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Clear Cell Papillary Renal Cell Carcinoma: A Rare Subtype

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j.urnal of Cancer Therapy 2011年第5期2卷 683-685页

作者： Armin Kamyab michael j. jacobs 不详

Introduction: Renal cell carcinoma (RCC) is generally divided into clear cell, papillary, and chromophobe subtypes. Clear cell papillary RCC is a recently described subtype. Case report: We report the case of a 42 year old female who was found on computed tomography scan of the abdomen to have a cyst which appeared to involve the right kidney. Pathology of the cyst wall revealed features consistent with a RCC, clear cell papillary type. Discussion: Clear cell papillary RCC are a recently described entity with less than 100 cases reported in the literature. Most cases in the literature have been associated with end-stage renal disease, however more case are being reported in patients without renal disease. Conclusion: Clear cell papillary RCC is a rare distinct entity in the spectrum of renal cell carcinoma. Based on the literature they appear to be clinically indolent tumors;however, more research is required to further characterize and prognosticate these rare tumors.

关键词： Renal Cell Carcinoma Clear Cell Papillary

Improved Outcomes in Gallbladder Cancer with Early Diagnosis and Negative Nodal Status

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j.urnal of Cancer Therapy 2012年第2期3卷 137-145页

作者： Lauren Smithson Christopher Keto Lorenzo Ferguson Sumet Silapaswan michael j. jacobs Ramachandra Kolachalam j.ffrey C. Flynn Vij.y K. Mittal Department of Surgery Providence Hospital and Medical Centers Southfield USA Department of Surgery Providence Hospital and Medical Centers Southfield USA.

Background: Gallbladder cancer (GBC) is a rare disease of the hepatobiliary tract characterized by silent presentation, poor prognosis, and limited therapy. Current imaging modalities, clinical symptoms and laboratory values are of limited value in diagnosis and tumour markers are used as a clinical adj.nct. Five year survival is 5% - 12% and a maj.rity of patients survive less than 1 year. Early identification, negative nodal status, and extended cholecystectomy improve survival;adj.vant therapy does not appear to play a role. Obj.ctive: To evaluate the effects of stage and nodal status of GBC on survival by analyzing clinical and radiological factors leading to preoperative diagnosis and appropriate subsequent management. Results: Forty-three patients (31 female, 12 male) had primary GBC. Average age was 69 years. The most common presenting symptom was pain (65%). Fifteen (35%) patients presented with acute cholecystitis;9 were suspicious for a mass. Ultrasound and computed tomography were the imaging modalities most often used. Preoperative diagnoses were made in only 7 (16%) patients, whereas 16 (37%) patients were diagnosed intra-operatively and 20 (47%) post-operatively. Adj.vant chemotherapy was offered in 16 (37%) patients. Average survival was 28 months (range 0.5 - 238 months), with a 5-year survival of 13% across all stages. Early GBC (stages 1 - 2) had a 5-year survival of 43%, and late GBC (stages 3 - 4) had no survival at 5 years, with an average survival of 9 months. Positive nodes decreased survival. Conclusion: Our results mirror what has been reported in the literature. Most patients presented with acute cholecystitis, with confounding clinical data, but few were preoperatively diagnosed with GBC. Imaging was rarely diagnostic. Late stage GBC, as well as node-positive status, had dismal outcomes with low 1-year and 5-year survival rates. Improved preoperative suspicion of early GBC would allow for more intentional curative resections, before nodes

关键词： Gallbladder Carcinoma Node Status Survival

Hepatic angiotensin-converting enzyme 2 expression in metabolic dysfunction-associated steatotic liver disease and in patients with fatal COVID-19

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World j.urnal of Gastroenterology 2024年第31期30卷 3705-3716页

作者： Angus K jacobs Steven D Morley Kay Samuel Katie Morgan Lyndsey Boswell Timothy j.Kendall David A Dorward j.nathan A Fallowfield Peter C Hayes j.hn N Plevris Hepatology Laboratory University of EdinburghEdinburgh EH164SBUnited Kingdom Scottish National Blood Transfusion Service Jack Copland CentreEdinburgh EH144BEUnited Kingdom Institute for Regeneration and Repair University of EdinburghEdinburgh EH164UUUnited Kingdom Edinburgh Pathology University of EdinburghEdinburgh EH164SBUnited Kingdom

BACKGROUND Metabolic dysfunction-associated steatotic liver disease(MASLD),characterised by hepatic lipid accumulation,causes inflammation and oxidative stress accompanied by cell damage and *** inj.ry(LI)is also frequently reported in patients hospitalised with coronavirus disease 2019(COVID-19),while preexisting MASLD increases the risk of LI and the development of COVID-19-associated *** of inj.ry at the cellular level remain unclear,but it may be significant that severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)which causes COVID-19,uses angiotensin-converting expression enzyme 2(ACE2),a key regulator of the‘anti-inflammatory’arm of the renin-angiotensin system,for viral attachment and host cell *** To determine if hepatic ACE2 levels are altered during progression of MASLD and in patients who died with severe *** ACE2 protein levels and localisation,and histological fibrosis and lipid droplet accumulation as markers of MASLD were determined in formalin-fixed liver tissue sections across the MASLD pathological spectrum(isolated hepatocellular steatosis,metabolic dysfunction-associated steatohepatitis(MASH)+/-fibrosis,end-stage cirrhosis)and in post-mortem tissues from patients who had died with severe COVID-19,using ACE2 immunohistochemistry and haematoxylin and eosin and picrosirius red staining of total collagen and lipid droplet areas,followed by quantification using machine learning-based image pixel *** ACE2 staining is primarily intracellular and concentrated in the cytoplasm of centrilobular hepatocytes and apical membranes of bile duct ***,ACE2 protein levels are elevated in non-fibrotic MASH compared to healthy controls but not in the progression to MASH with fibrosis and in ***2 protein levels and histological fibrosis are not associated,but ACE2 and liver lipid droplet content are significantly correlated across the MASLD *** A

关键词： Metabolic dysfunction-associated steatotic liver disease Angiotensin-converting enzyme 2 Immunohistochemistry COVID-19 COVID-19-associated cholangiopathy

CD4^(+)T cells produce IFN-I to license cDC1s for induction of cytotoxic T-cell activity in human tumors

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Cellular & Molecular Immunology 2024年第4期21卷 374-392页

作者： Xin Lei Daniël C.de Groot Marij.j.P.Welters Tom de Wit Ellen Schrama Hans van Eenennaam Saskia j.Santegoets Timo Oosenbrug Annemarthe van der Veen j.ris L.Vos Charlotte L.Zuur Noel F.C.C.de Miranda Heinz jacobs Sj.erd H.van der Burg j.nnie Borst Yanling Xiao Department of Immunology Leiden University Medical CenterLeidenThe Netherlands Oncode Institute Leiden University Medical CenterLeidenThe Netherlands Department of Tumor Biology and Immunology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Medical Oncology Oncode InstituteLeiden University Medical CenterLeidenThe Netherlands IMMIOS B.V. OssThe Netherlands Division of Medical Oncology The Netherlands Cancer InstituteAmsterdamThe Netherlands Department of Otorhinolaryngology Leiden University Medical Center LeidenThe Netherlands Department of Pathology Leiden University Medical CenterLeidenThe Netherlands

CD4^(+)T cells can"help"or"license" conventional type 1 dendritic cells(cDC1s)to induce CD8^(+)cytotoxic T lymphocyte(CTL)anticancer responses,as proven in mouse *** recently identified cDC1s with a transcriptomic imprint of CD4^(+)T-cell help,specifically in T-cell-infiltrated human cancers,and these cells were associated with a good prognosis and response to PD-1-targeting ***,we delineate the mechanism of cDC1 licensing by CD4^(+)T cells in *** CD4^(+)T cells produce IFNβvia the STING pathway,which promotes MHC-I antigen(cross-)presentation by cDC1s and thereby improves their ability to induce CTL anticancer *** cooperation with CD40 ligand(L),IFNβalso optimizes the costimulatory and other functions of cDC1s required for CTL response ***-I-producing CD4^(+)T cells are present in diverse T-cell-infiltrated cancers and likely deliver“help”signals to CTLs locally,according to their transcriptomic profile and colocalization with“helped/licensed”cDCs and tumor-reactive CD8^(+)T *** agreement with this scenario,the presence of IFN-I-producing CD4^(+)T cells in the TME is associated with overall survival and the response to PD-1 checkpoint blockade in cancer patients.

关键词： CD4^(+)T-cell help cDC1 licensing IFN-I signaling CD40 costimulation (cross-)presentation CTL priming Tumor control

Clear Cell Papillary Renal Cell Carcinoma: A Rare Subtype

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Operations management for competitive advantage / Richard B. Chase, Nicholas j. Aquilano, F. Robert jacobs. 9th ed.

j.urnal of Cancer Therapy 2011年第5期

作者： Armin Kamyab michael j. jacobs

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Dryland agriculture and rangeland restoration priorities in Afghanistan

丛书名： The Irwin/McGraw-Hill series. Operations and decision sciences.

2001年

作者： Richard B. Chase Nicholas j. Aquilano F. Robert jacobs.

来源：畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 评论

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j.urnal of Arid Land 2015年第3期7卷 391-402页

作者： michael j.jacobs Catherine A SCHLOEDER Philip D TANIMOTO Texas Agri Life Research Department of Ecosystem Science & Management2138TAMUCollege StationTX 77843-2138USA Oikos Services LLCFortineMT 59918USA Conservation Imaging Inc.AuburndaleMassachusetts 02466USA

Afghanistan is threatened by rangeland degradation.A quantitative visual analysis of Google Earth Imagery was used to systematically locate,characterize and quantify the current extent of rangelands in Afghanistan degraded as a consequence of dryland *** data were used in conj.nction with dryland agriculture locations to establish a climate envelope comprised by temperature and mean annual precipitation to create a geographical mask known to contain dryland *** this mask we created a grid of 100 km2 cells that we analyzed individually to access dryland agriculture *** limits to sustainable dryland agriculture and areas of high restoration priority were also assessed as was the distribution of rain-fed agriculture with respect to the location of traditional migration routes for extensive livestock *** extents of agriculture in Afghanistan,at both upper and lower elevations,correlated most closely with mean annual temperature（MAT） at the upper elevation limits,and with mean annual precipitation（MAP） at the lower elevation *** total,dryland agriculture comprised 38,980 km2 of former native *** was highest in the northwestern,northern and northeastern provinces of Herat,Badghis,Faryab,j.wzj.n,Sar-e-Pul,Samangan,Balkh,Baghlan,Kunduz,Takhar and Badakhshan,with the highest percentage of conversion occurring in *** MAP value of 〈400 mm is perceived by farmers as the current climatic limit to sustainable dryland agriculture across the northern regions of the *** this MAP value,approximately 27,677 km2 of converted rangeland met the need for restoration *** proj.ctions indicate that Afghanistan will become warmer and drier in the coming *** consequence of this trend is that the MAP threshold of 〈400 mm to sustainable dryland agriculture will become obsolete in the coming *** of currently converted rangelands is needed to restore critical grazing area

关键词： degradation climatic trends extensive livestock production dryland agriculture rangeland restoration

Theoretical and experimental investigations on an X-shaped vibration isolator with active controlled variable stiffness

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Applied Mathematics and Mechanics(English Edition) 2024年第8期45卷 1371-1386页

作者： Zeyu CHAI j.T.HAN Xuyuan SONG j.an ZANG Yewei ZHANG Zhen ZHANG College of Aerospace Engineering Shenyang Aerospace University jacobs School of Engineering University of California San Diego Key Laboratory of Vibration and Control of Aero-Propulsion System Ministry of EducationNortheastern University

A novel X-shaped variable stiffness vibration isolator(X-VSVI) is *** Runge-Kutta method, harmonic balance method, and wavelet transform spectra are introduced to evaluate the performance of the X-VSVI under various excitations. The layer number, the installation angle of the X-shaped structure, the stiffness, and the active control parameters are systematically analyzed. In addition, a prototype of the X-VSVI is manufactured, and vibration tests are carried out. The results show that the proposed X-VSVI has a superior adaptability to that of a traditional X-shaped mechanism, and shows excellent vibration isolation performance in response to different amplitudes and forms of excitations. Moreover, the vibration isolation efficiency of the device can be improved by appropriate adj.stment of parameters.

关键词： 70j.5 70K30 70K50 bionic vibration isolation nonlinear dynamics O322 prototype experiment variable stiffness structure X-shaped structure

Hemolysis results in impaired intestinal microcirculation and intestinal epithelial cell inj.ry

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World j.urnal of Gastroenterology 2011年第2期17卷 213-218页

作者： Sebastiaan j.Hanssen Tim Lubbers Caroline M Hodin Frits W Prinzen Wim A Buurman michael j.jacobs Department of Surgery Maastricht University Medical Center Cardiovascular Research Institute Maastricht Maastricht University Medical Center European Vascular Center Aachen-Maastricht Department of Vascular SurgeryUniversity Hospital Aachen Nutrition and Toxicology Research Institute Maastricht Maastricht University Medical Center Department of Physiology Maastricht University Medical Center

AIM:To study the effect of circulating cell-free oxy-hemoglobin(FHb) on intestinal microcirculation and intestinal epithelial inj.ry in a rat model. METHODS:To induce elevated intravascular circulating FHb,male Sprague-Dawley rats received water or FHb *** changes in j.j.num,ileum and colon were evaluated using fluorescent *** inj.ry was quantified as plasmatic release of ileal lipid binding protein(iLBP) and verified by histological analysis of the ileum. RESULTS:Water and FHb infusions resulted,when compared with saline infusion,in reduced intestinal microcirculation(after 30 min Pj.j.num and colon) .Circulating FHb levels correlated significantly with release of iLBP(Spearman r=0.72,P=0.0011) .Epithelial cell inj.ry of the villi was histologically observed after water and FHb infusions. CONCLUSION:This study shows that circulating FHb leads to a reduction in intestinal microcirculatory blood flow with marked inj.ry to intestinal epithelial cells. These data support the hypothesis that circulating FHb contributes to the development of intestinal inj.ry.

关键词：肠上皮细胞肠道损伤细胞损伤环和组织学观察生理盐水溶血卫生局