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Protocol for the development and validation of a clinical measurement tool for fear of disease progression and recurrence in cardiac patients

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chronic Diseases and Translational Medicine 2024年第3期10卷 195-204页

作者： Sarah T.clarke michael le Grande Barbara M.Murphy Robert Hester Alun c.Jackson Melbourne School of Psychological Sciences University of MelbourneParkvilleVictoriaAustralia Australian centre for Heart Health MelbourneVictoriaAustralia centre on Behavioral Health University of Hong KongPokfulamHong KongChina

Introduction: One in two cardiac patients fear having another heart event or their heart condition getting worse. Research in other chronic illnesses demonstrates that screening for fear of progression and recurrence is vital for adequately addressing such concerns in clinical care. The current project aims to develop and validate a measure for fear of progression and recurrence in cardiac ***: The Fear of cardiac Recurrence and Progression Scale (FcRP) will be developed through a multistep process. An initial item pool will be generated through a review of the literature and existing measures and consultation with and feedback from key informants. The item pool will be tested in a sample of over 250 adults who have ever had an acute coronary event, undergone cardiac surgery, or a chronic cardiac condition. Exploratory factor analysis will be used to identify the underlying factors, and Rasch analysis will be used to reduce the number of items. A short form version of the FcRP will be developed for use as a brief screening tool, informed by clinical relevance and Rasch psychometric ***: While many cardiac patients experience fears related to the progression or recurrence of their illness, there remains the need for a validated tool with which these concerns can be identified and measured. It is expected that the design and validation of the FcRP will aid identification of cardiac patients suffering from clinically significant levels of fear of progression and recurrence and facilitate the design of tailored psychological interventions to target these fears.

关键词： anxiety cardiac anxiety cardiac recovery cardiac rehabilitation depression fear of progression fear of recurrence psychological measurement psychosocial screening

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Molecularly engineered lignin to polyphenol via organocatalysis as an active sunscreen ingredient

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Journal of Bioresources and Bioproducts 2024年第2期9卷 197-210页

作者： Yuanlong Guo Pengcheng liu lei Deng changwei lui michael North Gang Hu Qitian Huang Zongbao Kent Zhao Haibo Xie Department of Polymeric Materials&Engineering Guizhou UniversityGuiyang 550025China KZJ New Materials Group Guizhou co.ltd. Guizhou 551200China Green chemistry centre of Excellence Department of ChemistryUniversity of YorkYork YO105DDUK Dalian Institute of chemical Physics Chinese Academy of SciencesDalian 116023China

Phenolation is one of the effective strategies to synthesize lignin-based polyphenols,improve lignin’s properties,and extend its value-added applications in biological,medicinal and cosmetic ***,by taking the structural feature advantage of lignin,an effective and green strategy was developed to molecularly engineer lignin into a robust lignin-3-(2-hydroxyphenyl)propionate ester(lPPE)derivative via a transesterification reaction between 3,4-dihydrocoumarin(DHc)and the aliphatic hydroxyls in lignin under *** strategy is optimized and the novel derivative was systematically characterized by ^(1)H,^(13)c and ^(31)P nuclear magnetic resonance(NMR)and Fourier transform infrared(FT-IR)*** findings indicated that the successful introduction of 3-(2-hydroxyphenyl)propionate groups using a OH groups/DHc/organic base mo-lar ratio of 1꞉1꞉0.3 at 120℃ for 6 h increased the content of phenolic hydroxyl groups from 1.7931 to 3.0179 mmol/g,and the lPPE exhibited excellent ultraviolet-absorbing and antioxidant per-formance with up to 90%free radical scavenging activity within 20 min using 5 mg/ml of *** addition,good biocompatibility and a high Sun protection factor(SPF)value of 40.9 were achieved at 5%(w)dosage of lPPE in the cream,indicating its significant application potential in sunscreen.

关键词： Phenolation of lignin Organocatalysis 3,4-dihydrocoumarin Antioxidant Sunscreen cream

Data augmentation for bias correction in mapping PM_(2.5) based on satellite retrievals and ground observations

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Geoscience Frontiers 2024年第1期15卷 17-28页

作者： Tan Mi Die Tang Jianbo Fu Wen Zeng michael l.Grieneisen Zihang Zhou Fengju Jia Fumo Yang Yu Zhan college of carbon Neutrality Future Technology Sichuan UniversityChengduSichuan 610065China Department of Environmental Science and Engineering Sichuan UniversityChengduSichuan 610065China Institute for Disaster Management and Reconstruction Sichuan UniversityChengduSichuan 610200China Department of land Airand Water ResourcesUniversity of CaliforniaDavisCA 95616United States chengdu Academy of Environmental Sciences ChengduSichuan 610072China Sichuan chengdu Ecological and Environment Monitoring center ChengduSichuan 610011China

As most air quality monitoring sites are in urban areas worldwide,machine learning models may produce substantial estimation bias in rural areas when deriving spatiotemporal distributions of air *** bias stems from the issue of dataset shift,as the density distributions of predictor variables differ greatly between urban and rural *** propose a data-augmentation approach based on the multiple imputation by chained equations(MIcE-DA)to remedy the dataset shift *** with the benchmark models,MIcE-DA exhibits superior predictive performance in deriving the spatiotemporal distributions of hourly PM2.5 in the megacity(chengdu)at the foot of the Tibetan Plateau,especially for correcting the estimation bias,with the mean bias decreasing from-3.4µg/m3 to-1.6µg/*** a complement to the holdout validation,the semi-variance results show that MIcE-DA decently preserves the spatial autocorrelation pattern of PM2.5 over the study *** essence of MIcE-DA is strengthening the correlation between PM2.5 and aerosol optical depth(AOD)during the data ***,the importance of AOD is largely enhanced for predicting PM2.5,and the summed relative importance value of the two satellite-retrieved AOD variables increases from 5.5%to 18.4%.This study resolved the puzzle that AOD exhibited relatively lower importance in local or regional *** results of this study can advance the utilization of satellite remote sensing in modeling air quality while drawing more attention to the common dataset shift problem in data-driven environmental research.

关键词： Aerosol optical depth Dataset shift Spatiotemporal Distribution Air quality monitoring Multiple imputation by chained equations

Risk factors for hepatocellular carcinoma associated with hepatitis c genotype 3 infection:A systematic review

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World Journal of Gastrointestinal Oncology 2024年第4期16卷 1596-1612页

作者： Hamzah Z Farooq michael James Jane Abbott Patrick Oyibo Pip Divall Naheed choudhry Graham R Foster Blizard Institute Queen Mary University of LondonLondon E12ATUnited Kingdom School of Health and Psychological Sciences University of LondonLondon EC1V 0HBUnited Kingdom University Hospitals of leicester library University Hospitals of Leicester NHS TrustLeicester LE39QPUnited Kingdom

BAcKGROUND Hepatitis c virus(HcV)is a blood-borne virus which globally affects around 79 million people and is associated with high morbidity and *** infection leads to cirrhosis in a large proportion of patients and often causes hepatocellular carcinoma(Hcc)in people with *** the 6 HcV genotypes(G1-G6),genotype-3 accounts for 17.9%of *** genotype-3 responds least well to directly-acting antivirals and patients with genotype-3 infection are at increased risk of Hcc even if they do not have *** To systematically review and critically appraise all risk factors for Hcc secondary to HcV-G3 in all ***,we studied possible risk factors for Hcc due to HcV-G3 in the literature from 1946 to *** This systematic review aimed to synthesise existing and published studies of risk factors for Hcc secondary to HcV genotype-3 and evaluate their strengths and *** searched Web of Science,Medline,EMBASE,and cENTRAl for publications reporting risk factors for Hcc due to HcV genotype-3 in all settings,*** Four thousand one hundred and forty-four records were identified from the four databases with 260 records removed as *** thousand eight hundred and eighty-four records were screened with 3514 *** hundred and seventy-one full-texts were assessed for eligibility with seven studies included for *** the seven studies,three studies were retrospective case-control trials,two retrospective cohort studies,one a prospective cohort study and one a cross-sectional study *** were based in hospital settings with four in Pakistan,two in South Korea and one in the United *** total number of participants were 9621 of which 167 developed Hcc(1.7%).All seven studies found cirrhosis to be a risk factor for Hcc secondary to HcV genotype-3 followed by higher age(five-studies),with two studies each showing male sex,high alpha feto-protein,directly-acting antivirals trea

关键词： Hepatocellular carcinoma Hepatitis c Genotype 3 Systematic review Blood-borne viruses liver cancer

Towards an actionable One Health approach

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贫困所致传染病(英文) 2024年第2期13卷 1-6页

作者： Zhang Xiao-Xi lederman Zohar Han le-Fei Schurer Janna M. Xiao li-Hua Zhang Zhi-Bing chen Qiu-lan Pfeiffer Dirk Ward michael P. Sripa Banchob Gabri?l Sarah Dhama Kuldeep Acharya Krishna Prasad Robertson lucy J. Deem Sharon l. Aenishaenslin cécile Dantas-Torres Filipe Otranto Domenico Grace Delia wang Yang li Peng Fu chao Poeta Patrícia Rahman Md. Tanvir Kassegne Kokouvi Zhu Yong-Zhang Yin Kun liu Jiming wang Zhao-Jun Guo Xiao-Kui Gong Wen-Feng Schwartl?nder Bernhard Ren Ming-Hui Zhou Xiao-Nong School of Global Health Chinese Center for Tropical Diseases Research Shanghai Jiao Tong University School of Medicine Shanghai People’s Republic of China Institute of One Health Shanghai Jiao Tong University Shanghai People’s Republic of China Medical Ethics and Humanities Unit Hong Kong University Hong Kong People’s Republic of China center for One Health University of Global Health Equity Butaro Rwanda college of Veterinary Medicine South China Agricultural University Guangzhou People’s Republic of China School of Ecology and Environment Hainan University Haikou Hainan People’s Republic of China Branch of animal and vector-borne diseases Division of Infectious Disease Control Chinese Center for Disease Control and Prevention Beijing People’s Republic of China centre for Applied One Health Research and Policy Advice Department of Infectious Diseases and Public Health Jockey Club College of Veterinary Medicine and Life Sciences City University of Hong Kong Hong Kong SAR People’s Republic of China Department of Pathobiology and Population Sciences Royal Veterinary College London United Kingdom Sydney School of Veterinary Science The University of Sydney Camden Australia Tropical Disease Research center Department of Tropical Medicine Faculty of Medicine Khon Kaen University Khon Kaen Thailand laboratory of foodborne parasitic zoonoses Department of translational physiology infectiology and public health Chair Faculty Committee on Internationalisation Faculty of Veterinary Medicine Ghent University Merelbeke Belgium Division of Pathology ICAR-Indian Veterinary Research Institute (IVRI) Bareilly Uttar Pradesh India Department of livestock Services Animal Quarantine Office-Kathmandu Budhanilkantha Kathmandu Nepal Parasitology Department of Paraclinical Sciences Faculty of Veterinary Medicine Norwegian University of Life Sciences ?s Norway One Government Drive Saint Louis Zoo Institute for Conservation Medicine St. Louis USA Groupe de Recherche en épidémi

Background Despite the increasing focus on strengthening One Health capacity building on global level, challenges remain in devising and implementing real-world interventions particularly in the Asia-Pacific region. Recognizing these gaps, the One Health Action commission (OHAc) was established as an academic community for One Health action with an emphasis on research agenda setting to identify actions for highest *** text This viewpoint describes the agenda of, and motivation for, the recently formed OHAc. Recognizing the urgent need for evidence to support the formulation of necessary action plans, OHAc advocates the adoption of both bottom-up and top-down approaches to identify the current gaps in combating zoonoses, antimicrobial resistance, addressing food safety, and to enhance capacity building for context-sensitive One Health *** By promoting broader engagement and connection of multidisciplinary stakeholders, OHAc envisions a collaborative global platform for the generation of innovative One Health knowledge, distilled practical experience and actionable policy advice, guided by strong ethical principles of One Health.

关键词： One Health Global Health One Health Action commission Research agenda

Evaluation of a hepatic biomarker of nutritional imbalance in juvenile red drum(Sciaenops ocellatus) fed 60% soybean meal-based diets using NMR-based metabolomics

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Animal Nutrition 2024年第1期16卷 45-61页

作者： Fabio casu Aaron M.Watson Justin Yost T.Gibson Gaylord Daniel W.Bearden michael R.Denson Marine Resources Research Institute South Carolina Department of Natural Resources Bozeman Fish Technology center United States Fish and Wildlife Service Marine Biochemical Sciences Group Chemical Sciences Division National Institute of Standards and Technology Hollings Marine Laboratory

A 12-week feeding trial with juvenile red drum(Sciaenops ocellatus) fed high-soybean meal(SBM) diets was conducted to investigate a putative biomarker of nutritional imbalance, N-formimino-l-glutamate(FIGlU). Three fishmeal-free, 60% SBM pelleted diets(named B12, Fol, and Met, respectively) were tested to evaluate the effects on growth performance and tissue metabolite profiles of supplementation of vitamin B12(0.012 mg/kg), folate(10 mg/kg), methionine(1 g/kg) respectively, above basal supplementation levels. A fourth SBM-based diet(named B12/Fol/Met) was formulated with a combination of B12, folate, and methionine to attain the above-mentioned target concentrations. A fifth 60% SBM diet(named FWS) with methionine supplementation(1 g/kg above basal supplementation levels), enriched with taurine, lysine and threonine as well as minerals, was also tested. This diet contained formulation targets and additives which have allowed for replacing fishmeal with plant proteins in rainbow trout feeds. control diets included a fishmeal-based diet(named FM), an unsupplemented basal 60% SBM diet(named SBM60), and a “natural” diet(named N) made up of equal parts of fish(cigar minnows), squid and shrimp as a positive reference for growth performance. Formulated feeds contained approximately 37% total crude protein, approximately 14% total crude lipid and were energetically balanced. Standard growth performance metrics were measured, and tissues(liver, muscle) were collected at week 12 to evaluate diet-induced metabolic changes using nuclear magnetic resonance(NMR)-based *** results show that the FWS diet outperformed all other SBM diets and the FM diet under all performance metrics(PlU was not detected in fish fed the N diet but was detected in those fed the SBM diets and the FM diet. Fish fed the FWS diet and the Met diet showed lower hepatic levels of FIGlU compared with the other SBM-based diets(Plementatio

关键词： Aquaculture Metabolomics Nuclear magnetic resonance Red drum Soybean meal N-Formimino-l-glutamate

Prospective cohort study on facial profile changes in infants with Robin sequence and healthy controls

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World Journal of Pediatrics 2024年第6期20卷 581-589页

作者： cornelia Wiechers Julian Sowula Karen Kreutzer christoph E.Schwarz christina Weismann michael Krimmel christian F.Poets Bernd Koos Department of Neonatology Tuebingen University HospitalCalwerstrasse 772076 TuebingenGermany center for cleft lip Palate and Craniofacial MalformationsTuebingen University HospitalTuebingenGermany Department of Orthodontics Tuebingen University HospitalTuebingenGermany Department of Oral and Maxillofacial Surgery Tuebingen University HospitalTuebingenGermany

Background Various conservative and surgical approaches exist to treat Robin sequence(RS),but their effects on facial profile and mandibular catch-up growth are unclear.A functional treatment concept,used in our centre for 25 years,includes an individualized palatal plate with a velo-pharyngeal extension and intensive feeding *** We performed a prospective study to objectively describe facial profiles in infants with RS treated with the above *** with isolated RS were admitted to our tertiary perinatal and national referral centre for craniofacial malformations between May 2018 and Nov *** with RS received 3D-photographs during clinically indicated *** controls were recruited from Dec 2018 to Sep 2019 and received 3D-photographs every 3 *** digitally measured jaw index(JI),defined as alveolar overjet(O)x maxillary arch(U)/mandibular arch(l),and the soft tissue reference points A’-point,Nasion’,B’-point angle(ANB’),describing the relative position of maxilla to mandible,were *** mixed models were used to examine time trajectories in JI and ANB’.Results A total of 2073D images,obtained in 19 infants with RS and 32 controls,were *** and ANB’decreased over time in both groups[for JI−0.18(95%cI−0.25 to−0.10);for ANB’:−0.40°per month[(95%cI−0.48 to−0.32)]]but remained lower in controls[for JI−2.5(95%cI−3.2 to−1.8);for ANB’-1.7°(95%cI−2.4 to−1.0)].Also,the ANB’model showed a significant effect of the interaction term diagnosis x *** Based on longitudinal 3D images,we describe changes in objective parameters of facial profile in infants with and without RS during the first year of *** findings indicate catch-up growth in infants treated for RS.

关键词： Infant Mandibular catch-up growth Pre-epiglottic Baton Plate Robin sequence Three-dimensional photography

Knock-out of BnHva22c reduces the susceptibility of Brassica napus to infection with the fungal pathogen Verticillium longisporum

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The crop Journal 2024年第2期12卷 503-514页

作者： Wanzhi Ye Roxana Hossain michael Prbsting Abdallah Abdelmegid Mohamed Ali lingyue Han Ying Miao Steffen Rietz Daguang cai Dirk Schenke Department of Molecular Phytopathology and Biotechnology Institute of PhytopathologyChristian-Albrechts-University of KielKielGermany Institut für Zuckerrübenforschung GöttingenGermany Plant Pathology Department Faculty of Agriculture and Natural ResourcesAswan UniversityAswanEgypt Fujian Provincial Key laboratory of Plant Functional Biology College of Life SciencesFujian Agriculture and Forestry UniversityFuzhou 350002FujianChina Hohenlieth-Hof NPZ Innovation GmbHHoltseeGermany

Verticillium longisporum(Vl43)is a soilborne hemibiotrophic fungal pathogen causing stem striping on oilseed rape(OSR)and severe yield *** for resistant varieties is the most promising approach to control this ***,we report the identification of Hva22c as a novel susceptibility factor and its potential for improving OSR ***22c is a member of the Hva22 gene family,originally described for barley(Hordeum vulgare).Several Hva22 members have been located at the endoplasmic ***22c is up-regulated in response to Vl43 in both Arabidopsis and *** demonstrate that knock-out of Hva22c in OSR by cRISPR/cas9 and its homolog in Arabidopsis by T-DNA insertion reduced plants’susceptibility to Vl43 infection and impaired the development of disease *** understand the underlying mechanism,we analysed transcriptomic data from infected and non-infected roots of hva22c knock-out and wild type *** identified a homozygous mutant with frame-shifts in all four BnHva22c loci displaying a vastly altered transcriptional landscape at 6 ***,a large set of genes was suppressed under mock conditions including genes related to the endomembrane *** the up-regulated genes we found several defense-related and phytohormone-responsive genes when comparing mutant to the wild *** results demonstrate that Hva22c is functionally required for a fully compatible plant-fungus *** loss of function reduces plant susceptibility,most likely due to endoplasmatic reticulum and Golgi dysfunction accompanied by additionally activated defense *** findings can help improve OSR resistance to *** infection.

关键词： Hva22c Susceptibility factor cRISPR/cas9 Brassica napus Arabidopsis Verticillium longisporum Resistance breeding

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Direct measurement of the break-out ^(19)F(p,γ)^(20)Ne reaction in the china Jinping underground laboratory(cJPl)

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Nuclear Science and Techniques 2024年第8期35卷 142-152页

作者： Yin‑Ji chen Hao Zhang li‑Yong Zhang Jian‑Jun He Richard James deBoer michael Wiescher Alexander Heger David Kahl Jun Su Daniel Odell Xin‑Yue li Jian‑Guo wang long Zhang Fu‑Qiang cao Zhi‑cheng Zhang Xin‑Zhi Jiang luo‑Huan wang Zi‑Ming li lu‑Yang Song liang‑Ting Sun Qi Wu Jia‑Qing li Bao‑Qun cui li‑Hua chen Rui‑Gang Ma Er‑Tao li Gang lian Yao‑De Sheng Zhi‑Hong li Bing Guo Wei‑Ping liu Key laboratory of Beam Technology of the Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Department of Physics and Astronomy The Joint Institute for Nuclear AstrophysicsUniversity of Notre DameNotre DameIN 46556USA School of Physics and Astronomy Monash UniversityClaytonVIC 3800Australia Facility for Rare Isotope Beams Michigan State UniversityEast LansingMI 48824USA Institute of Nuclear and Particle Physics and Department of Physics and Astronomy Ohio UniversityAthensOH 45701USA Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China china Institute of Atomic Energy Beijing 102413China college of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China college of Science Southern University of Science and TechnologyShenzhen 518055China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China Key laboratory of Nuclear Physics and Ion‑Beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Mathematics and Physics Handan UniversityHandan 056005China

calcium production and the stellar evolution of first-generation stars remain fascinating mysteries in *** one possible nucleosynthesis scenario,break-out from the hot carbon–nitrogen–oxygen(HcNO)cycle was thought to be the source of the calcium observed in these oldest ***,according to the stellar modeling,a nearly tenfold increase in the thermonuclear rate ratio of the break-out ^(19)F(p,γ)^(20) Ne reaction with respect to the competing ^(19)F(p,α)^(16) O back-processing reaction is required to reproduce the observed calcium *** performed a direct measurement of this break-out reaction at the china Jinping underground *** measurement was performed down to the low-energy limit of E_(c.m.)=186 keV in the center-of-mass *** key resonance was observed at 225.2 keV for the first *** a temperature of approximately 0.1 GK,this new resonance enhanced the thermonuclear ^(19)F(p,γ)^(20) Ne rate by up to a factor of≈7.4,compared with the previously recommended NAcRE *** is of particular interest to the study of the evolution of the first stars and implies a stronger breakdown in their“warm”cNO cycle through the ^(19)F(p,γ)^(20) Ne reaction than previously *** break-out resulted in the production of the calcium observed in the oldest stars,enhancing our understanding of the evolution of the first stars.

关键词： Nuclear astrophysics First stars Abundance of calcium Reaction cross section Reaction rate china Jinping underground laboratory(cJPl) JUNA

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