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A differential loss of nerve fiber layer thickness and retinal ganglion cell complex in toxic and nutritional optic neuropathy

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Advances in Ophthalmology Practice and Research 2021年第2期1卷 28-34页

作者： Aishwarya Sriram Yuan Miao Prem Subramanian jeffery S.Schultz Cheng Zhang Department of Ophthalmology Montefiore Medical CenterAlbert Einstein College of MedicineBronxNYUSA b Sue Anschutz Rodgers/UCHealth Eye CenterDepartment of OphthalmologyUniversity of Colorado School of MedicineAuroraCOUSA

*** Optic neuropathy can result from ischemia,compression,inherited causes,as well as toxins or nutritional *** and nutritional optic neuropathy is defined as visual impairment from damage to the optic nerve due to medication or other ingested toxins,or from a nutritional *** both tend to present as a painless bilateral progressive visual decline with dyschromatopsia and poor contrast sensitivity.1–3 The vision loss is typically a central or ceco-central scotoma due to high sensitivity of the papillomacular(PM)bundle to these insults,and the vision loss is usually not worse than 20/400 except in cases of methanol *** early stages,the optic nerve may appear hyperemic or mildly edematous,however the optic nerve most commonly appears *** is generally believed with disease progression into late stages,optic atrophy becomes apparent.

关键词： visual fiber typically

Establishment of highly efficient transgenic system for black soldier fly(Hermetia illucens)

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insect Science 2023年第4期30卷 888-900页

作者： Zongqing Kou Xingyu Luo Yuguo Jiang Bihui Chen Yu Song Yaohui Wang Jun Xui.jeffery K.Tomberlin Yongping Huang Key Laboratory of insect Developmental and Evolutionary Biology Center for Excellence in Molecular Plant SciencesShanghai Insttute of Plant Physiology and EcologyChinese Academy of SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina Department of Entomology Texas A&M UniversityCollege StationTXUSA

The black soldier fly(BSF),Hermetia illucens,is a promising insect for miti-gating solid waste problems as its larvae are able to bioconvert organic waste into valuable *** recently reported a high-quality genome assembly of the BSF;analysis of this genome sequence will further the understanding of insect biology and identify genes that can be manipulated to improve efficiency of *** enable genetic manip-ulation of the BSF,we have established the first transgenic methods for this economically important *** cloned and identified the ubiquitous actin5C promoter(Hiactin5C-p3k)and 3 endogenous U6 promoters(HiU6:1,HiU6:2,and HiU6:3).The Hiactin5C pro-moter was used to drive expression of a hyperactive variant of the piggyBac transposase,which exhibited up to 6-fold improvement in transformation rate when compared to the wild-type ***,we evaluated the 3 HiU6 promoters using this trans-genic ***6:1 and HiU6:2 promoters provided the highest knockdown efficiency with RNAi and are thus promising candidates for future Clustered Regularly interspaced Short Palindromic Repeats(CRiSPR)***,our findings provide valuable genetic engineering toolkits for basic research and genetic manipulation of the BSF.

关键词： actin5C promoter black soldier fly hyPBase transgenesis U6 promoter

EASE-DGGS:a hybrid discrete global grid system for Earth sciences

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Big Earth Data 2022年第3期6卷 340-357页

作者： jeffery A.Thompson Mary J.Brodzik Kevin A.T.Silverstein Mason A.Hurley Nathan L.Carlson Minnesota Supercomputing institute University of MinnesotaMinneapolisMNUSA GEMS informatics initiative University of MinnesotaMinneapolisMNUSA National Snow and ice Data Center Cooperative Institute for Research in Environmental SciencesUniversity of ColoradoBoulderCOUSA

Although we live in an era of unprecedented quantities and access to data,deriving actionable information from raw data is a hard *** observation systems(EOS)have experienced rapid growth and uptake in recent decades,and the rate at which we obtain remotely sensed images is *** significant effort and attention has been devoted to designing systems that deliver analytics ready imagery faster,less attention has been devoted to developing analytical frameworks that enable EOS to be seamlessly integrated with other data for quantitative *** global grid systems(DGGS)have been proposed as one potential solution that addresses the challenge of geospatial data integration and ***,we propose the systematic extension of EASE-Grid in order to provide DGGS-like characteristics for EOS data *** describe the extensions as well as present implementation as an application programming interface(APi),which forms part of the University of Minnesota’s GEMS(Genetic x Environment x Management x Socioeconomic)informatics Center’s APi portfolio.

关键词： Discrete global grid systems DGGS EASE Grid coordinate reference systems

Simplified heavy metal staining techniques demonstrated with Fast Plant leaf tissue

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Cell Research 1991年第1期 89-96页

作者： HARRiS JOSEPH B..THOMAS G. GUiLLiAMS jeffery A. SCHULTZ

Fast Plant(Brassica rapa,Cruciferae)leaf tissuefixed in glutaraldehyde-acrolein and post-fixed in os-mium,was examined for response to several easily-prepared heavy metal *** and uranium,separately and in combination,gave typical resultsacross the spectrum of cell *** a single stainfollowing osmium,bismuth produced images seeminglyequivalent to lead and *** acidproduced very good membrane delineation but produceda washed-out background image similar to that from *** compounds were especiallyresponsive to ruthenium;the cytoplasm and the matrixof all organelles were also stained very *** were no more demanding than traditionalstaining methods and may be easily used in research *** Plant materials are a reliable,quick andeasy source of living material.

关键词： Fast Plant leaf tissue Simplified heavy metal staining technique.

A Simple Structure Model for Enzyme Production by Phanerochaete chrysosporium

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Chinese Journal of Chemical Engineering 2003年第4期11卷 414-419页

作者：郑重鸣 FOOYinDin jeffery Philip Obbard 林建平岑沛霖 Department of Chemical & Environmeotal Engineering National University of Singapore 10 Kent Ridge CrescentSingapore 119260 Department of Chemical Engineering Zhejiang UniversityHangzhou 310027 China

in order to understand the behavior of ligninolytic enzyme production by white rot fungi Phanerochaete chrysosporium, study on time courses and a mathematical model for the production of lignin peroxidase (LiP) and manganese peroxidase (MnP) of the fungi was undertaken. Based on the Monod-Jacob operon model, the ligninolytic enzyme would be synthesized in the absence of a related repressor. The repressor is assumed to be active in the presence of ammonia nitrogen, and as combined as co-repressor, it causes the inhibition of enzyme synthesis. The model can explain the mechanism of extracellular ligninolytic enzyme production by white rot fungi. The results,as predicted by the model, correspond closely to those observed in experimental studies. in addition, some light is also shed on unmeasured variables, such as the concentrations of repressor and mRNA that are related to the enzyme synthesis.

关键词： secondary metabolite lignin peroxidase (LiP) manganese peroxidase (MnP) model simulation white rot fungi represser mRNA

维普期刊数据库

Nanotrap-enabled quantification of KRAS-induced peptide hydroxylation in blood for cancer early detection

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Nano Research 2019年第6期12卷 1445-1452页

作者： Zaian Deng Zhen Zhao Bo Ning jeffery Basilio Karen Mann Jie Fu Yajun Gu Yuanqing Ye Xifeng Wu Jia Fan Paul Chiao Tony Hu College of Health Science and Environmental Engineering Shenzhen Technology UniversityShenzhen 518118 China School of Biological and Health Systems Engineering Virginia G. Piper Biodesign Center for Personalized DiagnosticsThe Biodesign InstituteArizona State UniversityTempeArizona 85287USA Department of Nanomedicine Houston Methodist Research InstituteHoustonTexas 77030USA Pathology and Laboratory Medicine Weill Cornell Medical CollegeNew York New York 10065USA Center for Molecular Design and Biomimetics The Biodesign InstituteArizona State UniversityTempeArizona 85287USA Department of Laboratory Medicine Clinical CenterNational Institutes of HealthBethesdaMaryland 20892USA Department of Molecular Oncology H. Lee Moffitt Cancer CenterTampaFlorida 33612USA Department of Molecular and Cellular Oncology The University of Texas MD Anderson Cancer CenterHoustonTexas 77030USA School of Medical Laboratory Tianjin Medical UniversityTianjin 300203China Department of Epidemiology The University of Texas MD Anderson Cancer CenterHoustonTexas 77030USA

Circulating peptide is a potential source of biomarkers for cancer ***,the existence of large molecular weight proteins in plasma have a disastrous effect on circulating peptides isolating and ***,nanotrap fractionation following by mass spectrometry have been applied to quantify the levels of bradykinin (BK) and hydroxylated bradykinin (Hyp-BK) as a relative measure of KRAS-regulated prolyl-4-hydroxylase alpha-1 (P4HA1) which may serve as early diagnosis marker for pancreatic ductal adenocarcinoma (PDAC).We found that P4HA1 can be upregulated by KRASG12v,which is a PDAC driver mutation,using HPNE/KRAS and HPNE *** we revealed that P4HA1 is overexpressed in PDAC tumors,compared to normal and inflamed pancreatic *** interference revealed that P4HA1 activity was primarily responsible for Hyp-BK *** spectrometry analysis revealed that plasma Hyp-BK/BK ratio was higher in PDAC than pancreatitis patients and healthy controls,while the area under the receiver operating characteristic (ROC) curve (AUC) is 0.8209 (95%Cl,0.7269-0.9149).The Hyp-BK/BK association with PDAC was reproduced in another cohort,where this ratio was found to increase with advancing tumor *** novel findings paved the way for wider applications of Nanotrap coupled mass spectrometry as a powerful tool for revealing biosignatures from plasma.

关键词： nanotrap hydroxylation level bradykinin pancreatic ductal adenocarcinoma

Advanced breast cancer metastasized in the brain: treatment standards and innovations

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Journal of Cancer Metastasis and Treatment 2023年第1期9卷 170-184页

作者： Elizabeth Klaas Eric Sung Esaan Azizi Melanie Martinez Arnav Barpujari.jeffery Roberts Brandon Lucke-Wold Department of Neurosurgery University of FloridaGainesvilleFL 32610USA

Breast cancer continues to be a difficult disease to treat due to high rates of *** to the brain presents a unique and often overlooked *** this focused review,we discuss the epidemiology of breast cancer and which types frequently metastasize to the *** treatment approaches are highlighted with supporting scientific *** role of the blood-brain barrier and how it may become altered with metastasis is *** then highlight new innovations for Her2-positive and triple-negative breast ***,recent directions for luminal breast cancer are *** review serves to enhance understanding of pathophysiology,spark continued innovation,and provide a user-friendly resource through tables and easy-to-process figures.

关键词： Breast cancer innovation blood-brain barrier luminal metastasis new directions

Minimizing variability:Standardized approach to retroperitoneal single-port robot-assisted ureteral reconstruction

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UroPrecision 2024年第3期2卷 82-93页

作者： Aleksandra Walasek jeffery Lin Lee Zhao Department of Urology Massachusetts General HospitalBostonMassachusettsUSA Department of Urology New York UniversityNew YorkNew YorkUSA

Evidence suggests that robot-assisted ureteroplasty is a safe and feasible management option of ureteral *** retroperitoneal approach to ureteral reconstruction using single-port(SP)robot can be beneficial in challenging cases of patients with prior history of abdominopelvic surgery or ***,we present a standardized approach to retroperitoneal SP robot-assisted ureteral reconstruction,highlighting the advantages of this technique in selected clinical scenarios.

关键词： clinical outcome robotic surgery robotic ureteroplasty retroperitoneal ureteral reconstruction single-port(SP)robot

维普期刊数据库

A Study in the Variation of G

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Journal of High Energy Physics, Gravitation and Cosmology 2022年第3期8卷 558-578页

作者： Armando Vega-Colon jeffery A. Secrest Department of Physics and Astronomy Armstrong Campus Georgia Southern University Savannah USA

There are indications that the Newtonian gravitational constant may not be a constant but may vary with respect to some other physical parameter. Various possible characterizations of Newton’s gravitational parameter as a function of the cosmic scale parameter are proposed and studied within the framework of classical Newtonian cosmology. A number of toy cosmologies with varying Newtonian gravitational parameters are developed and analyzed. The numerical solutions to the temporal evolution of the universe from the Friedmann equation are examined and discussed as well as kinematic observables. Finally, other avenues of research are addressed.

关键词： Newton’s Gravitation Constant Cosmology Fundamental Constants