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Failed biliary cannulation: Clinical and technical outcomes after tertiary referral endoscopic retrograde cholangiopancreatography

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World journal of Gastroenterology 2011年第45期17卷 4993-4998页

作者： michael P Swan michael j bourke Stephen j Williams Sina Alexander Alan Moss Rick Hope David Ruppin Department of Gastroenterology and Hepatology Westmead Hospital

AIM: Prospective evaluation of repeat endoscopic retrograde cholangiopancreatography (ERCP) for failed Schutz grade 1 biliary cannulation in a high-volume center. METHODS: Prospective intention-to-treat analysis of patients referred for biliary cannulation following recent unsuccessful ERCP. RESULTS: Fifty-one patients (35 female; mean age: 62.5 years; age range: 40-87 years) with previous failed biliary cannulation were referred for repeat ERCP. The indication for ERCP was primarily choledocholithiasis (45%) or pancreatic malignancy (18%). Successful biliary can- nulation was 100%. The precut needle knife sphincterotomy (NKS) rate was 27.4%. Complications occurred in 3.9% (post-ERCP pancreatitis). An identif iable reason for initial unsuccessful biliary cannulation was present in 55% of cases. Compared to a cohort of 940 nave pa-pilla patients (female 61%; mean age: 59.9 years; age range: 18-94 years) who required sphincterotomy over the same time period, there was no statistical difference in the cannulation success rate (100% vs 98%) or postERCP pancreatitis (3.1% vs 3.9%). Precut NKS use was more frequent (27.4% vs 12.7%) (P = 0.017). CONCLUSION: Referral to a high-volume center following unsuccessful ERCP is associated with high technical success, with a favorable complication rate, compared to routine ERCP procedures.

关键词： Failed endoscopic retrograde cholangiopancreatography Failed biliary cannulation Unsuccessful biliary cannulation Tertiary referral endoscopic retrograde cholangiopancreatography Needle knife sphincterotomy Biliary cannulation Precut sphincterotomy Post endoscopic retrograde cholangiopancreatography pancreatitis

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An Impact of Hydrostatic Extraction Scheme on BMRC's Global Spectral Model

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Advances in Atmospheric Sciences 1992年第3期9卷 269-278页

作者：盛华 William bourke Terry Hart Institute of Atmospheric Physics Academia Sinica Beijing Australian Bureau of Meteorology Research Centre Australian Bureau of Meteorology Research Centrehere are two important features in geophysical fluid dynamics. One is that the atmospheric and oceanic equations of motion include the Coriolis force another is that they describe a stratified fluid. The hydrostatic extraction scheme or standard stratification approximation posed by Zeng (1979) reflects the second aspect of geophysical fluid dynamics. There exist two major advantages in this scheme accurate computation of the pressure gradient force can be obtained over steep mountain slopes and the accumulation error in vertical finite differencing can be reduced especially near the tropopause.Chen et al (1987) introduced the hydrostatic extraction scheme into a global spectral model which attained preliminary success at low resolution. Zhang and Sheng et al (1990) developed and improved the hydrostatic extraction scheme in a global spectral model in which C0 the parameter that represents the stratification of the reference atmosphere changes not only with height but also with latitude. The scheme has been incorporated BMRC's global spectral model (IAPB). Four 5-day forecasts have been performed to test the IAPB with the hydrostatic extraction scheme. Objective verifications demonstrate a positive effect of the hydrostatic extration scheme on BMRC's model particularly at upper levels over the tropics and the Antartic region.

There are two important features in geophysical fluid dynamics. One is that the atmospheric and oceanic equations of motion include the Coriolis force; another is that they describe a stratified fluid. The hydrostatic extraction scheme, or standard stratification approximation, posed by Zeng (1979), reflects the second aspect of geophysical fluid dynamics. There exist two major advantages in this scheme; accurate computation of the pressure gradient force can be obtained over steep mountain slopes, and the accumulation error in vertical finite differencing can be reduced, especially near the *** et al (1987) introduced the hydrostatic extraction scheme into a global spectral model, which attained preliminary success at low resolution. Zhang and Sheng et al (1990) developed and improved the hydrostatic extraction scheme in a global spectral model, in which C0, the parameter that represents the stratification of the reference atmosphere, changes not only with height, but also with latitude. The scheme has been incorporated BMRC's global spectral model (IAPB). Four 5-day forecasts have been performed to test the IAPB with the hydrostatic extraction scheme. Objective verifications demonstrate a positive effect of the hydrostatic extration scheme on BMRC's model, particularly at upper levels, over the tropics and the Antartic region.

关键词： An Impact of Hydrostatic Extraction Scheme on BMRC’s Global Spectral Model

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Non-physician endoscopists: A systematic review

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World journal of Gastroenterology 2015年第16期21卷 5056-5071页

作者： Maximilian Stephens Luke F Hourigan Mark Appleyard George Ostapowicz Mark Schoeman Paul V Desmond jane M Andrews michael bourke David Hewitt David A Margolin Gerald j Holtmann Department of Gastroenterology and Hepatology Princess Alexandra Hospital Faculty of Medicine and Biomedical Sciences University of Queensland Department of Gastroenterology and Hepatology RBWH Department of Gastroenterology and Hepatology Gold Coast Hospital QLD 4215 Department of Gastro-enterology and Hepatology Royal Adelaide Hospital and University of Adelaide St Vincent’s Hospital University of MelbourneMelbourne VIC 3010Australia Department of Gastroenterology and Hepatology Westmead HospitalUniversity of Sydney School of Medicine University of Queensland Department of Gastroenterology Queensland Elizabeth II Jubilee HospitalCoopers PlainsBrisbane QLD 4108Australia Department of Colon and Rectal Surgery Ochsner Clinic Foundation Ochsner Clinical SchoolUniversity of Queensland

AIM:To examine the available evidence on safety, competency and cost-effectiveness of nursing staff providing gastrointestinal(GI) endoscopy ***:The literature was searched for publications reporting nurse endoscopy using several databases and specific search *** were screened against eligibility criteria and for *** searches yielded 74 eligible and relevant articles; 26 of these studies were primary research articles using original datasets relating to the ability of nonphysician *** publications included a total of 28883 procedures performed by non-physician ***:The number of publications in the field of non-specialist gastrointestinal endoscopy reached a peak between 1999 and 2001 and has decreased thereafter.17/26 studies related to flexible sigmoidoscopies,5 to upper GI endoscopy and 6 to *** studies were from metropolitan centres with nurses working under strict supervision and guidance by specialist *** distribution of publications showed the majority of research was conducted in the United States(43%),the United Kingdom(39%)and the Netherlands(7%).Most studies conclude that after appropriate training nurseendoscopists safely perform ***,in relation to endoscopic competency,safety or patient satisfaction,all studies had major methodological *** were often not randomized(21/26studies)and not appropriately *** relation to cost-efficiency,nurse endoscopists were less costeffective per procedure at year 1 when compared to services provided by physicians,due largely to the increased need for subsequent endoscopies,specialist follow-up and primary care ***:Contrary to general beliefs,endoscopic services provided by nurse endoscopists are not more cost effective compared to standard service models and evidence suggests the *** significant shortcomings and biases limit the validity and

关键词： Nurse endoscopist Cost-benefit Servicemodel Patient satisfaction Outcome parameter

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High density genetic map and quantitative trait loci(QTLs)associated with petal number and flower diameter identified in tetraploid rose

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journal of Integrative Agriculture 2021年第5期20卷 1287-1301页

作者： YU Chao WAN Hui-hua Peter M.bourke CHENG Bi-xuan LUO Le PAN Hui-tang ZHANG Qi-xiang Beijing Key Laboratory of Ornamental Plants Germplasm Innovation&Molecular Breeding/National Engineering Research Center for Floriculture/Beijing Laboratory of Urban and Rural Ecological Environment/Engineering Research Center of Landscape Environment of Ministry of Education/Key Laboratory of Genetics and Breeding in Forest Trees and Ornamental Plants of Ministry of Education School of Landscape ArchitectureBeijing Forestry UniversityBeijing 100083P.R.China Plant Breeding Wageningen University&ResearchWageningen 6700 AJThe Netherlands Beijing Advanced Innovation Center for Tree Breeding by Molecular Design Beijing Forestry UniversityBeijing 100083P.R.China

Rose is one of the most important ornamental and economic plants in the *** rose cultivars are primarily tetraploid,and during meiosis,they may exhibit double reduction or preferential chromosome ***,the construction of a high density genetic map of tetraploid rose is both challenging and *** this study,a tetraploid rose population was used to conduct a genetic analysis using genome sequencing.A total of 17382 single nucleotide polymorphism(SNP)markers were selected from 2308042 detected *** with 440 previously developed simple sequence repeats(SSR)and amplified fragment length polymorphism(AFLP)markers,a marker dosage of 6885 high quality markers was successfully assigned by GATK software in the tetraploid *** markers were used in the construction of a high density genetic map,containing the expected seven linkage groups with 6842 markers,a total map length of 1158.9 c M,and an average inter-marker distance of 0.18 c *** trait locus(QTL)analysis was subsequently performed to characterize the genetic architecture of petal number and flower *** major QTL(qpnum-3-1)was detected for petal number in three consecutive years,which explained 20.18–22.11%of the variation in petal *** QTLs were detected for flower diameter;the main locus,qfdia-2-2,was identified in two consecutive *** results will benefit the molecular marker-assisted breeding of modern rose *** addition,this study provides a guide for the genetic and QTL analysis of autotetraploid plants using sequencing-based genotyping methods.

关键词： rose tetraploid genetic linkage map QTLs

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大堡礁的价值有多高？

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空中英语教室（高级版．彭蒙惠英语） 2018年第5期 21-21,42,43页

作者： michael Heath Chris bourke

当人类危及全世界最大的活体结构时，经济学家想出了一个新的解决方案：为这个结构贴上价格标签。澳大利亚的大堡礁比日本国土面积还大，可以从宇宙中观察到，也拥有地球上最复杂的生态系统。不过，大堡礁也遭到气候变迁、农业径流、沿... 详细信息

当人类危及全世界最大的活体结构时，经济学家想出了一个新的解决方案：为这个结构贴上价格标签。澳大利亚的大堡礁比日本国土面积还大，可以从宇宙中观察到，也拥有地球上最复杂的生态系统。不过，大堡礁也遭到气候变迁、农业径流、沿海开发与非法捕鱼的危害。

关键词：大堡礁价值经济学家国土面积澳大利亚生态系统气候变迁沿海开发

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In the name of the rose:a roadmap for rose research in the genome era

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Horticulture Research 2019年第1期6卷 948-964页

作者： Marinus j.M.Smulders Paul Arens Peter M.bourke Thomas Debener Marcus Linde jan De Riek Leen Leus Tom Ruttink Sylvie Baudino Laurence Hibrant Saint-Oyant jeremy Clotault Fabrice Foucher Plant Breeding Wageningen University and ResearchP.O.Box 3866700 AJ WageningenThe Netherlands Faculty of Natural Sciences Institute for Plant GeneticsMolecular Plant BreedingLeibniz University of HannoverHerrenhäuser Strasse 230419 HannoverGermany ILVO Plant Sciences UnitFlanders Research Institute for AgricultureFisheries and FoodCaritasstraat 399090 MelleBelgium BVpam CNRS FRE 3727UJM-Saint-ÉtienneUniv.LyonSaint-EtienneFrance IRHS Agrocampus-OuestINRAUniversitéd’AngersSFR 4207 QuaSaV42 rue Georges Morel BP 6005749071 BeaucouzéFrance

The recent completion of the rose genome sequence is not the end of a process,but rather a starting point that opens up a whole set of new and exciting *** to a high-quality genome sequence other genomic tools have also become available for rose,including transcriptomics data,a high-density single-nucleotide polymorphism array and software to perform linkage and quantitative trait locus mapping in *** cultivars are highly heterogeneous and *** vast diversity in cultivated roses can be explained through the genetic potential of the genus,introgressions from wild species into commercial tetraploid germplasm and the inimitable efforts of historical *** can now investigate how this diversity can best be exploited and refined in future breeding work,given the rich molecular toolbox now available to the rose breeding *** paper presents possible lines of research now that rose has entered the genomics era,and attempts to partially answer the question that arises after the completion of any draft genome sequence:‘Now that we have“the”genome,what’s next?’.Having access to a genome sequence will allow both(fundamental)scientific and(applied)breeding-orientated questions to be *** outline possible approaches for a number of these questions.

关键词： breeding cultivar linkage

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Experiences Impacting the Quality of Life of Mothers of Children With Autism and Intellectual Disability

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Psychology Research 2014年第8期4卷 666-684页

作者： jenny Fairthorne Colleen Fisher jenny bourke Helen Leonard Telethon Kids Institute University of Western AustraliaPerth Australia School of Population Health University of Western Australia Perth Australia Telethon Kids Institute University of Western Australia Perth Australia

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High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array

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Horticulture Research 2016年第1期3卷 68-75页

作者： Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus j M Smulders Wageningen UR Plant Breeding Wageningen University&ResearchWageningenNL-6700 AJThe Netherlands Roath BV EindhovenThe Netherlands Pheno Geno Roses D.O.O.Bulevar oslobođenja 65a 21000 Novi SadSerbia

Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted *** tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental *** rose breeding,crosses with unintended parents occur *** developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one *** of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal *** densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 *** with the strawberry(Fragaria vesca)genome was *** ICM1 corresponded to *** pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to *** ICM2 corresponded to parts of *** pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6.

关键词： breeding linkage dosage

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西方伦理学史

西方伦理学史

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作者： (美)布尔克(Vernon j. bourke)

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我在伦敦买了一头狮子

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2016年

作者： (澳) 安东尼·布尔克约翰·兰道尔

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