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CHO cell cytotoxicity and genotoxicity analyses of disinfection by-products： An updated review

journal of Environmental Sciences 2017年第8期29卷 64-76页

作者： Elizabeth D.Wagner michael j.Plewa Safe Global Water Institute University of Illinois at Urbana-Champaign 1101 W Peabody Dr. Urbana IL 61801 United States Department of Crop Sciences University of Illinois at Urbana-Champaign 1101 W Peabody Dr. Urbana IL 61801 United States

The disinfection of drinking water is an important public health service that generates high quality, safe and palatable tap water. The disinfection of drinking water to reduce waterborne disease was an outstanding public health achievement of the 20 th *** unintended consequence is the reaction of disinfectants with natural organic matter,anthropogenic contaminants and bromide/iodide to form disinfection by-products（DBPs）.A large number of DBPs are cytotoxic, neurotoxic, mutagenic, genotoxic, carcinogenic and teratogenic. Epidemiological studies demonstrated low but significant associations between disinfected drinking water and adverse health effects. The distribution of DBPs in disinfected waters has been well defined by advances in high precision analytical chemistry. Progress in the analytical biology and toxicology of DBPs has been *** objective of this review was to provide a detailed presentation of the methodology for the quantitative, comparative analyses on the induction of cytotoxicity and genotoxicity of103 DBPs using an identical analytical biological platform and endpoints. A single Chinese hamster ovary cell line was employed in the assays. The data presented are derived from papers published in the literature as well as additional new data and represent the largest direct quantitative comparison on the toxic potency of both regulated and emerging *** data may form the foundation of novel research to define the major forcing agents of DBP-mediated toxicity in disinfected water and may play an important role in achieving the goal of making safe drinking water better.

关键词： DBPs Mammalian cell cytotoxicity Mammalian cell genotoxicity

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Homopteran Vector Biomarkers for Efficient Circulative Plant Virus Transmission are Conserved in Multiple Aphid Species and the Whitefly Bemisia tabaci

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journal of Integrative Agriculture 2012年第2期11卷 249-262页

作者： Michelle Cilia michael Bereman Tara Fish michael j MacCoss stewart Gray USDA-ARS Robert W. Holley Center for Agriculture and Health Tower Road Ithaca New York 14853 USA Department of Plant Pathology and Plant-Microbe Biology Cornell University Ithaca New York 14853 USA Department of Genome Sciences University of Washington Seattle Washington 98195-5065 USA

Plant viruses in the families Luteoviridae and Geminiviridae are phloem restricted and are transmitted in a persistent,circulative manner by homopteran *** fluorescence 2-D difference gel electrophoresis to compare the proteomes of F2 genotypes of Schizaphis graminum segregating for virus transmission ability,we recently discovered a panel of protein biomarkers that predict vector *** we used aphid and whitefly nucleotide and expressed sequence tag database mining to test whether these biomarkers are conserved in other homopteran *** gene homologs that shared a high degree of predicted amino acid identity were discovered in two other aphid species and in the whitefly Bemisia *** reaction monitoring mass spectrometry was used to validate the expression of these biomarkers proteins in multiple aphid vector *** conservation of these proteins in multiple insect taxa that transmit plant viruses along the circulative transmission pathway creates the opportunity to use these biomarkers to rapidly identify insect populations that are the most efficient vectors and allow them to be targeted for control prior to the spread of virus within a crop.

关键词： aphid whitefly Schizaphis graminum Bemisia tabaci Acyrthosiphon pisum Toxoptera citricida Myzuspersicae proteomics biomarker circulative transmission begomovirus luteovirus geminivirus leaflaopper,selected reaction monitoring SRM mass spectrometry targeted proteomics Skyline

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Vascular anomalies associated with hepatic shunting

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World journal of Gastroenterology 2020年第42期26卷 6582-6598页

作者： michael j Schmalz Kadakkal Radhakrishnan Department of Pediatric Gastroenterology Cleveland ClinicClevelandOH 44106United States Department of Pediatric Gastroenterology Children's HospitalCleveland ClinicClevelandOH 44106United States

Congenital vascular anomalies affecting the liver have been described in the scientific literature for *** these malformations begins with knowledge of hepatic vascular *** have applied numerous classification systems to describe both intrahepatic and extrahepatic shunts,which can confuse the reader and *** our experience,focusing on one classification system for extrahepatic shunts and one for intrahepatic shunts is *** many patients with these shunts carry good long-term prognosis thanks to advances in imaging to better detect shunts earlier and classify *** intervention by skilled radiologists and surgeons have also limited complications arising from dynamic shunts and can avoid a liver *** hepatic shunts are not the only vascular condition affecting the *** hemorrhagic telangiectasia,also known as Osler Weber Rendu syndrome,particularly type 2,may have varying severity of hepatic involvement which warrants longitudinal care from an experienced ***,congenital hemangiomas,often first identified on the skin and oral mucosa,also can affect the *** most will resolve in infancy and childhood,the pediatric hepatologist must understand how and when to treat persistent lesions and their *** article serves as a concise reference to help clinicians better care for patients with these rare conditions.

关键词： Hepatic Shunt Pediatric Hemangioma Congenital Vascular

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Harnessing artificial intelligence for identifying conflicts of interest in research

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World journal of Methodology 2025年第1期15卷 6-8页

作者： Abdulqadir j Nashwan Department of Nursing&Midwifery Research Hamad Medical CorporationDoha 3050Qatar

This editorial explores the transformative potential of artificial intelligence(AI)in identifying conflicts of interest(COIs)within academic and scientific *** harnessing advanced data analysis,pattern recognition,and natural language processing techniques,AI offers innovative solutions for enhancing transparency and integrity in *** editorial discusses how AI can automatically detect COIs,integrate data from various sources,and streamline reporting processes,thereby maintaining the credibility of scientific findings.

关键词： Artificial intelligence Conflicts of interest Transparency Research integrity Natural language processing

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Eating as a motivated behavior:modulatory effect of high fat diets on energy homeostasis,reward processing and neuroinflammation

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Integrative Zoology 2018年第6期13卷 673-686页

作者： michael j.BUTLER Lisa A.ECKEL Department of Psychology and Program in Neuroscience Florida State UniversityTallahasseeFloridaUSA

Eating is a basic motivated behavior that provides fuel for the body and supports brain *** ensure survival,the brain’s feeding circuits are tuned to monitor peripheral energy balance and promote food-seeking behavior when energy stores are *** brain’s bias toward a positive energy state,which is necessary to ensure adequate nutrition during times of food scarcity,is evolutionarily conserved across mammalian species and is likely to drive overeating in the presence of a palatable,energy-dense *** models of diet-induced overeating have played a vital role in investigating how the drive to consume palatable food may override the homeostatic processes that serve to maintain energy *** animal models have provided valuable insights into the neurobiological mechanisms underlying homeostatic and non-homeostatic eating,motivation and food reward,and the development of obesity and related ***,we provide a brief review of this literature and discuss how diet-induced inflammation in the central nervous system impacts the neural control of food intake and regulation of body *** connection between diet and the immune system provides an exciting new direction for the study of ingestive behavior and the pathophysiology of obesity.

关键词： high fat diet inflammation obesity

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Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna jennifer Aguilar Emily Lee William j.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

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Harnessing naturally occurring mutations for T-cell therapy:a potential new avenue to enhance treatment efficacy

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Signal Transduction and Targeted Therapy 2024年第5期9卷 1799-1801页

作者： michael Hiltensperger jürgen Ruland Kilian Schober Mikrobiologisches Institut-Klinische Mikrobiologie Immunologie und HygieneFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany Institute of Clinical Chemistry and Pathobiochemistry School of MedicineTechnical University of MunichMunichGermany TranslaTUM Center for Translational Cancer ResearchTechnical University of MunichMunichGermany German Cancer Consortium(DKTK) HeidelbergGermany German Center for Infection Research(DZIF) partner site MunichMunichGermany FAU Profile Center Immunomedicine Friedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

In a recent study published in Nature,Garcia et *** a sophisticated approach to identify fitness-enhancing mutations for T cells that was inspired by cancer evolution.1 The identified CARD11-PIK3R3 gene fusion enhanced tumor rejection and persistence of engineered T cells in multiple tumor models and might have the potential to improve efficacy of adoptive T-cell therapies in cancer patients.

关键词： cancer potential

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‘Visual excitation’ in Richard Neutra’s residential architecture: An analysis using weighted graphs and centrality measures

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Frontiers of Architectural Research 2022年第6期11卷 1092-1103页

作者： michael j.Dawes ju Hyun Lee michael j.Ostwald Faculty of Arts Design&ArchitectureSchool of Built EnvironmentUniversity of New South WalesSydney2052Australia

The famous modernist architect Richard Neutra argued that movement through,and understanding of a building could be choreographed by controlling the visual stimuli that is available to a *** claims are tested by quantifying the lines of sight and intelligibility of five of Neutra’s residential designs.A computational method,weighted axial line analysis,is used to investigate lines of sight and movement in five of Neutra’s house *** cumulative lengths of axial lines required to reach public and private spaces are compared,and centrality measures are calculated for each design that are weighted with line length *** metrics are calculated from these centrality *** first hypothesis,that visual stimuli in Neutra’s architecture is greater when accessing public rather than private spaces is supported by the *** second hypothesis,that Neutra’s architecture is highly intelligible,is not supported by the *** research tests two theories used to explain the works of a famous architect and it develops a new variation of well-known Space Syntax technique,to account for axial line lengths.

关键词： Richard Neutra Modernism Space syntax Weighted axial map Centrality measures

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The disruption of protein-protein interactions with co-chaperones and client substrates as a strategy towards Hsp90 inhibition

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1446-1468页

作者： michael A.Serwetnyk Brian S.j.Blagg Department of Chemistry and Biochemistry Warren Family Research Center for Drug Discovery and DevelopmentUniversity of Notre DameIN 46556USA

The 90-kilo Dalton(kD) heat shock protein(Hsp90) is a ubiquitous,ATP-dependent molecular chaperone whose primary function is to ensure the proper folding of several hundred client protein *** many of these clients are overexpressed or become mutated during cancer progression,Hsp90 inhibition has been pursued as a potential strategy for cancer as one can target multiple oncoproteins and signaling pathways *** first discovered Hsp90 inhibitors,geldanamycin and radicicol,function by competitively binding to Hsp90’s N-terminal binding site and inhibiting its ATPase ***,most of these N-terminal inhibitors exhibited detrimental activities during clinical evaluation due to induction of the pro-survival heat shock response as well as poor selectivity amongst the four ***,alternative approaches to Hsp90 inhibition have been pursued and include C-terminal inhibition,isoform-selective inhibition,and the disruption of Hsp90 protein-protein *** the Hsp90 protein folding cycle requires the assembly of Hsp90 into a large heteroprotein complex,along with various co-chaperones and immunophilins,the development of small molecules that prevent assembly of the complex offers an alternative method of Hsp90 inhibition.

关键词： Hsp90 Protein-protein interactions Disruptors Natural products Small molecules Peptidomimetics

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Reviewing the Oceanic Nino Index(ONI) to Enhance Societal Readiness for El Nino’s Impacts

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International journal of Disaster Risk Science 2020年第3期11卷 394-403页

作者： michael H.Glantz Ivan j.Ramirez Consortium for Capacity Building/INSTAAR.University of Colorado BoulderCO 80309USA Department of Health and Behavioral Sciences University of Colorado DenverDenverCO 80204USA

NOAA’s Oceanic Nino Index(ONI)is used to record for historical purposes the occurrence and duration of El Nino episodes,based on the monitoring of sea surface temperatures(SSTs)in the central Pacific *** ONI is used to identify the onset of an above average SST threshold that persists for several months,encompassing both the beginning and end of an El Nino *** first appearance of an anomalous seasonal value of 0.5℃suggests with a high probability that an El Nino could emerge,but for heightened warnings,one must wait for several *** this article,we proposed that the ONI value of 0.7℃identifies a tipping point at which the El Nino event becomes locked in,which can provide additional lead time for mitigative actions to be taken by societal decision *** preliminary findings suggest that a first appearance of 0.7℃value could serve as a credible marker of El Nino’s locked-in phase,which can provide additional credibility to the current 0.5℃El Nino onset indicator for at-risk societies to get ready for El Nino’s foreseeable societal and ecological impacts.

关键词： Advisory Disasters Early warning El Nino El Nino Southern Oscillation ENSO Hydrometeorological hazards Oceanic Nino Index ONI

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