检索结果-南通市图书馆

Review:Do Horses Receive Optimum Amounts of Glutamine in Their Diets?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Veterinary Science Research 2020年第1期2卷 1-15页

作者： michael i.lindinger The Nutraceutical Alliance TorreviejaAlicante03185Spain

in some species of growing mammals glutamine is an essential amino acid that,if inadequate in the diet,is needed for normal growth and *** is thus sometimes considered to be a conditionally essential amino acid in some species.A review of studies that have measured L-glutamine concentrations([glutamine])in horses demonstrates that plasma[glutamine]has routinely been reported to be much lower(~330μmol/L)than in other mammals(>600μmol/L).Plasma[glutamine]represents the balance between intestinal transport into the blood after hepatic first pass,tissue synthesis and cellular *** hypothesis is proposed that sustained low plasma[glutamine]represents a chronic state of sub-optimal glutamine intake and glutamine synthesis that does not meet the requirements for optimum *** this may be without serious consequence in feral and sedentary horses,there is evidence that provision of supplemental dietary glutamine ameliorates a number of health consequences,particularly in horses with elevated metabolic *** present review provides evidence that glutamine is very important(and perhaps essential)for intestinal epithelial cells in mammals including horses,that horses with low plasma[glutamine]represents a sub-optimal state of well-being,and that horses supplemented with glutamine exhibit physiological and health benefits.

关键词： Conditionally essential amino acid intestinal health,immune health Hypoglutaminemia Skeletal muscle Glutamine metabolism

Dietary Cucumis melo Reduces Markers of Muscle and Articular inflammation Following High-intensity Exercise in Horses

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Veterinary Science Research 2020年第1期2卷 24-34页

作者： Jennifer L.MacNicol michael i.lindinger Anna K.Shoveller John P.Cant Wendy Pearson Department of Animal Biosciences University of GuelphGuelphOntarioN1G 2W1Canada The Nutraceutical Alliance BurlingtonONCanada

We evaluated the antioxidative and anti-inflammatory potential of daily oral supplementation with a proprietary powdered Cucumis melo pulp(CMP)on exercise-induced markers of articular and muscular oxidative stress and inflammation in 12 *** performed a high-intensity exercise test immediately prior to,and then following,3 weeks of daily supplementation of 1 g powdered CMP(CMP;n=8).Controls(Co;n=8)underwent the same exercise and sampling regime but were not *** and synovial fluid(SF)samples were taken 24 h prior to exercise(BL),and at 1 and 24 h following *** and SF were analysed for prostaglandin E2(PGE2),total antioxidant status(TAS),nitrite and superoxide dismutase(SOD)*** was analysed for glycosaminoglycans(GAG),and plasma was analysed for thiobarbituric acid reactive substances(TBARS).Comparisons were made using repeated measures with the initial exercise test as a *** was an increase in SF SOD activity in the CMP *** to Co at 1 h,CMP reduced nitrite and GAG in SF,as well as maintained plasma TAS and lymphocyte *** 24 h,plasma PGE2 and creatine kinase were lower in horses receiving *** weeks of supplementation with CMP reduced markers of articular and skeletal muscle oxidative stress and inflammation in response to high-intensity exercise in *** antioxidants may provide a useful adjunct to the daily nutrition plan of horses undergoing regular exercise training and competition.

关键词： Oxidative stress inflammation Skeletal muscle Synovial fluid Antiinflammatory

A review of control strategies used for morphing aircraft applications

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第4期37卷 436-463页

作者： Muhammed S.PARANCHEERiViLAKKATHiL Jafar S.PiLAKKADAN Rafic M.AJAJ Mohammadreza AMOOZGAR Davood ASADi Yahya ZWEiRi michael i.FRiSWELL Department of Aerospace Engineering Khalifa University of Science and TechnologyAbu DhabiUnited Arab Emirates Department of Aerospace Engineering Advanced Research and Innovation Center(ARIC)Khalifa University of Science and TechnologyAbu DhabiUnited Arab Emirates Department of Mechanical Materials&Manufacturing EngineeringUniversity of NottinghamNottingham NG72RDUK Department of Aerospace Engineering Adana Alparslan Turkes Science and Technology UniversityTurkey College of Engineering Swansea UniversitySwansea SA18ENUK

This paper reviews the various control algorithms and strategies used for fixed-wing morphing aircraft applications. it is evident from the literature that the development of control algorithms for morphing aircraft technologies focused on three main areas. The first area is related to precise control of the shape of morphing concepts for various flight conditions. The second area is mainly related to the flight dynamics, stability, and control aspects of morphing aircraft. The third area deals mainly with aeroelastic control using morphing concepts either for load alleviation purposes and/or to control the instability boundaries. The design of controllers for morphing aircraft/wings is very challenging due to the large changes that can occur in the structural, aerodynamic, and inertial characteristics. in addition, the type of actuation system and actuation rate/speed can have a significant effect on the design of such controllers. The aerospace community is in strong need of such a critical review especially as morphing aircraft technologies move from fundamental research at a low Technology Readiness Level(TRL) to real-life applications. This critical review aims to identify research gaps and propose future directions. in this paper, research activities/papers are categorized according to the control strategy used. This ranges from simple Proportional integral Derivative(PiD) controllers at one end to complex robust adaptive controllers and deep learning algorithms at the other end. This includes analytical, computational, and experimental studies. in addition, the various dynamic models used and their fidelities are highlighted and discussed.

关键词： Control strategies Morphing aircraft Shape morphing Flight dynamics Aeroelasticity

Microscale shaping and rounding of ridge arrays and star pattern features on nickel mould via electrochemical polishing

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances in Manufacturing 2024年第2期12卷 207-226页

作者： Sana Zaki Nan Zhang michael D.Gilchrist School of Mechanical and Materials Engineering University College DublinBelfieldDublin 4Ireland

High quality micro mould tools are critical for ensuring defect-free production of micro injection moulded *** demoulding stage of the micro injection moulding can adversely affect the surface integrity due to friction,adhesion and thermal stresses between the metallic mould and polymeric replicated *** the present work,we propose the use of precision electropolishing(EP)as a shaping and polishing process to control the draft angle and fillet radius of micro features in order to ease *** defects that occur in replicated polymer parts include cracks,burrs and distorted features.A nickel mould having multiple linear ridges and star shape patterns was designed for the present investigation to have characteristic dimensions ranging from 10μm to 150μm and with various aspect ratios to study the effect of electropolishing on modifying the shape of micro features and surface morphology.A transient 2D computational analysis has been conducted to anticipate the effect of shaping on the Ni mould after electrochemical polishing with non-uniform material removal rates,based on the distribution of current *** experimental results indicate that after shaping using EP,the draft angle of star-patterns and linear patterns can be effectively increased by approximately 3.6°,while the fillet radius increases by up to 5.0μ*** controlling the electropolishing process,the surface roughness can be maintained under 50 *** work uses a green and environmental friendly nickel sulfamate electrolyte which can be effective for shaping of nickel micro features without causing any surface deposition.

关键词： Micro feature shaping and electropolishing Micro mould tools Green electrolyte Demoulding micro patterns

Anisotropic time-dependent behaviors of shale under direct shearing and associated empirical creep models

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1262-1279页

作者： Yachen Xie michael Z.Hou Hejuan Liu Cunbao Li Shenzhen Key Laboratory of Deep Engineering Sciences and Green Energy Shenzhen UniversityShenzhen518060China institute of Subsurface Energy Systems Clausthal University of TechnologyClausthal-Zellerfeld38678Germany State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China

Understanding the anisotropic creep behaviors of shale under direct shearing is a challenging *** this context,we conducted shear-creep and steady-creep tests on shale with five bedding orientations (i.e.0°,30°,45°,60°,and 90°),under multiple levels of direct shearing for the first *** results show that the anisotropic creep of shale exhibits a significant stress-dependent *** a low shear stress,the creep compliance of shale increases linearly with the logarithm of time at all bedding orientations,and the increase depends on the bedding orientation and creep *** high shear stress conditions,the creep compliance of shale is minimal when the bedding orientation is 0°,and the steady-creep rate of shale increases significantly with increasing bedding orientations of 30°,45°,60°,and 90°.The stress-strain values corresponding to the inception of the accelerated creep stage show an increasing and then decreasing trend with the bedding orientation.A semilogarithmic model that could reflect the stress dependence of the steady-creep rate while considering the hardening and damage process is *** model minimizes the deviation of the calculated steady-state creep rate from the observed value and reveals the behavior of the bedding orientation's influence on the steady-creep *** applicability of the five classical empirical creep models is quantitatively *** shows that the logarithmic model can well explain the experimental creep strain and creep rate,and it can accurately predict long-term shear creep *** on an improved logarithmic model,the variations in creep parameters with shear stress and bedding orientations are *** abovementioned findings,a mathematical method for constructing an anisotropic shear creep model of shale is proposed,which can characterize the nonlinear dependence of the anisotropic shear creep behavior of shale on the bedding orientation.

关键词： Rock anisotropy Direct shear creep Creep compliance Steady-creep rate Empirical model Creep constitutive model

From seawater to hydrogen via direct photocatalytic vapor splitting: A review on device design and system integration

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers in Energy 2024年第3期18卷 291-307页

作者： Hongxia Li Khaja WAHAB AHMED Mohamed A.ABDELSALAM michael FOWLER Xiao-Yu WU Technology innovation institute Masdar CityAbu Dhabi 9639United Arab Emirates Department of Chemical Engineering University of WaterlooWaterlooON N2L 3G1Canada Department of Mechanical and Nuclear Engineering Khalifa University of Science and TechnologyAbu Dhabi 127788United Arab Emirates Department of Mechanical and Mechatronics Engineering University of WaterlooWaterlooON N2L 3G1Canada

Solar-driven hydrogen production from seawater attracts great interest for its emerging role in decarbonizing global energy consumption. Given the complexity of natural seawater content, photocatalytic vapor splitting offers a low-cost and safe solution, but with a very low solar-to-hydrogen conversion efficiency. With a focus on cutting-edge photothermal–photocatalytic device design and system integration, the recent research advances on vapor splitting from seawater, as well as industrial implementations in the past decades were reviewed. in addition, the design strategies of the key processes were reviewed, including vapor temperature and pressure control during solar thermal vapor generation from seawater, capillary-fed vaporization with salt repellent, and direct photocatalytic vapor splitting for hydrogen production. Moreover, the existing laboratory-scale and industrial-scale systems, and the integration principles and remaining challenges in the future seawater-to-hydrogen technology were discussed.

关键词： seawater hydrogen photocatalytic vapor splitting solar-driven

New perspectives on biology,disease progression,and therapy response of head and neck cancer gained from single cell RNA sequencing and spatial transcriptomics

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Oncology Research 2024年第1期32卷 1-17页

作者： GERWiN HELLER THORSTEN FUEREDER ALEXANDER michael GRANDiTS ROTRAUD WiESER Division of Oncology Department of Medicine IMedical University of ViennaVienna1090Austria Ludwig Boltzmann institute for Hematology and Oncology Medical University of ViennaVienna1090Austria

Head and neck squamous cell carcinoma(HNSCC)is one of the most frequent cancers *** main risk factors are consumption of tobacco products and alcohol,as well as infection with human papilloma *** therapeutic options comprise surgery,radiation,chemotherapy,targeted therapy through epidermal growth factor receptor inhibition,and immunotherapy,but outcome has remained unsatisfactory due to recurrence rates of~50%and the frequent occurrence of second *** availability of the human genome sequence at the beginning of the millennium heralded the omics era,in which rapid technological progress has advanced our knowledge of the molecular biology of malignant diseases,including HNSCC,at an unprecedented ***,microarray-based methods,followed by approaches based on next-generation sequencing,were applied to study the genetics,epigenetics,and gene expression patterns of bulk *** recently,the advent of single-cell RNA sequencing(scRNAseq)and spatial transcriptomics methods has facilitated the investigation of the heterogeneity between and within different cell populations in the tumor microenvironment(e.g.,cancer cells,fibroblasts,immune cells,endothelial cells),led to the discovery of novel cell types,and advanced the discovery of cell-cell communication within *** review provides an overview of scRNAseq,spatial transcriptomics,and the associated bioinformatics methods,and summarizes how their application has promoted our understanding of the emergence,composition,progression,and therapy responsiveness of,and intercellular signaling within,HNSCC.

关键词： Head and neck squamous cell carcinoma Tumor microenvironment immunotherapy Gene expression Omics

Considerations for the use of porcine organ donation models in preclinical organ donor intervention research

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Models and Experimental Medicine 2024年第3期7卷 283-296页

作者： Frazer i.Heinis Shaheed Merani Nicholas W.Markin Kim F.Duncan michael J.Moulton Lance Fristoe William E.Thorell Raechel A.Sherrick Tami R.Wells Matthew T.Andrews Marian Urban School of Natural Resources Institute of Agriculture and Natural ResourcesUniversity of Nebraska-LincolnLincolnNebraskaUSA Division of Transplantation and Vascular Surgery Department of SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA Department of Anesthesiology University of Nebraska Medical CenterOmahaNebraskaUSA Division of Cardiothoracic Surgery Department of SurgeryUniversity of Nebraska Medical CenterOmahaNebraskaUSA Clinical Perfusion Nebraska Medicine-Nebraska Medical CenterOmahaNebraskaUSA Department of Neurosurgery University of Nebraska Medical CenterOmahaNebraskaUSA Nutrition and Health Sciences College of Education and Human SciencesUniversity of Nebraska-LincolnLincolnNebraskaUSA Department of Comparative Medicine University of Nebraska Medical CenterOmahaNebraskaUSA

Use of animal models in preclinical transplant research is essential to the optimization of human allografts for clinical *** models of organ donation and preservation help to advance and improve technical elements of solid organ recovery and facilitate research of ischemia-reperfusion injury,organ preservation strategies,and future donor-based *** considerations include cost,public opinion regarding the conduct of animal research,translational value,and relevance of the animal model for clinical *** present an overview of two porcine models of organ donation:donation following brain death(DBD)and donation following circulatory death(DCD).The cardiovascular anatomy and physiology of pigs closely resembles those of humans,making this species the most appropriate for pre-clinical *** are also considered a potential source of organs for human heart and kidney *** is imperative to minimize animal loss during procedures that are surgically *** present our experience with these models and describe in detail the use cases,procedural approach,challenges,alternatives,and limitations of each model.

关键词： animal model brain death circulatory death organ transplantation

The energetics of cellular life transitions

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Life Metabolism 2024年第3期3卷 12-20页

作者： Anna S.Monzel michael Levin Martin Picard Department of Psychiatry Division of Behavioral MedicineCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States Department of Biology Tufts UniversityMedfordMA 02155United States Allen Discovery Center at Tufts University MedfordMA 02155United States Wyss institute for Biologically inspired Engineering Harvard UniversityBostonMA 02115United States Department of Neurology H.Houston Merritt CenterColumbia Translational Neuroscience InitiativeCollege of Physicians and SurgeonsColumbia University Irving Medical CenterNew YorkNY 10032United States New York State Psychiatric institute New YorkNY 10032United States Robert N Butler Columbia Aging Center Columbia University Mailman School of Public HealthNew YorkNY 10032United States

Major life transitions are always difficult because change costs *** findings have demonstrated how mitochondrial oxidative phosphorylation(OxPhos)defects increase the energetic cost of living and that excessive integrated stress response(iSR)signaling may prevent cellular identity transitions during *** this perspective,we discuss general bioenergetic principles of life transitions and the costly molecular processes involved in reprograming the cellular hardware/software as cells shift *** energetic cost of cellular differentiation has not been directly quantified,representing a gap in *** propose that the iSR is an energetic checkpoint evolved to(i)prevent OxPhos-deficient cells from engaging in excessively costly transitions and(ii)allow iSR-positive cells to recruit systemic energetic resources by signaling via GDF15 and the brain.

关键词： energy mitochondria signaling pathway growth differentiation factor 15 energy balance development