,progression and *** Ninety-eight patients were included of which 74(75%)had metastatic and 24(25%)had locally advanced disease at the time of treatment with *** median age was 60(range,22-86)*** number of patients with extrahepatic cholangiocarcinoma,gall bladder cancer and intrahepatic cholangiocarcinoma were 10,17 and 71,*** was used as 1st,2nd,3rd or 4th–Nth lines in 8,50,36 and 4 patients,*** duration on FOLFIRI in the entire cohort was 2.2(range,0.5-8.4)*** median PFS and overall survival were 2.4(95%confidence interval(CI):1.7-3.1)and 6.6(95%CI:4.7-8.4)mo,*** PFS for patients treated with FOLFIRI in 1st,2nd,3rd or 4th–Nth lines were 3.1,2.5,2.3 and 1.5 mo,*** patients received concurrent bevacizumab(n=13)or EGFR-targeted therapy(n=5)with FOLFIRI,with a median PFS of 2.7 mo(95%CI:1.7-5.1).CONCLUSION In this largest multi-institution retrospective review of 98 patients with BTC treated with FOLFIRI,efficacy appears to be modest with outcomes similar to other cytotoxic chemotherapy regimens.

关键词： Biliary tract neoplasms Fluorouracil Irinotecan Cholangiocarcinoma Retrospective studies

Drug Induced Liver Injury: Review with a Focus on Genetic Factors, Tissue Diagnosis, and Treatment Options

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2015年第2期3卷 99-108页

作者： Tawfik Khoury Ayman Abu Rmeileh Liron Yosha Ariel A.Benson Saleh Daher Meir mizrahi Department of Medicine Hadassah-Hebrew University Medical Center Jerusalem Israel Department of Gastroenterology Hadassah-Hebrew University Medical Center Jerusalem Israel Center for Advanced Endoscopy Harvard Medical School Beth Israel Deaconess Medical Center Boston MA USA

Drug-induced liver injury (DILI) is a rare but potentially life threatening adverse drug *** may mimic any morphologic characteristic of acute or chronic liver disease,and the histopathologic features of DILI may be indistinguishable from those of other causes of liver injury,such as acute viral *** this review article,we provide an update on causative agents,clinical features,pathogenesis,diagnosis modalities,and outcomes of *** addition,we review results of recently reported genetic studies and updates on pharmacological and invasive treatments.

关键词： DILI Hepatotoxicity Treatment

Carbides Formation in MarM247 Directional Solidified during Stress-Rupture Test at High Temperature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Minerals and Materials Characterization and Engineering 2023年第5期11卷 131-142页

作者： Daniel Moreno Itzik mizrahi Yuri Lipkin Vasiliy Zevin Elinor Itzhak Zion Harush Beth Shemesh Engines Ltd. FAA & EASA Beth Shemesh Israel

In our study, stress-rupture tests were conducted at elevated temperatures to examine the impact of high temperature on MarM247 LC (low carbon). Our main objective was to investigate the alterations in the microstructure, particularly the carbon precipitation, during long-term stress-rupture tests. It was observed that cracks developed near the sample neck, following the path of the carbides and the gamma matrix, rather than occurring in the gamma-gamma prime eutectic. This occurred despite the formation of carbides because of prolonged exposure to high temperature and load, and the crack propagation did not follow that path. Based on these findings, we suggest that a reduction in the carbon content of Mar-M247 LC can enhance the sample's lifespan when subjected to temperatures below 760˚C and a stress of 690 MPa.

关键词： MarM247 Carbides Stress-Rupture High-Temperature Crack-Propagation

Azathioprine-induced fever in autoimmune hepatitis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2013年第25期19卷 4083-4086页

作者： Tawfik Khoury Jacob E Ollech Shmuel Chen Meir mizrahi Meir Shalit Departments of Internal Medicine Hadassah-Hebrew University Medical Center Departments of Gastroenterology and Hepatology Gastroenterology and Liver Disease Institute Hadassah-Hebrew University Medical Center Jerusalem

Underdiagnosis of drug-induced fever leads to extensive investigation and prolongation of hospitalization, and may lead to multiple unnecessary invasive procedures and a wrong diagnosis. Azathioprine is a widely used immunosuppressive drug. We report a case of a 53-year-old female patient diagnosed with autoimmune hepatitis treated with azathioprine, who presented to the emergency room with a 6-wk history of fever and chills without other associated symptoms. Since the patient's fever was of unknown origin, she was hospitalized. All treatment was stopped and an extensive workup to explore the source of fever and chills was performed. Results of chest X-ray, viral, urine, and blood cultures, autoimmune serology, transthoracic and transesophageal echocardiography, and abdominal ultrasound revealed no source of infection. A rechallenge test of azathioprine was performed and the fever and chills returned within a few hours. Azathioprine was established as the definite cause following rechallenge. Fever as an adverse drug reaction is often unrecognized. Azathioprine has been reported to cause druginduced fever in patients with inflammatory bowel disease, rheumatoid arthritis, and sarcoidosis. To the bestof our knowledge there have been no previous reports documenting azathioprine-induced fever in patients with autoimmune hepatitis. The occurrence of fever following the readministration of azathioprine suggests the diagnosis of drug-induced fever, particularly after the exclusion of other causes. A careful rechallenge is recommended to confirm the diagnosis.

关键词： Autoimmune hepatitis Adverse drug reactions Azathioprine Drug fever