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NECAB family of neuronal calcium-binding proteins in health and disease

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Neural Regeneration Research 2025年第5期20卷 1236-1243页

作者： Diones Bueno michael k.E.Schafer Sudena Wang michael J.Schmeisser Axel Methner Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Department of Anesthesiology University Medical Center of the Johannes Gutenberg-UniversityMainzGermany Institute of Anatomy University Medical Center of the Johannes Gutenberg-UniversityMainzGermany

The N-terminal EF-hand calcium-binding proteins 1–3(NECAB1–3) constitute a family of predominantly neuronal proteins characterized by the presence of at least one EF-hand calcium-binding domain and a functionally less well characterized C-terminal antibiotic biosynthesis monooxygenase domain. All three family members were initially discovered due to their interactions with other proteins. NECAB1 associates with synaptotagmin-1, a critical neuronal protein involved in membrane traffick.ng and synaptic vesicle exocytosis. NECAB2 interacts with predominantly striatal G-protein-coupled receptors, while NECAB3 partners with amyloid-β A4 precursor protein-binding family A members 2 and 3, k.y regulators of amyloid-β production. This demonstrates the capacity of the family for interactions with various classes of proteins. NECAB proteins exhibit distinct subcellular localizations: NECAB1 is found in the nucleus and cytosol, NECAB2 resides in endosomes and the plasma membrane, and NECAB3 is present in the endoplasmic reticulum and Golgi apparatus. The antibiotic biosynthesis monooxygenase domain, an evolutionarily ancient component, is ak.n to atypical heme oxygenases in prok.ryotes but is not wellcharacterized in vertebrates. prok.ryotic antibiotic biosynthesis monooxygenase domains typically form dimers, suggesting that calcium-mediated conformational changes in NECAB proteins may induce antibiotic biosynthesis monooxygenase domain dimerization, potentially activating some enzymatic properties. However, the substrate for this enzymatic activity remains uncertain. Alternatively, calcium-mediated conformational changes might influence protein interactions or the subcellular localization of NECAB proteins by controlling the availability of protein–protein interaction domains situated between the EF hands and the antibiotic biosynthesis monooxygenase domain. This review summarizes what is k.own about genomic organization, tissue expression, intracellular localization, interac

关键词： calcium EF hand mitochondria nervous system signal transduction

Mitochondrial therapeutics and mitochondrial transfer for neurodegenerative diseases and aging

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Neural Regeneration Research 2025年第3期20卷 794-796页

作者： Neville ng Michelle Newbery Nicole Miles Lezanne Ooi Molecular Horizons and School of Chemistry and Molecular Bioscience University of WollongongWollongongNSWAustralia

Mitochondrial dysfunction and neurodegeneration:progressive neurodegenerative diseases affect a significant proportion of the population;in a single year,there are as many as 276 million disabilities and 9 million dea... 详细信息

关键词： degenerative diseases Mitochondrial

Robust interface and excellent as-built mechanical properties of Ti–6Al–4V fabricated through laser-aided additive manufacturing with powder and wire

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 154-168页

作者： Fei Weng Guijun Bi Youxiang Chew Shang Sui Chaolin Tan Zhenglin Du Jinlong Su Fern Lan ng k.y Laboratory for Liquid-Solid Structural Evolution and processing of Materials Ministry of EducationShandong Engineering&Technology Research Center for Superhard MaterialSchool of Materials Science and EngineeringShandong UniversityJinan 250061China Institute of Intelligent Manufacturing Guangdong Academy of SciencesGuangzhou 510095China Singapore Institute of Manufacturing Technology 5 Cleantech Loop636732Singapore

The feasibility of manufacturing Ti-6Al-4V samples through a combination of laser-aided additive manufacturing with powder(LAAM_(p))and wire(LAAM_(w))was explored.A process study was first conducted to successfully circumvent defects in Ti-6Al-4V deposits for LAAM_(p) and LAAM_(w),*** the optimized process parameters,robust interfaces were achieved between powder/wire deposits and the forged substrate,as well as between powder and wire *** characterization results revealed the epitaxial prior β grains in the deposited Ti-6Al-4V,wherein the powder deposit was dominated by a finerα′microstructure and the wire deposit was characterized by lamellar α *** mechanisms of microstructure formation and correlation with mechanical behavior were analyzed and *** mechanical properties of the interfacial samples can meet the requirements of the relevant Aerospace Material Specifications(AMS 6932)even without post heat *** fracture occurred within the interfacial area,further suggesting the robust *** findings of this study highlighted the feasibility of combining LAAM_(p) and LAAM_(w) in the direct manufacturing of Ti-6Al-4V parts in accordance with the required dimensional resolution and deposition rate,together with sound strength and ductility balance in the as-built condition.

关键词： laser-aided additive manufacturing powder deposition wire deposition interfacial characteristic mechanical behavior

Solving sparse non-negative tensor equations： algorithms and applications

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Frontiers of Mathematics in China 2015年第3期10卷 649-680页

作者： Xutao LI michael k. ng School of Computer Engineering Nanyang Technological University Singapore 639798 Singapore Centre for Mathematical Imaging and Vision and Department of MathematicsHong Kong Baptist University Hong Kong China

We study iterative methods for solving a set of sparse non-negative tensor equations （multivariate polynomial systems） arising from data mining applications such as information retrieval by query search and community discovery in multi-dimensional network.. By mak.ng use of sparse and non-negative tensor structure, we develop Jacobi and Gauss-Seidel methods for solving tensor equations. The multiplication of tensors with vectors are required at each iteration of these iterative methods, the cost per iteration depends on the number of non-zeros in the sparse tensors. We show linear convergence of the Jacobi and Gauss-Seidel methods under suitable conditions, and therefore, the set of sparse non-negative tensor equations can be solved very efficiently. Experimental results on information retrieval by query search and community discovery in multi-dimensional network. are presented to illustrate the application of tensor equations and the effectiveness of the proposed methods.

关键词： Nonnegative tensor multi-dimensional network information retrieval community iterative method multivariate polynomial equation

Lik. a G6-nal:transcriptional control of G-protein coupled receptors during oligodendroglial development

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Neural Regeneration Research 2025年第7期20卷 2001-2002页

作者： Tim Aberle michael Wegner Institut für Biochemie Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Multilayered control of myelination:Quick.saltatory conduction of action potentials along nerve fibers requires the electrical insulation of axons by myelinating *** the central nervous system,this role is tak.n up by *** are mark.d by the expression of the lineage determinants Sox10 and Olig2 and arise from oligodendrocyte precursor cells(OpCs)during embryonal *** the majority of OpCs differentiate into mature oligodendrocytes when nearby axonal segments require myelination,a small subpopulation of OpCs persist as a progenitor ***,the timing of myelination and maintenance of the OpC pool both need to be precisely *** transcription factors either positively or negatively affect oligodendrocyte differentiation and maintenance of the OpC pool as components of a complex gene regulatory network.reviewed in Sock.and Wegner,2021).Network.activity is additionally influenced by extracellular signaling molecules that bind to receptors on the oligodendroglial cell surface and activate intracellular signaling *** the receptors are link.d to the network.is poorly understood so far,but pivotal to understanding the overall regulation of central nervous system(CNS)myelination in response to environmental *** insights were recently gained for Gpr37(Schmidt et al.,2024),a G-protein coupled receptor(GpCR)with k.own relevance in differentiating oligodendrocytes(Yang et al,2016).

关键词： gained insulation conduction

MODIFIED NEWTON＇S ALGORITHM FOR COMpUTIng THE GROUp INVERSES OF SIngULAR TOEpLITZ MATRICES

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Journal of Computational Mathematics 2006年第5期24卷 647-656页

作者： Jian-feng Cai michael k. ng Yi-min Wei Department of Mathematics The Chinese University of Hong Kong Hong Kong Department of Mathematics Hong Kong Baptist University Hong Kong School of Mathematical Sciences Fudan University Shanghai 200433 China ~ Key Laboratory of Mathematics for Nonlinear Sciences (Fudan University) Ministry of Education

Newton＇s iteration is modified for the computation of the group inverses of singular Toeplitz matrices. At each iteration, the iteration matrix is approximated by a matrix with a low displacement rank. Because of the displacement structure of the iteration matrix, the matrix-vector multiplication involved in Newton＇s iteration can be done efficiently. We show that the convergence of the modified Newton iteration is still very fast. Numerical results are presented to demonstrate the fast convergence of the proposed method.

关键词： Newton's iteration Group inverse Toeplitz matrix Displacement rank.

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao michael S.Wolfe Computational Medicine program and Department of pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-Secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-Secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-Stay-Trim,”“Sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook.is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

BLOCk.TRIAngULAR pRECONDITIONERS FOR SYSTEMS ARISIng FROM EDGE-pRESERVIng IMAGE RESTORATION

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Journal of Computational Mathematics 2010年第6期28卷 848-863页

作者： Zhong-Zhi Bai Yu-Mei Huang michael k. ng LSEC ICMSEC Academy of Mathematics and Systems Science Chinese Academy of Sciences Beijing 100190 China School of Mathematics and Statistics Lanzhou University Lanzhou 730000 China Department of Mathematics Hong Kong Baptist University Kowloon Tong Hong Kong

Signal and image restoration problems are often solved by minimizing a cost function consisting of an l2 data-fidelity term and a regularization term. We consider a class of convex and edge-preserving regularization functions. In specific, half-quadratic regularization as a fixed-point iteration method is usually employed to solve this problem. The main aim of this paper is to solve the above-described signal and image restoration problems with the half-quadratic regularization technique by mak.ng use of the Newton method. At each iteration of the Newton method, the Newton equation is a structured system of linear equations of a symmetric positive definite coefficient matrix, and may be efficiently solved by the preconditioned conjugate gradient method accelerated with the modified block.SSOR preconditioner. Our experimental results show that the modified block.SSOR preconditioned conjugate gradient method is feasible and effective for further improving the numerical performance of the half-quadratic regularization approach.

关键词： Block.system of equations Matrix preconditioner Edge-preserving Image restoration Half-quadratic regularization.

EFFICIENT BOX-CONSTRAINED TV-TYpE-l^1 ALGORITHMS FOR RESTORIng IMAGES WITH IMpULSE NOISE

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Journal of Computational Mathematics 2013年第3期31卷 249-270页

作者： Liyan Ma michael k. ng Jian Yu Tieyong Zeng School of Computer and Information Technology Beijing Jiaotong University Beijing 100044 China Department of Mathematics Hong Kong Baptist University Hong Kong China

In this paper, we study the restoration of images simultaneously corrupted by blur and impulse noise via variational approach with a box constraint on the pixel values of an image. In the literature, the TV-l^1 variational model which contains a total variation （TV） regularization term and an l^1 data-fidelity term, has been proposed and developed. Several numerical methods have been studied and experimental results have shown that these methods lead to very promising results. However, these numerical methods are designed based on approximation or penalty approaches, and do not consider the box constraint. The addition of the box constraint mak.s the problem more difficult to handle. The main contribution of this paper is to develop numerical algorithms based on the derivation of exact total variation and the use of proximal operators. Both one-phase and two-phase methods are considered, and both TV and nonlocal TV versions are designed. The box constraint [0, 1] on the pixel values of an image can be efficiently handled by the proposed algorithms. The numerical experiments demonstrate that the proposed methods are efficient in computational time and effective in restoring images with impulse noise.

关键词： Image restoration Impulse noise Total variation Nonlocal total variation proximal Operators.