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Defining the role of bariatric surgery in polycystic ovarian syndrome patients

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World Journal of Diabetes 2012年第4期3卷 71-79页

作者： Shaveta M Malik michael l traub michael l traub Department of Obstetrics and GynecologyStaten Island University Hospital Island Reproductive Services Staten IslandNY 10314United States

Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder in *** meet PCOS criteria,women must have a combination of hyperandrogenism,anovulation and ultrasound *** 10% of all reproductive age women worldwide show signs of *** women often seek care for gynecological or body image concerns,many PCOS women are at risk for metabolic syndrome (MS).Many of the metabolic consequences are overlooked and un-dertreated by physicians because these patients tend to be young,reproductive age *** and obesity coexist commonly with *** young women are predisposed to glucose abnormalities and ulti-mately diabetes mellitus,dyslipidemia and eventually cardiovascular *** surgery can be an ef-fective means of weight loss in PCOS *** techniques have become safer and less invasive over time and have been found to be effective in achieving significant weight *** options have also in-creased,giving patients more *** surgery may prevent or reverse metabolic *** surgery may also have reproductive benefits in PCOS *** bariatric surgery has historically been performed in older,reproductive aged women,it has recently gained favor in adolescents as *** is of particular importance due to the prevalence of both PCOS and MS in *** of PCOS and MS certainly requires a combination of medical therapy,psychological support and lifestyle *** treatments are difficult and often frustrating for pa-tients and *** surgery can be effective in achieving significant weight loss,restoration of the hypothalamic pituitary axis,reduction of cardiovascular risk and even in improving pregnancy ***-mately,bariatric surgery should be considered part of the treatment in PCOS women,especially in those with MS.

关键词： Polycystic ovarian syndrome Metabolic syn-drome Bariatric surgery Obesity Pregnancy Infertility

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减重手术在多囊卵巢综合征治疗中的作用

中国微创外科杂志 2013年第1期13卷 78-80,86页

作者：王恺京徐安安朱江帆 Shaveta M.Malik michael l.traub 同济大学附属东方医院普外科上海200120 Department of Obstetrics and Gynecology Staten Island University Hospital

多囊卵巢综合征（polycystic ovarian syndrome,PCOS）是女性常见内分泌紊乱性疾病,其发生率近10%。表现为无排卵、高雄激素血症及超声显示卵巢的多囊改变。多数患者伴有代谢综合征（metabolic syndrome,MS）,表现为高血压、高血脂、肥... 详细信息

多囊卵巢综合征（polycystic ovarian syndrome,PCOS）是女性常见内分泌紊乱性疾病,其发生率近10%。表现为无排卵、高雄激素血症及超声显示卵巢的多囊改变。多数患者伴有代谢综合征（metabolic syndrome,MS）,表现为高血压、高血脂、肥胖、胰岛素抵抗及糖耐量异常。

关键词：多囊卵巢综合征内分泌紊乱性疾病治疗手术减重高雄激素血症代谢综合征糖耐量异常

Analysing the quality of Swiss National Forest Inventory measurements of woody species richness

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Forest Ecosystems 2020年第3期7卷 478-488页

作者： Berthold traub Rafael O.Wüest Scientific Service NFI Swiss Federal Research Institute WSLZürcherstrasse 1118903BirmensdorfSwitzerland Spatial Evolutionary Ecology Swiss Federal Research Institute WSLZürcherstrasse 1118903BirmensdorfSwitzerland

Background: Under ongoing climate and land-use change, biodiversity is continuously decreasing and monitoring biodiversity is becoming increasingly important. National Forest Inventory(NFI) programmes provide valuable timeseries data on biodiversity and thus contribute to assessments of the state and trends in biodiversity, as well as ecosystem functioning. Data quality in this context is of paramount relevance, particularly for ensuring a meaningful interpretation of changes. The Swiss NFI revisits about 8%–10% of its sample plots regularly in repeat surveys to supervise the quality of ***: We analysed the relevance of observer bias with equivalence tests, examined data quality objectives defined by the Swiss NFI instructors, and calculated the pseudo-turnover(PT) of species composition, that is, the percentage of species not observed by both teams. Three attributes of woody species richness from the latest Swiss NFI cycles(3 and 4) were analysed: occurrence of small tree and shrub species(1) on the sample plot and(2) at the forest edge, and(3) main shrub and trees species in the upper ***: We found equivalent results between regular and repeat surveys for all attributes. Data quality, however,was significantly below expectations in all cases, that is, as much as 20%–30% below the expected data quality limit of 70%–80%(proportion of observations that should not deviate from a predefined threshold). PT values were about 10%–20%, and the PT of two out of three attributes decreased significantly in NFI4. This type of uncertainty –typically caused by a mixture of overlooking and misidentifying species – should be considered carefully when interpreting change figures on species richness estimates from NFI ***: Our results provide important information on the data quality achieved in Swiss NFIs in terms of the reproducibility of the collected data. The three applied approaches proved to be effective for evaluating the quality of plot

关键词： Biodiversity Data quality Equivalence test Forest inventory Monitoring Observer agreement Richness Pseudo-turnover

The urgency of Agriculture Green Development

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Frontiers of Agricultural Science and Engineering 2020年第1期7卷 108-109页

作者： Guido SCHMIDT-traub UN Sustainable Development Solutions Network(SDSN) New YorkNY 10115USA

As Shen et *** other authors lay out convincingly in this special issue,Agriculture Green Development(AGD)is an urgent imperative for China and the ***,high-productivity agriculture is vital for food security and economic development,particularly in a country like China,which comprises 20%of the world’s population but only has 8%of the arable land.

关键词： Agriculture Development land

Stress-activated kinases as therapeutic targets in pancreatic cancer

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World Journal of Gastroenterology 2021年第30期27卷 4963-4984页

作者： Benno traub Aileen Roth Marko Kornmann Uwe Knippschild Joachim Bischof Department of General and Visceral Surgery Ulm University HospitalUlm 89081Germany

Pancreatic cancer is a dismal disease with high incidence and poor survival *** the aim to improve overall survival of pancreatic cancer patients,new therapeutic approaches are urgently *** kinases are key regulatory players in basically all stages of development,maintaining physiologic functions but also being involved in pathogenic processes.c-Jun N-terminal kinases(JNK)and p38 kinases,representatives of the mitogen-activated protein kinases,as well as the casein kinase 1(CK1)family of protein kinases are important mediators of adequate response to cellular stress following inflammatory and metabolic stressors,DNA damage,and *** their physiologic roles,they are responsible for the regulation of cell cycle progression,cell proliferation and differentiation,and *** of the underlying pathways consequently has been identified in various cancer types,including pancreatic *** targeting of those pathways has been the field of interest for several *** success in earlier studies was limited due to lacking specificity and off-target effects,more recent improvements in small molecule inhibitor design against stress-activated protein kinases and their use in combination therapies have shown promising in vitro ***,targeting of JNK,p38,and CK1 protein kinase family members may actually be of particular interest in the field of precision medicine in patients with highly deregulated kinase pathways related to these ***,further studies are warranted,especially involving in vivo investigation and clinical trials,in order to advance inhibition of stress-activated kinases to the field of translational medicine.

关键词： Pancreatic cancer Stress-activated protein kinases Mitogen-activated protein kinases c-Jun N-terminal kinases Casein kinase 1 Small molecule inhibitor

Safety of epinephrine for anaphylaxis in the emergency setting

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World Journal of Emergency Medicine 2013年第4期4卷 245-251页

作者： Joseph P Wood Stephen J traub Christopher lipinski Department of Emergency Medicine Mayo Clinic HospitalPhoenixAZ 85054USA

BACKGROUND:While epinephrine is the recommended first-line therapy for the reversal of anaphylaxis symptoms,inappropriate use persists because of misunderstandings about proper dosing and administration or misconceptions about its *** objective of this review was to evaluate the safety of epinephrine for patients with anaphylaxis,including other emergent conditions,treated in emergency care ***:A MEDlINE search using PubMed was conducted to identify articles that discuss the dosing,administration,and safety of epinephrine in the emergency setting for anaphylaxis and other ***:Epinephrine is safe for anaphylaxis when given at the correct dose by intramuscular *** majority of dosing errors and cardiovascular adverse reactions occur when epinephrine is given intravenously or incorrectly ***:Epinephrine by intramuscular injection is a safe therapy for anaphylaxis but training may still be necessary in emergency care settings to minimize drug dosing and administration errors and to allay concerns about its safety.

关键词： Allergy Anaphylaxis Epinephrine Safety Cardiovascular side effects

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波形蛋白-核酸复合物诱导的多特异性单抗

中国科学（B辑） 1994年第4期24卷 376-381页

作者：阎锡蕴 S.Kühn P.traub 中国科学院微生物研究所北京100080 Max-Planck-Institute of Cell Biology FRG

本文首次采用中间纤维波形蛋白(vimentin)-核酸复合物免疫Balb/c小鼠,通过杂交瘤技术制备了一组多特异性单克隆抗体(polyspecific McAb),这些抗体能够分别与波形蛋白、DNA、磷脂以及其它生物化学结构不同的生物大分子结合,其抗原特异性... 详细信息

本文首次采用中间纤维波形蛋白(vimentin)-核酸复合物免疫Balb/c小鼠,通过杂交瘤技术制备了一组多特异性单克隆抗体(polyspecific McAb),这些抗体能够分别与波形蛋白、DNA、磷脂以及其它生物化学结构不同的生物大分子结合,其抗原特异性与病人血清中的自身抗体(autoantibody)极为相似。抗原表位分析结果表明,抗体所识别的波形蛋白NH_2末端恰是波形蛋白结合DNA的位点。多特异性单抗的研制将为研究抗体交叉反应机制、自身抗体来源以及核酸与蛋白质的相互关系提供了一条新的途径。

关键词：波形蛋白核酸单克隆抗体

Integrating climate, biodiversity, and sustainable land-use strategies:innovations from China

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National Science Review 2021年第7期8卷 13-17页

作者： Guido Schmidt-traub Harvey locke Jixi Gao Zhiyun Ouyang Justin Adams lin li Enric Sala M.Rebecca Shaw Sebastian Troёng Jing Xu Chunquan Zhu Changxin Zou Tianxiao Ma Fuwen Wei Sustainable Development Solutions Network Beyond the Aichi Targets Task Force IUCN World Commission on Protected Areas Yellowstone to Yukon Conservation Initiative Center for Satellite Applications on Ecology and Environment Ministry of Ecology and Environment Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Tropical Forest Alliance World Economic Forum Worldwide Fund for Nature National Geographic Society Conservation International Chinese Research Academy of Environmental Sciences Nature Initiatives and Tropical Forest Alliance World Economic Forum Nanjing Institute of Environmental Sciences Ministry of Ecology and Environment Institute of Zoology Chinese Academy of Sciences

To reverse the accelerating degradation of biodiversity and ecosystem services(‘nature’) and climate [1,2], the Convention on Biological Diversity (CBD)and the UN Framework Convention on Climate Change (UNFCCC) will hold major meetings in 2021. We argue that, as a critical priority, countries need to design and implement integrated national strategies to achieve the goals of the three Rio Conventions (including the UN Convention to Combat Desertification—UNCCD) using spatially explicit analyses and policies. This integration can maximize co-benefits and help manage trade-offs to meet the Sustainable Development Goals(SDGs). Nature-based solutions (NBS)provide an important framework for such integration.

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聚对苯二甲酸丙二酯纤维的物理机械性能

国外纺织技术（化纤．染整．环境保护分册） 1996年第6期 1-3页

作者： H.l.traub 徐向春

不象聚对苯二甲酸乙二酯或对苯二甲酸丁二酯,聚对苯二甲酸丙二酯(PTMT)作为纺织纤维原材料仍未取得任何重要地位。这可能是由于丙二醇(1,3—丙二醇)过去不能达到足够的纯度和供应数量。但是,有时候是可能得到纤维级质量的1,3—丙二醇的... 详细信息

不象聚对苯二甲酸乙二酯或对苯二甲酸丁二酯,聚对苯二甲酸丙二酯(PTMT)作为纺织纤维原材料仍未取得任何重要地位。这可能是由于丙二醇(1,3—丙二醇)过去不能达到足够的纯度和供应数量。但是,有时候是可能得到纤维级质量的1,3—丙二醇的,于是状况有了改变,促使研究PTMT纤维纺织应用方面的物理机械性能与染色性。

关键词：聚酯纤维 PTMT 物理机械性能